things that caught our eye this week

Most Complete Human Genome Yet Genetic knowledge is so important, helping in everything from the effectiveness of drugs to predicting inherited diseases. So we welcome this nice little incremental step reported in Nature Briefings.

An international consortium has sequenced the most complete version of the human genome ever, more than 20 years after researchers published the first draft. Around 200 million more bases now fill gaps — including the protective end-caps of chromosomes, known as telomeres, and central dense knobs called centromeres that help to orchestrate replication. The group announced on Twitter that they have sequenced another previously missing section — the Y chromosome. It “really gives us some insight into regions of the genome that have been invisible”, says genomicist Deanna Church.Science | 9 min read
Reference: Science papers

An apple a day? The scary threat of antibiotic-resistant organisms just won’t go away. There is evidence that the way we process and store fruit, even the humble apple, may be driving the new evolution of superbugs. Here’s Joe Davies for the Mail:

https://www.dailymail.co.uk/health/article-10672025/Fungicides-used-apples-fresh-driving-drug-resistant-strains-deadly-bug.html

Cutting construction carbon There’s little doubt that the building industry is a big source of carbon emissions. They are well aware of this, but point out that you can’t exactly stop building new things! Maybe this Swedish idea will show a way to solve this tricky problem

The only credit we could find for this was Microsoft News-so thanks to the so far anonymous author!

https://www.msn.com/en-gb/money/technology/sweden-s-innovative-wooden-skyscraper-captures-as-much-carbon-as-10-000-forests/ar-AAVAvd3?ocid=m

And remember-all the advances we have alluded to above come from one simple thought process. You accept facts, however difficult they may be. You put them together using logic, and see if it works. If it doesn’t you like for more facts, or try a new logic.

The stupid, such as conspiracy theorists, never explain facts. They just explain them away. Instead of logic they just have huge rambling arabesques of special pleading. They achieve nothing and can lead to nothing positive. See you next week.

#carbon emissions #antibiotics #dna #genome

2022 marks one hundred years since the publication of TS Eliot‘s famous poem The Waste Land. To celebrate this auspicious landmark, we at LSS are going to offer our own contribution-means of interpretation, you might say- to the celebrations of this remarkable work of literature. Cocktails. Many indeed will be the Modernists, post modernists, Marxists, structuralists, feminists and all sorts of other -ists who will have their say . But tonight, as you gather for readings with family, friends or those in the public bar, you will have your own special LSS method of literary criticism to offer. All you do is to take a few lines from the poem, and find a refreshing mix to match. Simple. So let’s get started

April is the cruellest month, breeding/lilacs out of the dead land mixing.…

Stop there! All a bit cold and austere-so what better way to capture mixing that than a classic Dry Martini? Here’s a good old 10:1 mix from Diffords ,that’s shaken, not stirred. A couple of these and you’ll be muttering Bin gar keine Russin, whatever that means!

https://www.diffordsguide.com/cocktails/recipe/4976/dry-martini-101-ratio-preferred-shaken

And talking of lilacs why not try a Moonlight cocktail? A delicious mix based around dry gin and Cointreau, our researcher chose this especially for the Creme de violette liquer that so subtly captures the tones of Eliot’s first stanza. We thank once again, ladies and gentlemen, the immortal Diffords-what a site!

https://www.diffordsguide.com/cocktails/recipe/2510/moonlight-cocktail-gaz-regans

Winter kept us warm, covering/Earth in forgetful snow, feeding

If it’s winter cocktails you’re after, Mr Eliot, the BBC Good Food guide has a whole list to warm the hearts of any poetry group. Click below for the Winter whisky sour, hot toddy and sloe gin fizz, to name but a few!

https://www.bbcgoodfood.com/recipes/collection/winter-cocktail-recipes

OK, here’s what to do next . Below you will find a link to the whole text, courtesy of The Poetry Society. Why not hack through, pick out a few lines and select an accompanying drink from your favourite menu book? Or even make your own! The Waste Land is long, difficult text. If we at LSS have done our bit to make it more accessible to a wider public, then our work for this week is done indeed.

Shantih, shantih, shantih-which means “cheers and bottoms up” in Sanskrit.

https://www.poetryfoundation.org/poems/47311/the-waste-land?msclkid=dd214c22b1bd11ecb797d1df1ca90d07

When we were persuaded to start this blog (and the Facebook page that proceeded it) it was mainly to promote research into new antibiotics and lend humble aid to charities like antibiotics research uk [1] who were doing so much in this great cause

Since then it’s grown, as we realised all progressive causes are interlinked. But we are still happy to tell you when something good happens in our Original Cause. And something in our newer fields of interest, so to speak. We’ve got one such of each today, and so without further ado, let’s see what they are

Teixobactin synthesised. Long standing readers will recall our reports of promising antibiotic candidates being dug out of the ground. The trouble was to synthesise them on an economic scale. Now, as John Ely reports for the Mail, a British team has worked up an original American discovery into something more applicable. [2] And what an argument this is for transnational cooperation and cross frontier collaboration!

Carbon Capture pays If you want something to work long term, find a way for someone to make money from it. Nature Briefings [3] has an excellent article on how we might start using all that spare carbon dioxide that’s kicking about to make things we can sell back to ourselves. There are some great diagrams and graphics if you click in, but here’s there summary Making stuff from CO2. Thoughtful, full and well-considered.

Many companies are chasing an alluring idea: divert greenhouse gases away from the atmosphere and use them to make products that are both virtuous and profitable. Some are boutique items for the climate-conscious shopper — vodka or diamonds, for example. Most are staples of the global economy: fuels, polymers, other chemicals and building materials. But there are tough questions about whether CO2 recycling genuinely benefits the climate: most of the products made this way will lock the gas away only temporarily.Nature | 15 min read

[1]https://www.antibioticresearch.org.uk/?msclkid=a34d2968b01011eca7fe747f954dc123

[2] https://www.dailymail.co.uk/health/article-10664041/Game-changing-antibiotic-line-defence-against-superbugs-study-suggests.html

[3] briefing@nature.com

#antibiotics #microbial resistance #teixobactin #carbon capture #recycle ##climate change

No, it doesn’t upset the applecart. But the view that Evo-Devo (Evolutionary Developmental Biology) gives us is potentially as exciting as the microscope and the telescope were in the seventeenth century. It is the study of the deep genetic relationships between different organisms, and it has led to some astounding insights in evolution and the way it works . And of course the knowledge gained could help us in all sorts of ways.

Ever since the early nineteenth century, scientists had noticed the remarkable similarities between the embryos of wildly different creatures such as sea squirts and elephants. But the was no molecular or genetic explanation as to why. However, the twentieth century revolution in molecular genetics and it associated technologies have changed all that to reveal some astounding insights:

*The same genes have been conserved for hundreds of millions of years, for the same purposes. For example the Distal-less gene complex is implicated in the structures which let such diverse creatures as flies, fish, chickens and sea urchins to get about. And everything else of course.

* So the main structural genes seem to evolve little and slowly. The big changes seem to be in the way they are switched on and off

* This in turn suggests it could be possible to to produce a reliable genetic portrait of the last common ancestor of all animals and the way it moved. Could this have been in the late Pre-Cambrian Ediacaran fauna?

*Is it possible that, at least early on, environmental influences were being “picked up” and conserved by the epigenetic systems around the core genomes? Well bless my Lamarckian socks if that one’s true!

This article in Wikipedia is a great starting point , but there’s plenty more out there if you want to give it a try. Go on-thinking about things in new ways will keep you young!

https://en.wikipedia.org/wiki/Evolutionary_developmental_biology#:~:text=Evolutionary%20developmental%20biology%20%28informally%2C%20evo-devo%29%20is%20a%20field,between

#evolutionary developmental biology #precambrian #ediacaran #repressor #dna #rna #genes #epigenetics

things we noticed this week

Best writing There are different styles of writing, but we have always liked the terse reality prose which started in journalism, but was made literature by authors like Hammet and Hemmingway. Here is a marvellous example by Elliott Ackerman for The Atlantic

https://www.theatlantic.com/ideas/archive/2022/03/american-volunteer-foreign-fighters-ukraine-russia-war/627604/

_{we thank Mr Peter Seymour of Hertfordshire for this example}

Don’t take your eye off global warming There may be a war on, as they say but our other existential problems haven’t gone away. Hence this rather bleak assessment of the future of the great barrier reef. Great Bleaching Event… from Nature Briefings

The Great Barrier Reef is experiencing its fourth mass bleaching event in the past six years. The Great Barrier Reef Marine Park Authority (GBRMPA) confirmed the event following aerial surveys that showed widespread bleaching across a representative sample of 750 reefs, despite the cooling effect of the La Niña weather system. “It is important to note that bleached coral is stressed but still alive,” said the GBRMPA in a statement. “If conditions moderate, bleached corals can recover from this stress, as was the case in 2020.” Scientists have urged the United Nations cultural organization UNESCO to declare the reef ‘in danger’ to raise awareness that it is “nearing its tipping point, beyond which the reef will lose its function as a viable ecosystem”.The Guardian | 6 min read & The Conversation | 6 min read

Development versus Biodiversity Whenever developers smash up another piece of green land they nowadays make dubious claims about how it benefits things like biodiversity and sustainability. We have always wondered how concrete can possibly capture more carbon than trees do. As this article for the Conversation by three biologists with rather long names makes clear

https://theconversation.com/biodiversity-why-new-rules-to-ensure-nature-benefits-from-building-projects-could-fail-179701?u

Batman returns-sort of The diversity and abilities of bats has always been a source of wonder, and in the UK the few remaining examples are rightly protected. But as our Australian Correspondent Mr Gary Herbert has found, you can sometimes have too much of a good thing AP for the Guardian

https://amp.theguardian.com/world/2016/jun/11/it-smells-so-bad-you-can-taste-it-bats-plague-australian-tourist-town

Robot Appeal We at LSS have longed for the day when robots can take away a lot of the drudgery in things like cleaning, cooking and ironing (we will defend gardening to the death however!)The problem has always been to make the pesky things clever enough and skilled enough to do microtasks. So this one about them peeling bananas,from the Mail by Shivali Best, offers real hope:

https://amp.theguardian.com/world/2016/jun/11/it-smells-so-bad-you-can-taste-it-bats-plague-australian-tourist-town

sorry about lack of cocktails this week-the robot broke down!

#robot #AI #global warming #climate change #bats #australia #development #ukraine

Sergiy Stakhovsky could have had it all. A fine tennis player (he once beat Federer at Wimbledon) a good income, wife, kids and lots of international connections. But Stakhovsky is Ukrainian. So when Mad Vlad Putin sent his forces smashing into Ukraine (note his forces- little Vlad didn’t go himself, it’s too dangerous) Stakhovsky had a choice. Continue with his comfortable lifestyle or go back to fight. Carefully sending his family to safety, he then went back to Ukraine, where he now carries a gun in the front line. That, gentle readers, is what we call courage. Principle. And moral imagination. All the qualities lacking in the Russian top echelons, who watch as their leader leads their great country to destruction. You can read about Sergiy Stakhovsky in our link to a piece from the Mail [1] But a lot of outlets are carrying his story.

But, you say, the media in the free world can thunder all they like, but it won’t make a blind bit of difference in Russia. Ol’Pooters has an iron grip on the media and all independent outlets have been closed down, the staff murdered or sent to slave labour camps. True, but there are still ways that ordinary Russians can find out the truth about what is being done in their name.

Radio Free Europe/Radio Liberty not only carries a wealth of stories on Russia and other countries but also has a full guide to how you can bypass blocking [2] By careful use of VPNs and other devices, you can still get round Putin’s secret police and have the chance to make your own mind up about things.

BBC World Service Throughout the dark days of the Second World War people in occupied lands depended on the clear and objective voice of the BBC to sustain their belief in freedom. Nothing has changed. Now the BBC is to get more money, as this article from the Guardian shows. Again there is a handy guide to VPN ways of dodging the censors and getting to the truth.

Ukraine is fighting for all the values we believe in. Freedom of information and judgement. Reason. Learning. Honesty. Please support them in any way you can.

[1] https://www.msn.com/en-gb/news/other/ukrainian-tennis-star-speaks-out-as-he-leaves-family-behind-for-war/ar-AAVbvmp?ocid=BingNewsSearch

[2] https://www.rferl.org/a/russia-censorship-vpn-reporting/31737775.html

[3] https://www.theguardian.com/media/2022/mar/23/bbc-world-service-to-get-extra-41m-to-support-ukrainian-and-russian-services?

#sergiy stakhovsky #roger federer #resistance #radio liberty #vpn #bbc world service #ukraine #russia #putin #war in Ukraine

We got so many hits yesterday with our “World Government” musings that we decided to throw you some more. And written by better people. So here’s some thoughts from Margaret McMillan in the Guardian [1] and Wikipedia [2], always a standby in dark times.

It’s not that we are starry-eyed converts to the idea. We see the problems with it, and we will certainly come back to them in later posts. These texts are jumping off points and we hope you will read beyond them.

So far the nation state has served us well-there’s no denying that. Yet there are so many problems which a world government would solve so much better. From technological problems like global warming and new medicines to economic ones like chronic inequality. And medical ones, such as the case of Mr Putin. And one other thing. Many current nations grew by the fusion of what were once proud independent polities. France from the Fusion of Normandy, Anjou, Provence, Burgundy and the others. China was a set of autonomous states in the Spring and Autumn phase and then in the time of the warring Kingdoms. Yet no one would deny now it is China-and has done much better as a result.

There is so very much to think of-how a world Government could be achieved and sustained requires immense thought. But if the old model is as broken as it now seems, we should at least be casting around for alternatives.

[1] https://www.theguardian.com/books/2021/nov/22/the-big-idea-is-world-government-possible?msclkid=bd9cc2b8a9cb11ec94837619fdb345a2

be advised: even Wikipedia admit this has multiple issues

[2]https://en.wikipedia.org/wiki/World_government#:~:text=World%20government%20or%20globa

#world government #nation state #china #russia #ukraine #global warming #antibiotic resistance #france

The last part in out little series on the consequences of this war

According to Tim Marshall [1] and many others, the real cause of this war is Geography. Russia can never be secure while it is surrounded by wide flat plains over which invading armies can cross with ease. And so it must push out to create buffer zones in places like Poland or the Baltic States, to ensure that a Grand Armee or Wermacht can never threaten it again. And so in turn those neighbouring lands queue up to join NATO, the EU or anything else that will save them from subjugation to the Kremlin. Russia must always try to dominate, and its neighbours to resist, until the end of time.

Nothing kills so effectively as lines drawn on maps. A glance at the origins of the First and Second World Wars will reveal their deadly presence on places like Danzig or Belgium. Millions died so some cartographer could re draw them.

Russia could never invade the Baltic States if a World Government had an army to stop them. But why should they? Northumbria no longer wars with Mercia, firstly because the UK Government stops them. Secondly because both are in a larger polity-England. And so it is with France and Germany, because both are now in the EU. And this thought is true in most places in the world. Is there an armed frontier between Victoria and New South Wales? Yet there is between the two Koreas. Compare these two observations alone and you understand much about the problem.

So far the Nation State represents the highest and best form of human organisation. It is able to command great loyalty. Yet in a world with nuclear weapons these advantages may soon become impossible to sustain. Many things which were once good in their day outlive their usefulness. Videos. Horses and carts. Stone Tools. 45rpm records. Castles. Sailing ships. Burning witches. Might it be time now for the nation state to give way to a world government which would make people like Putin irrelevant? What form such a government might take, and how it shall be achieved will require much thinking. We shall certainly return to it.[1]

[1] https://www.standard.co.uk/culture/books/prisoners-of-geography-ten-maps-that-tell-you-everything-you-need-to-know-about-global-politics-by-tim-marshall-review-a2488801.html?m

[2] https://www.newstatesman.com/international-politics/geopolitics/2022/03/why-russia-is-a-prisoner-of-geography

#ukraine #russia #poland #baltic states #putin #ukraine #geography

things that caught our eye in the last seven days

This war started in 1998 According to Allan Little, who was there, the roots of our present troubles lie in the botched attempts to modernise Russia in the 1990s. They failed: the economy collapsed, Putin came to power and the death certificates of thousands of innocents were effectively signed.

https://www.bbc.co.uk/news/world-europe-60767454?at_campaign=KARANGA&at_medium=RSS&msclkid=e5e2c27da76311ec8eb840d1afd07bd9

Can Kitty go veggie? Probably not according to Pete Wedderburn of The Guardian. Your cat is an obligate carnivore, like many other creatures in the natural world. But read the article and judge for yourself.

https://www.theguardian.com/commentisfree/2022/mar/18/dog-vegan-cats-killers-plant-based-diet-pets-food?msclkid=e4e11d70a76411ec83e534344e79

Solar Power Stations in Space? Science Fiction writers from Isaac Asimov onwards have toyed with the idea of giant solar arrays in orbit beaming free energy down to earth. Jovana Radulovic of the Conversation explains how that possibility just got one step nearer:

https://theconversation.com/a-solar-power-station-in-space-heres-how-it-would-work-and-the-benefits-it-could-bring-179344?utm_medium=email&utm_ca

More shells in the Seychelles For us, turtles and kin have always been one of the true wonders of the ocean. But human ignorance and greed have driven them almost to extinction. So we liked this heart-warming success from the beautiful Seychelle islands of the Indian Ocean. (For the record it’s joint effort between our regular chums Nature Briefings and the Conversation)

To make soup for European tables, green turtles (Chelonia mydas) in Seychelles were once hunted almost to extinction. Now the species is thriving, thanks to the protection of Aldabra Atoll, a favourite turtle nesting ground, in 1968. Three researchers who took on the task of analysing decades of data about nesting females, tracked by the huge tractor-like trails they leave in the sand, describe how the conservation success was achieved.The Conversation | 5 min read

Help Ukraine here We haven’t always seen eye to eye with the Daily Mail. But financially speaking, it’s a completely honest organisation, which is why we chose them for our donation to Ukraine. Whatever your background politically please could you consider their donation page foryour contribution? The money is still desperately needed.

https://www.dailymail.co.uk/news/article-10580683/Heres-help-Donate-Mail-Force-Ukraine-Appeal.html?msclkid=6fafd764a76711ec94822a0c6b3ed6b8

#russia #yeltsin #putin #tyranny #solar power #cat #diet #turtles #seychelles #ukraine

The days are growing longer and the long dark nights of winter are becoming a memory. Sometimes a sheltered sunny spot can feel almost warm , and you can pause to watch the daffodils at their March peak of splendour. What better way to celebrate than a specially designed spring cocktail? This week we’ve got ten for you, all from the BBC Good Food website.

You could choose a positively primaveral Pink Lady. Or mix a refreshing Rhubarb Gin. Or what about a frisky White Rabbit? Click below and try for yourself.

^{The BBC Good Food website is a treasure trove of recipes and mixes, and as such an important contribution to our civilisation. When you’ve clicked on cocktails, why not explore this amazing site further-perhaps to see a nice recipe for that Easter Sunday lunch?}

https://www.bbcgoodfood.com/recipes/collection/spring-cocktail-recipes?msclkid=c2377d71a6e411ecbf967e915064ddb9

#spring #cocktails #bbc