Streptococcus crisis: it’s about more than antibiotics

Whenever we see images of hungry, starving children (and they’re all over the news right now), our first reaction is “what a waste of human capital!” Somewhere in that crowd is a future Einstein, Marie Curie, or JS Bach. Whose potential will never be available to the rest of us. Their life has been ruined by the starvation and violence all around them. Contrary to the assertions of certain right-wing news outlets, the effects of poverty are well documented.[1] They show up in things like learning, fine motor control, growth, social skills, and health. Which brings us back to yesterday’s blog, and a reader’s response to it.

In the blog (LSS 5 Dec 22),we stated that the streptococcus A crisis in the UK was yet another reason to speed development of new antibiotics. But as regular reader Gaynor Lynch pointed out, this is essentially a reactive response to the crisis. It ignored the causal factors. In particular, Gaynor stated

Prevention is much better than cure“…..adding that  “good nutrition is essential to support the immune system.”

And how right she was we found when we did a little digging. There seems to be a clear and unequivocal link between childhood deprivation and sub-development of the immune system. The literature is rather vast, but this link to the HuffPost gives a good, journalistic level jumping off point [2] For those who like their details detailed, we include a review study from Plos One, but be warned-it’ll take more than one cup of strong black coffee to get through this one.

You can read all of Gaynor’s thoughts in the comments section to yesterday’s blog. But we couldn’t help thinking: it’s going to take years and lots of money to develop a new generation of antibiotics. In the meantime, how about a little spend on food for hungry children? It could be a long-term investment.

[1] https://www.childfund.org.au/stories/how-does-poverty-impact-child-development/

[2] https://www.huffpost.com/entry/4-ways-that-poor-childhood-nourishment-can-affect-lifelong-health_n_587d0102e4b09281d0ebcc52

[3] https://www.bing.com/search?q=effects+poor+nutrition+children+immune+system&qs=n&form=QBRE&sp=-1&pq=effects+poor+nutrition+children+immune+system&sc=

#childood health #antibiotics #poverty #deprivation #preventive medicine

Streptococcus outbreak shows antibiotics are more important than ever

We don’t know about you, gentle readers of foreign lands, but here in the UK we’re witnessing an uptick in Streptococcus A infections. And this is worrying. It’s already killed six children and has hospitalised more. Why? Who? Where What? and all those other questions they try to teach you on management training courses. Michelle Roberts has a good go at answering these for the BBC [1]. But since her article, it’s got worse, and the Prime Minister is now involved as Kevin Rawlinson explains in the Guardian.

There are two things that worry us a little. Firstly, although this bacterium is normally benign, it can cause some truly terrifying cases, as you’ll see if you click on our links. We note particularly the iGAS syndrome, which is what happens when it gets behind your immune defences.

But what concerns us most of all here is the following sentence. which we confess to have lifted lock, stock and barrel from Michelle’s article

“……..strep A is treated with antibiotics”

Except when it isn’t. Because as well-established readers of this little blog will know, there won’t be any antibiotics soon, unless we really and truly pull our fingers out. And anyway, what if a new antibiotic resistant form evolves? The rate at which humanity is squandering its current antibiotic reserves suggests that day will be sooner rather and later. So how many children will die then?

[1] https://www.bbc.co.uk/news/health-63836093

[2] https://www.theguardian.com/society/2022/dec/05/higher-levels-of-strep-a-in-uk-could-be-due-to-covid-pandemic-says-health-chief

#Streptococcocus #antibiotic resistance #health

Weekly round up: Addictions, T.Rex, Quantum Computers, religion, China Crisis and an Irish song

these caught our eye

This is a big one Quantum computing is so very new and so very powerful (confession: and difficult to understand) that we assumed no one could do anything useful with it for years. Wrong, wrong and wrong again as this story from Nature Briefings explains. This will change the world, sooner than we know. Wormhole inside a quantum computer

Physicists have sent quantum information through a simulated wormhole in a ‘toy’ universe that exists only inside a quantum computer. The tunnel is analogous to passages through space-time that might connect the centres of black holes in the real Universe. “The surprise is not that the message made it across in some form, but that it made it across unscrambled,” write the authors of an analysis published alongside the study in Nature. Some scientists think that such experiments could help to unite the theories of quantum mechanics and gravity in the simplified realm of toy universes, leading ultimately to the answer to one of the biggest problems in physics: a real-world quantum theory of gravity.Nature | 5 min read
Go deeper with an expert analysis by theoretical physicists Adam Brown and Leonard Susskind in the Nature News & Views article (7 min read, Nature paywall)

Reference: Nature paper

Online Addictions Someone once told us of a casino in Las Vegas where, if you won too much, they sent the heavies round to your room and took the money back by force. How true this story is we’ll never know. But the gambling industry will certainly go to great lengths to part people from their money, as this story from Bloomberg shows. What will they do with quantum computing when it finally arrives on your smartphone?

https://www.bloomberg.com/graphics/2022-gambling-addiction-stories-how-uk-got-hooked-on-online-casino-betting/?leadSource=uverify%20wall

thanks to P Seymour for this story

Losing my Religion Is the UK becoming a secular society? The decline in adherence to the Christian Religion shown by these figures would seem to indicate so. It seems to be a trend across many societies. But fans of religion should not despair. The prosperous centuries from up to about 200AD saw a decline in faith in the old Gods like Jupiter and so on. But this was followed by an enormous revival, first in Christianity then Islaam. The names of the Gods change, faith in them does not.

https://www.bbc.co.uk/news/uk-63792408

thanks to P Semour for this story

Can’t do right for doing wrong We at LSS tend to think that Mr Xi was trying to do his best to protect his people from COVID-19. Albeit in a way different to western countries. But even his best efforts have reached an impasse. If he stays in lockdown, the economy tanks and the people get restless. If he opens up, the virus (and many others) will spread like wildfire. Tricky balancing act needed as this one from The Conversation shows:

Touchy Feely Tyrannosaurs Did Hitler like dogs? Dis Jack the ripper buy flowers for his mum? Now there’s news that Tyrannosaurus rex, the world’s most fearsome dinosaur, may have been a big softie at heart. Wekll, perhaps as this story from The Guardian makes clear

https://www.theguardian.com/science/2022/nov/29/another-slice-of-triceratops-barbara-did-the-fearsome-t-rexes-take-care-of-their-sick

Irish Spirit The Irish never gave up their culture and independent spirit despite centuries of foreign oppression. It’s produced a great feisty culture, especially in literature and music. To end this week, we’ve chosen one of our old favourites, where the Pogues and the Dubliners combined in an incredibly spirited rendition of The Irish Rover

#quantum computing #wormholes #gambling #addiction #religion #dinosaur #tyrannosaurus rex #china #covid-19 #dubliners #pogues

You will be a minority one day

One thing about evolution-it keeps happening. However inconvenient that may seem to some who lead comfortable lives. Up to know, LSS has tended to emphasise what happened in the past. Slime moulds, Dinosaurs, Fox News viewers, that sort of thing. But what will our evolution look like in the future? Anders Sandberg, writing in the Conversation offers some fascinating clues. [1]

He thinks our future belongs to cyborgs- human machine hybrids, running on AI computer implants. With physical and mental powers far beyond those of Homo sapiens. While the planet itself can be returned to the wild, its devastated ecological and meteorological systems painfully rebuilt. And maybe even some of the mess cleared up, we pray?

And what of actual flesh and blood humans? Chances are that a few may survive as “holdouts”, a bit like the Amish or other groups on reservations, preserved by the tolerance of the more advanced societies around them. True minorities. And maybe that’s no bad thing. Maybe we should all learn a little humility right now.

#evolution #AI #robotics #cyborg #terminator #replicant

Is hydrogen the way to green aviation?

Poor old aviation! it’s had a bit of a kicking from all those groups who want to save the planet, and rightly so. According to the World Wide Fund for Nature[1] the number of passengers globally is expected to go from 2.4 billion (2010) to 8.3 billion by 2030. That’s an enormous rise in CO2, plus all the other pollutants caused by jet aircraft, such as nitrates, particulates and of course all that noise! Do you really need to make that business trip to Frankfurt in the age of zoom and what’s app? Or a boozy week in Benidorm? We understand why people ask these questions. But we fear that cutting back on mass travel runs a severe danger of throwing out the baby with the bathwater.

We at LSS have sometimes been accused of putting the cart before the horse. It has even been alleged that we have been guilty of crossing bridges before we come to them. But we would never, under any circumstances run the risk of throwing out the baby with the bathwater. Especially on questions of aviation. For it is our settled belief that there is nothing so conducive to breaking down the barriers between peoples as mass cheap travel. Take it away, and the masses will sink into isolated, mutually hostile groups, except now they have nuclear weapons.

Alternatives are needed. We have already noted the possibilities offered by airships (LSS 26 5 21), and we also offer a quick guide here to solar powered flight [2]. Now it’s just possible that a third way exists: hydrogen fuel. Which, as every schoolchild knows, burns clean and green to leave nothing more than water. Jasper Jolly has a piece in the Guardian which describes the efforts of Rolls Royce to power aeroengines with hydrogen fuel. [3] The answer? Well, at the moment it only seems to work for turbo prop engines (the type you get on short haul domestic routes) Yet a start has been made, and by one of the best engineering companies in the world. Maybe we can still keep that baby intact, even as all the nasty dirty bathwater is thrown out for good. [4]

Declaration of interest: Rolls Royce once gave us a magnificent pair of cufflinks and an attaché folder, both of which we still treasure to this day

[1]https://www.worldwildlife.org/initiatives/cutting-aviation-pollution

[2] ttps://www.oxfordsaudia.com/en/blog/solar-powered-airplanes-the-history-and-future-of-solar-flights/

[3] https://www.theguardian.com/business/2022/nov/28/rolls-royce-easyjet-test-aero-engine-hydrogen

[4] https://www.rolls-royce.com/innovation/net-zero/decarbonising-complex-critical-systems/hydrogen.aspx

#aviation #hydrogen #short haul #rolls royce #global warming #climate change

Weekly Round Up: Money, Racism, health, and a dance

stories that intrigued this week

Lost Coin? The Crisis of the Third Century AD was one of the inflection points of world history. War, invasion, currency collapse, pandemic…these fifty-odd years were when the world moved decisively from the humanistic Classical to the religious Middle Ages. Whether the ephemeral Emperor Sporian existed or not, his story sheds light on a terrible period. Here’s the detective work which may have uncovered him:

https://theconversation.com/how-we-used-ancient-coins-to-show-a-fake-roman-emperor-was-real-195272?utm_mediu

Lost Money? We don’t know about cryptocurrencies at the moment, but investors at the conservative end of the financial market also have their woes. Glorifi Bank was started to address the concerns of depositors who were concerned that the banks of Wall Street were becoming too woke, liberal and lefty (surely some mistake?-ed). How this noble aim panned out is summarised rather aptly here:

https://www.huffingtonpost.co.uk/entry/anti-woke-bank-closes-3-months-peter-thiel-toby-neugebauer_n_638006b4e4b06ef4a542ab6d?ncid=A

thanks to P Seymour for this story

Bones and bias Science is supposed to be objective, free of bias and equal to all. That’s the idea, anyway. However, it isn’t long before someone starts presenting their interpretations as incontrovertible truth, with all the social implications that flow from it. Today we present how this happened in Paleoanthropology. But it wasn’t the first place, nor will it be the last.

In Bones and Bodies, forensic anthropologist Alan Morris takes us on a journey to the past, revealing racist interpretations of historically important fossils and artefacts related to the origin of humanity. “The tour is fascinating, demoralizing and insightful,” writes reviewer Fatimah Jackson, a biological anthropologist. “Combing through more than 100 years of scholarship, Morris lays bare how anthropologists built a ‘scientific’ justification for the low status they afforded peoples of African descent, particularly in South Africa, and how this justification became part of a systematic effort to ensure African peoples’ disenfranchisement.”Nature | 6 min read

Dirty Old River We don’t know about your country, but for the last 12 years the rivers and seas of England have slowly transformed into open sewers, filled with toxins and detritus. And it has become a lot worse since the lifting of EU protections after 2020. That admirable organisation Surfers against Sewage is fighting a lonely battle for so many-anglers, boaters, swimmers and anyone who might think that not getting typhoid is part of a quality life. Today we link to their latest report. But surely even readers of The Sun can grasp that clean water is good for the tourism industry?

ttps://sas.org.uk/waterquality2022

The virus wakes As if Russia hadn’t caused enough trouble, news of a dormant virus waking from the melting tundra is the stuff of science fiction

https://www.dailymail.co.uk/sciencetech/article-11461367/Ancient-virus-lain-frozen-Siberian-permafrost-48-

A Little Dance Number The old art deco films of the 1930’s breathed and elegance and charm uncatchable in the uncouth, disco ordinated gyrations observed in modern “clubs” and other places of entertainment. To show you how it was done, here’s Fred and Ginger at their best from Swing Time (1936) It’s worth a lot, lot more than 50 cents.

#romans #sewage #bank #pandemic #dance

Friday Night Cocktails: England v USA

Well, the talking and the build-up are nearly over. In less than two hours from writing this, the teams will walk out and we will see how special the Special Relationship really is. (Most Americans have never heard of it). So-how does a cocktail column cope with such an important clash of the nations? By recourse to that first-rate website Tasteatlas, of course. They have provided us with handy lists of the ten most popular English Cocktails, and the ten most popular American ones. What is more, every entry has a picture, a brief history and handy instructions on how to make one.

If you’re watching the match in England, they recommend that you mix up from one of the following: Corpse Reviver, Pink Gin, Tom Collins, Black Velvet, Boilermaker, Bramble, Vesper, Espresso Martini, Gimlet and the Black and Tan. [1]

But if you tune in from the USA, you could try: Zombie, Screwdriver, Moscow Mule, Mai Tai, Sex On the Beach, Cosmopolitan, Tequila Sunrise, Piña Colada, Old-Fashioned, and Bloody Mary [2]

Whatever you choose, we wish football fans everywhere an enjoyable evening (afternoon in the United States) and may the best team win, as they say in the true sporting spirit.

But before we go, a brief note on terminology. The word “football” means just that-football. The clue’s in the name. You use your feet. There is a trend in some parts of America to use the word “soccer”. We’ve never heard it used, and we doubt that anyone in the rest of the world has either. Meanwhile Americans use the word to describe a curious “sport” which would be better termed “Rugby with hats”. Why anyone would wear a hat to play rugby is beyond our powers of explanation. It’s like that other game we saw one night in Santa Barbara-Cricket with no stumps.

The things some people do!

[1]https://www.tasteatlas.com/most-popular-cocktails-in-england

[2] https://www.tasteatlas.com/most-popular-cocktails-in-usa

#world cup #football #cocktails #england #usa

Antibiotics: Afraid it’s still not getting better

Sorry readers, but the old problem of microbial resistance to antibiotics just isn’t going away. As it’s popped up four times in the news this week, we’d thought we’d give you a summary outside of the bounds of our weekly roundup, and suggest at least one thing you could do to help.

Sky News got the ball rolling with this piece on Monday. [1] OK, it’s UK-centric, but the same deadly pattern applies everywhere. dear readers. The stone in the shoe is simple: the bad news is up, again. If you want some base line figures to convince people in the pub/school/supermarket, this is a good jumping-off place.

The squandering of antibiotics in lazy farming practices would be bad enough. But now the antibiotics from farms are leaking into the water table, massively increasing the chances of resistance appearing in nature. This piece by Adam Vaughn for the Times looks at studies in rivers in Britain. But once again the chances are it could be a river near you. [2]

Asking people to do it less has been a preoccupation of religious fundamentalists, educationalists, malthusians and party hosts for centuries. We never dreamed that we, as a kind of sciencey, rationalist style blog would join them. But what if they don’t do it less? Once answer is to hand out massive morning after doses of antibiotics. With the grim potential consequences which Nature Briefings makes clear: Concern over Preventive Antibiotics for STIs

A health department in the United States has become one of the first to recommend that people who are at high risk of getting a sexually transmitted infection (STI) take a preventive dose of antibiotics after unprotected sex. Clinical trials have shown the strategy can reduce infections such as chlamydia, syphilis and gonorrhoea. But some researchers worry it will contribute to antibiotic resistance. Researchers say guidelines about use are important for informing people about the safety of a strategy they might already be using. “People should have access to this tool, if it makes sense for them and their lifestyle,” says sexual-health physician Jenell Stewart.Nature | 6 min read

The reason we bang on about all this is made clear by a second piece from Nature Briefings Bacterial Infections the Second Biggest Killer Globally. That’ s even more than Vladimir Putin‘s wildest dreams! Well, the headline says it all, but just in case, here’s the text. And plenty of references for you to click on in your coffee break.

Bacterial infections were associated with close to 8 million deaths in 2019, making them the second biggest killer globally after coronary heart disease. Death rates differed widely by region, from 230 deaths per 100,000 people in sub-Saharan Africa to 52 deaths per 100,000 across western Europe, North America and Australasia. “These new data for the first time reveal the full extent of the global public health challenge posed by bacterial infections,” says study co-author Christopher Murray.AFP | 3 min read
Reference: The Lancet paper

Well, some decent people are refusing to let all this go. In the UK we have a charity called Antibiotics research UK who try to fund new research raise awareness and try to do all the things they can to stem the tide. But they’re small, and they need money. They have lots of international connections, so if anyone can donate, you’re helping your own country too. Go on, have a bang on this one, mate, [3] to paraphrase the actor Ray Winstone. In the long run, it’s a much better bet than a World Cup match.

With thanks to Mr John Read of Henley-on-Thames for the first two parts to this story

[1] https://news.sky.com/story/antibiotic-resistance-not-a-problem-we-can-ignore-as-even-new-medications-fail-to-tackle-infections-12752398

[2] https://www.thetimes.co.uk/article/antibiotic-resistant-bacteria-found-in-rivers-near-pig-and-poultry-farms-x38gl3x0n?shareToken=e13a9b2

[3] https://www.antibioticresearch.org.uk/small-research-grants/reports-from-2018/

#antibiotics #microbial resistance #superbugs #vladimir putin #world cup

Health warning: Poverty is bad for your genes

Older readers may recall their parents’ and grandparents’ tales of The Depression. That enormous economic disater between 1929 and 1933, caused by the dodgy dealings of financiers, free market fundamentalists and complicit politicians (shorten this to Republican Party?-ed). Internationally it led to the rise of Hitler and Japanese militarism, and we all know where that led. Domestically, it led to homelessness, unemployment and grinding poverty.

The effects of poverty on things like learning attainment, physical development and general health are well established, But can it actually affect your genetic make-up, your DNA-and thereby say with you for life? Unfortunately, the answer is beginning to look like “Yes”. Nature Briefings has showcased an intriguing study which looked at the genetic material from people born between 1929 and 1939, the key years for the poverty caused by the Depression and its aftermath. We reproduce their lead here as usual, but truly urge you to click on the link they provide and see the main report. It really looks as if the poverty of those years was affecting the epigenetics of its victims-the markers and tags which determine when genes are deployed, when they are switched on and off, and so on,

This of course raises deep questions about individual freedom. What greater effect can someone else have than to change your genes for life? It has implications in the abortion debate currently raging in the USA, as the authors make clear. For us, there is a deeper question: can epigenetic changes be passed to subsequent generations? It’s a big question, and we’ll do no more than point you to the Wikipedia [1] article on the topic. But think of the implications if it’s true.

The Great Depression Shaped Peoples’ DNA

The cells of people who were conceived during the Great Depression show signs of ageing faster than they should. The changes were measured in the cells’ epigenome, the chemical tags attached to DNA that determine how and when genes are expressed. Researchers say that the patterns they have uncovered could be tied to higher rates of disease and death.Nature | 5 min read
Reference: PNAS paper

[1] https://en.wikipedia.org/wiki/Transgenerational_epigenetic_inheritance

#epigentics #dna #poverty #depression #wall street crash

How to find the money to solve all our problems

Close your eyes and think of a warm tropical island. You know the sort…white sands, palm trees and those funny umbrellas made out of bits of old coconut. And full, absolutely full, of money that was earned using the legal, transport and defence systems of countries from which the said money was quickly extracted before any tax could be paid upon it.

According to Tax Justice Network [1] there is between $21 and $32 trillion sitting in offshore tax havens around the world. That’s enough to pay for a decent health service, education system, old age care and a reasonable defence budget or everyone in the world. The amounts squabbled over in day-to-day politics are negligible by comparison. All our problems with climate change adaptation and renewable energy could be solved by taking back just a fraction of that money. Your money, because the chances are that you did much of the work to create it, before it was spirited away.

Where are these tax havens? How did the whole sorry system come about? Before some of you accuse us again of being too Anglocentric, we have to say that the UK and the City of London have been pretty instrumental in bringing all this about. But they are far from being the only culprits, as Philip Inman [3] makes clear. Meanwhile, for those who like their History, Oliver Bullough has a nice little series [2] which, unlike many of the links we post here, invites you to listen, rather than read. So there’s a refreshing change.

Money must flow, jurisdictions must have their sovereignties, we won’t dispute that. But who rightfully owns that money, and who benefits from recondite notions like sovereignty are questions which we would ask you to think about carefully indeed.

[1] https://taxjustice.net/faq/how-much-money-is-in-tax-havens/

[2]https://www.bbc.co.uk/programmes/m0017t8k

[3] https://www.theguardian.com/business/2021/mar/09/uk-overseas-territories-top-list-of-worlds-leading-tax-havens

#tax haven #offshore #shell company

see also LSS 15 12 2021