Quick cocktails for Christmas morning guests

One thing about Christmas morning-it’s going to be busy. Those crucial hours between eleven o’clock and one o’clock when half the street drops in, yet you dare not forget the relatives who are staying, or the steadily building drumbeat of the Christmas Dinner preps, can be frantic. You need to entertain them, you need to shut them all up. Above all you need to do it quickly and painlessly so you can concentrate on higher matters like Yorkshire Puddings and Brandy butter.

As there will be no miracle worker present who will to turn your water in wine, here is our guide to three boozy, plus one virtuous, easy-make cocktails.. Above all they’re simple: Each requires but one or two ingredients: a little ice , the right glasses and a few eco friendly straws, and you become the perfect hostess/host. And just to make it even easier, we have stripped out all those pesky shakers, strainers and other complicated mixing equipment which will only complicate matters and generate further washing up, Our making times assume you have all the ingredients ready to go: a safe assumption, as LSS readers are known for their wise foresight.

Gin Sling (see left above) Put 4-5 ice cubes into a hurricane glass , add one measure of cherry brandy and three of gin. Stir and top up with cold sparkling water .Decorate with one cherry, add 1 straw. Estimated preparation time : 25 seconds

Champagne cocktail (see centre) To a classic champagne flute add 1 brown sugar cube and cover with one measure brandy. Add a tiny dash of angostura, and top up with champagne. Decorate with a cherry and serve. Tip: Have a tissue nearby in case the wine bubbles over Estimated preparation time : 40 seconds

Harvey Wallbanger (see right above) Put plenty of ice in a tall glass and add 1 measure of vodka. and a half measure of Galliano. Top up with fresh orange juice and stir. A slice of orange will decorate, You will need a two straws. Estimated preparation time : one minute

And our Non alcoholic for the drivers: A delicious fruit punch. We are nothing here if not responsible, and know that good people never drive with alcohol in their system. What’s more there’s almost no preparation time with this one, as you can buy/prepare most of the ingredients the day before. All you do is add 750 ml of fresh orange juice, 750 ml cranberry juice, 400 ml of pineapple juice to a large punchbowl. Keep it in the fridge for an hour or two before serving. When ready to go, add lots of ice sparkling water and slices of colourful fruits like oranges. lemons and pineapples. You can adjust the amounts to serve as many or few people as you like. We know it’s tasty, because we have experienced more than one non sober guest ask for their own serving of this stuff, just adding a little gin or vodka to get the right Christmas spirit.

We hope the day goes well.

#christmas day #holidays #parties #cocktails

Our recipes inspired by one of our most treasured possessions: The Ultimate Cocktail Book, published by Paul Hamlyn in 2003, and which we still use today!

Why Taxes are good for you #7: but why you still won’t want to pay them

It’s time to wrap up our counter-intuitive series Why Taxes are good for you. We started it as a slightly cheeky riposte to the massively funded and relentlessly intolerant opposition who insist that taxes must be, always and everywhere, a despicable evil. In the first part we met the industrious but not very knowledgeable Dave Watford who expounded upon the best of their arguments from his post at the bar of the Dog and Duck. We went on to learn the rather chilling truths about life in a low tax nirvana, where their are no laws, roads nor health services and violent death lies around every corner. Part three considered the little known but incredibly well documented story of 18th Century China whose low taxes led it to be conquered by the tax- funded armies of ruthlessly hypocritical western nations. Whatever else they are for, taxes are good for your health as we showed in part 4. We felt that part 5, despite being a historical argument, was crucial. No taxes equals no economy. And if you really do want to get rich, the best chance of doing it is by starting from a well-taxed society, as our part six concluded. We provided lots of links and books and that sort of thing for you to read in order to draw your own conclusions. And so we said ” Quod erat demonstrandum“

Except it wasn’t. Isn’t. And probably never will be. Because we forgot one thing. The benefits of taxes are long term, and require an immediate short term loss. Think how Dave Watford sees it. Money taken from his pocket to pay for armies, nurses, roads is not there now. Indeed, some of those hospitals, schools and museums may not even have been built yet. But Dave feels that loss of money very personally. Money which he could spend here, and now on, any number of Bright Shiny Things. And it is no good telling him “Dave-most of these Bright Shiny Things, that you covet so desperately, will have no value in the long term. Remember how you longed for an Austin Healey, a record by the Bay City Rollers, Watneys Red Barrel, a bottle of Hirondelle, a quadrophonic stereo? All good in their day, no doubt-but are they quite what they were, have not other things come along to take their places?

But Dave knows things that we do not. Has studied authors that we have never heard of. Like Thorstein Veblen who as long ago as 1899 showed that people buy Bright Shiny Things not because those things are useful, but to signal the wealth, status and sophistication of the buyer. To consume conspicuously, ostentatiously, vainly, and emptily. To doom themselves thereby to domination by rich men, and to conquest by foreign ones. Oh well. We tried to warn.

Veblen, T: The Theory of the Leisure Class: An Economic Study in the Evolution of Institutions (1899).

#economics #taxes # finance #history #veblen #consumer society #production #marketing

Psychiatric Disorders: Is this discovery a game-changing moment?

Why can we not do more to address psychiatric disorders? We have always regretted the lack of a robust model which links biological cause to behaviour (LSS 11 5 22;14 9 24 et al) Without this treatment can never achieve the same efficacy as it has for thousands of “physical” disorders such as infectious diseases, cancers or deficiency diseases.

Today It is our earnest hope that all this may be about to change. Read this Hidden links between psychiatric condition from Nature Briefing

DNA data from more than one million people suggests that the genetic risk factors linked to many psychiatric conditions fall into five clusters that cut across current diagnostic boundaries. For example, attention deficit hyperactivity disorder and autism, which are classified as separate conditions, both fall into the neurodevelopmental category. The findings hint that the fact that people tend to be diagnosed with multiple disorders at once is a reflection of shared underlying biology, and could help to create a more biologically based way of understanding psychiatric conditions.

Nature | 5 min read
Reference: Nature paper

If this work can be confirmed and extended, then it offers a tantalising possibility: this particular observable gene cluster is associated with this set of behaviours. And not another set of behaviours, which turn have their own identifiable gene cluster. Simple. Robust. Falsifiable. Empirical. What’s more, the clusters seem to make a curious rule-of-thumb sense. One for neurodevelopmental disorders such as ASD and ADHD. The second for internalising disorders such as anxiety, depression and so on. A third for compulsive ones like OCD and anorexia. A fourth for psychotic ones such as bipolar and schizophrenia And a fifth for substance abuse disorders. Simply put , each cluster may have particular underlying neurological architecture. In which case the underlying mechanism may be discerned; and treatment found.

Now for the caveats. First of all, it’s early days and we need to see how the work holds up against existing diagnostic frameworks. Secondly, only a fool would rule out epigenetic and environmental contributions to psychiatric malfunction. As for the thought of any treatments based on the new findings-well, they have to be decades away if possible at all,.

And yet….to end on a personal note. Nothing is sadder, nothing so moves us as seeing yet another lost soul, another hopeless cry for help, in the face of a victim pf psychiatric disorder. And to know the terrible sufferings imposed upon themselves, their families, carers and the professionals who come up against them, which includes anyone from emergency service workers to housing professionals. And to know that nothing can be done, despite the whole of modern science and learning. But now, just maybe, we have a real game changer on our hands, There is something to pray for this Christmas.

#psychiatric disorders #mental health #medicine #neurology #health #society

New antibiotic for gonorrhoea: more good news for antibiotic resistance fans everywhere

Once more we feel that things are moving in our direction. And just in time for Christmas too! Thanks to a story by the redoubtable Kat Lay of the Guardian, we bring you news of not one, but two new antibiotics, gentle readers. Both Zoliflodacin and Gepotidacin have passed major trials and have been approved this very month by the US Food and Drug Administration. Always a major step in their progress to world-wide use.[1]

We will keep our bit short today. Kat’s excellent story is a lucid and succinct presentation of all you need to know-infection rates, strains, statistics and the marvellous groups of educated, open minded people who have worked so hard to get humanity to this stage. Suffice it to say you might wish to learn more about Global Antibiotic Research & Development Partnership (GARDP) who seem to be just the sort of people we have been hoping to have around in this crisis (thanks for that, Kat) So, go on-click.

Hardened fans of LSS and the antibiotics resistance community in general will be aware of our earlier thoughts on this aspect of the problem(LSS 19 2 24; 12 9 24) It is a genuine pleasure to see advances being made, and not just in STDs, after more than ten years of campaigning. The antibiotics crisis is not over yet; but compared with where we were about 2015, this feels better. So, although we are not going to let up, enough time has been bought to devote a little of it to another of our bêtes noires: the intractable mystery of mental illness and its causes. But this time, we think there’s hope there too. Don’t miss our next amazing blog.

[1https://www.theguardian.com/global-development/2025/dec/16/health-antibiotic-resistance-drugs-superbugs-sexually-transmitted-gonorrhoea

[2]https://gardp.org/

#antibiotic resistance #microbiology #health #medicine #bacteria #STD #GARDP

Why taxes are good for you #6: The best thing for an Enterprise Economy

As we approach the end of this series, we could not resist two more arguments which have always irritated the “taxes are evil” lobby. If only because we haven’t met one of them who has come up with a convincing counter argument. And the first should be beloved of all: taxes are a superb way to control inflation. As Britain and the US began to gear up for the Second World War the sheer enormity of the spending needed ran the risk of runaway inflation. It was Keynes in How to Pay for the War who saw the answer. Taxes, he argued would not provide the money; they would suck excess cash from everyones’ wallets , thereby keeping prices on a relatively stable trajectory. The US applied a similar philosophy in its own way [1] The economy grew at unprecedented rate, bringing prosperity to all. And there was a an even more significant side effect, which led to prosperity lasting for decades thereafter.

Because in both Britain and the US, vast defence spending contracts generated an equally vast ecology of institutions, government departments, University research labs and the rest. All beavering away at new discoveries, new ideas and shiny technologies. No wonder the years 1945 -1970 are remembered so fondly as times of progress and prosperity . Names like Rolls Royce, Boeing and McDonnell Douglas are just the tiniest iceberg tips. If you want to know more, trying kicking off from the site of the US’ famous famous DARPA[2] a seed bed for an almost fractal cornucopia of new ideas. Even things we use today like GPS, the internet, and advanced semiconductors are all horses from this stable. By contrast, the economic ascendancy of western countries only really declined after the tax and regulation reforms of the Thatcher-Reagan years when Proud Finance finally crushed Humble Industry.

Why does this all work? Because ultimately the State is able to take a risk which private enterprise capital cannot. We don’t blame them: this is not a moral failing, just a question of numbers and distributed risk. Its true that in some countries private banks have a much more supportive relationship with their local industries: but these tend to be lands where such innovations as Regulations and Industrial Planning are celebrated, and not seen as wicked socialist evils. Leave aside the fact that taxes pay for the roads, hospitals and schools which provide entrepreneurs with a ready supply of able workers. Their real benefit is to create a vast pool of opportunity in which enterprise can afford to reach losses and profits in turn, and keep coming back for more. After all-what use is a football club without a League to play in? We will be revisiting these and other thoughts in the last of our series. Hold on to your seats.

[1]https://www.federalreservehistory.org/essays/wwii-and-its-aftermath

[2]https://www.darpa.mil/research

#fiscal #tax #financialisation #keynes #second world war #inflation #research and development #history #economics

George Monbiot on the arc of History

There’s a simple view of history as series of pageants. Kings fight glorious battles, heroes like Nelson and Genghis Khan kill lots of people, talented artists like Michaelangelo gaily paint frescoes of the male nude all over the walls of some slightly dodgy cleric’s new palace It’s interesting, it’s fun, it excites podgy old men who have never been in a war to dress up in funny costumes. There’s only one problem with it, in fact,

It’s bollocks.

Starting slowly at first, reading the works of much clever people like Professor Kennedy[2] [3] we realised that History is driven by deep slow moving inexorable forces: things like climate, infant survival rates and technology. Britain rose because it was the first to develop modern commercial and industrial processes. It fell when other countries started to do those things better. Rome succeeded, for a while ,because it turned the Mediterranean Sea into a single trading zone in an epoch when sail was the most economic means of transport. It fell when plagues and climate change so decimated its population that it could no longer defend the frontiers of that zone. Above all it’s demographics, economics and logistics that determine the fate of nations, not battlefield heroics.

It is in this light that we present this article by George Monbiot of the Guardian. [1] For it attempts to address this single determining factor, both in our lives-and those of the next four or five generations to come. It doesn’t matter if you love immigration, or hate it. Whether you thought everything would solved by a rising population or a falling one, (as we used to). See this more as advice from a wise accountant to a failing family firm “this much is in your coffers, therefore these will be your spending options” In world terms, the arc is very simple. The population will grow a little while longer. Then it will start to fall. Precipitously. All decisions on defence, finance culture, even our own little idées fixées like antibiotics and climate change, shall be made in the light of this simple, ineluctable fact.

We have followed Monbiot on many topics for years; his writings are always stark and cogent. We urge to you look him up and read more. But today, for now, we beg you to read this one, It should lend perspective like nothing else.

[1] https://www.theguardian.com/commentisfree/2025/dec/12/europe-migrants-birth-rates-immigration-countries

[2]Paul Kennedy, The Rise and Fall of the Great Powers: Economic Change and Military Conflict from 1500 to 2000 (New York: Random House, 1987).

[3] Kyle Harper, The Fate of Rome: Climate, Disease, and the End of an Empire (Princeton: Princeton University Press, 2017).

#history #population #demographics #immigration ##economics

Hottest years make chilling reading. Here’s how you can still do something about Climate Change

The facts-objective, verified and indisputable- are chilling. The last three years of this decade have been the hottest on record. Vast areas are now being ravaged by wildfires or drowning in immeasurable floods. The latest gloomy news comes from Nature Briefing: a group of people who are as calm, objective and well-informed as any we have come across. :early Temperatures Reach Dangerous Highs, they report:

This year looks likely to tie with 2023 as the second-hottest ever on record. Last year was the hottest. “The three-year average for 2023-2025 is on track to exceed 1.5 ℃ for the first time,” says Samantha Burgess of the European Union’s Copernicus Climate Change Service, referring to the Paris Agreement pledge to limit global warming to 1.5 °C above pre-industrial levels. “These milestones are not abstract — they reflect the accelerating pace of climate change and the only way to mitigate future rising temperatures is to rapidly reduce greenhouse gas emissions.” Euronews | 2 min read

As we were once more digesting these gloomy words in the LSS Boardroom, Selina the tea lady came in with this morning’s refreshments. “Good heavens!” she observed. Well, that was the gist of what she observed. “Are you lot really going to put out another gloomy blog on Climate Change? Give them some hope, for once, why don’t you” Again we paraphrase: suffice to say we understand where her grandchildren derived the terms they used when we tried to stop them from vandalising the cars in the office car park. But she is right: why don’t we tell you that there is something you can do? Take agency and all that. It shall be by supporting or donating to the organisations which we have listed below. We have chosen all of them for their integrity, hard work and track records. But above all for their moderate, pragmatic approach to this problem. We are deeply suspicious of more extreme outfits who in our view only help Big Oil by alienating ordinary people. Here, then is that list. All need money. It is nearly Christmas. We leave you to join the dots between those last statements.

World Wide Fund for Nature | WWF

Greenpeace UK

Home | Carbon180

Friends of the Earth | Home

Rainforest Alliance | Creating a Better World for People and Nature

For professional reasons we will be unable to produce another blog until next week

#global warming #climate change #big oil #pollution #ecology #environment

Now AI is designing antibodies too

Photo by Nataliya Vaitkevich on Pexels.com

Do you understand the human immune system, or the even vaster world of immunology? Neither do we. Too big, too vast, too complicated. And that’s despite 43 years of trying and working along side some pretty nifty immunologists, back in the day. But AI does, Fresh from its triumphs on protein design (LSS passim) its superior intelligence has now been turned on the knotty problem of how to run up new antibodies. Read this, AI designed antibodies race towards trials from the indefatigable Nature Briefing

Scientists say they are on the cusp of turning antibodies designed by artificial intelligence (AI) into potential therapies just a year after they debuted the first example of an entirely AI-designed antibody. Previously, the structure of antibodies proved somewhat of a black box to AI models. But new and improved models — such as an updated version of AlphaFold — have more successfully predicted the shape of flexible structures that give antibodies the specificity they need to bind to foreign molecules. Researchers at several companies now say they’ve designed ‘drug-like’ antibodies. Nature | 5 min read

There’s a lot to unpick here, and we won’t try to do it all. The first thing that stands out is how quickly this is moving from proof of concept to clinical reality, The second is that the possibility that designed antibodies will target receptor sites hitherto off-limits to their natural predecessors. Think infectious diseases first, and rightly. But the implications for cancer therapy -and dare we hope, neurodegenerative diseases?- are clear after a moment’s reflection. Designer antibodies will greatly reduce the need for much animal immunisation and testing. And, perhaps a best of all, a thriving commercial ecosystem of start-up companies is beginning to form around the new learning, ready to turn it into everyday reality in a hospital or medical prectice near you, gentle reader.

Although we can’t claim credit for these advances-you all know us too well- we think it striking that they have come from the qualities we prize . Careful observation. Null hypotheses testing. Slow steady work. And always looking for what proves you wrong not what proves you right. Those qualities are what save lives and generally make them better. A shame that they are being abandoned now by a hysterical ignorant population and so many of its foolish leaders.

#immunology #antibodies #medicine #health #cancer #disease #biotechnology

Why taxes are good for you #5: No taxes= no economy

Let’s go back to part one of this series where our old friend Dave Watford is leaning on the bar of the Dog and Duck. Complaining how the government takes all his money in taxes and” if he ditnt ‘av ter pay no (expletive deleted) taxes his wife wouldn’t ‘av ter (expletive deleted) work at all!” It’s a widely held view, assiduously promoted by certain very well funded “think” tanks. In fact it’s the exact opposite of how a real economy works. Or exists at all. All the evidence suggests that without taxation, and the government to enforce it, there could have been no economy. Humanity would have frozen at the level of sheep grazers and dirt farmers.

It worked something like this Once there was a King somewhere in old Mesopotamia: and he invented something called an Urg, No one wanted it much at first. Until the King said: ”everyone has to pay ten Urgs a year in taxation. Which I will enforce.” Suddenly the Urg had value because-everyone needed it to pay the taxes. They started to work and trade to earn and swap all the Urgs they needed to pay the King. Who helpfully kept the whole process going by creating more Urgs which he issued to people in order that they could pay their taxes…….suddenly roads were built, trade networks flickered into life, and huge buildings like ziggurats started going up. “Ah!”. cry the detractors, “all these things were gong on before there was money!” It was Keynes who nailed this fallacy. Money is about much more than coins, and came much earlier, he said. Money is all about the network of obligations, debts and credits, which by their redemption make trade possible. The whole point of the king was to ensure that these contracts were enforced. Coins came much later in the archaeological record, as a convenient technological advance to the system. . The electronic banking of their day, if you like.[1] [2]

We’ve talked before how kings use taxes to pay for armies and policemen and courts and other things to keep its citizens safe. But below that level, they are even more fundamental to the very existence of an economy. Without them there would be no Dog and Duck bar for Dave to lean on. He would depend on home brewed beer and home spun clothes. And, as it was mainly women who produced all those sorts of things (they do most of the work in agricultural societies), think of this Dave:-she would indeed ‘av ter work, mate. Innit.

[1] The History Of Taxation In Ancient Civilizations: A Comprehensive Overview Of Early Fiscal Systems And Their Impact

[2] The Shocking Origins of Money Hidden in 1,000-Year-Old Artifacts

[3] Kelton, S The Deficit Myth John Murray 2021 see especially pp 25 et seq

#archaeolgy #economics #history #taxes #money #coins

Identity Protective Cognition. Will this be the real cause of human extinction?

Have you ever stood in a pub and listened to a group of men talking? Are they really exchanging information? Trying to learn, to incorporate new facts and modify their opinions? Or do they just stand there, declaiming little nuggets of information, signalling their belonging to the group, and their status in it? We think its about 6% the former and 94% the latter. If that is the case, the implications for how people think, the very way they use and incorporate facts are disturbing indeed.

Dan Kahan[1] [2] and Brendan Nyhan[3] suggest this is exactly what happen in most peoples minds, most of the time. They think that considerations like pride and group loyalty far outweigh the effects of evidence and logical process. Our space is limited; but we hope the extensive bibliographies below will convince readers of the essential value of their insights, “If I admit I am wrong, then I have lost face” is where most people come from. And suddenly we see: This terror of looking weak, of jeopardising social status, lies behind so many of the mysteries we have struggled with here for five years now. Why does emotion seem to always triumph over reason? Why do objective facts, on things like Climate Change or vaccination, so utterly fail to change preconceived views? How indeed have issues of pure science become mired in questions of group identity and gender role?

Veteran readers will recall our long-held belief that reason and evidence are the principal survival adaptations of this species. We can never be as strong as bears, nor swim as well as whales. It was these qualities of intelligence that allowed a small weak ape to survive, and prevail. There have been times when these qualities did indeed seem to dominate, briefly. And other times when these qualities were almost extinguished by barbaric ignorance and brutality. Somehow, reason survived and recovered, and even went on to brief triumphs in eras such as the Renaissance or the Enlightenment. The difference now is that the threats such as Climate Change or pollution are existential. If not addressed, this species will become extinct. Yet the very people who might solve these problems-scientists, lawyers, independent journalists- are becoming fewer. Their voices drowned, their budgets starved by the hysteria of the mob and its angry leaders. If humanity is to survive, intelligent people must find ways to first protect themselves, and then prevail once more. But how, and if we have enough time, are complete unknowns,

Kahan, Dan M.; Peters, Ellen; Dawson, Ellen; Slovic, Paul. “Motivated Numeracy and Enlightened Self-Government.” Behavioral and Brain Sciences 38 (2017): e56.

Kahan, Dan M.; Braman, Donald; Gastil, John; Slovic, Paul; Mertz, C.K. “Culture and Identity-Protective Cognition: Explaining the White Male Effect in Risk Perception.” Journal of Empirical Legal Studies 4, no. 3 (2007): 465–505.

Nyhan, Brendan. “When Corrections Fail: The Persistence of Political Misperceptions.” Political Behavior 32, no. 2 (2010): 303–330.

#reason #education #psychology #science #learning