


Readers will recall the ancient controversy over claims that Autism was caused by the MMR vaccine. We didn’t believe those claims much then, and probably even less so now. But amid all the shouting we think that a point was missed. Is there really a single psychiatric condition called “autism”; or does that word conceal more than one condition lurking underneath?(see also LSS 28 8 25; 15 5 25 et seq)
Michael Marshall examines this question in a wide ranging article for the New Scientist[1] Now : when you do things as well as Marshall and the New Scientist do, you’ve every right to put it behind a paywall. So for those of you who can’t go round we’ll zoom in on two of the more intriguing research projects MIchael discusses, as they also hint at another topic we’ve also covered recently: but see below for that.
Firstly: what really does lie beneath the word autism? In different studies Dr Conor Liston and Dr Natalie Sauerwold were both able to group people with autism into four reliable categories according to the traits which their subjects presented. Unfortunately, the two classifications that each scientist came up with did not always overlap . But both teams were using different techniques: and of course this work is very new. Intriguingly for LSS readers Dr Liston also found
That brain regions with altered circuitry in autistic people……also showed characteristic changes in gene expression……
But being a good journalist , Michael warns us against over interpretation here. Modifications in neural architecture may not be caused solely by underlying genes: they could also be due to the brain re-wiring itself, to compensate for defects in an entirely different region, whose construction is the responsibility of an entirely different set of genes.
Hardened members LSS community will recall our enthusiastic blogs ( LSS 15 12 25; 29 2 25) wherein we discussed the exciting findings which do indeed hint at a demonstrable link between gene frequencies and reliable patterns of behaviour. Neither those findings, nor these ones on autism, are yet conclusive. But they show which way the wind is blowing: and we think it is in a hopeful direction
#autism #psychiatric disorder #neurological disorder #genetics


























