Friday Night Feast of Fun: What to Wear for Cocktails

A few years ago (LSS 15 5 20) we received a plaintive call for help from a reader in Bridport in Dorset. He posed an age old and much-debated question: how should the Gentleman of Fashion dress for Friday Night Cocktail?. And this is the answer we gave

“Dear Mr AF: the rules on this have always been very prescriptive, but fair. In winter, a dark blue or black jacket, striped shirt, creased chinos and smart black shoes. Tie; anything regimental. old school, or your golf club. The building, not the thing you hit the ball with! In summer you may sport a light jacket, summer being defined as any date from Easter Sunday until the final Bank Holiday in August. You may of course wear a Panama. But don’t wear it indoors, or you will look like a numpty.”

Well, we will not change a dot or comma of that answer. Rules of dress are timeless, like rules of Golf or Morality. What you see above is how it is ladies and gentleman and we can no mor exchange that than we can ask for a rewrite on one of the Ten Commandments. (not even the one about Adultery) But we will add an appendix. A coda if you like, to recognise the times we live in.

Because since that blog was published quite a lot has changed. global temperatures have climbed by roughly 0.3 °C, 2024 became the hottest year ever recorded at about 1.55 °C above pre‑industrial levels , mountain glaciers have kept shrinking with more than 27 m water‑equivalent lost since 1970 and record mass losses in five of the past six years , and extreme events—heatwaves, storms, floods, droughts, and fires—have intensified across almost every corner of the biosphere. Yes, it’s got hotter, quite a lot hotter and it’s not just because you are standing too near the barbecue fire, ladies and gentlemen. So, just as St Benedict wisely relaxed monastic rules to make them more bearable , we are going to relax the Cocktail Code. A bit. In the warmest weather only. Gentleman may, with discretion, wear a polo shirt if working at the barbecue or serving the drinks, provided that you clear it first with the Guests.

Well there’s our advice . It’s nearly Six British Summer Time as we pen these lines, so we, like many of you are already thinking of slipping in to the time-honoured garb and wolfing down that first Pimms. We hope you enjoy your evening too, wherever you are.

#cocktails #clothes #global warming #st benedict #climate change #pimms #gin

Round-up: More Amoc Havoc, IQ Blues, immunity-and is the prequel to Terminator?

Photo by Monstera Production on Pexels.com

George Monbiot shares fears of Amoc Havoc

Last week we showcased a piece by Damien Carrington about the rising dangers of a collapse in the Atlantic Meridional Overturning Circulation(LSS 16 4 26) Several outlets took up the theme, But it took a writer as prescient as George Monbiot to put it into wider context:

https://www.theguardian.com/commentisfree/2026/apr/23/catastrophic-climate-event-scientists-atlantic-system-collapse-billionaire-existential-crisis.

A critical eye for IQ

We’ve always had our doubts about IQ tests, and not just because we’re rubbish at them. Now an eminent researcher in psychology shares our concerns that such tests on their own are sufficient to guess at a child’s future development.

https://theconversation.com/the-truth-about-child-iq-research-shows-it-fluctuates-and-may-be-an-unreliable-predictor-of-future-success-27156 nMargherita Malanchini

Running up that hill-it doesn’t hurt ……

Immune cells linked to endurance in mice reports Nature Briefing. Is this what’s going on inside the cells of top athletes?

B cells — the ‘security guards’ of the immune system — also provide crucial support for muscles during exercise. B-cell-deficient mice performed worse on strength and endurance tests than did mice with healthy B-cell counts. Researchers found that the absence of B cells lowers the amount of the amino acid glutamate, which is associated with improved mitochondrial and skeletal muscle function, released by the liver. A lack of glutamate in muscle tissue and the bloodstream could explain the decrease in exercise performance, they suggest.

Nature | 4 min read
Reference: Cell paper

Human machine barrier gets ever more blurred

News that Barcelona surgeon Dr Juan Aibar has successfully implanted electrodes into the brain of an unfortunate sufferer from Tourettes syndrome reinforces another old trope of this blog. That our ability to create functioning interfaces between nervous tissue and artificial technology is advancing ever further. Perhaps you could ask Arnold Schwarzenegger where it might end, or rather Terminate (this El País article by Jessica Mouzo is in Spanish)

https://elpais.com/salud-y-bienestar/2026-04-22/electrodos-en-el-cerebro-para-mitigar-el-sindrome-de-tourette-grave-los-tics-mas-fuertes-junto-con-gritos-y-

Quote of the week “But the prophet, which shall presume to speak a word in my name, which I have not commanded him to speak… even that prophet shall die.” — Deuteronomy 18:20,

Harsh words for someone!

#climate change #global warming #amoc #neurology #medicine #immunology #intelligence testing

When Bacteria Explode: a new clue in the old antibiotic arms race

Bacteria are relentlessly evolving resistance to our attacks with antibiotics and phages — but how? If we understood their tricks a little better, we might still have a chance of avoiding the lethal pandemics of antibiotic‑resistant organisms otherwise waiting in the wings. A new paper from researchers at the John Innes Centre[1] has now shed light on at least one way that whole populations of bacteria may be secretly defending themselves from our ministrations.

The team found that the bacterium Caulobacter crescentus has an extraordinary switch mechanism that can cause it to “explode” under certain conditions. When it does, it releases tiny virus‑like particles containing fragments of its own DNA. Pertinent to our quest, gentle reader, is that some of this DNA may include instructions on how to resist antibiotics — or perhaps even the bacteriophages we deploy against them. The researchers also identified the components of this switch, which go by the snappy names LypABC and CdxB. They don’t yet know exactly what flips the switch, but they have their suspicions.

All of this is good news for those of us following the antibiotic‑resistance story. We now have a clearer picture of how at least one type of bacterium spreads resistance among its own members. And if we know what these switches are, we have a fighting chance of intervening to turn them off. If, as the researchers suspect, the presence of a hostile phage is indeed one of the triggers, then this is a very great step forward indeed

[1]A bacterial CARD–NLR-like immune system controls the release of gene transfer agents

Emma J. Banks, Pavol Bárdy, Ngat T. Tran, Phuong M. Nguyen, Boris Stojilković, Kevin Gozzi, Abbas Maqbool & Tung B. K. Le Nature Microbiology (2026)C

[2]John Innes Centre | Excellence in plant science, genetics and microbiology

#antibiotic resistance #bacteria #dna #genes #virus #bacteriophage #health #medicine

Farewell Robert Skidelsky. If you want to know more about the current mess, read this

No one over thirty will forget the terrifying autumn of 2008. For on September 15^th of that year the collapse of Lehman Brothers initiated the acute phase of a chronic financial crisis, tumbling the world economy towards final ruin. And as the indefatigable Larry Elliott [1] notes in the Guardian, in his masterly obituary of Robert Skidelsky, the ruling classes of the west were utterly bewildered:

…… there was almost universal disbelief that the crisis was happening. The entire economic establishment – politicians, bankers, Treasury officials, analysts and pundits – were caught unawares, because according to the free-market orthodoxy there was no chance of such a catastrophe occurring

Robert Skidelsky (1929-2026) might have known better. Having devoted a lifetime to studying the works of John Maynard Keynes, he presumably shared that thinker’s suspicion of the axiomatic beneficence of untrammelled Free Markets. Ironically by the summer of 2008 even he felt the Keynesian game was up, and was contemplating other projects, as Elliott points out. Then, as they say-It happened.

For a few fleeting months Keynes was in vogue again, so desperate was the plight of the Great and Good. Interest rates were cut. Money printed. Governments borrowed and spent, Catastrophe was averted. And then? Well, in Britain the Cameron government was elected and reverted to the via dolorosa of financial orthodoxy. Cutting the budget was all that mattered, as if a nation was like a grocer’s shop in a small market town. Keynes was firmly shown the door: and the consequences of poverty, lost growth, wasted lives and appalling political outcomes are with us to this day.

Like Keynes, Skidelsky was not a tribal Party man, having variously flirted with Labour, the SDP, the Tories, and even Jeremy Corbyn in his time. Both Keynes and Skidelsky preferred solutions that worked, reason and evidence over belief and emotion. And both knew that Keynes’ essential insight was that money is about a lot more than just cash, or even more sophisticated accountants’ tricks like stocks and shares. Money is really a network of obligations, contracts, promises and deliveries which facilitate the flow of energy through human societies and by which they live. Any system which depends ultimately on the unregulated competition of lone individuals will ultimately corrupt the information and break the trust on which all depend. A truth now lost in the declining plutocracies of the west, but which certain other parties have understood very well

[1] Lord Skidelsky obituary | Robert Skidelsky | The Guardian

[2] Skidelsky, Robert. John Maynard Keynes: 1883–1946: Economist, Philosopher, Statesman. London: Penguin Books.

#robert skidelski #JM Keynes #economics #politics #financial crash

Beyond the Nation State #6: The Cost of Nations

Identity, it is said, is the most important thing a People can have. So what better way to guarantee that identity than by taking back control and assuring it inside a sovereign nation state.? It’s a very popular policy at the moment, so there must be advantages. But it’s worth at least noting the counterfactual argument, because it has consequences for what we try do here.

If you’re going to have a sovereignty worthy of the name, you must have the following: Defence, Intelligence, Borders, Customs, Taxes, Tariffs, Executive, Legislature, Judiciary, Foreign ministry ,Legal system, Central bank, Currency, Police and Regulators. To say nothing of the fixed obligations such as pensions you inherited from the larger state you have left. You could opt for health education, culture, policy, tourism and transport as well; but these are discretionary. So could smaller entities bear all these costs if they went it alone? Could California? (large-ish) Wales?(medium) Or Jersey? (rather small, with due respect). Take Wales as a hypothesis : let’s say the UK spends £50 billion on Defence and Wales is 3.1% of its population. That ratio would entitle an independent Wales to £1.5 billion. Would they be as well defended? The answer is no. For one thing they would have to set up entirely new structures of command, procurement, intelligence and all the other essentials of a modern force. Secondly, there is the brute fact that larger purchases always generate cheaper prices for anything Defensive-aeroplanes, tanks, guns, even the dusting cloths you need to keep them clean. Bulk purchase means cheaper unit cost. And it works the other way. Even a superb Welsh manufacturer of tanks would only enjoy tiny assured domestic markets, making its borrowing and production costs prohibitive in a world market. That is why American giants like Ford and General Motors thrived in the twentieth century: they had fixed access to the largest Single Market then available. That is why nations which have tried to downsize, like the UK after Brexit, have struggled so badly ever since.

The argument to grow polities into larger units is the same as that for growing companies. Economy of scale and stripping out fixed costs. A World Government would only need one of each the exhaustive list above. Imagine the procurement advantages in any number of things-medicines, schoolbooks, computers or even those wretched dusters again. What a saving for taxpayers! A single world Ministry of Defence would enjoy the highest possible bargaining power against its suppliers, cutting the cost of the $2.7 trillion we spend as a planet on defence by whole orders of magnitude. Of course, if there were a World Government most defence spending would become unnecessary anyway, as most nations’ armies exist sole to defend against other nations’ armies. But that’s something for another day

#nation state #history #politics #economics #world government

Breakthrough for blindness, an old lesson re-learned: and a mystery question

Leber congenital amaurosis, called LCA for short, is the most common form inherited sight loss in children[1] It’s caused by defects in a cluster of genes including RPE65 and until recently was quite untreatable. Now, as Ian Sample reports for the Guardian,[2] a team of researchers have effected a major new treatment called Luxturna: a gene‑replacement therapy delivered by injecting a working copy of the RPE65 gene directly under the retina. By giving retinal cells the functional gene they’re missing, it restores the visual cycle and can improve light sensitivity, visual function, and navigation ability in people with RPE65-related Leber congenital amaurosis. Interestingly the team comprises a husband and wife called Jean Bennett and Albert Maguire who share the prestigious Breakthough Prize [3] with their colleague Katherine High.

Regular readers will share our admiration for the work of this remarkable trio. They may note moreover that the researchers have something else to teach us, something that strongly concurs with opinions often expressed in this blog:

Bennett said it was a “tremendously exciting time” for scientific and medical research, but warned that the US administration’s attacks on science could “cause damage for generations to come”, leading her to fear a brain drain that the country would struggle to recover from.

“Agendas have become politicised, government agencies that support basic and applied research have been undermined, knowledgeable advisers and experts have been dismissed or have fled and revised guidelines contradict decades of rigorous research,”

Says it all really. But don’t just sit around reading it here:tell your friends and neighbours. For us there still remains outstanding question. Is Albert Maguire by any chance a relation of Ken Maguire, one of the best pub landlords of the 1990s, being sometime manager of the superb Latymers in Hammersmith Road London W14?

[1]Leber congenital amaurosis – Moorfields Eye Hospital

[2]‘Oscar of science’ awarded to team behind gene therapy that restores lost vision | Science | The Guardian

[3]Breakthrough Prize – Wikipedia

#LCA #Blindness #gene therapy #medicine #health #science #research #pub #beer

Round up: Electric cars, Aerial DNA, AI unemployment and a truly topical quote

Wolf. Original public domain image by U.S. Forest Service (source) is licensed under CC-CC0 1.0

Permanently plugged in The war in the Persian Gulf is causing oil prices to soar But even if they drop again, Electric cars are finally here to stay argues this piece from The Conversation

https://theconversation.com/electric-vehicles-pass-tipping-point-breaking-the-link-with-oil-prices-280655?utm_medium=email&utm_campaign=Latest%2

There’s something in the air A few years ago researchers learned how to use environmental DNA, such as in the mud of old caves, to map the species of the past. Now the studies have been given a contemporary twist as this piece in Nature Briefing shows

The air around us is teeming with the DNA of various organisms, ranging from people to viruses. Over the past decade, researchers have been learning how to collect airborne DNA and use it to study the movement of individual species, entire ecosystems or even attacks with biological weapons. But some hurdles remain: scientists still aren’t sure for how long DNA can persist in the air, or how far it can travel. And some experts worry that DNA plucked from the air could inadvertently reveal the characteristics of people that haven’t consented to such analysis

Nature | 12 min read

AI is a people problem Do you think AI will destroy jobs or create them? The real question and answer is not the technology , but how governments and societies respond, according to this piece from the Guardian by Larry Elliott

AI is destroying jobs – and the energy crisis could make that much worse | Larry Elliott | The Guardian

Hungry like the Wolf We loved this story of Neukgu a two-year-old Wolf who escaped from Daejeon Zoo in South Korea and spent nine days on the lam before being finally recaptured, giving his human supervisors a dog’s life in the process The BBC has the story

Neukgu: South Korea’s runaway wolf finally captured after nine-day search – BBC News

Quote of the week Since The Pope, Jesus Christ, Religion, and certain other almost equally eminent figures have cropped up in the news so much this week, we thought this little snippet seemed appropriate

12 How art thou fallen from heaven, O Lucifer, son of the morning! how art thou cut down to the ground, which didst weaken the nations!

13 For thou hast said in thine heart, I will ascend into heaven, I will exalt my throne above the stars of God: I will sit also upon the mount of the congregation, in the sides of the north:

14 I will ascend above the heights of the clouds; I will be like the most High.

Isiah 14: 12-14

Now-who on earth might that apply to, do you think?

#electric cars #big oil #DNA #AI #economics #wolf #south korea

Collapse in AMOC equals havoc

Photo by Chris LeBoutillier on Pexels.com

In theory, you can rebuild after a war. But if the Atlantic currents collapse there will be no rebuilding. Because the change will be irreversible, and anyway there will be no economy left to rebuild with. That’s now a real possibility according to this story from Damian Carrington of the Guardian.[1] [2] We start with something called the AMOC or Atlantic Meridional Overturning Circulation for short.

The world of oceanography and currents can all seem a bit remote from everyday life. But to plunge in briefly: Global warming has been adding colossal amounts of fresh meltwater—especially from Greenland—into the North Atlantic. This reduces salinity and density, in turn preventing surface water from sinking, which is the key engine of the AMOC. As sinking slows, the whole circulation weakens and it will eventually tip into a collapsed state. The question is when and what are the chances? According to Damien:

they found an estimated slowdown of 42% to 58% in 2100, a level almost certain to end in collapse.

And what will that collapse look like? After the initial shock, a permanent series of frozen winters in western Europe. There will be catastrophic ruptures in food chains as fields ice over, fish stocks migrate and transport is disrupted. Societies will face massive dislocation as people migrate from flooded coastal regions and river valleys. In turn producing massive conflicts on higher ground, as refugees discover that they are suddenly immigrants in what used to be “their” country.

Leaving you, gentle readers, with a choice on the balance of probabilities. You can rely on the findings of scientists [3] who have studied this issue assiduously for more than three decades and whose work is publicly available for anyone to examine. Or you can rely on opinions expressed in online comment sections. Everyone is entitled to an opinion. The real question is which source of information a reasonable and informed person would choose to act upon.

[1] Critical Atlantic current significantly more likely to collapse than thought | Oceans | The Guardian

[2] Atlantic meridional overturning circulation – Wikipedia

[3] Observational constraints project a ~50% AMOC weakening by the end of this century | Science Advances

Global warming #climate change #atlantic ocean #amoc #flood #ice age #ecological collapse

Flynn Coleman sees hope in Artemis

We are sometimes accused of being too gloomy here. Too admonitory, too censorious, scolding and sanctimonious. Preachy. Lecturing. Hectoring, perish the thought. Even didactic in certain circumstances. Judgemental was another one hurled at us by younger colleagues back in the nineties. Doesn’t everyone have to make judgements? we replied. We didn’t cause them to lead lives of frivolity greed and sensual indulgence, we simply pointed out a few obvious truths.

All of which may be impeding us from getting our message across at times, perhaps. So to make amends we have selected this rather upbeat article by a certain Flynn Coleman who writes in the Guardian. [1] He cites the Artemis 2 moon mission as his text and contrasts it with acts of brutality and ignorance back here on earth. Like Iraq in 2006 or the the high commands of certain nations in our own more troubled tomes. He invokes the spirit of the great Jim Lovell, a man whose intelligence and courage were displayed on both the Apollo 8 and 13 missions Above all its the duality which intrigues. Your species species can reach for the stars. You are more than the bunch of angry ape men we keep telling you that you are.

And Flyn’s final point is: you can choose to be one or the other. But read it for yourselves, gentle readers. And at least thank us for doing something Nice for a change.

[1]This week saw humanity at its worst. Artemis II told the opposite story | Flynn Coleman | The Guardian

#war #peace #artemis mission #space #moon #humanity #ethics

CART-T therapy takes three big steps forward

Once again we are indebted to that excellent organisation Nature Briefing for this opportunity to showcase another giant step forward for that old LSS favourite CAR-T therapy. [1]Well, three steps actually: as you will find out if you read this extract which they have titled One CAR-T to cure them all

A woman with an ultra-rare combination of three autoimmune diseases has had no symptoms since receiving a single dose of engineered immune cells. Researchers used the woman’s own T cells to develop chimeric antigen receptor (CAR) T cells that targeted a protein on her B cells — the culprits behind her trifecta of autoimmune conditions. The woman experienced no side effects from the treatment, and fourteen months on she doesn’t take any medication for her conditions, says haematologist Fabian Müller, who helped to develop the treatment.Nature | 5 min read
Reference: Med paper

Breakthroughs like this don’t come from wishful thinking, magical explanations, or comforting stories about how the world ought to work. They come from the scientific method: from hypotheses that can be tested, data that can be challenged, and results that must survive scrutiny. When we follow that discipline, we get therapies that save lives. When we don’t, we get nothing but anecdotes and disappointment. The contrast speaks for itself We have other tasks for other publishers today, and must attend to them But we hope the foregoing leaves you with a tiny quantity of Hope

[1]CAR T-cell therapy | Cancer Research UK

#CAR-T #cancer #medicine #science #health #reason #auto immune disease