If you want to know the truth about cancer, ask Liz O’Riordan

Because she’s seen it from both sides, is why. First she was a doctor, who like, worked in the field? And then because, she got it herself, right? Became a patient, and experienced all the heart stopping, roller coasting, will-I -won’t-I? chain of emotions that all her own patients did. If those aren’t qualifications enough, gentle readers, we don’t know what are. And-she has one other which seals the deal as far as we’re concerned. Read on, and you will learn what that is.

We came across Dr O’Riordan in the course of listening to a series called Marianna in Conspiracyland on BBC Radio 4 [1] Not having an especially large legal department we must be careful what we say. But the programme details the activities of the types of people who disparage reason-based science and evidence-based medicine. And instead offer a dubious range of alternative theories, explanations and prescriptions to people who are scared out of their wits by a cancer diagnosis. In the nicest possible way, the programme tried to explain the consequences of choosing these paths of treatment, And Dr O’Riordan was one of the speakers they called in their support. A little bit like the prosecution in a criminal case calling an expert witness in DNA or drugs, as t’were.

Because since her own diagnosis and treatment, Dr O’Riordan has spent her days ceaselessly writing, speaking, making media appearances, all to one end. Refuting fallacies, identifying illogicalities, reasoning with the unreasonable. In books like The Cancer Roadmap [2] she tries to explain the science behind why cancers develop and grow, what the best treatments are, and why so-called “alternative systems” don’t seem to be up to much. In this undertaking she joins a great tradition of rationalists and sceptics starting with Lucian of Samosata,[3] and stretching all the way through to people like Peter Medawar, Carl Sagan and Dr Ben Goldacre.

But she goes one step further. Because she never condemns or sneers at anyone. Instead she tries to ask why people turn from rational medicine to alternatives and faith. In other words she deploys human qualities of empathy and compassion. And we could all learn from that. For years on this blog we have bemoaned the growth of fake information, conspiracies and general rubbish which grows on the interweb like the digital equivalent of a cancer. Not just in cancer theory; in matters like global warming, politics and economics. Hasn’t done much good. Somehow, the easy, comforting answer outpaces the complicated rational one each time, and by ratios of thousands. We are in danger of becoming the last generation of enlightened, rational thinkers, perhaps for thousands of years. Time to listen to Liz and her methods. Soon.

[1]https://www.bbc.co.uk/programmes/m001mssm

[2]https://liz.oriordan.co.uk/author/

[3]https://en.wikipedia.org/wiki/Lucian

[4]https://en.wikipedia.org/wiki/Ben_Goldacre

#cancer #medicine #alternative medicine #rational #empirical #science #health

More on the deadly dangers of stress (sorry, but you need to know this)

Photo by Michael Willinger on Pexels.com

A few decades ago, a friend remarked how his brother had left a stable happy marriage for a much younger woman at work. It didn’t last long- the man in question died a few years later of Crohn’s disease. The new relationship didn’t turn out very happily, as I learned from passing gossip. “Going over the side” they used to call it, back in the day. It seemed unremarkable enough -until a few years later a work acquaintance of about the same age and circumstances suffered a similar fate. Raising the question: was the knowledge of the awful decisions they had both made eating away inside, burning with stress, until their poor immune systems broke down altogether? This was the start of a trope we have followed ever since. We have alluded to it several times on these pages(LSS 2210 24; 23 8 20} to name but a few. Now we are glad to see our concerns addressed by altogether more weighty and learned persons (surely not?-ed)

For Nature and its brilliant Briefing arm have put the matter at the forefront of their latest editions Read this, Time to Take Stress seriously, if you don’t believe us:

When George Slavich’s father died suddenly, the clinical psychologist was well aware of how the stress could affect his health, but his health-care providers weren’t as interested. “The experience highlighted a paradox between what I know stress is doing to the brain and body, and how little attention it gets in clinical care,” says Slavich. He is among the researchers investigating how the body reacts to stress and how it contributes to deadly diseases.Nature | 11 min read

You see George isn’t any old George. He is a clinical psychologist at UCLA, no less. And he has launched a project with many other eminent scholars to research the link between stress and many disorders that plague us all, from heart and respiratory disorders to all kinds of psychological and psychiatric ones. Is there good stress? Is there bad? What causes each, and how to cure them? All these questions are now front and centre of George’s research. You can read more here[1] and here[2]

For the last fifty years or so, the whole psychological imperative has been to make people work ever faster for longer for ever lower wages. it is supposed to make us all more prosperous and happy, or something. What if it is doing the opposite?

[1]https://www.nature.com/articles/d41586-025-02066-z?utm_source=Live+Audience&utm_campaign=5e2c1eb595-nature-briefing-daily-20250708&utm_medium=email&utm_term=0_-33f35e09ea-

[2]https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2024.1471084/full

#immune system #stress #coronary disease #psychology #chronic illness #overwork #health

Weekly Round up: Air Pollution, Gene therapy and raspberries

Air pollution is the new smoking Stopping smoking has led to massive falls in rates of lung cancer. But this fearsome disease is still lurking out there. The current cause? Air pollution ,as Ian Sample explains for the Guardian

https://www.theguardian.com/science/2025/jul/02/air-pollution-lung-cancer-dna-mutations-study

Gene therapy chalks up another win Ok,today it’s one particular form of deafness, attributable to one particular gene, as Maoli Duan explains for the Conversation. But: the more science you do the more you learn. Meaning other disabilities may one day prove susceptible as well. And the more you spend on scientific research the more you get benefits like this. A lesson rapidly being forgotten in the United States of America

https://theconversation.com/gene-therapy-restores-hearing-in-toddlers-and-teenagers-born-with-congenital-deafness-new-research-258112?utm_medium

Machines that out think humans It’s the scary nightmare of science fiction films from Blade Runner to the Terminator series. Up until recently the idea still seemed to be fiction. All that may be about to change as Nature Briefing reports

An artificial-intelligence system called Centaur can predict the decisions people will make in a wide variety of situations — often outperforming classical theories used in psychology to describe human choices. Trained on data from 160 psychology experiments in which 60,000 people made more than 10 million choices, the system can simulate human behaviour in tasks from problem-solving and gambling, and even those it hasn’t been trained on. Using Centaur, “you can basically run experimental sessions in silico instead of running them on actual human participants”, says cognitive scientist and study co-author Marcel Binz.

Nature | 4 min read
Reference: Nature paper

Friday Night Feast Raspberries and Ice cream We are not all gloom and serious stuff here. Thinking it was time for a quick Friday Fun feature, we realised that we’d done strawberries several times (LSS passim), In which case the humble raspberry can make a really pleasant alternative, especially if combined with ice cream instead of cream. After all, even if we are on a diet-you, gentle reader may not be. So- eat a bowl for us we used to love it.

#cancer #AI ~pollution #gene therapy #raspberries

Bit of a round up: Yes Men, Fusion, Bowel Cancer, molecular shuttles and seething in the Sahel

Overwhelmed by a huge flood of suggestions , the only way we could cope was to pull them into this handy easy to access guide to some of the most significant happenings of the week. You don’ have to click on all of them

Will the Yes men Bring Down Donald Trump? As organisations get successful they attract more people who are adept at climbing the ladder rather than doing the job. The USA is somewhere near peak Trump at the moment. The Conversation warns how bad advice could end all in tears

https://theconversation.com/trump-surrounds-himself-with-sycophants-its-a-terrible-way-to-run-a-business-and-a-country-257391?utm_medium=email&utm_campaign=Latest%20from

Fusion on Trent The person who sent us this idea has had to endure our enthusiasm for nuclear fusion for more than fifty three years, despite the fact that it hasn’t worked for fifty of them. Now all that may be about to change in Nottinghamshire in the UK as The I newspaper explains https://inews.co.uk/news/politics/limitless-clean-energy-nuclear-fusion-3711971

^{thanks to P Seymour} ^{via Apple News}

Weighing the risks of bowel cancer Inequality leads to poor diets. Poor diets lead to obesity. Obesity leads to bowel cancer. How ironic, therefore, to see a riff on this theme in the Mail, of all places. But there it is so, there you go, as they say(that’s enough cliches-ed)

https://www.dailymail.co.uk/health/article-14756279/Doctors-discover-vital-new-clue-search-cause-mystery-bowel-cancer-explosion-50s.html

Shuttle and open We’ve riffed a bit ourselves here about the blood brain barrier over the years. It’s a pretty tough problem for those who would like to treat various disorders of the central nervous system. Now new hope come sin the form of molecular shuttles as Nature Briefing explains

To reach the brain, drugs must pass through the highly-selective blood-brain barrier. Large molecules, such as antibodies, don’t cross easily, if at all. Now, small chemical tags that can ‘shuttle’ drugs across the barrier are offering a way forward. Several such shuttles, which take advantage of natural transport systems, are in the works. Some have already been trialled in rare diseases, with signs of success. The field is in its infancy, but these shuttles promise to revolutionize treatments for diseases from Alzheimer’s to cancer.Nature | 10 min read

When scientists have a bone to pick It is an invariable law in paleontology , especially of the human kind, that the rancour of the disputes between its protagonists is in inverse proportion to the numbers of remains they have to work with. There is no better example of fear and loathing than the disputes over the bones of Sahelanthropus, the famous Toumai, which was once hailed as the uber-ancestor of us all. Before you hand over the world to an Aristocracy of the Educated, as some advocate, read this.

https://www.theguardian.com/science/2025/may/27/the-curse-of-toumai-ancient-skull-disputed-femur-feud-humanity-origins?CMP=Share_iOSApp_Other

#cancer #bowel #nuclear fusion #dona;d trump #health #medecine #alzheimers #sahelanthopus

Brand New Antibiotic- a last hurrah for Harvard University?

Today we are brining you news of one of the best stories we’ve covered in many a long year of campaigning. Today Hofman-La Roche have announced late stage trials of a brand new antibiotic called Zosurabalpin. If all goes well it could be ready for clinical practice very soon. [1] We’ve been following this for a while now (LSS 1 4 24; The Conversation 5 1 24)[3] : it’s extraordinarily gratifying to see the long process so near to fruition.

There’s much to be excited about at a pure scientific level. Zosuralpin is designed to go after the particularly deadly bacterium Acinobacter baumannii, which can kill up to 50% of its victims. It’s one of those gram negative ones with a double cell wall. Zosurabalpin tackles this in a new way, specifically targeting lipopolysaccharides which the organism uses to maintain the integrity of those walls. For the first time since we entered the world of antibiotics, a gram negative bacteria, the ones which used to really concern the great Professor Garner and the other founders hasa been cornered. But that’s not our main learning point today.

Because Hofman did not develop this alone. Like all modern research it was international and collaborative. The international partner they chose was Harvard University, the oldest in the United States Of America, and one of the best in the world. Until recently. For as astute readers will know, this institution has recently been on the end of a tremendous kicking from President Donald Trump (pictured above with some of his supporters) and other members of his government. We are not certain yet if this will end terminally for Harvard. But at the very least, the time they spend defending themselves from their barbaric assailants would be time better spent developing new antibiotics. It’s worth balancing consequences like that against the savage impulses of the unreasoned, the unlearned and the unintelligent.

[1]https://www.ineosoxford.ox.ac.uk/news/new-antibiotic-class-shows-promise-against-drug-resistant-bacteria

[2]https://www.lbc.co.uk/news/health/new-antibiotic-could-defeat-resistant-superbug-human-test-zosurabalpin/

[3]https://theconversation.com/new-antibiotic-zosurabalpin-shows-promise-against-drug-resistant-bacteria-an-expert-explains-how-it-works-220564

#antibiotic resistance #hofman La roche #zosurabalpin #gram negative #medicine #healh #harvard #donald trump #harvard

Cancer testing saves lives-and shows why science works

Today we a re going to talk about cancer. In the UK alone it kills 167 000 people annually, which is about 29% of all recorded deaths . Meanwhile about 3.5 million people are trying to live with it on a daily basis. The statistics for your country will be comparable, gentle reader. Nothing would cheer us more than to report some good news. And today we think we can, courtesy oft the far sighted Professor Peter Sasieni and his team at London’s Queen Mary University via the Mail [1] [2]

Professor Sasieni and his team are not pioneering cures directly. Their skill is devising new ways of testing. To detect the terrible disease early, before it can wreak havoc, and unleash the cures when they have the optimal chances of success. The linked article is a good summary of all the wonderful work they are doing. But we have filleted out this tiny quote which will give you some flavour of what they are achieving

Yearly screening under the fast tumour growth scenario led to a higher number of diagnoses than usual care – 370 more cancer signs were detected per year per 100,000 people screened. There were also 49 per cent fewer late-stage diagnoses and 21 per cent fewer deaths within five years than patients receiving usual care.

If that’s not hope we don’t know what is

But there’s a deeper story here. For us, the best working definition of intelligence is how you respond to reality. You may have a lot of money, talk well, and even have a genius IQ. But if you ignore facts, deny them, or distort them, then you are a fool. There’s no mystery about science. It is simply a way of collecting true facts and organising them according to the rules of logic, which is what Professor Sasieni has done. This works globally for things like changes in the climate. It works locally, for things like diseases in the human body such as a diagnosis of cancer To deny truth once is the start of denying it always. With fatal results.

[1]https://www.dailymail.co.uk/health/article-14694059/blood-tests-detect-earliest-signs-cancer-prevent-advanced-stage.html

[2]https://www.qmul.ac.uk/wiph/people/profiles/peter-sasieni.html

#cancer #testing #screening #health #medicine

Is this plastic eating bacterium the ultimate in antibiotic resistance?

Bacteria that mutate to resist the strongest known antibiotics. At this blog, it’s in our DNA, if you will pardon the flippant quip. But-get this-what if the bacterium in question starts eating the walls you are trying to contain it in? Sounds fantastic, like the plot of one of those old 1950s B movies. Read this piece called Hospital Superbug eats Medical Plastic from the admirable Nature Briefings

Pseudomonas aeruginosa — a strain of bacterium that often causes antibiotic-resistant infections in hospitals — can produce an enzyme that can break down medical-grade plastic. Researchers found that the enzyme, dubbed Pap1, can break down a plastic called polycaprolactone that is commonly used in health care because of its biodegradable properties. The ability to break down plastic could explain why these microbes persist in hospital environments, says biomedical scientist and study co-author Ronan McCarthy.Nature | 4 min read
Reference: Cell Reports paper

We’ve put up the Cell Reports posting for you too here[1]in case the clicker above does not get you through

So is this it? The big one? A wave of highly infectious bacteria that not only eats us humans, but gleefully chomps its way through the very defensive systems we use use to contain it? Possibly, yes. But-let’s keep our Alans on, as they used to say in the old Guy Ritchie movies. For there are two good reasons to do so.

First, it’s only eating one type of plastic, so far. There are lots of others which could be deployed for special medical uses which will be less vulnerable.

Secondly, the fact that this plastic is indeed biodegradable, and that something has found a way to do it, offers great hope. Imagine a plastics ecosystem wherein every bottle, every carton, each piece of wrapping is open to attack by this Pap-1 enzyme. Potentially it opens the way to clean beaches, litter- free hedgerows and unblocked rivers and sewers. There is no reason that the genes to make the enzyme could not be spliced into a safer organism than Pseudomonas aeruginosa. It’s an ill wind that blows no one any good, we say.

[1]https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00421-8

#plastics #antibiotics #microbial antibiotic resistance #science #ecology #pollution

More good news on dementias

Photo by Andrea Piacquadio on Pexels.com

Dementia is our own internal pollution. Clear that pollution away, and the brain may start to function well again. If the systems which clear it slow down with age, then of course you won’t think so well. That is the startling new research reported today in the Mail by the admirable Syeeda Saad. [1] According to Syeeda and the rather clever scientists whom she channels, the brain is well equipped with these clearance systems when we are born. [2] They go by such recondite names as microglia, glymphatic and lymphatic systems. They clean up all the horrible waste we produce as we think-bits of cells, proteins, toxins, what have you. If they don’t, you accumulate all this detritus and your brain slows down, exactly like a sewage system blocked with fatbergs (yuck!-ed) [3]

Essentially the ingenious researchers target lymphatic networks outside of the brain in order to boost the clean-up systems within it. And get this-they have found new pathways called T Cell gateways which let them overcome the blood brain barrier, a wall that has bedevilled researchers for decades. [3]

All in all rather hopeful. Though as everyone admits these discoveries are at the early, tentative stage. Meanwhile there are lots of proven methods we can apply in order to reduce the risk of developing dementias. Including unpleasant ones like eating less junk food, drinking less booze and getting more exercise. There’s a thought. And here’s another to close. The team of scientists who did all this useful, public spirited, and one day profitable research are based at Washington University in the United States of America, What will become of them and their University in the financial and intellectual climate currently prevailing in that fallen country?

[1]https://www.dailymail.co.uk/femail/article-14560527/neuroscientist-remove-brain-waste-prevent-dementia-age.html

[2]https://www.vice.com/en/article/clearing-brain-waste-could-prevent-dementia-in-the-future/

[3]https://www.nature.com/articles/nature14432

#alzheimers #dementia #brain #t cells #lymphatic #medicine #health

Round Up: Unpleasant drinks, New antibiotics for old, weight loss and clever cats

What’s in the water? Water is good for you, beer is bad. True, up to a point, especially for those of us who worry about our girth. But think before you drink, as they say. There may be more in that innocent glass of tap water than you bargained for, as this piece from The Conversation makes clear. Forever Chemicals in our drinking water……………

https://theconversation.com/forever-chemicals-are-in-our-drinking-water-heres-how-to-reduce-them-241645?utm_medium=email&utm_campaign=Latest%20from%20The%

Clever moggy finds new virus Ailurophiles of all lands will applaud the tale of this serendipitous kitty who brought home a mouse that contained a hitherto-unknown, and rather scary virus, to his biochemist owner. Here’s the Daily Mail

https://www.dailymail.co.uk/health/article-14021477/florida-rodent-virus-human-infection-potential.html

Antibiotics from the past Leafing through our old pharmacopoeias and other databases may yet be an important new source of antibiotics. God knows we need to look anywhere and everywhere. Fortunately, Science Alert shows the way, with really good graphics(yes we always like those)

https://www.sciencealert.com/forgotten-antibiotic-from-decades-past-could-be-a-superbug-killer

Can weight loss drugs boost your mental health? We at LSS recommend no drug or substance, as we are not doctors. But we will report on new reports about those drugs, provided these are covered by reputable outfits such as New Scientist. Here’s one about new research into possible mental health benefits of these new weight loss drugs which are so fashionable in today’s Zeitgeist, as t’were. Two caveats: once again, don’t do anything with these until you’ve spoken to your doctor; and, moreover, you’ll have to jump the paywall on this one. _{Thanks to G Herbert}

https://www.newscientist.com/article/mg26234953-900-the-surprising-mental-health-and-brain-benefits-of-weight-loss-drugs/

#weight loss #mental health #antibiotic #cat #pollution #forever chemicals #serendipity #medicine health

Processed Foods: Reader Feedback

Photo by Anna Tukhfatullina Food Photographer/Stylist on Pexels.com

Today we reproduce the comment of our regular reader Ms Gaynor Lynch, on our recent piece about processed foods. Many thanks to her for taking the time to contact us:

Ultra-processed foods are bad for you – full stop. They are highly addictive and affect your brain chemistry so that you crave them more. Emerging research suggests ultra processed foods are particularly bad for not just the gut but the heart and brain as well, with mood and cognition badly affected.

Professor Tim Spectre is the go expert on the gut https://zoe.com/post/tim-spector-gut-tips,

There is an excellent excellent article in National Geographic on brain health but there is a pay wall. It may be available through your library service.

https://www.nationalgeographic.com/premium/article/ultra-processed-foods-damage-brain-depression-anxiety-cognitive-decline#:~:text=Although%20many%20ultra-processed%20foods%E2%80%94soda%2C%20candy%2C%20energy%20bars%2C%20fruit-flavored,brain%2C%20with%20mood%20and%20cognition%20taking%20a%20hit.

Abstract of research article in the journal Neurology on associations between ultra-processed food consumption and adverse brain health outcomes. Free, paywall to full article.

https://www.neurology.org/doi/10.1212/WNL.0000000000209432

We at LSS think that this whole issue is only going to grow in the next few years and welcome the thoughts of any other readers who might care to join the debate

#nutrition #obesity #food #diet #sustainability #health #heart