Round up Birth order, resistant fungus, solar missions and much more

a few examples from this week’s news

Is Birth order Destiny? We’ve long been intrigued by the thought that your birth order-whether you’re a sibling or an older child, older brother, younger sister,etc-affects your personality and life chances. Latest twist in the saga is this piece about disease from the Independent: Study suggests first-born children are more likely to develop neurological conditions and second-born are more prone to substance abuse

https://www.independent.co.uk/news/science/first-and-second-born-disease-risk-b3028407.html?fbclid=IwY2xjawTicCtwZG9mBWV4dG4DYWVtAjEwAGJyaWQRMFU1SjR6Q2hsamtwamFOMUxzcnRjBmFwcF9pZBAyMjIwMzk

Recalcitrant Fungus “A drug-resistant fungus that kills thousands of hospital patients in the U.S. every year survives on human skin by hijacking the body’s immune response, scientists have just discovered.” declares Newsweek. So it’s not just bacteria then?

https://www.newsweek.com/deadly-fungus-kills-thousands-every-year-scientists-found-where-it-hides-12297119?utm_medium=Social&utm_source=Facebook&fbclid=IwY

Is all this heat doing in your brain? A few years ago we published a blog speculating that extra carbon dioxide from global warming may be affecting our health (LSS 2 11 20) Well that may or may not be the case: but all that extra heat may well be affecting our brains, as this article from The Conversation makes clear indeed

https://theconversation.com/too-hot-to-think-why-extreme-heat-can-affect-how-well-our-brain-works-289170?utm_medium=email&utm_campaign=Latest%20

Yet more quantum complexity As if quantum physics wasn’t already difficult enough to follow, what with all those bosons, muons hadrons and quarks, Nature Briefing has just made our life a little more difficult with this piece about the Gluon How are we meant to remember all this?

A team of physicists says it has observed strong evidence of a mysterious ‘glueball’, a particle made up of force-carrying gluons. The team says that a particle known as X (2370) is mostly made up of these glueballs — clusters of the gluons that bind quarks to form protons and neutrons and hold them inside the nucleus of an atom. There is no single smoking gun that proves that this particle is made of glueballs, says particle physicist Bruce Yabsley. But the findings are “quite persuasive”, he says. The group presented their results at the International Conference on High Energy Physics in Natal, Brazil, last week.

Nature | 5 min read

Why won’t ET phone us? Normally our Friday purpose is to bring you short snappy pieces before Cocktail Hour. But this Guardian Long Read on why those pesky aliens have never shown up is so very good that we felt it our duty to bring it to you nevertheless

https://www.theguardian.com/news/2026/aug/11/the-great-silence-why-havent-we-found-any-aliens-yet

India’s day in the Sun If there’s one nation that is making huge leaps-commercial, technological, scientific- it is India. Proof if you want more comes from this admirable solar mission Aditya L1, admirably reported by the BBC

Aditya-L1: Indian solar mission’s new findings throw light on enduring Sun mysteries – BBC News

Quote of the week

Behold, how good and how pleasant it is for brethren to dwell together in unity!” — Psalm 133:1

#india #space #solar #global warming #antibiotic resistance #birth order #physics #climate #psychology #family #health #medicine

Incurable cancers-don’t pick and choose your Science

Over the years we’ve enjoyed bringing you good‑news cancer stories. Only a fraction of what’s available in the wider media, of course, but we try to showcase the ones that matter. And we think you will agree, gentle readers, that the overall direction of travel has been encouraging. Immunotherapy, CAR‑T, genomic sequencing — these are just a few of the leaps and bounds of the last decade. Compared with the situation in 1996, or even 1966 when tobacco was almost de rigueur, you might reasonably feel a measure of satisfaction.

Except, of course, for the truly intractable and life‑wasting tumours that still hover over all our lives. Poised and ready to strike, like a swarm of sinister angels from hell.

Our personal list might include Triple Negative Breast Cancer (TNBC), pancreatic adenocarcinoma, glioblastoma, and certain forms of ovarian and liver cancer. This handy list from ScienceDirect offers an excellent jumping‑off point for anyone who wants to learn more. [1] At which point the Reflective Reader might conclude: “More research to be done.” And there’s the rub, as Shakespeare would have it.

For over those same ten years we have drifted into an age when Science, Research and Investigation are increasingly at a discount rather than a premium. Attacks on climate science, vaccination, and epidemiology are nothing new — but they have increased in fury and frequency, and have afforded licence to dispute the findings of any reasonable and learned experts. Recall the vitriol poured on economists who challenged the latest popular fads in constitutional or economic matters, or sociologists who advocate a more rational approach to any number of issues around crime, the family and poverty. For a broader survey of these attacks on the physical sciences in general, see this link to The Skeptical Inquirer.[2], although for the sociological and economic tropes we have alluded to you’ll have to look elsewhere.

But it is not the specific assaults on rationality that matter so much as the intellectual climate they create. Facts are selected, conclusions jumped to, and the passion is for triumph rather than knowledge. Research is a human, social phenomenon, and it is as sensitive to the social trends around it as winds are to a warming climate. Some people may feel they gain by refusing to reason. But they will pay a long price in untreatable cancers, incurable epidemics, and broken economies.

How to remind them they still have time to make a choice?

[1] The 10 deadliest cancers, and why there’s no cure | Live Science

[2] The Disturbing Attacks on Science | Skeptical Inquirer

# Triple Negative Breast Cancer # glioblastoma # CAR-T # alcohol # cannabis #health #medicine #Climate Science

AI designed Bacteriophages: Synthetic Life-or synthetic Evolution?

Ever attentive to our readers’ clamour for more good news on antibiotic resistance we bear yet another story on the synthesis of Artificial Intelligence with the frontiers of cellular biology to produce yet another remarkable advance. Yet we think, gentle readers, that this story may have far deeper significance for the evolution of life on this planet and who knows, several of the neighbouring ones in our Solar System, and today we will tell you why.

First the story, showcasing the work of the assiduous James Gallagher of the BBC.[1] Researchers at Stanford University[2] have used the AI systems Evo 1 and Evo 2 to design a new generation of entirely synthetic bacteriophages which have already proved effective against certain strains of E.coli. We will let our links tell the story of the ingenious Brian Hie and Samuel King and what their teams have accomplished: but regular readers will realise what a valuable new therapeutic technique this could be. Good journalist that he is, Gallager covers certain warnings too: but that is the BBC for you: balanced, nuanced and still true to its Reithian principles 100 years on.

But if you will forgive us, we think this is our opportunity to record why we think all this AI-meets-biology trope we have been covering for some years is truly significant. And it is this. For millions of years, organisms under attack-by parasites, predators, whatever- have relied on the slow, wasteful grind of Darwinian natural selection to stumble toward defence. Now, for the first time, a host species has stepped outside that blind process. With AI‑designed bacteriophages, the human brain—admittedly an organ shaped by old school evolution—is beginning to direct its own evolutionary responses by compressing what once took thousands of generations into deliberate, rapid invention. Not synthetic life, exactly, but something stranger: synthetic evolution. And, if human attempts to colonise the moon and nearby planetary systems are successful, these may be the new sorts of life forms that come to inhabit those worlds. Not sad old Darwinian selected eucaryotes like ourselves and our pet cats. Just a thought.

With thanks to Mr G Herbert and our in-house team of researchers who implored us to break our weekend embargo to bring you this story

[1]https://www.bbc.co.uk/news/articles/c5y3j3ngevmo

[2] AI designs a novel E. coli killer | Stanford Report

#AI #bacteriophages #genomes #health #medicine #antibiotic resistance #evolution #biology #future

Alternatives to a World Government#2: the deep, deep problem with a consumer society

All our breezy prescriptions for a World Government will fail miserably if they don’t address the same problem that the Governments of the Nations are grappling with. And one of the biggest is the widening gap between People and Rulers. Almost within days of arriving in office, the government of our poor namesake Sir Keir Starmer found itself plagued by a deep and inveterate hostility from the voters.

Those same voters demand endlessly lower taxes, then complain bitterly about potholes, weak defence and the lack of capacity in the prison system. They demand an end to red tape and regulation while simultaneously clamouring for restrictions on immigration, the sale of certain drugs, and the use of the internet by minors. Where has such demanding — and self‑contradictory — behaviour come from?

One possible source, we wondered (and at first this was mere speculation), is consumer society. For decades people have been born and raised in a milieu that specialises in gratifying their capricious wants: for sweet foods, for psychologically active substances, and for ever faster ways of travelling towards the next traffic jam. We do not blame companies like Amazon, Netflix or Deliveroo; they have simply perfected trends in a culture a century in the making.

So we asked: do people now demand the same instantly gratifying solutions from politicians that they expect from fast‑food companies?

Readers will be glad to know that help arrived from a much deeper thinker. We came across the work of a remarkable philosopher, Luke Yates, whose book was published in that far‑off year of 2022. Modern society, Luke argues, is based on consumption practices: convenience, speed and instant gratification. If this is how people come to perceive politics, then our outlook is dire indeed.

For, as those of us in the — er — more reflective- elements of the population have known for centuries, politics isn’t like that at all. Its word‑cloud comprises such elements as slow, procedural, available resources, nuance, evidence and above all: choose options. To expect any politician, world emperor or local councillor to wave a magic wand and solve all is to chase mare’s nests and even, dare we say it, bark at the Moon.

Which leads us to a third, depressing metaphor: dead ducks. For if Luke’s thesis is even halfway reasonable, our plan for a World Government will solve absolutely nothing at all.

Oh well. We tried.

Luke Yates (2022), How everyday life matters: everyday politics, everyday consumption and social change, Consumption and Society, 1(1): 144–169.

#world government #luke yates #consumer society #politics#economics #culture

Only evidence will do: book review from Nature Briefing

What happens when Belief triumphs over evidence? Here’s one example. For most of human history, childbirth was dangerous in a way modern readers struggle to imagine. In Europe in the early 19th century, maternal mortality in hospitals could reach 10–20% in bad years. Women died not from the birth itself but from the mysterious, terrifying scourge of puerperal fever. And the explanations? The usual cocky self-serving assertions like miasmas, divine wrath, atmospheric changes. Most Doctors were confident; they knew. When thinkers like Semmelweiss suggested that the cause was filthy medical practices which spread a lethal agent he called “germs,” he was hounded from his profession. The carnage continued until Pasteur and others were finally able to show the true causes, which they did using controlled experiments, rigorous data ,and logical interpretation of their findings.

Those who think such battles to be long won would do well to read the following book review from Nature Briefings. It’s called How we know: the rise of evidence based medicine, But it’s really a gateway to how we know about anything, as opposed to just believing our own first guess

In Beyond Belief, science journalist and Nature editor Helen Pearson charts the rise of evidence-based medicine and explores how rigorous research has transformed health and social policy. Pearson shares examples of success stories, in which solid evidence overturned bad practices, and the people behind them, many of whom were treated as mavericks for championing randomized trials. “Anyone can read and enjoy the book, yet there are nuggets for experienced readers,” writes public-policy researcher Peter John in his review. “The author writes as a believer, and her passion is engaging.”

Nature | 8 min read

At this blog we have tried many times that only reason and evidence will ultimately ameliorate the human condition. But nowhere have we done as well as this book does. And the need is not just in medicine, but in all areas such as climate physics, economics and what still passes for political life. The central problem m is that humans are wired for belief, not evidence. Intuition, anecdote, tradition, and authority shape most human decision‑making. Cognitive biases — confirmation bias, availability bias, motivated reasoning establish certainty long before any data has arrived. Yet the cost of ignoring evidence is enormous: this summer wildfires are again raging across Europe in a way unknown before 2020. Pearson’s remedy is the same old list our side has been pushing since the age of Sir Francis Bacon : demand clear causal claims, ask what the comparison group was, look for replication,, distrust single studies, favour interventions tested in real‑world conditions, accept that “what works” is often context‑dependent But try explaining all that in the bar of the Dog and Duck.

Beyond Belief: How Evidence Shows What Really Works by Helen Pearson (Princeton, 2026)

BBC – History – Francis Bacon

#medicine #science #evidence #reason #experiments #rationality #disease #climate change #politics

Heroes of Learning: The Master Kong (that’s “Confucius ” to you and me)

The most grievous defect of our Heroes of Learning series is that up to now, it has focussed almost entirely on subjects and thinkers from the Western Tradition. Which defect grows from our immersion in a cultural and educational system which has assumed that only Westerners ( and those being, largely, white men) have anything worthwhile to say on matters of philosophy and governance. A conceit cruelly exposed by current developments, especially in nations which have long nurtured independent traditions. Time then, with our world readership to look at other systems and thinkers. And we can think of no better place to start than The Master Kong(“Confucius” in the western tradition) who lived in the China’s Spring and Autumn Period probably between about 551 and 479 BC, making him a near predecessor of such western sages as Plato and Aristotle.[1]

Unlike those refined thinkers, Kong spent a lifetime in the dangerous hurly burly of government service, experiencing wars, coups and even a period of exile. It made him ask above all ”what is the basis for a stable social order? How can the state be made harmonious with the people?” To westerners all the way from Plato through Enlightenment philosophers to moderns such as Rawls, the answer has always been: “ reform the laws; and: institute a just constitution.” But for Master Kong, no set of laws, no constitution can long survive the actions of a venal and unstable ruler. For centuries, westerners seemed to have the answers. But recent experience of leaders who mistake authority for wisdom, bureaucracies that reward compliance over candour, and publics that lose trust when officials and private corporations behave without integrity, have shown this arrogance to be profoundly mistaken. Confucius inverts all: he insists that the State cannot exist without ethical leadership, truthful counsel and restraint. His Analects[2] [3] (actually compiled by his followers after his death exalt character, duty and wisdom as the basis for this stable State. And that these virtues must first of all be prized and cultivated by the leader and his counsel, before any other men will follow them

These teachings have been rediscovered and re-invented many times, becoming interwoven into the warp and weft of Chinese civilisation. They still inform the actions and thinking of leading statesmen to this day. The world has need of harmony and just order now. The prizes of attaining them are almost within grasp. The penalty of failing to do so will be lethal indeed. Has the world still time to learn from The Master Kong?

[1] Confucius – Wikipedia

[2]Confucio – Analectas, trad. Anne‑Hélène Suárez Girard, Editorial Trotta, Madrid, 2012.

[3]Edward Slingerland – Analects of Confucius: With Selections from Traditional Commentaries, Hackett Publishing, 2003.

#master kong #confucius #china #civilisation #order #law #governance #state #anarchy #politics

Alternatives to a World Government: Part #1 of a new series

All the thinkers we admire say the same thing really: what is your alternative explanation? Bayes insists on always balancing two probabilities. Russell on always looking at the opposite point of view, Keynes on first establishing if your pet idea is general or just a special case. And Daniel Kahneman on checking which bit of your brain you’re thinking with anyway. Which brings us round to our universal panacea, a World Government. We’ve made the case for it a number of times here(LSS passim) so veteran readers will know our diagnosis: most of the problems of the world appear intractable because nation states can never work together with sufficient speed and co-operation to resolve them. Hence economic stagnation, growing xenophobia and a rapid breakdown of the ecological systems upon which we all depend for Life.

Hang on: because aren’t we muddling diagnosis with solution? In which case abolishing the nation state becomes a futile quest, and our World Government a mare’s nest. Are there other diagnoses of our ills which, if correc.t could address all these ills while safely retaining our systems of Governance.? We ought look at them : we owe our readers that much. And so we drew up a list of other possible root causes, which we cheerfully present below. We shall examine them in the coming weeks. Our candidates include Economic inequality. Institutional decay, Technological acceleration, and its concomitant, cognitive overload., Economic model exhaustion, Tribalism and Media systems and collapse of a common narrative

None of them are mutually exclusive and we will find overlapping themes, read similar authorities and consider facts more than once as we move through the series. So bear with us. But one thing we do know: one of you out there, maybe more than one, will have an idea we haven’t thought of. So if you want to put a candidate on the list let us know. In any case we look forward to all of you accompanying us on this next journey.

# bayes #jm keynes # bertrand russell #daniel kahneman #history #economics #politics #governance #technology

Should we blame Alan Greenspan for everything that’s gone wrong?

Photo by Andrea Piacquadio on Pexels.com

As historians of the future pick through the rubble of America’s decline and fall after its supreme triumph in 1991, they will ask one plaintive question: “How was such a winning position thrown away so decisively — and so quickly?” There will be plenty of blame to go around, plenty of suspects against whom fingers will be pointed. But one name keeps coming up again and again: Alan Greenspan, Chairman of the Federal Reserve of the United States from 1987 to 2006.

Today, the case for the prosecution against “ol’ Al” is made loudly, cogently, and with devastating clarity by Robert Reich, US Secretary of Labor under Clinton and now a professor at Berkeley.

We really think you should read this [1] — especially if you have a home, a family, a community, and, most pertinently of all, a job where the salary has not risen significantly in twenty years or so. But for those pressed for time, Reich summarises what he sees as Greenspan’s masterpiece of misjudgement thus:

“If any single person was responsible for the financial crisis of 2008, it was Greenspan… the worst collapse since 1929… resulted from the deregulation of Wall Street that Greenspan advocated.”

“He pushed Clinton and Congress to repeal the Glass–Steagall Act, which since the 1930s had separated investment banking from commercial banking, thereby preventing banks from gambling with personal savings. He also argued vigorously against regulating derivatives — essentially financial bets on financial bets — that later proved to be weapons of mass financial destruction.”

Yet we ask: is the culprit really Greenspan? Or is it actually ourselves?

Greenspan was widely regarded by critics as an enthusiastic advocate of the ultra‑rich and the values they espouse: hierarchy, conspicuous consumption, obsessive individualism. Whether these are virtues or vices is a matter of debate — but they were adopted enthusiastically by wide sections of the population for decades, making the task of Greenspan and his Wall Street fellow‑travellers infinitely easier.

For the ultimate illusion they peddled was Common Sense: it makes sense to reduce the deficit, for what is a nation but a giant household? Well, it is a bit — but mostly it isn’t. So things like infrastructure, research, and health go into the “nice‑but‑we‑can’t‑afford‑it” ledger too many times, and slowly but surely decline acquires a momentous, unstoppable hegemony of its own.

So don’t just blame Greenspan — blame ourselves for buying into a system that puts that sort of man into that sort of job. And hope that future societies develop much more judicious HR policies.

[1] RIP Alan Greenspan: you were charming, powerful and wrong | Robert Reich | The Guardian

#business #economics #united states of America #alan greenspan #robert reich #finance #markets

Round up for this week: What’s the biggest living thing. how many quantums in an atom, lupus progress-and international relations

Fungal internet Its not whales or trees:Some of the largest living things on our planet are actually vast networks of microscope white fungi growing beneath the ground on which we unthinkingly tread as The Conversation explains;

https://theconversation.com/fungal-highways-are-vast-yet-hidden-underground-new-study-285166?utm_medium=email&utm_campaign=Latest%20from%20The%20Conversa

Don’t expect Putin to go quietly if he loses in Ukraine If you think current developments in the Russian Ukraine war might lead to a status quo ante bellum, think again ,as this prescient article from the Guardian makes clear

https://www.theguardian.com/commentisfree/2026/jun/14/vladimir-putin-ukraine-war-borders-russian-president

Plant a tree in ‘73, plant some more in ‘74 was a Government slogan from our long distant youth But maybe trees won’t save us from climate change as well as we thought they might as this piece from The Guardian explains

Trees may store less planet-heating carbon than hoped, study suggests | Greenhouse gas emissions | The Guardian

A bestiary of bosons Nothing so defeats us as the vast and baffling variety of particles ,waves and other strange things that make up the modern atom .So we welcomed this article from Nature Briefing which tries to make sense of the matter

How many elementary particles are there?

Even if you know your fermions from your bosons, the actual number of fundamental particles — the electrons, quarks and other building blocks of physics — is still uncertain. From the 17 that feature on posters on classroom walls, “where you stop depends on your taste for complexity and mystery”, explains science writer Natalie Wolchover. “Plausible answers range from 17 to — in all seriousness — 995.5.”

Quanta | 13 min read

Lupus in remission Just before we pressed the “SEND” button, our researchers insisted that this encouraging story about a new immunological technique which seems to be turning the tide on the debilitating disease of Lupus went in, Good for them. here’s the BBC

‘I’ve never been this good’ – revolutionary immune reset puts lupus in remission – BBC News

Quote of the week

He that hasteth with his feet sinneth.” (Proverbs 19:2)

#lupus #immunology #fungi #Russia #physics #quantum physics #vladimir putin #trees

So just how big is Artificial Intelligence going to be anyway?

Go into any pub, stand in any supermarket queue, and you’ll hear some one talking about “this ‘ere artificial intelligence wotsit, guvnor.” Some, especially the elderly and bewildered, are overwhelmingly hostile. Others like ourselves reference it from time to time in specialist settings like the development of new drugs and other molecules. Yet others, visionaries indeed, see it as the absolute future, already indelibly written. So how significant will it be really, and what changes might it effect? To find out, we thought we’d compare it with other big turning points in the History of the World and see how it shapes up by awarding each event an LSS Significance Verdict (SV) Ready?

1950s Rock and Roll replaces the Big Bands Well , you could make just as big a noise with far fewer musicians, and the lyrics got better. But in the bigger scheme of things-nah, not really SV 1/10

1780s Industrial Revolution There had been wind and water mills, but the first time the power of muscles was replaced by machines on a truly worldwide scale, although mess it created still needs clearing up. In human terms at least this must go down as quite a biggie. SV 5/10

2320 BC Writing For the first time data could be captured and stored outside of human memory. This immensely helped the development of early agrarian civilisations as well as giving us writers like Dante and Shakespeare On the other hand it has also given us popular newspapers, graffiti and those funny little jokes you find when you open up Christmas Crackers SV 5/10

3.351 287 years BC, Tuesday 27^th June: Invention of tools Now we’re getting somewhere . The great Arthur C Clarke said this was a big one because the tools themselves shaped the biological evolution of their owners : teeth shrank because they were less needed, hands became more delicate to make ever finer tools, and so on. Some think AI will have this effect on the current human species, but we think it could be bigger than that (see below) SV 7/10

390 000 000 years BP Vertebrates come on land Because humans are vertebrates and write all the Prehistory books, they big this up as one of the great steps in time. It isn’t, as any arthropod, mollusc or plant will tell you: they had already climbed up there 100 million years before. SV 3/10

1,250 000 000 years BP Fusion into eucaryotes Now we are talking .Somewhere around this time a small bacterium that lived free took up its home in the cytoplasm of a larger organism called an Archaea. The new cells were a sort of hybrid , each retaining their own DNA, but fusing into a successful new organism called Eucaryota. Which includes all plants, fungi and animals that currently live or have ever lived on this planet. One type is even trying to get into space albeit slowly and not very well. If both AI and humans could fuse their identities into a single superorganism, then we predict a very bright future for them indeed. And an end to all these chats about “Is AI going to take us over?” SV 9/10

So what do you think gentle readers? What steps would you choose? The invention of fire? Language? The sudden demise of platform soles and flared trousers round about late 1975? Each thesis will have its opponents and defenders. But one thing is certain. AI is here to stay so we had better get used to it.

#technology #history #Artificial Intelligence #IT #evolution #industrial revolution #space travel