Hello we’re back-and we have Nobel Prizes!

First of all, apologies for our forced and utterly unwanted absence. But Domestic Renovations, and the sorts of people who carry them out, can be as tiresome and time-consuming as any other human relationship which the Gentleman Scholar must negotiate -domestic staff mistresses and lovers, cleaners, mechanics, and countless others. All require patient listening, multiple cups of tea and hefty pay offs, if only to still their incessant demands for even a moment. But here we are back again where it counts-with you, gentle readers. And we are glad to say that we return with one of our favourite sequences of the year. It’s Nobel Prize season again. [1]

For us, the Nobel prizes are the very essence of what this blog is all about. That careful learning and scholarship are not only what lifts our lives above the miserable condition of wild apes (well, some of us): they constitute the only only possible escape route from our current plights, many of which are serious and grave. And this time we think we can prove it. with the help of three of the very winners themselves-how’s that for endorsement, ladies and gentlemen? That’s the prize which will receive our first detailed attention, in the next blog: but let’s start with a roll call of the stupendously intelligent people who have stood out this year as the cream of humanity

Physics: John Clarke Michel H Devoret John M Martins Amazing work “for the discovery of macroscopic quantum mechanical tunnelling and energy quantisation in an electric circuit” Yup, we kind of lost too it after the fourth word in the citation, but we’ll try to understand it better in time for a later blog

Chemistry Susuma Kitagawa Richard Robson Omar M Yaghi Want to capture Carbon dioxide, water in the desert, store toxic gases and many other things? These discoveries will let you do all of them. If this isn’t right on the raison d’etre of this blog, we don’t know what is. Again, come back later for more

Physiology and/or Medicine Anything in these fields must be close to an LSS reader’s heart. So the work of Mary E Brunkow, Fred Ramsdell and Shimon Sakaguchi on the tricky world of the immune system requires our most emphatic hats-off

Literature and Peace Intelligence can be of the Emotional kind as well as the academic, as many of us discover with agonising slowness and pain. So although these subjects lie outside the remit of our blog we are proud to give honourable mentions to László Krasznahorkai and Maria Corina Machado respectively (is she a relative of Antonio Machado the famous Spanish poet, we wonder?-ed)

But finally our first next blog on this subject, as t’were, will be devoted to the patient Economics work of Joel Mokyr, Phillipe Aghion and Peter Howitt. Because finally they have shown at Nobel level, what we have believed for so long. It’s science and learning that drives the economy. Which is where we go next time.

[1] https://www.nobelprize.org/all-nobel-prizes-2025/

#nobel prizes #economics #physics #chemistry #medicine #physiology #economics

How climate change drives the return of deadly diseases

We never thought we’d see it. But Malaria is making a comeback in the British Isles [1] According to the latest findings from the UK Health Security Agency(UKHSA) cases rose by a whopping 32% from 2022 to 2023 making them the highest in 20 years. More than 2000 cases in fact. Now some of this is due no doubt to travel bounce backs after the COVID 19 pandemic. But once put into a broader context. the real pattern becomes both clear and alarming. Global warming is driving a massive spread of insect vector diseases. Dangerous diseases that almost seemed under control until the oil companies unleashed climate change on an innocent world

Staying with Britain just for now, William Hunter of the Mail [2] reports on the appearance of two deadly mosquitoes in the UK: the Egyptian mosquito Aedes aegypti and the appropriately named Tiger mosquito Aedes albopictus. For now these are isolated events, and under current conditions their spread may even be containable. But every year the climate gets a little warmer. Every year brings a higher chance that these vectors will spread their deadly triple load: Dengue Fever, Chikungunya and Zika. With all the consequences which wel- seasoned readers of this blog will recall from our earlier outings on this theme (see LSS 25 3 25, 25 10 21 and many others)

We confess to becoming a little angry when we we write stories like this: such disasters could have been so avoidable. Once, not so long ago these diseases were unknown in this islands except as travellers’ tales, or as the province of medical specialists. Now a wave is crossing the world. We know what the remedy is. If by any chance you are a parent reading these lines: this story is one more line of evidence among many. Your children can never be truly safe until global warming is finally controlled and reversed.

[1]https://ukhsa.blog.gov.uk/2025/05/21/how-we-protect-the-uk-from-vector-borne-diseases/

[2]https://www.dailymail.co.uk/sciencetech/article-15151429/tropical-diseases-britain-mosquitoes-dengue-fever.html

[3]https://wellcome.org/news/how-climate-change-affects-vector-borne-diseases

#disease #malaria #dengue fever #climate change #g;obal warming #health

Co-LAB-oration, or why its good news UK is back in Horizon

Science is good for economic growth. It’s theme we’ve touched on before in this blog(LSS 4 10 23; 1 3 24) So any initiative that builds on this incontrovertible fact will meet with our approval. if only because we want a higher standard of living next year. Which is why we showcase this article by Lisa O’Carroll of the Guardian [1] which reviews progress of the UK’s revived membership of the EU administered Horizon Programme, which tries to bring together the efforts of scientists technologists and scholars from across many countries.

It may soothe the objections of our more rabid eurosceptic readers, to learn that almost half the members (20:27) are not in the European Union, but are located as far afield as Canada and New Zealand (“is that Bri’ish Empoire enuff fer yer, Guv?”) But because science is a collaborative process it helps if you can recruit your teams from close neighbours, if only because it saves on things like travel costs on the day of the interview. We need not discourse long on close financial and technological links as Lisa covers them well in her article. It’s a cultural link of a different stripe which makes us think that rejoining was the right decision.

For what the UK and its fellow members have in common is that they are open societies, where information and people flow freely. The other possible partner, the USA, is showing strong signs of both damaging the free flow of information as well as launching major attacks on both the funding and the very work of scientists, as our readers well know. The Horizon programme and the countries that contribute, are the genuine heirs of both the Renaissance and Enlightenment. Societies that abandon the practice of truth and reason soon fall into cultural and economic stagnation. Just as being in UEFA is a sound bet for British Football Clubs, so is Horizon for British Universities. A good news day forr once

[1]https://www.theguardian.com/science/2025/aug/12/uk-recovers-position-horizon-europe-science-research-eu-brexit

[2]https://commission.europa.eu/funding-tenders/find-funding/eu-funding-programmes/horizon-europe_en

#science #technology #economics #EU #UK #renaissance #enlightenment #donald trump

The economic costs of antibiotic resistance

Down the years we’ve tended to cover the health risks of antibiotic resistance , and the various scientific and medical developments in the field. We haven’t written so much on the economic risks. And frankly, that’s been a blind spot.

Now a very clear sighted article by Anna Bawden of the Guardian[1] makes those potential costs very clear indeed. Drawing on report from the prestigious Centre for Global Development [2] Anna serves up some chilling facts Get this:

A UK government-funded study shows that without concerted action, increased rates of antimicrobial resistance (AMR) could lead to global annual GDP losses of $1.7tn over the next quarter of a century.

Breaking it down by countries:

The research calculated the economic and health burden of antibiotic resistance for 122 countries and forecast that in that in this most pessimistic scenario, by 2050, GDP losses in China could reach just under $722bn a year, the US $295.7bn, the EU $187bn, Japan $65.7bn and the UK $58.6bn.

That alone should give the thoughtful 5% of us pause for thought. But it’s Anna’s background which makes this a great article. For it comes at a time when countries like the USA and the UK are busily cutting their overseas aid budgets. Which is shows a worrying lack of self interest on their parts. For one thing, antibiotic resistance will not be confined to poorer countries: but it is much more likely to develop in them. Secondly, being at the forefront of pioneering science can spin off the most amazing business and technological opportunities for the more astute kind of entrepreneur. And thirdly, and most acutely for their voter base: if the health system in those poor contries collapses, guess where their populations will pitch up? “Stands ter reason,dunnit, mate?” as our old friend Dave Watford is fond of stating. Thanks, Dave- you’ve got it right this time.

[1]https://www.theguardian.com/society/2025/jul/20/superbugs-could-kill-millions-more-and-cost-2tn-a-year-by-2050-models-show

[2]https://www.cgdev.org/media/forecasting-fallout-amr-economic-impacts-antimicrobial-resistance-humans

#antibiotic resistance #health #medicine #economics

Could this new mRNA vaccine end cancer?

In the UK alone cancer accounts for 24% of all deaths.[1] Which means you, gentle reader have a close to one in four chance of going that way. You might hope that someone might do something about it. Today we bring you news that somebody has, via the industrious Luke Andrews of the Daily Mail [2] But before then, a tiny apology.

Because in reporting this we have no desire to disparage the heroic efforts of scientists, doctors, fund raisers and honest-to-God patients who have already done so much to ameliorate and already effect cures for this terrible disease. Luke’s story could be a game changer-but only because it comes at the ned of an enormous process of scholarship and research. That said, it is truly exciting. Firstly, because it tries to use the new mRNA vaccines which came of age during the COVID 19 pandemic. Secondl, because it offers a hope, however tentative at this stage, of a universal vaccine. Luke explains matters really well,. with all the links you need to the source journals, so we’ll leave you to him. Upbeat to say the least.

Vaccines are a contentious subject. We have talked about cancer vaccines here before(LSS 24 5 21 et al) and are aware of the mixed reactions we get. We suspect that not all anti-vaxxers are bad people: among them you will will find the stubborn types who refuse to accept any information coming down from above on whatever subject. Grit in the wheels of the machine; but one day you just might need them. But we in what might be called the empirically based community have our uses too.(we invented the computer you’re reading this on) it’s time for a dialogue, instead of hissing and growling at each other like so many cats and dogs. The patients deserve that.

[1]https://www.cancerresearchuk.org/health-professional/cancer-statistics/mortality

[2]https://www.dailymail.co.uk/health/article-14919401/immune-hack-vaccine-mrna.html

#mRNA #cancer #vaccine #medicine #health

Closing the Fleming Fund-a bad day for antibiotics

One of the few certain things in life, apart from death and taxes, is to go to the bar of the Dog and Duck and there eavesdrop on opinions on the question of the UK Foreign Aid budget. “We got omeless on ahr streets, an dere sendin billions abrawd!” “We’re taxed to the ilt, an’ they’re givin it away!” are some of the politer opinions we dare repeat here. How ironic for them to see a hated Labour Government make the very cuts they so long for. But our pleasure is short lived..

For the Government seems ready to abolish The Fleming Fund. [1] A body set up in 2015 and named after the the illustrious pioneer of penicillin, the fund states its purpose as a

UK aid programme supporting up to 25 countries across Africa and Asia to tackle antimicrobial resistance. The Fund is managed by the Department of Health and Social Care and invests in strengthening surveillance systems through a portfolio of country and regional grants, global projects and fellowship schemes.

But-what goes around comes around, as the old saying has it. Antibiotic resistant superorganisms know no national boundaries. If they evolve in the third world, they will be here soon. This decision appears to be very short sighted.

We sympathise with a government caught in a hard place between the obdurate creed that says taxes must never rise, and the urgent need for spending to achieve at least a minimal defence capacity. Perhaps the real problem is not economic, or biological, but philosophical. For if the world is divided into competing nation states, what choice does each government have but to look after its own immediate interests? And if nations arm, each in mutual fear of its neighbours, what hope for spending on international co-operative efforts like the Fleming Fund? Perhaps the trick for LSS and its readers is not to develop more antibiotics, but to persuade millions of the sorts of people who go to the Dog and Duck to realise this simple truth.

_{thanks to J Read}

[1]https://bsac.org.uk/closure-of-the-fleming-fund-risks-undermining-uk-leadership-on-amr/

[2]https://www.flemingfund.org/about-us/

#fleming fund #overseas aid #antibiotic resistance #health #medicine #microorganisims

Calling all Billionaires: Please read this blog

John Caudwell[1] is no fool. Anyone who has started a company like Phones4U and turned it into a multibillion pound company must be pretty well endowed in the brains department. Yet he has one particularly intriguing belief. He believes in meritocracy: he is deeply suspicious of the idea of inherited wealth. If you want to know more about why you can hear home talking to Tony Hawks in this podcast [2] Tony Hawks is Giving Nothing Away on the BBC. But essentially Caudwell thinks that in the long run his children will lead healthier, happier lives if they have to make their own way. Like he did.

We don’t know about individuals. But we know societies function better if the follow Caudwell’s prescriptions. Old LSS hands will recall our long time advocacy of the works of Thomas Piketty [3] and Wilkinson and Pickett. [4]Who show that societies with more equal economic structures have better health outcomes, lower crime, more scientific innovation and much higher social mobility, than less equal peers. One of their key findings was that wealth hoarded into family dynasties is one of the key blockers of healthily mobile societies.

Which is why Caudwell has joined the Giving Pledge. [5]No it’s not a marxist commie plot: it’s run by some of the richest people on the planet. In the words of the organisation’s own website:

Pledgers support a wide array of issues in every corner of the globe and give in a multitude of ways. What unites them is a shared promise and a commitment to creating an impact.

Wealth can be spent in two ways. It can be wasted in endless competitions as to who drinks the best bottle of wine, drives the fastest Rolls Royce or has the biggest yacht. Or it can be re invested like this creating a healthier better world, with-who knows?-maybe even enough antibiotics. if you really want to spend your money to make your children safe, this is the way to do it. If you are a billionaire, thank you for reading. If you are not-find one gentle readers, and press the works of the Giving Pledge into their hands.

[1]https://en.wikipedia.org/wiki/John_Caudwell

[2]https://www.bbc.co.uk/sounds/brand/m002fj92

[3] Thomas Piketty Capital in the 21st Century Harvard University Press 2014

[4] Richard Wilkinson and Kate Pickett The Spirit Level Penguin 2009

[5]https://www.givingpledge.org/pledger/john-caudwell/

#john caudwell #the giving pledge #economics #philanthropy # equality #social mobility

Why a falling population will solve most of our problems

Photo by Kostiantyn Stupak on Pexels.com

Back in the 1970s we used to worry about rising population the way we worry about antibiotics now. Problems like pollution, energy shortages and even climate change were being discussed in the better pubs in the area where we grew up. Birth rates were soaring around the world. Everyone agreed that by 2010 there were going to be far,far too many people for the planet to support (and you wondered why you weren’t invited to more parties?-ed)Since when the situation has changed. Rulers, particularly of the more authoritarian sort, are fretting that their populations are actually starting to fall. The reason this keeps them awake at night, they asseverate, is that thereby there will not be enough young workers to keep pensioners in the style of living to which they have become accustomed (although we privately suspect they have darker motives) “Make women have more children!” is their cry. How about “the pram is the tank of the Home Front!” Or has that one been used already?

The reality is rather different as Larry Elliott points out so limpidly in this short piece for The Guardian [1] A falling population means less pressure on oceans, air and land. Less need for antibiotics! More seats in cinemas and restaurants! And, quite quickly, a rising GDP per head of population. As for the economic thing: a single modern worker produces and consumes far more GDP and products than a hundred medieval farm hands. To keep the economy growing you just need to raise the standard of living, you don’t need more workers

But as committed feminists we have another sort of worry. If you really want women to have more children, you will have to take them out of universities and higher education generally. Re- structure the wage market so men are again the main breadwinners. Recreate ideologies of patriarchy and submission, a bit like those currently popular in Afghanistan. is that what you really want?

[1]https://www.theguardian.com/commentisfree/2025/jul/02/britain-falling-birthrate-economy-politics

#feminism #pollution #population #economics #ecology

Why Keir Starmer can never be Clement Attlee

We apologise to overseas readers for the parochial references in this blog: but are our problems so different from yours?

As we write BBC Radio 4 is running a series about the 1945 General Election and the marvellously successful Labour Government that followed it.[1] For six years the United Kingdom had the most serendipitously achieving administration it had experienced since Elizabeth I. As he listens (assuming he has time) our current Prime Minister must ask himself “Why can’t I do what Clement Attlee did? Why is the concatenation of problems-defence, economy, social policy- so absolutely, stupendously overwhelming that even my own backbenchers are in such overwhelming revolt? [2]

No one doubts Starmer’s intelligence. Or courage. Or good intentions. However,the problems run too deep, and in our opinion are insoluble if the nation state is the means chosen to solve them. Clement Attlee inherited a world where companies, and the financial structures that supported them essentially existed at a national level (or within the imperial frameworks those nations had created) So the writ of Westminster really did run, and no one could afford to ignore it. Legislation passed by a British Government really did have the power to shape lives. Improve them sometimes,even, as the creation of the NHS and NATO so admirably demonstrated.

If Starmer’s government fails it will fall to Reform UK to make the necessary budgetary adjustments which Labour could not. A hint of the difficulties they may face comes from Warwickshire where a brave 18 year old has bravely taken the reigns of their new Council.[3] He states his belief as “Brexit, sovereignty and a strong and united family unit”.

Perfectly admirable and defensible beliefs, even if one disagrees with one or more of them intellectually. Unfortunately his manifesto raises many questions. Like : what is sovereignty? How far can it be sustained in a world where almost half of all available investment capital is in private hands? Can a country the size of the UK create and sustain its own industries against production runs in the power of giant corporations, or countries the size of China and India? How long did City States like Milan and Florence sustain their sovereignties against giant antagonists like Spain and France? Your Renaissance history will help here, but don’t worry: you won’t have to read it for long.

Antagonists they may seem, but both Starmer and Reform are two of a kind. A national government may have some power to alleviate, sometimes, if enough of its supporters let it. Its days of initiative and creation are long gone. Keir Starmer will never be Clement Attlee. And no one will be Winston Churchill either.

[1]https://www.bing.com/search?q=bbc+radio+series+1945+election&form=ANNTH1&refig=6F075FD8E25341758E4FFB72C8969982&pc=HCTS

[2]https://www.theguardian.com/politics/2025/jun/26/no-10-government-talks-labour-rebels-attempt-quash-welfare-bill-revolt

[3] https://www.theguardian.com/politics/2025/jun/26/reform-warwickshire-council-head-rob-howard-quits-after-five-weeks-leaving-18-year-old-in-charge

#Labour #Reform UK #politics #economic #nationalism #finance #trade #economics

Weekly round up: Animal chats, monkey business, patronising the working classes-and why Prudence is dear to us

a few stories to get you doing the work for a change

Hope for Alzheimers It’s an understated truth, but the general ageing of the population is one of the most significant trends in human history. That’s why doing everything we can to understand it is so important. We took heart from this new Alzheimer’s test which shows real promise The I paper via Apple News https://inews.co.uk/news/health/blood-test-scientists-alzheimers-nhs-3733762_{thanks to P seymour}

Nigel Farage is becoming the true tribune of the working class in Britain reports the acute mind of Andy Haldane. Because Farage realises that immigration and inter ethnic jealousies it engenders are the prime motivating force for most humans, way ahead of housing, health and certainly education.. And we have noticed a tendency among the educated classes(not Haldane) to sneer at ordinary people like builders and taxi drivers for nurturing these hatreds. Remember one thing: the high-consumption high-energy life styles of these so called educated classes are causing the ecological collapse which causes immigrants to flee to richer countries in the first place. Don’t be surprised if the lower orders , who are the first to encounter all the new neighbours, begin to act in emotional and inconvenient way. The Guardian

https://www.theguardian.com/politics/2025/jun/08/nigel-farage-like-a-tribune-for-working-class-former-bank-of-england-economist-andy-haldane

Monkey Pandemic -echoes of Gibbon? Pandemics start small, but eventually cause the Decline and Fall of vast empires. That’s the clear lesson from History. Which is why we take this warning Sierra Leone mPox raises fear of spread from the redoubtable Nature Briefing very seriously indeed

A surge of mpox infections in Sierra Leone has stretched the country’s health-care system, sparking fears that the virus will spread to neighbouring countries in West Africa. Sierra Leone has confirmed more than 3,000 infections in the last month, and an analysis of viral genomes suggests there have been at least four times more infections than officially reported, says genomic epidemiologist Edyth Parker. The recent withdrawal of US funds for foreign aid will make curbing the outbreak even more difficult, experts say.Nature | 5 min read
Reference: Virological.org analysis

If I could talk to the animals Ever since the early days of iconic simians like Washoe, Kanzi and Flipper the Dolphin, researchers have been hoping to crack the code of animal language. But would be Dr Doolittles should beware: such languages may not exist, warns this prescient article from the Conversation. Making the hunt for them a wild goose chase. Or should that be a mare’s nest? (that’s enough flippancy–ed)

https://theconversation.com/animals-cant-talk-like-humans-do-heres-why-the-hunt-for-their-languages-has-left-us-empty-handed-258321?utm_medium=email&utm_campai

Prudence always The Beatles White album was for us the least of their works. It seemed to be full of rather self indulgent essays in mediocrity and could have done with being cut down from two of those funny black shiny things to one. However, one song does stand out. Dear Prudence, covered by many, was always best in the original

https://www.bing.com/videos/riverview/relatedvideo?&q=beatles+dear+prudence&&mid=63C4B520F9B93453531963C4B520F9B934535319&&FORM=VRDGAR

#nigel farage #immigration #alzheimers #mPox #pandemic #linguistics