We learn something new about cancer from a great website called The Scientist

One thing we value here is a well‑written science story that tells us something we didn’t know — and does so in a trustworthy, responsible way. Not the sensationalist, attention‑grabbing material that flashes across our screens all too often. So when our researchers came across Colorectal Cancer and Childhood Exposure to a Common Gut Bacterium by Laura Tran in The Scientist[1], we decided to look at the source itself, to see whether it deserves a place among the canon of science‑news providers we consider worthy of your attention, gentle readers.

As you might expect, The Scientist specialises in clear, sober reporting: across the biosciences, speaking very broadly. The style is terse and informative, closely aligned in spirit with the journals and institutions it covers. There’s a strong news section, a quarterly print magazine, topic‑based browsing, and a generous set of resources. Our test search — naturally, Antibiotics — produced several well‑illustrated, highly informative pieces.

If pressed, we’d say the ideal reader is intelligent, graduate or postgraduate, and probably working somewhere in the life sciences. But there is plenty here for teachers preparing a good science lesson too. Or even two.

Our verdict: not as bite‑sized as Nature Briefing, nor as magazine‑like as New Scientist, The Scientist nevertheless earns a worthy place alongside them as a provider of news and ideas for the educated and reasonable community (that’s us, gentle readers). And in an age when so much content is shaped for attention rather than understanding, that’s a very important thing indeed.

And having satisfied ourselves that The Scientist is indeed a sober and reliable chronicler of the biosciences, we can turn to the story that brought us there in the first place. It is a quietly important one: evidence that early‑life exposure to certain strains of that perfectly ordinary gut bacterium — Escherichia coli carrying a particular genetic island — may leave a mutational fingerprint that shows up years later in colorectal tumours. No melodrama, no scare‑stories, just the steady accumulation of data: mutational signatures, epidemiology, and the slow, careful work of linking mechanism to disease. This is exactly the sort of thing the scientific enterprise does well, and exactly the sort of thing we like to bring to your attention.

[1] https://www.the-scientist.com/childhood-exposure-to-bacterial-toxin-tied-to-early-onset-colorectal-cancer-72952?fbclid=IwY2xjawSxsvNleHRuA2FlbQIxMABicmlkETBVNUo0ekNo

#cancer #medicine #science #life science #research #laboratory #start up #biotechnology

CRISPR meets Epigenetics: a marriage made in Heaven

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a natural defence system found in bacteria, which scientists have turned into a programmable way to edit genes with extraordinary precision. In practice, it comprises two parts: a guide RNA that acts like a GPS to find the exact spot in DNA, and a Cas9 enzyme that acts like molecular scissors to cut the DNA. Once the DNA is cut, scientists can delete, fix, or replace genetic sequences inside a living cell. Our first Cover seems to have been over six years ago (LSS 23 11 20), since when we have noted a startling range practical applications from areas as diverse as horse breeding, and sickle cell medicine, to its relationship with blue sky techniques such as Base Pair editing, CART and programmable therapeutics (LSS passim).

How gratifying then to see CRISPR-based tools now partnered with epigenetics, that other old favourite of these humble pages! Once again the lead is taken by the indispensable Nature Briefing, now our go-to for all new things Scientific Their summary CRISPR’s next act: editing the epigenome tells you most of what you need to know. But some readers may well wish to click on the handy link too

A handful of start-up firms are testing therapies that target specific epigenetic markers — essentially chemical groups that sit on DNA and the proteins that it is wound around — to treat everything from high cholesterol to a rare muscular disorder. Changing these chemical markers can switch genes on or off. Some existing medications influence epigenetic markers, but these drugs act broadly and lack specificity. A new cadre of scientists has found ways to precisely alter the epigenetic signals that influence specific genes.

Nature | 15 min read

There is much here to gladden the hearts of all who believe in Reason and Learning. The technique seemingly so radical a few short years ago is not only becoming routine, it is embedding itself into the wider corpus of medical and scientific practice. Practicable applications are multiplying and the opportunities to reduce human and animal suffering are thereby multiplying. If anyone asks us “why do you take such an interest in the progress of the Arts, Sciences and Letters?” one answer we give is: because of things like this.

If you want to know more about epigenetics, or molecular biology in general, then we cannot do better than recommend the works of the great Professor Carey:

Carey, Nessa. The Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance.London: Icon Books, 2011. New York: Columbia University Press, 2012. ISBN: 9781848312920 (Icon Books); 9780231530712 (Columbia UP).

Carey, Nessa. Hacking the Code of Life: How Gene Editing Will Rewrite Our Futures.London: Icon Books, 2019. New York: Columbia University Press, 2019. ISBN: 9781785784972 (Icon Books); 9780231549769 (Columbia UP).

#molecular biology #genetics #epigenetics #CRISPR Cas 9 #medicine #health #DNA #RNA

Gene Megacluster: a really big moment in antibiotic research

The idea of whole and unexpected possibilities in antibiotic research excites our highest hopes-and those of readers who have accompanied us on this journey for years. None more so than this report from Nature Briefing Gene Megacluster boosts antibiotic arsenal. We’ve set up their usual summary, plus links: and then we’ll try to answer a few of your questions as best we are able

A newly discovered gene ‘megacluster’ in Streptomyces bacteria enables them to produce a variety of potent antibiotic compounds. These compounds act as a multi-pronged offensive weapon against other species, with each targeting different stages of the bacterial metabolic process. It’s more difficult for bacteria to develop resistance to attacks that hit several targets, so the discovery could lead to the development of new antibiotics, experts say. The research has “discovered something new in a system so extensively studied — hidden in plain sight,” says medicinal chemist Mark Blaskovich

Nature | 4 min read
Reference: Nature paper

So, what is this gene megacluster? An unusual stretch of DNA in Streptomyces that encodes four distinct families of natural-product antibiotics, including: one compound entirely new to science, another never previously recognised as an antibiotic, and two known families deployed in a new coordinated fashion. Not a bad haul for one discovery, we think.

What does it do in Streptomyces? All four molecules target biotin (vitamin B7)—a universal cofactor required for growth, cell division, and metabolic enzyme function in most bacteria. They attack different points in the biotin pathway: production, uptake, use, and availability, aided by flanking streptavidin genes that bind up free biotin.

Why is this discovery genuinely new? Well , all sorts of reasons: here are a few of the best

–Co-location is unheard of: Antibiotic biosynthetic pathways are usually scattered across the genome. Here, four unrelated antibiotic families sit side-by-side, implying intentional evolutionary selection.

–Coordinated multi-antibiotic strategy: Natural antibiotics typically act alone. This cluster encodes a team of molecules that hit the same vulnerability from different angles—something not previously documented.

–Hidden in plain sight :Streptomyces genomes have been mined for decades, yet this megacluster was overlooked because genome-mining tools historically focused on single-product clusters. We love this bit, as regular readers will have already discerned

–It appears to be widespread. The megacluster is present across multiple Streptomyces species, suggesting an ancient, conserved strategy rather than a rare curiosity.

Could similar clusters exist in other organisms? Likely, yes. The discovery provides a road map for genome mining that looks for coordinated multi-pathway clusters, not just single biosynthetic islands Early research might do better to focus on procaryotes rather than eucaryotes-but who knows?

How could it help us to develop new antibiotics? This is the Big One for us , isn’t it? Lots of ways potentially, but as of late June 2026 three practical routes suggest themselves:

1. Direct development of the four biotin-targeting molecules. Because they attack different steps in the same essential pathway, they could be: used individually, combined as a cocktail, or engineered into hybrid molecules. Multi-target antibiotics are inherently harder for pathogens to resist. So that will teach them we’re serious this time.

2. Synthetic biology reconstruction. The megacluster’s architecture can be transplanted into: Streptomyces strains, E. coli or yeast expression systems, or modular cell-free platforms, permitting all sorts of scaling and production advantages

3. Drug discovery by analogy The discovery provides a template: look for clusters that coordinate attacks on other essential pathways (e.g., folate, isoprenoid synthesis, lipid II). Genome mining guided by this logic could uncover dozens of new multi-pronged antibiotic families.

4. Biotin-pathway inhibitors as a new class Biotin metabolism is conserved across many pathogens, including Gram-negatives—historically hard to target. These molecules could seed a new class of antibiotics that bypass existing resistance mechanisms

At this blog we tend to rate discoveries by the possibilities they open rather than the questions they answer. By that metric, this one is big indeed-and we think you’ll al agree with that.

#antibiotic research #antibiotic resistance #health #medicine #biotechnology #genetic engineering #research #bacteria

Vaccines: it’s a question of Anthropology not Biology: Gillian Tett knows why

Why doesn’t evidence cut through? Why do reason and learning so often fail? They’re themes that have haunted this blog since its inception way back in the COVID‑19 days of 2020. Aren’t we supposed to be the heirs of the Renaissance, the Enlightenment, and all that? Maybe part of the answer lies in this story about the UK and Japan, and their startlingly different experiences with their respective HPV vaccination programmes, as detailed in this excellent Conversation article by Professor Justin Stebbing of Anglia Ruskin University [1].

On the face of it, vaccines are a winner: the biology is clearly understood, they save lives, and they have eliminated numerous diseases [2]. Which explains the success of the UK rollout of the HPV vaccine: Justin has a barrage of juicy statistics, but in his words the NHS now feels able to publish a plan to eliminate cervical cancer as a public health problem in England by 2040. Compare that with Japan, where following a reasonable start, the HPV vaccine campaign collapsed into desuetude. There were media stories, the government lost its nerve: the result is” that among girls born in certain years, coverage fell from around 70% to below 1%, and it remained at that level for years“. And Justin explains the dreary consequences at some length.

So why can’t we understand the difference between the two countries? In the end, vaccine hesitancy has very little to do with the science and everything to do with the stories people swim in. The biology stays constant; what shifts is the cultural weather around it. A rumour here, a misframed headline there, a neighbour’s anecdote, a politician’s stumble — tiny changes in narrative that can tilt whole communities from confidence to doubt. Vaccination succeeds or fails not in the laboratory but in the social world: in trust networks, identity cues, and the fragile ways humans decide whom to believe. It is anthropology, not virology, that explains why one hospital bed stays empty and another does not.

In other words, public health is really about anthropology, not biology. One person who understands this well is Gillian Tett, whose formidable book Anthro‑Vision [3] argues that the real drivers of human behaviour are rarely the numbers on the page but the cultural currents beneath them — the stories people trust, the tribes they belong to, the risks they feel rather than calculate. Public health often talks in data, but people decide in narrative. A stray rumour, a clumsy headline, a shift in group mood can undo months of scientific clarity, while a well‑placed story or trusted voice can restore confidence just as fast. And suddenly this becomes true of many of the things that preoccupy us here — climate change, economics, even the long arc of female emancipation. For all our “LSS are the heirs‑of‑the‑Age‑of‑Reason,” for all our Whiggish rhetoric, we’ve missed one important truth. People are not how we would like them to be. And this book tells us a lot about why.

[1]https://theconversation.com/the-hpv-vaccine-works-but-only-if-we-keep-trusting-it-285618?utm_medium=email&utm_campaign=Latest%20from%20The%20Conversation%20fo

[2] Why vaccination is important and the safest way to protect yourself – NHS

[3]Tett, Gillian. Anthro‑Vision: How Anthropology Can Explain Business and Life. London: Random House Business, 2021.

#vaccination #public health # HPV #anthropology #biology #culture #history

Should nicotine be included the war on drugs?

When that paragon of unimpeachable virtue Richard Milhous Nixon announced the War on Drugs back in 1971, we counted ourselves among his most fervid supporters. It chimed with our most basic principle: people must be stopped from enjoying themselves wherever and when that is possible. And when some of those people are pot-smoking hippies or degenerate cocaine fiends, how much more satisfying still was that act of repression! But yet, as always, the Devil Whispered in Our Ear: If we were banning all that weed and charlie and smack and billy whizz because they altered minds and caused social problems, then what about nicotine and alcohol? Didn’t Jesus seem to take a relaxed view of the matter, both in the famous wedding at Cana (John 2 10 ), and in the Last Supper (Matthew 26:27–29) At least the company didn’t light up cigars at the end of the meal-but boy, did these passages pose us some problems!

Since when things have slipped still further. As if they didn’t have enough problems with fossil fuels and rising sea levels already, the nation of Palau has dropped another logic bomb upon the Comfortable nations of the world Read this Should Nicotine be regulated like drugs? from Nature Briefings

A call by the Pacific island nation of Palau for nicotine to be regulated like narcotics by the United Nations will trigger an assessment and a vote by member states. If nicotine were to be added to the UN Convention on Psychotropic Substances, it would effectively make it illegal to sell nicotine products that aren’t considered medicinal, says nicotine-treatment specialist Renee Bittoun. But tobacco-company lobbying makes it unlikely that nicotine will be added to the list, says Bittoun. Nature | 4 min read

Whatever next, gentle readers? Will they free up restrictions and red tape on the sale of tea and coffee? Will they start alleging the thrill people get from driving fast cars is like that from cocaine-and bring in speed restrictions? Or will some sect of uber – Free Market Liberals, followers of Adam Smith or something, seize power and then abolish all restrictions on all neurologically active substances? We can’t decide whether we are going to be oppressed by Communists or Capitalists: but we await our fate in trepidation.

[1] War on drugs – Wikipedia

#tobacco #nicotine #palau #pollution #free market #war on drugs #cannabis #cocaine #heroin #alcohol

Diabetes: another benefit of the BCG Vaccine?

A couple of years ago we did a piece called Did your long-ago BCG Vaccine save you from dementia? In which we reported that the famous BCG (Bacillus Calmette-Guérin) vaccine was also proving efficacious in cases of bladder cancer and certain types of dementia. (LSS 2 12 24) Well today things just became even more intriguing. Read this from Nature Briefing, Century Old Vaccine helps control diabetes;

A tuberculosis vaccine developed in the 1920s helps to regulate blood sugar in people with certain types of diabetes, enabling them to reduce their insulin use. The findings demonstrate yet another beneficial off-target effect of the Bacillus Calmette–Guérin vaccine, derived from a weakened form of the bacterium that causes tuberculosis in cows. The shot has been approved to treat bladder cancer in the United States and is being investigated against conditions such as Alzheimer’s disease. The results were presented at the American Diabetes Association meeting on 7 June.

Nature | 5 min read

And the Learning Point? When we did Training and Teaching, they always told us that we had to have a learning point. So we think it’s this:

Vaccines are one of civilisation’s quiet miracles:[2] you design them for one threat, and decades later they’re still paying unexpected dividends — BCG for TB, then bladder cancer, then dementia, and now hints of protection against diabetes. That’s what real science does: it compounds. You invest once, and the benefits echo for generations. But if you decide, like the climate denier or the old‑school smoker, that evidence is optional and expertise a nuisance, you’re effectively betting your long‑term future against the only tool that has ever reliably improved it. Reality is not something you can pick and choose.

[1] BCG vaccine – Wikipedia

[2] Vaccines and immunization

#vaccination #BCG #tuberculosis #cancer #dementia #diabetes #health #medicine #research

More on AI and Antibiotics-and it’s good news

Once again, the source for our blog today comes from the excellent Nature Briefing, who are always in the forefront of scientific research in every field. Today we are showcasing their piece AI is taking on antibiotic resistance because we think they’re picking up on some real game-changing developments, and we really want you to know about them.

Let’s start with their usual helpful summary, as it’s a good general overview. But this time we earnestly beg you to click on the link they have provided: read below to find out why.

Antibiotics are an effective, but somewhat indiscriminate solution to some gut infections. Helpful species of gut bacteria get caught in the crossfire, which increases the likelihood that drug-resistant bacterial strains will evolve. Researchers are now designing drugs to selectively target disease-causing species with the help of artificial intelligence. Some teams are using AI to screen drug molecules for the most promising candidates quickly and cheaply. Others have developed tools that predict how drug molecules bind to protein targets to reveal a drug’s mechanism of action, reducing the need for wet-lab experiments.

Nature | 15 min read

Because if you do, you will step into a world of research where Information Science and Biological Science are meeting: which of course is more and more these days isn’t it? You will learn about:

Jonathan Stokes of McMaster University in Canada who have pioneered the use of AI to test their newest molecule called enterololin and thereby strip out all kinds of old-skool testing processes.

Regina Barzilay of MIT who with her team have done much of the AI work to set this up for Jonathan She is a remarkable woman who has been hunting down the link between antibiotics and AI since 2018-how’s that for far sightedness, folks?

You’ll be able to name check tools like Diffdock , RdKit and Chemprop which these people use to do all this-how’s that going to sound in the pub?

And a woman called Molly Bartlett who’s something called a Chemical Informatician at London’s Imperial College. As we still have a tenuous connection to that august institution we sometimes write in to their alumnus mag and tell them what a good job they’re doing, knowing we speak for all of you, gentle readers.

And much more besides, Especially if you do the decent thing and sign up to go behind the paywall.

Funny, isn’t it? If our first name were Donald (it isn’t) we might note how much this progress a) seems to come from despised places like Canadia and Englandland b) how somehow these evil foreigners still find ways to work with Unitedstatespersons c) maybe if you want to find cures for important things you may have to look at other methods in addition to earnest prayer d) if I were getting bigly older, perhaps approaching my eightieth birthday for example, I might like to have a few antibiotics around. Just a thought.

# Antibiotic research #Artificial Intelligence ~medicine #health #bacteria

Round up of the week: What happens when you don’t educate women, and what happens when you do

Taliban v education Further depressing news from Afghanistan about the crack-down on female education. Oh well, it’s up to them, but they will be the long term losers, as every possible statistic will soon start to show. The Conversation has the details:

https://theconversation.com/what-happened-to-afghanistans-female-academics-283000?utm_medium=email&utm_campaign=Latest%20from%20The%20Conversation%20for%20June%201%202

Yet more hope on cancer Here’s what happens in societies that do educate women. A new drug that goes by the snappy name of GRWD5769 may be on the brink of transforming prospects for late-stage cancer patients To rub the point in we’ve stories from opposite ends of the political spectrum our old stand-bys,The Mail and the Guardian.

Wonder pill shrinks tumours in a third of patients with six hard-to-treat cancers, early trial shows | Daily Mail Online

.Smart drug that strips cancer cells of ‘invisibility cloak’ can shrink tumours by 30%, trial shows | Cancer | The Guardian

Super El Niño Better keep your ice cubes ready if you read our cocktail column (LSS passim) Because you are going to need them says the Mail, who, despite what you might think, are having a good Climate Crisis.

Super El Niño is on its way: Scientists warn there’s now an 80% chance the unusual climate pattern will arrive this summer – bringing extreme heat ‘nearly EVERYWHERE’ | Daily Mail Online

AI and Vaccines come together Are we a medical blog or an AI one? Looks like the difference doesn’t matter any more, as the two fields seem to be in fusion. This is a remarkable one, gentle readers so if you need a bit of cheering up, read it, from the BBC

‘World-first’ vaccine designed by artificial intelligence – BBC News

CAR-T enables kidney transplants reports Nature Briefing Yet Another LSS Favourite New Techniques (FNT) takes yet another encouraging step forward, this time in the world of transplant medicine:

A single dose of engineered immune cells has helped three people with ‘highly sensitized’ immune systems to receive life-saving kidney transplants. People in this group are often ineligible for transplants because their bodies usually reject the donated organ. Researchers engineered the recipient’s own immune cells into chimeric antigen receptor (CAR) T cells that ultimately reduce the trouble-making antibodies that push their immune systems into overdrive. More than a year after receiving the cells, the three people are now living with new kidneys and without notable side effects.

Nature | 5 min read
Reference: New England Journal of Medicine paper 1 & paper 2

We think that lot more or less makes our point for today. Except for this thought from some American bloke:

An investment in knowledge pays the best interest.” — Benjamin Franklin

#cancer #CAR-T #Artificial Intelligence #transplants #climate change #health #medicine #women #education #afghanistan

Chikungunya: another potential Climate Change epidemic?

News that we’re in for a record El Niño[1] this year brings a depressing thought is Climate Change going to deliver a whole new wave of tropical diseases alongside all those floods. fires and migrations? We’ve touched on this before (LSS 25 10 21,14 11 23, 2 10 25) but had rather hoped that it had all gone away. It hasn’t, as this excellent article by Shivali Best of the Mail [2] explains in forensic detail. And it’s her work we’ll be riffing on today, with a little help other sources.[3]

Shivali takes Chikungunya virus as her theme. It’s a nasty little disease caused by an alphavirus of the Togaviridae group. Discovered in Tanzania in 1952 it delivers a painful cocktail of symptoms including fever and severe joint pains: the latter may be extremely debilitating and long-lasting. But the real problem lies in its vectors, the famous yellow fever mosquito Aedes aegypti and the scarily named tiger mosquito (a. albopictus) Do they call it that because of its bite? Not only does climate change allow these insects to spread to lands where the cold had formerly precluded their presence. The same warming allows the virus to breed up to five times faster inside the mosquito. Before you ask: there are vaccines of sorts underway: but progress has been slowed because most of the money has been spent on wars and shopping malls.

And so Chikungunya joins the long sorry list of diseases spreading due to global warming. To which we could append Malaria, Dengue, Zika, Lyme, Tick Born Encephalitis, Vibrio group……..enough! LSS readers are a well-informed lot. They know what’s happening. They know why. The real task before us all is how to clear up the damage, and make those culpable pay for it

[1]Prepare for El Niño, UN warns – it could be the strongest in decades – BBC News

[2]Chikungunya virus is heading for Europe: Scientists warn mosquito-borne tropical disease could spread to major cities thanks to climate change | Daily Mail

[3]Chikungunya fact sheet

#chikungunya #malaria #climate change #disease #vector #epidemic #health #mosquito

Broaden your mind with these two great brain stories from Nature Briefing

We believe that research into the human brain is the flip side of research into Artificial Intelligence. As the two will one day coincide, the more we know about both the better. So when Nature Briefing, that go-to Record for all things new and scientific, puts out not one but two (two, folks!) stories on the human brain, we felt it our solemn duty to bring you them both.

We have always believed that scaring people into doing things is counter-productive in the long term. Our worse fears are confirmed by this piece called Stress stops the Brain Joining the dots.

Acute stress makes it difficult to connect memories of past experiences with fresh information — a process crucial for making deductions. This could explain why people struggle to show insight under pressure. During psychological tests that involved making links between indirectly related pictures, brain imaging showed altered activity in the hippocampi of people who had been through a stressful mock interview compared with those of people who’d had to complete a simpler task, which suggests that their brains hadn’t inferred connections between the images as strongly.

Nature | 5 min read

Reference: Science Advances paper

Every epoch casts reality in its own image The Victorians though that everything in the world worked like a steam engine. Around 1910 they thought all was electric circuits. And Cold war people put us all down as computers. Every picture of the brain is an analogue, an attempt only as this piece The Brian is no machine makes clear.

In The Brain, In Theory, neuroscientist Romain Brette makes the case to move away from the predominant model of the brain, which treats the organ like a computer. Brette argues that engineering metaphors are often vague and misleading, and attempts to breathe life back into brain science by focusing on the study of the nervous system on biology. “Brette’s take-down of the field’s dominant theoretical frameworks is systematic,” writes neuroscientist Àlex Gómez-Marín in his review. “The book is intense and intricate. One can get lost in it, but it is worth the adventure.”

Nature | 7 min read

So our advice is study both of the above with close attention, gentle reader. It’s a no-brainer!

#neuroscience #artificial intelligence #biology #IT #nervous system #logic #stress