Ten years looking for new antibiotics: how are we doing?

How’s the campaign to get more antibiotics going?” We still sometimes get asked this in pub or supermarket. Not surprising really, after more than ten years on the job. And to answer that question we can think of no one better than the acute Julia Kollewe of the Guardian whose piece is as good a state-of- play message ( Pipeline of New Drugs to fight superbugs is “worryingly thin,” experts warn) as any we’ve seen for some time[1] So, what’s the score? How indeed is humanity meeting this existential challenge?

Not too well, actually. The bad news is that antibiotic resistant infections are still very much on the rise. More than 40% of known antibiotics lost potency between 2018 and 2023.[2] The number of antimicrobial projects run by big pharmaceutical companies has actually declined in the last five years. But you can read these and many other statistics from Julia and her linked organisations for yourself.

There are some bright spots: hats off to the UK’s GSK ,Japan’s Shionugi and Otsuka, and certain valiant American firms in California. But America’s real giant, Pfizer, seems to be falling off the pace-not surprising we think, given the political end cultural climate they now have to work in.

But for us Julia’s killer trope was to consult the learned Ara Darzi, an expert in cancer treatment. Who adduces the following gloomy thought:

New therapies mean cancer can be fought, “but then sadly patients succumb to an infection that was treatable a decade ago”, Lord Darzi said at the launch of the AMF report, adding: “You don’t win a game if you have three good strikers and your defence is weak.”

Cancer is indeed a deadly illness. And cures should be sought. But what’s the point if the poor patient dies three days later from an infection? That is why your interest in new antibiotics is still important, gentle reader: please keep supporting us.

[1] Pipeline of new drugs to fight superbugs is ‘worryingly thin’, experts warn | Pharmaceuticals industry | The Guardian

[2] Tools to fight AMR exist, but industry-wide action is needed to tilt the battle against superbugs | Access to Medicine

#antibiotic resistance #microbiology #health #medicine #drugs

VIR 5500: Promising new treatment for Prostate Cancer

Immunotherapy, which involves training the body’s own defence systems such as T-cells to attack cancerous tissues, has been one of the medical success stories of the last twenty years. Yet some cancers still demonstrate a certain recalcitrance in the face of the new ministrations. Unfortunately, one of them is Prostate cancer, the most common form of cancer in men, killing up to 1.5 million of them annually. But not only does this report by Nicola Davis of the Guardian [1] offer hope of real progress, it has some deeper lessons for those of us in the evidence-based thought-modulated community(EBTM). Which means you, gentle reader.

All immunotherapy depends on T Cell engagers (TCEs) which form a bridge between certain sites on the T Cell and on the tumour cell. Anyone working with them to try to cure prostate cancer encounters two difficulties. Generally, traditional TCEs can be pretty indiscriminate, leading to side issues like massive cytokine storms and problems with dose toxicity. Specifically, prostate cancer cells have a knack of resisting T cells, making immunotherapy especially hard to apply. Now a team led by the admirable Professor de Bono in collaboration with Vir Biotechnology[2] is trialling a new form of molecular cloaking treatment called VIR-5500 which masks the T-cells right up to the moment when they are in contact with the prostate cancer cells. A protease in the malign cells then activates the T-cells, unleashing their curative effect. We won’t spoil Nicola’s summary of the results, which you can read in her article. But you will find them impressive to say the least.

All of which goes to show what curiosity-driven basic science can achieve when money is spent on it. VIR -5500 could not have existed without decades of molecular immunology, protein engineering, tumour cytology and many other disciplines hidden away in unmanly places like university departments and research institutes. Which is ironic, because many of the butch types at the Dog and Duck, who routinely perform their masculinities by loudly decrying scientific research into things like climate change, will be the first to suffer when prostate cancer comes along. But History always teaches the same lesson to the deluded in the end.

[1] Researchers praise ‘stunning’ results of new prostate cancer treatment | Prostate cancer | The Guardian

[2] Our Strategy | Vir Biotechnology

#prostate cancer #immunotherapy #t cells #health #medicine #science #molecular biology

IsoDDE: mixed-race love child of Biology and Information Science has a great future

One of the most exciting stories we have followed at this blog is the way new AI systems are suddenly speeding up the production of new drugs and other biological molecules (see LSS 1 12 20 et al) This week has seen another exciting step in the form of a new AI tool from Isomorphic labs. Read this piece, Drug discovery AI is akin to Alpha Fold 4 from Nature Briefing

Isomorphic Labs — a biopharmaceutical spin-off of Google DeepMind — has unveiled a new, powerful artificial-intelligence tool for predicting how proteins interact with drugs. The tool, called IsoDDE, can outperform other AI systems such as the open-source Boltz-2 and physics-based methods at determining binding affinity between a protein and potential drug. These skills have impressed scientists, but they highlight that IsoDDE is proprietary, and the technical paper that accompanied its announcement offers scant insight into how to achieve similar results.

Nature | 5 min read

The research and development of new drugs is one of the most arduous tasks that befalls the intelligent community. The central problem is pretty simple: how do you get your marvellous new drug to stick to a protein, and make the whole thing work the way you want it to? Proteins are not hard rigid statues of marble: they are soft, spongy and change shape in unpredictable ways when you put a new drug up against them. That’s the gap in function into which all that time, money and thought disappears. In theory new AI tools like Iso DDE (and others on the way no doubt) should rapidly speed the whole process by predicting myriad of possible shape changes as the molecular systems are brought together.[2] Moreover, to predict new bits on the target protein which we hadn’t thought of, where the drug might be made to stick to, And possibly, to crunch the numbers around all those new bits of protein, polypeptide and other molecules which are thrown up in the research process, to see if they have any likely uses as well. When we were young, Information Science and Biology were completely different disciplines with different faculties, buildings and career paths. It’s funny to watch them coming together so fructiferously, to produce such exciting offspring

[2]https://storage.googleapis.com/isomorphiclabs-website-public-artifacts/isodde_technical_report.pdf

#drugs #medicines #researh #AI #biology #health

Can your cat save you from cancer?

Cats: our feline friends: variously cute, lovable, admirable and beautiful. They’re becoming more and popular as pets. Which brings several advantages in the treatment of cancer, believe it or not. Like dogs, their nearest rival, they are exposed to all the same molecular slings and arrows of everyday domestic life-cleaning products- foods, fuels, what have you-as we are. But we also share more genetic material with them then we do with our canine chums. Moreover cancer is rapidly becoming a major cause of mortality in middle aged to elderly cats just as it is to humans in that stage of. It’s a set up for ground breaking studies. And Miguel Ángel Criado for El País and Helen Briggs of the BBC have two excellent reports on a groundbreaking study which has done exactly that. (teaser: one of these links is in Spanish, and one in English-can you guess which?)

The study, co-led by the learned Dr Louise van der Weyden of the Wellcome-Sanger Institute is the first really large map of oncogenic(cancer related) aspects of the cat genome. It’s full of intriguing details, which you can read by clicking on the marvellous articles which we have hyperlinked. But we could not resist a tiny spoiler, concerning Dr Weyden’s discoveries around the gene FBXW7 , a tumour‑suppressor gene whose loss helps drive aggressive forms of human breast cancer. Intriguingly, the same gene is frequently mutated in feline tumours. This cross‑species echo suggests that cats and humans may share a conserved vulnerability in the FBXW7 pathway, making our kitties unexpected partners in understanding this cancer mechanism.

And the conclusion? We need to help cats to help us. You could give to a cancer charity [3] You could give to a cat charity[4] But knowing our readers to be generous types we have included sufficient hyperlinks for you to do both!

[1] El mayor mapa genético del cáncer de los gatos abre la puerta a tratamientos compartidos con humanos | Salud y bienestar | EL PAÍS

[2]https://www.bbc.co.uk/news/articles/cvg3n7j8xyqo?at_campaign_type=owned&at_link_type=web_link&at_format=link&at_ptr_name=facebook_page&at_link_origin=BBC_N

[3] https://www.cancerresearchuk.org/get-involved/donate?

[4] Cats Protection | UK’s Largest Cat Welfare Charity

#cancer #breast cancer #cats #medicine #health #research #genome #oncology

Stanford’s new discovery is a marvel-but can we really call it a vaccine?

Today we are happy to present one of the best news stories we’ve ever covered in our long years on this blog. It’s the announcement of a new type of vaccine from Stanford University. But it’s so mind bogglingly different from all the others we’ve come across that we genuinely wonder if it should be called vaccine at all! The details may be found in this crisp article from the excellent James Gallagher of the BBC [1] Essentially, it’s a nasal spray, so far tested only in mice, that offers protection against several viruses including colds, flu and COVID 19. Also against bacteria such as Staphylococcus aureus and Acinetobacter baumannii, two long known antibiotic resistant inhabitants of these pages.

Now, traditional vaccines have worked the same way ever since the pioneering work of Jenner. One organism=one vaccine, with the immune system trained to recognise one small target area of the invading organism. It’s as precise as a sniper; but can only ever protect you against one disease. The brilliant team at Stanford have taken an utterly new approach and decided to tackle the pathway by which a whole bunch or organisms make their attack. In this case the lungs. So it doesn’t matter if you are hit with a COVID 19 virus, the common cold, flu, the bacterial chums we noted above or even certain allergens. The macrophages of the lungs have been fired up and stand ready to repel any hostile borders-and will remain that way for several months[2]

Right, back to the question we started with: as this is so different from anything we were taught in school, can we really call it a vaccine? Well. If you define a vaccine as “ a molecular entity that trains the immune system to respond more effectively to a future biological threat” then yes, it is. But compared to the old ones it is a conceptual leap of awesome power. We doubt it will replace “old -skool” specific vaccines; their efficacy is just too good to waste. But as a completely new, game changing intellectual concept-well we think the sky’s the limit

[1] Single vaccine could protect against all coughs, colds and flus, researchers say – BBC News

[2] Science (2026)
“An intranasal vaccine activating innate immune danger pathways protects mice against diverse respiratory pathogens.”
Published: 19 February 2026

Lead author: Dr. Olivia Martinez, PhD
Stanford University School of Medicine
Department of Microbiology & Immunology

#health #vaccine #colds #flu #antibiotic resistance #virus #bacteria #immune system

Air Pollution and Alzheimer’s: grim news

We’ve written a lot about air pollution over the years (LSS passim) Mainly to say that air pollution, particularly in the form of PM_2.5 particles can do all sorts of harm to your lungs and circulatory systems. A fact well-attested by some of the sharpest medical minds on the planet as this WHO report shows[1] But now there is increasing evidence that these pesky particles may play a big part in the massive wave of dementia and neurodegenerative disease that is sweeping across the world. The latest evidence is summarised by Professor Eef Hogervorst for The Conversation.[2] And it’s pretty grim.

Air pollution and the deadly particles it chucks out are associated with all kinds of activities beloved of certain US politicians and their followers. Fossil fuels; road transport; old style heavy industries; good ol’ boys roun’ the barbecue fire, and that sort of thing. But how do you measure it, and separate out other plausible causes? A rather nifty US study started by mapping Medicare claims for dementia by postcode and PM _2.5 particle density. Other factors such as smoking, bad diets and poverty were also considered. The latter was admirably controlled by factoring in Medicaid eligibility, a sure indicator of low wealthin the US. We often use the phrase Killer Quote here: this time it’s more than a rhetorical flourish

…….pollution levels in the areas studied were, on average, about twice as high as the limit set by the World Health Organization (WHO). ………..The researchers found that the increased Alzheimer’s risk in polluted areas remained even after taking high blood pressure, stroke and depression into account

Eef goes on to explain how and why PMs are pulverising your grey matter: but click on! For she does it much better than we ever could.

And our thoughts, gentle readers? Firstly, the work confirms other reports we’ve noticed [3] Secondly the impressive size of the sample. Above all the careful attempts to control other factors such as diet and poverty; we know you prefer thoughtful scholarship over blind jumping to conclusions. Nothing is yet conclusive: but the hypothesis that air pollution causes other forms of dementia fits the available data so very much more closely than anything else does seems to us to be as close to one as you can get.

[1] WHO global air quality guidelines: particulate matter (‎PM2.5 and PM10)‎, ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide

[2] https://theconversation.com/air-pollution-may-directly-contribute-to-alzheimers-disease-new-study-275873?utm_medium=email&utm_campaign=Latest%20from%20The%2%5B2%5D

[3] The effect of ambient air pollution (PM2.5) on dementia risk | Nature Aging

#air pollution #fossil fuels #smoke #alzheimers #dementia #WHO #health #medicine

How a frozen bacterium might stop the great ESKAPE

For microbiologists the great ESKAPE is not an old film on the telly at Christmas. It’s a classification of the six most deadly antibiotic resistant bacteria which they work with. These are of course: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.In other words, the bacteria that most effectively “escape” the effects of antibiotics, and thus sit at the heart of our current global antimicrobial‑resistance crisis. Now hope that they might be controlled is emerging from the icy caves of the Carpathian Mountains. And you might be forgiven for thinking that at first sight it actually makes things worse.

Because frozen in the ancient soil of Carpathian caves lies a bacteria with the snappy name Psychrobacter SC65A.3 -and it’s no less than 5,500 years old. We we’ve got two covers for you today: one in Spanish from that excellent newspaper El País by Miguel Ángel Criado and one from the Mail by Shivali Best. Both wax eloquent on its dangers: it seems resistant to at least a dozen of the best-known antibiotics. But here’s the rub: the same evolutionary toughness which let it develop these remarkable powers of resistance has also let it develop remarkable powers as an enemy of other bacteria. Including many of those on our ESKAPE list.

The natural tendency of people is to look at the scary side of anything: and thereby jump to the worst possible conclusions. We know that our readers are the ones who suspend belief a little longer, and always look deeper. In the long run that’s the only type of thinking that will release us from the antibiotics resistance crisis. And many others

[1] Hallada una bacteria helada hace 5.000 años capaz de plantar cara a superpatógenos | Ciencia | EL PAÍS

[2] Prehistoric killer superbug discovered in 5,000-year-old ice is resistant to 10 modern antibiotics, study warns | Daily Mail Online

#antibiotic resistance #microbiology #medicine #health #bacteria #ESKAPE

Narco Warriors: brilliant new podcast on the war that’s shaped two centuries

Photo by Journal of Studies on Alcohol and Drugs on Pexels.com

We’ve always been pretty much against the illegal drugs trade, if that is still a safe thing to say. For its reach and power give it the heft of many a nation. Its turnover is estimated to be between $300-$600 billion per year. If you throw in all the deaths-from assassinations, associated diseases and economic disruption, then these at 500 000 a year are more than many nations’ mortality statistics. And like any State, it has organised armed soldiers, trained and ready to kill. No wonder so much effort has gone in to controlling the sale and distribution of illegal drugs since the nineteenth century. when the Chinese attempted to control the illegal importation of opium. Narco Warriors, a podcast series from highly experienced journalist Lindsay Charlton is the latest attempt to chronicle the long decades of this deadly and interminable war.

Charlton and his team of researchers have assembled hardened veterans of the war-customs officers, investigators, police officers- as well as those who operate in its shadowy intelligence led nooks and corners. The listener is taken on a vast sweep of lands and seas, of shootings, confrontations, agency turf wars and many earnest intelligent brave people trying to do the best jobs they can for their countries. And we salute them, above all for their endless dedication to the public good: for its clear that people of this calibre could have made a lot more money a lot more safely in many other walks of life. And there we might end it. Except for one thought, which that old Devil has just come round and whispered into our ear.

What is a drug anyway? If you say that cannabis, cocaine and heroin are highly dangerous and addictive substances, then you must say the same for alcohol and nicotine. But these are sold openly on the streets in many western countries. Indeed the attempt by the United States to prohibit alcohol from 1919 to 1933 was one of the most unhappy and unsuccessful enterprises which that country ever undertook . For one thing, it was an object lesson in facilitating the rise of violent organised crime, a historical irony not without relevance to present policy. The real problem is that the appetite for cocaine, heroin and alcohol are all driven by human demand. Gangsters are simply those capitalists who supply the illegitimate part and operate according to the same laws of supply and demand as their peers in legal sectors of the economy. As for that demand -there is strong evidence that it is fuelled by rampant economic inequality and the associated poor housing and social and economic insecurity which that entails. In which case the State’s resources would be better spent on building homes, schools and raising the minimum wage rather than on all those flashy speedboats and burly types in uniforms. But: society made its choices long ago, and who are we to call them wrong? If you want to know the consequences of those choices, told by the people who were there, then listen to the first episode [1] And all the subsequent ones of course!

[1]https://audioboom.com/posts/8855552-narco-terrorism-the-forever-war

#drugs #addiction #narcotrafficers #law enforcement #police #transport #smugglingm #opium wars

Food: is it quite as good as you thought?

Food is everywhere these days. Shelves groan with glossy cookbooks, restaurants and gastropubs queue up for tax breaks, and the airwaves are thick with chirpy kitchen‑dwellers—some dropping their aitches with theatrical enthusiasm, others sounding as if they’ve just strolled out of a rowing club bar. Everywhere you look, there’s another beaming evangelist waving a saucepan and assuring us that their latest ‘blend’ is nothing short of a revelation. One could be forgiven for thinking that food itself has become a national moral project, a jolly good thing in which we are all expected to take an interest.

However the readers of our little blog being a thoughtful lot, we thought we’d put up two stories which might provide a little counter-balance to the general merriment. The first from the indefatigable Kat Lay of the Guardian (clearly she knows about more than just antibiotics) does not suggest food is bad per se. But it does suggest that being extremely careful about what you eat, and who is selling to you might be a very good idea[1] Her headline tells you exactly what we mean: Ultra-processed foods should be treated more like cigarettes than food – study

“OK, OK”. you say, “but wot I eat is my choice, innit, guvnor? If I ain’t doin’ no one else no ‘arm, wosser problem?” Well according to Nature Briefing, Eating Well is about more than your health, this might be:

Debates over what to eat — more protein, say, or less ultra-processed food — often neglect any mention of how our food systems affect the biosphere that keeps us alive. But nutrition doesn’t exist in a vacuum, notes Earth-systems scientist Johan Rockström. He co-chaired the latest update to the Planetary Health Diet, which aims to optimize human health globally and reduce environmental and social harms. It notes that “global greenhouse-gas emissions could be cut by 20% by 2050 by eating healthily, reducing food waste and adopting sustainable production practices”, writes Rockström. “If diets remain unchanged, however, emissions will increase by 33%.”Nature | 7 min read
Reference: The EAT-Lancet Commission on healthy, sustainable, and just food systems report

We want humanity to survive, really we do. If you went extinct there would be no one to man the check out tills at supermarkets and we’d have to use those ghastly check-out-yourself tills that are so slow, complicated and inconvenient. Yeah food is alright, sometimes. But as the old saying goes-be careful what you wish for.

[1]https://www.theguardian.com/global-development/2026/feb/03/public-health-ultra-processed-foods-regulation-cigarettes-addiction-nutrition

#food #nutrition #climate change #obesity #health #fat #protein #fast food #processed food

Two new stories give fresh hope on cancer

Two stories give us hope of real progress in understanding and treating cancer. The first from the excellent Emma Gritt of the Mail [1] concerns the work of the great Dr Mariano Barbacid whose work has been so crucial in elucidating and developing the whole theory of oncogenes and the role they play in cancer. His team has been studying the effects of three drugs on the KRAS gene, deeply implicated in the development of the pancreatic form of the disease. But: don’t read us, read Emma-she knows a lot more than we do

The second story, from the inimitable Ian Sample of the Guardian [2] concerns the application of the Google Deep Mind AI tool to study genetic drivers of cancer-and other diseases too. To quote Ian:

“We see AlphaGenome as a tool for understanding what the functional elements in the genome do, which we hope will accelerate our fundamental understanding of the code of life,” Natasha Latysheva, a DeepMind researcher, told a press briefing on the work.

Once again click!. You’ll get a lot more from Ian than you will from us.

Both stories blend into two of our old LSS favourites. Firstly, the use of AI to look at complex biological patterns which humans alone struggle to perceive. (LSS 1 12 20 et seq) Secondly, that repeatable frequencies in DNA may be tied, probabilistically, to repeatable patterns of symptoms. Veteran readers will recall our hopes that this methodology may apply to psychiatric disorders too: (LSS 18 12 25 and 29 12 25). Of course, we expect to learn of environmental and epigenetic factors as well. But if we are right, these genetic advances may provide a firmer starting point for future investigations than we have now. How much more is achieved when facts are sacrosanct, not convenient entities to be selected and disposed according to the immediate convenience of their user! A lesson which certain US politicians and the news channels which so fanatically support them would do well to learn.

[1] Huge pancreatic cancer breakthrough as scientists achieve ‘permanent disappearance’ of disease with new triple-threat approach tested in lab | Daily Mail Online

[2]Google DeepMind launches AI tool to help identify genetic drivers of disease | Genetics | The Guardian

#AI #deep mind #cancer #genes #DNA #medicine #health #oncogenes #psychiatric disorder #heart disease