It is our honest opinion, patient readers, that the terrible problem of psychiatric disorder is on the point of being understood. On the same level that is, as illnesses such as measles, salmonella poisoning or scurvy. We think we know why, as we will explain below. But first to the work which gives us this hope, following as it does on our recent blog Psychiatric Disorders: is this a game changing moment? (LSS 18 12 2025)
Writing for the Guardian, David Shariatmadari reviews The Divided Mind by Edward Bullmore, a profoundly learned man who has devoted his life to investigating and alleviating the sufferings of those afflicted by mental disorders. It is a sweeping book, magisterially covering the disputes between the warring schools of thought and the decades of honest but often misguided attempts to effect cures and diagnoses. Too much to cover here, but we implore you to read the review, if not the book itself [1] [2] But, in a nutshell, it was this passage that truly excited us
(shariatmadari notes the remarkable process in understanding diseases like TB),then :
Schizophrenia may finally be on the cusp of that transformation – something truly momentous, given the puzzle this strange and brutal disease has posed for so long. As Bullmore carefully explains, advances in scanning, maths, genomics and immunology have piled up to give us a clearer understanding of the illness. It is probably caused by the abnormal development of brain networks in childhood and adolescence; this, the evidence suggests, happens under the influence of immune dysfunction, and the cause of that is variation in a broad range of genes, interacting in particular ways with the environment. Triggers can include infections, abuse, social stress or drug use.
And now for why we are so hopeful. We genuinely think that the work of Bullmore, and the scholars covered in the last blog, suggest that at last a new paradigm has formed. It has only been possible because of advances in disciplines like Immunology, complexity theory, genetics and catastrophe theory, and the technologies to support the vast data sets which this new learning requires. And with them should come the key concepts of robust diagnosis, risk factor, causal mechanism and, please, God-lasting ameliorations. We stress again that we do not belittle the heroic efforts of past investigators, who did not have the tools now available. New paradigms never make the old ones wrong. But they suddenly solve the problems the last one could not, and open the way to new lines of discovery which the old one could never have predicted. Einstein did not refute Newton, he simply went beyond. And it was the same for thinkers like Darwin, Kepler and Planck. It is our honest opinion that another such paradigm shift has arrived, gentle readers, We hope it will make the life of the world better too,
[2]The Divided Mind: A New Way of Thinking About Mental Health by Edward Bullmore is published by New River (£20). To support the Guardian buy a copy at guardianbookshop.com. Delivery charges may apply.
#psychiatric disorder #health #immunology #genetics #complexity #disease #medicine
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