Fish farms in Space? They might be closer than you think

One thing about Science Fiction: the food in future worlds always seems a bit dodgy. From Soylent Green through 2001: A Space Odyssey all the way to Red Dwarf, it’s all a bit artificial. Despite the ingenious efforts of valiant biochemists and microbiologists,[1] it’s not really the same. But wait, gentle readers! Almost unbelievably a brilliant French Scientist called Dr Cyrille Przybyla really believes he has a way of serving up a tasty plate of fresh real Sea Bass in the dining room of a lunar colony, assuming we all survive to construct one.

According to Kim Willsher of the Guardian, it’s not so outlandish as it sounds.[2] Apparently our finny friends have been making trips into space since the 1970s. All Dr Przybyla and his his Lunar Hatch Project are doing at this stage is sending a few up to the ISS to see how they get on. But, if it’s a success-who knows. Bass are exceptionally rich in omega 3 and B group vitamins, all of which are good for fighting muscle loss which comes with low gravity or zero gravity environments. Being fish, they’re already weightless in effect, so they won’t care anyway. The idea of putting them into enclosed, self sustaining eco systems might be very feasible on the moon. We now know there’s plenty of water up there, so that potentially exorbitant problem is largely solved.

There’s so much to like about this idea. Firstly it’s new different thinking: but not so new that bits of it haven’t been tried already. Secondly, a cautious, step-by-step approach is being applied-always a good sign of a successful project. Thirdly, it addresses a real need. No wonder the Chinese are getting interested, as Kim points out. that’s because they look to the future, instead of wasting all their time and energy trying to restore a lot of rusty old factories whose time has long since passed. We think there’s a lesson in there somewhere.

[1]https://www.bbc.co.uk/news/articles/cp34wzql2xvo

[2]https://www.theguardian.com/environment/2025/apr/28/sea-bass-in-space-lunar-hatch-fish-farms-moon-aquaculture

#space exploration #fish farms #nutrition #sea bass #ifremer

Do glaciers have political opinions? and some other mystery questions do get you thinking

Instead of all those discourses on things like microbiology or economic history, we thought we’d offer you something a little different today, gentle readers. We’ve decided to come up with one of those puzzle exercises, you know, brain teasers they call them. So here are 11 questions designed to get you thinking, to stretch the old grey matter as t’were. And the good news is: Most of the answers will be available somewhere on the Interweb, or via the websites we have so helpfully posted below.

1 How do you explain the change in the ratio of C₁₃ to C₁₂ in the atmosphere since 1850? Why did this ratio seem have fallen especially quickly after 1950?

2 Since 1750 about 2400 gigatonnes of carbon dioxide have been added to the atmosphere. If this call came from volcanoes, why is the isotopic signature of atmospheric CO₂so different from that from volcanic sources?

3 Do glaciers retreat because they share the political opinions of the Green Party, or is all this melting caused by something else?

4 Why have global surface temperatures increased by 1.2% since the late nineteenth century, but stratospheric temperatures actually fallen?

5 Why is the ocean warming faster than the land? Why would the land warm fastest first if all this were caused by the Sun?

6 Why does spring arrive earlier and earlier in the Northern hemisphere?

7 Do fish conspire with extremists,or have their migrating patterns changed for other reasons?

8 What is causing all these temperature rises anyway?

9 Why is the atmosphere of Venus so hot? And why is the atmosphere of Mars so cold?

10 Do you think rises in sea levels will drive increases in human migration?

11 If scientists are right about cures for cancer, physics, astronomy computers and many other things, why are they suddenly wrong about climate science?

[1]https://royalsociety.org/news-resources/projects/climate-change-evidence-causes/

[2]https://science.nasa.gov/climate-change/evidence/

[3]https://www.climate.gov/news-features/climate-qa/what-evidence-exists-earth-warming-and-humans-are-main-cause

#climate change #global warming #climate science #carbon dioxide #ecology #pollution

Gepotidacin marches on

Gentle readers we’re more than happy to present the next chapter in the story of Gepotidacin. Against all the gloom and doom we serve up here, it really is a wonderful new class of antibiotic We have covered it before (LSS 30 1 23 ; 17 4 23) but today Manuel Ansede of El País [1] serves up a handy little resumé, not only of where we are now, where we have come form, and all kinds of hyperlinks to bring you up to speed. We can add little but to such erudition as Manuel’s. But for the sake of long term readers will riff on these few -humbly derived- observations

Firstly, this really is a new class of antibiotic., going by the snappy name of triazaacenaphthylene bacterial topoisomerase inhibitors. Unlike traditional antibiotics that target bacterial cell walls or protein synthesis, gepotidacin disrupts bacterial DNA replication by inhibiting two essential enzymes: DNA gyrase and topoisomerase IV. Which as most readers will instantly recall, are crucial for bacterial DNA replication and cell division. Thought so.

Secondly its already showing real world efficacy against all kinds of bacteria, including antibiotic-resistant strains like methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Neisseria gonorrhoeae. Get that: real science works.

Thirdly, to make our old LSS point: effective action in medicine takes time. It requires teams of intelligent people. Who do not act alone, but exist in an ecosystem of universities . research institutes and government agencies. Which in turn requires careful nurturing , funds and right to feel safe enough to make long term plans without bullying and interference from the proudly ignorant and impulsive. American readers take note.

[1]https://elpais.com/ciencia/2025-04-14/el-primer-antibiotico-descubierto-en-30-anos-llega-justo-a-tiempo-de-evitar-que-la-supergonorrea-sea-imposible-de-tratar.

#gepotidacin #antibiotics #antibiotic resistance #health #medicine

Three fascinating examples of scientific detective work

Photo by u041bu044eu0441u0438 u0414u0440u0435u043cu0430u043bu043eu0432 on Pexels.com

We have three stories for you this morning. Not only because the stories themselves are intriguing. But because they illustrate the scientific method at its best. Persistence. Careful collection of the data, Thoughtful analysis. And above all this” Extraordinary claims require extraordinary evidence.” It’s from the first of today’s features. But it runs like a thread through all of them, and much else that is done by scientists, and all true scholars everywhere. It is of course the antithesis of the claims of conspiracy theorists, hucksters and plain incompetents everywhere.

Floods in the Mediterranean We’ve known the idea that the Mediterranean Sea was once a hot dry basin, a sort of desert land. Until one fine day about five million years ago when a truly humungous great flood burst through the Straits of Gibraltar, turning the whole, thing into that vast lake suitable for swimming, sailing and other watersports which it remains to this day. The proponents of the theory, Daniel Garcia Castellanos and Paul Carling were careful to say this Zanclean Flood was just that, a theory, Until recently they found that the alignment of hills in Sicily. plus the way that rocks of the right age were lying around there, confirmed it nicely. Detective work worthy of Comissario Montalbano, that island’s most famous son!

https://theconversation.com/the-largest-flood-in-earths-history-burst-through-gibraltar-and-sicily-and-refilled-the-entire-mediterranean-in-just-a-few-years-249242?utm_medium=email&utm_campaign=Lat

Awesome Jaw About 20 years ago, a large ugly looking jaw was dredged up off the coast of Taiwan. No one knew exactly how old it was or how it fitted into the jigsaw of human evolution. Now some incredibly skilful work extracting and analysing proteins from it have revealed it to belong to a Denisovan, that intriguing third branch of modern humanity Here’s Nature Briefing: Mysterious Taiwan Fossil is Denisovan

A fossilized jawbone discovered more than 20 years ago belonged to an ancient group of humans called Denisovans. Named Penghu 1, the jawbone was dredged up by fishing crews 25 kilometres off the west coast of Taiwan. The confirmation that the bone belonged to a Denisovan — the result of more than two years of work to extract ancient proteins from the fossil — expands the known geographical range of the group, from colder, high-altitude regions to warmer climates.Nature | 5 min read
Reference: Science paper

Standoffish Saharans Moving forward from the dawn of humanity to the dawn of agriculture, Chris Melore of the Mail has an intriguing story about the ancient proto-Neolithic populations of North Africa. Careful molecular detective work has revealed that they tended to keep themselves isolated from the population flows across the rest of the world which were happening about 7000 years BP. And this has quite profound implications for how agriculture and herding must have spread. One school has always held that Neolithic techniques were carried as cultural tropes by tribes who migrated out of the fertile crescent (a bit like the way particular European customs and technologies were carried to North America) The other school always held that local people came up with these ideas for themselves, perhaps with a bit of help from conversations with early travellers and traders. This evidence of isolated North Africans invented stock breeding and grazing economies independently is a definite plus for the second school and its ways.

https://www.dailymail.co.uk/sciencetech/article-14600327/Newly-mummies-reveal-new-human-ancestor-broke-humanity-thousands-years-ago.html

Careful thoughts, provisional conclusions. This is what we are all about here, and we hope you are too. Perhaps more people could be like this, if they had been given a fairer life. It is a thought we will pursue in the next blog

#neolithic #paleolithic #geology #agriculture #denisovan ##dna #protein

Neural Maps show American Science at its best. But for how much longer?

If you want to explore the potential of a vast unknown region, first make a map of it. This why many of the finest minds from the sixteenth to the nineteenth century were cartographers. The human brain, with its astronomical numbers of circuits and connections, is our century’s equivalent of an unknown continent. Where the prizes( in medical research, pharmaceuticals and lucrative spin off disciplines) will go to those who have the best idea of the layout of the territory they are exploring. Which is why it came as no surprise to find that a multi-university team of American researchers have emerged as some of the foremost neurological cartographers of the year

Hannah Devlin of the Guardian reports the work of the teams from Baylor College, The Allen Institute and Princeton who have combined different techniques to create a 3-D circuit diagram of the neurons in a mouse brain. Now, there are some riders to note: this is only a tiny portion of the brain, comprising 84 000 neurons, half a billion synapses and about 5.4 km of the neuronal equivalent of wiring. Tiny numbers compared to the colossal sizes of a human brain, or that of an elephant or a dolphin. But it’s a start. Hannah quotes experts who honestly compare this work to the human genome project around the turn of the century. We need not remind readers as intelligent as ours of all the potential which that unlocked.

So: American researchers at the cutting edge. Princeton. Big research teams. “Yawn,” they said in the newsroom, “Where’s the story?” Well the story lies in the context of the consistent cuts in science funding by a certain Donald J Trump and his Administration. [2] It’s not just the money, it’s the attacks on the confidence and independence of the institutions themselves which stunt the development of a healthy research sector. And ultimately kill the goose which has laid so many eggs.(please-no more cliches!-ed) From the 1930s onwards America thrived by taking in the best researchers, and letting them work at what they excelled. Every science magazine you picked up, every episode of the old Horizon series on BBC, had an American somewhere in it. They even got to the Moon. Now there is a real danger that all that talent, all that potential will flow elsewhere. So far the EU and UK have not really go their act together. But they are waking up to the opportunity. Perhaps the first whole-brain maps will be made in Cambridge. The English one, that is.

with thanks to J Read

[1]https://www.theguardian.com/science/2025/apr/09/us-scientists-create-most-comprehensive-circuit-diagram-of-mammalian-brain

[2] https://www.scientificamerican.com/article/trump-administration-attacks-on-science-trigger-backlash-from-researchers/

#neurology #princeton #research #donald j trump #science #biology #brain

Is that an Antibiotic in the Azaleas?

We started out as an antibiotics blogs, and we’ll always defer to it when a good story comes up. So don’t be surprised as we offer you a really good story, which we found in Nature Briefing, that inestimable source of the very best stories on science and all its ramifications. Scientists unearth new anitbiotic-literally

Researchers searching far and wide for new antibiotic molecules have discovered one in their own backyard. The new molecule — found in soil samples collected from a lab technician’s garden — targets a broad range of disease-causing bacteria and doesn’t appear to be toxic to human cells. From the soil samples, the team spotted a lasso-shaped molecule they named lariocidin, which is produced by Paenibacillus bacteria. Lariocidin attaches to structures called ribosomes in bacteria, which disrupts their protein production. The molecule slowed the growth of a range of common bacterial pathogens, including many multidrug-resistant strains.Nature | 4 min read
Reference: Nature paper

We know, gentle readers that we can occasionally overdo the bad news a tad on these pages. Today we’re glad to tip the balance back a little the other way.

If you want to receive the very latest on science and cutting edge technology, you won’t do beetr than sign up to Nature Briefing. We don’t know of anything as good as this which is still absolutely free. What’s more they have some sub briefing sites on more specialist areas if your want to keep up with a particular area why not visit these sites and see for yourself?

briefing@nature.co

Nature Briefing: Careers — insights, advice and award-winning journalism to help you optimize your working life
Nature Briefing: Microbiology — the most abundant living entities on our planet – microorganisms – and the role they play in health, the environment and food systems
Nature Briefing: Anthropocene — climate change, biodiversity, sustainability and geoengineering
Nature Briefing: AI & Robotics — 100% written by humans, of course
Nature Briefing: Cancer — a weekly newsletter written with cancer researchers in mind
Nature Briefing: Translational Research — covers biotechnology, drug discovery and pharma
#antibiotic resistance #bacteria #microorganisms #medicine #health #research

Alphafold for RNA?

Model – Flu Virus Protein, CSIRO, circa 2000 by Photographer: Rodney Start is licensed under CC-BY 4.0

Back in 2023 we praised the achievements of Google Deep Mind and its Alphafold system for predicting protein structures (LSS 23 2 23) The step change in productivity , (no disrespect to human biochemists) was so remarkable that we compared it to the invention of stone tools. Since when it has pretty much become a standard tool in medical research.

So much for proteins. What about RNA? Advances in understanding its structure, maybe even making a little of our own, might convey enormous medical benefits. Read this from Nature Briefings Seeking an alphafold moment for RNA

Protein-structure-prediction tools such as AlphaFold have transformed biology. But RNA is a tougher nut to crack: it poses unique molecular challenges, and relatively few data are available to train computational models. So researchers have been getting creative, building a toolkit to aid the prediction of RNA structure that incorporates the latest developments in artificial intelligence.Nature | 10 min read

“A tough nut to crack” Indeed. For one thing RNA has always suffered from that “middle child” syndrome, lost between its more glamorous siblings, DNA and proteins. So there is a lot less data to feed into the AIs. And even the main forms, t-RNA and m-RNA are fiendishly complicated, like any biological macromolecule. Fortunately, there is a superb article from the main part of Nature by Diana Kwon[1] which lays out the problems and challenges with great clarity; well worth a glance, However the advantage of getting on top of RNA and bringing it, so to speak, into the twenty first century could be colossal, Never forget that it was an m-RNA vaccine that finally got the SARS-Cov-2 virus on the run. That is a glimpse of what might one day be acheived.

[1]https://www.nature.com/articles/d41586-025-00920-8?utm_source=Live+Audience&utm_campaign=bc74eaec70-nature-briefing-daily-20250326&utm_medium=em

#rna #AI #alphafold #medical research #biotechnology #nucleic acids #proteins #vaccines

When a culture turns away from science, its decline begins

Fans of the old Jacob Bronowski TV series The Ascent of Man will recall a key episode. In the early seventeenth century the Catholic Church decided to persecute aspiring scientist Galileo Galilei. In 1633 the Inquisition even put him on trial for having discovered that the Earth goes round the Sun. Using the threat of torture, they forced him to deny this simple reality. Bronowski’s take on all this was to assert that this was the key step which sent the Catholic part of Europe (hitherto the dominant bit) into decline. Scientists and scholars fled to the more tolerant environment of Protestant Europe, whose economies benefitted accordingly. The few Catholic thinkers of note remaining (Descartes and Pascal spring to mind) But they were like the last rays of a setting sun, before darkness and superstition suffocated all.

A one off? Special pleading? History suggests otherwise. From about the 8th Century to the 13th of the Christian Calendar (apologies to Islamic readers, but let it do for now) the Islamic world was dominant not only in trade and war, it was supreme in all the skills of learning and science. Thinkers such as Al Khwarizmi, Ibn Sina (known as Avicenna in western lands) and Al Birani made contributions to human learning which will last forever. Yet, starting about the middle of the twelfth century CE there was a slow but steady trend away from reason and science towards deeper religious orthodoxy as Hilel Ofek explains in his essay Why the Arab World rejected Science [1] Slowly the northern nations began to close the gap and eventually move ahead. Nearer our own time Corelli Barnett showed how Britains decline began as abstract studies of things like Latin and Greek came to dominate the Universities, while subjects like science and engineering were accorded second rate status. [2] [3] The values of a well entrenched landed aristocracy won out over the more plebian instincts of the middle class . With long term disastrous consequences for Britain’s place in the world

And the relevance of all this? Across the western world, there is now a strong, growing and incredibly well-funded movement against science and objective evidence. [4]It’s felt in policy debates on economic questions, university funding, on vaccines, and above all in the swirling brawls around climate science and global warming. The temptation is to put all this down to the ebbs and flows of political debate. But that is to miss the point. Questions of science are not political. They are not open to understanding by the mental tools developed for political and religious debate. A nation, a whole culture is being continually weighed in the balance, and can fall at any time. Is this now happening in the so called “advanced ” western nations.

[1]https://www.thenewatlantis.com/publications/why-the-arabic-world-turned-away-from-science

[2]Corelli Barnett The Collapse of British Power 1972

[3[ Corelli Barnett The Audit of War 1986

[4]https://www.theguardian.com/commentisfree/2025/mar/20/kemi-badenoch-net-zero-brexit-right-clima

#science #global warming #climate change #reason #history #christianity #islaam #british empire

Is human evolution a mess? Depends how you look at it

When we were young, we believed in a Story. First there was Australopithecus, a toolless, speechless, walking chimp. He begat a brave pioneer called Homo erectus, a handy sort of chap who at least had decent looking tools and invented fire. He begat two sons: a hairy, primitive savage one called Neanderthal Man, who deservedly came to a sticky end. And a tall, cool handsome one which called itself Homo sapiens (“the wise man”), in one of the most outrageous acts of vanity and self-delusion in history.

The truth turned out to be far more complicated. Even looking at the story of the last 500 000 years , when everyone was about as modern as you can get. First Neanderthals have been getting steadily cleverer for the last forty years or so. They probably had language, clothes and y even art, goddammit. Along came another relative, the Denisovans who were similarly equipped. And then came the geneticists lead by the inimitable Professor Paabo, whose discoveries have upended everything , blurred every category and wiped every line. Latest instalment in this trope comes from the discoveries of the learned Professor Cousins of Cambridge University which we channel both from Jonathan Chadwick of the Mail[1] and for those with a little more time, the original paper itself [2] The story of the last million years or so is not of some heroic hero on a quest for self-improvement. But bunches of largely helpless bipeds pushed hither and thither by the vagaries of climate and geology, splitting, meeting and breeding; spawning a mishmash of different types which their distant descendants come along and label with important- sounding names. And we think we see a pattern in all this.

Firstly :you know a lot less than you think you do. We have been tracking human evolution for nearly sixty years now, so we can be fairly confident about that statement. Secondly: there is always something buried out there which is going to upend everything you know; so stay cautious. Thirdly: someone in another field is going to park their intellectual tanks on your lawn sooner or later, reducing your omniscient learning to at most part of things, not the whole of it. And finally:-human evolution makes a pretty good paradigm for all other learning. Not just hard sciences, not just social sciences but also things like history and economics. Beware of anyone who knows the answers, because they are not telling the truth.

[1]https://www.dailymail.co.uk/sciencetech/article-14508089/Scientists-hidden-chapter-human-evolution.html

[2]https://www.nature.com/articles/s41588-025-02117-1

#homo sapiens #dna #genetics #neanderthal #anthropology #science #knowledge #evolution

Recycling the way to new antibiotics

If there was one thing that has always been too much for us, it is trying to understand the fiendish complexity of the immune system. At school, at our various universities, trying again during the COVID pandemic…..we have never really got past T and B. So when the BBC announced this morning that a whole new part of it had been discovered,[1][2] you might have expected us to hold our collective heads in our hands and groan.

Far from it, gentle reader. For the new discovery has opened the possibility of a whole new class of antibiotics sitting right there in every cell of the body. An astute group of scientists led by Professor Yifal Herbl at Israel’s prestigious Weiszman Institute of Science have found that proteases, a regular part of cell function, may be able to unleash significant antibacterial function. A protease normally functions like the recycle department of your local council, chopping down old proteins and getting them ready for use. But the team found that many of the little peptides produced have strong antibiotic properties. Like the good scientists that they are, they then ran two objective tests. Do the proteases work as well as conventional antibiotics? And if you disable them, does the cell become more vulnerable to infection? To which the answers, broadly speaking, are Yes and Yes.

Once again we stress that this research, and its development into useful therapies, is still at early stages. Which we always do when we cover new points of departure like this. Yet it is, indubitably, a new departure, And it has been sitting there unnoticed until now. Something which has always tickled our fancy here, as regular readers will know. Hats off to Professor Herbl and her team. And-readers! Every tome a journalist publishes on the antibiotics crisis, why not write a very short e mail of thanks to them? They’ll love you for it.

_{with thanks to Gaynor Lynch}

A note on today’s links We have two straight news stories and a link to the Weiszman Institute, to give you staring points. However, we could not get past paywalls to the Nature articles, and we doubt you will be able to as well

[1]https://www.bbc.co.uk/news/articles/cpv4jww3r4eo

[2]https://phys.org/news/2025-03-cellular-trash-reveals-immune-defense.html

[3]https://www.weizmann.ac.il/pages/

#antibiotics #proteases #immune system #peptides #microbes #bacteria #ealth #medicine