Making an end to Cervical Cancer, making a start on an end to Alzheimers- two stories of real hope

At a time when ignorance and anger are gleefully presenting themselves as the new norms, it’s heartening to see that some people are still active on our side. And achieving real, substantial progress. That’s why we’re proud to bring you two stories which show what educated minds, still employing the twin discipline of fact and reason, have achieved lately.

Repurposing old medicines. Regular readers will will recall our enthusiasm for lateral thinking, using old things which were there all along to do unexpected new ones. So Sharon Wooller of the Mail has a triple whammy for us this week.[1] After screening 80 commonly used drugs or vaccines , ingenious scientists at the University of Exeter selected three that might have a bearing on the terrible scourge of Alzheimers disease. They are: Viagra, which stops those pesky tau plaques from building up. Riluzole which may actually bring them down. And the shingles vaccine Zostavax which may also affect the immune system. Now we know the brain barrier frontier is pretty much down (LSS passim) this has to be a powerful runner, gentle readers. But best of of all is why these scientists set out to do this. To quote Sharon. in a nutshell:

Making drugs from scratch can take ten to 15 years and cost billions of pounds, with no guarantee they will work.

If you cant afford new ones, why not try a few old ones? Quod erat demonstrandum

Cervical success People can co-operate, even across national lines, when there is “cause sufficient”. One of these was cervical cancer, which not only blighted and destroyed lives, but effectively deprived the world of much of the better half of its workforce. Two releases today from GAVI and the WHO evince the remarkable strides in the vaccination programmes which have done do much to eliminate this disease. Hats off not just to the scientists, but also to the intrepid field workers who have combed the wildest, remotest corners of the earth, employing the most recondite means, to save lives and afford a brighter future to millions [2] [3]

When we read stories like these we know we are not alone. Our side is still out there. And unless they crush all universities and research institutes everywhere, we shall be back one day. For keeps.

[1]https://www.dailymail.co.uk/health/article-15298699/Viagra-Alzheimers-drugs-hope.html

[2] https://www.gavi.org/news/media-room/cervical-cancer-vaccines-save-over-1-million-lives-lower-income-countries

[3]https://www.who.int/news/item/17-11-2025-world-marks-cervical-cancer-elimination-day-as-countries-accelerate-action

#vaccine #drug #medicine #alzheimers #cervical cancer #women #health

Heroes of Learning: Svante Pääbo

It’s hard to remember how different human evolution was before Svante Pääbo and his transformative discoveries in genetics. There were some bones, but they were bit few and fragmentary. People argued interminably over them like so many medieval nominalists and realists. There were tools, and heroic studies of the scratches thereon. People spent lifetimes following various primates in and out of the rain forest: but it is hard to say whether a chimpanzee is really like a human ancestor, or a baboon is : or is not.

Then in 1997 at the Max Planck Institute in Leipzig, Svante Paabo announced a breakthrough: the actual DNA from inside the mitochondrion of a real (dead) neanderthal. For the very first time here was something tangible, data rich, and available for statistical scrutiny. Now we knew who we were, and who they were. As if that were not enough, in 2009 his team announced a whole Neanderthal genome. Then came immortality: on the floor of a cave in distant Siberia came a tiny bone which Pääbo showed to be a third type of human: the Denisovans. The utter. twisted, anastomosing complexity of the modern human story became clear: and with it the implication that it had always been thus. Giving him the Nobel Prize in 2022 must have been the easiest decision since that monkey in 2001: a space odyssey thought a horse skull might be a good place to land a good thwack.

But the real significance of Svante Pääbo lies deeper. It’s in the observable phenomenon that every so often some genius comes along and turns a field upside down. That every debate, however heated and angry, will one day become futile as more gets found out. It’s like that in all sciences, and a good many non sciences too. The biggest mistake any of us can make is to think we have all the answers. Thanks Svante Pääbo for showing there’s always something new around every corner.

[1]https://en.wikipedia.org/wiki/Svante_P%C3%A4%C3%A4bo

#genome #dna #human #neanderthal #anthropology #evolution science

Nature Briefing on a brand new antibiotic(or was it there all along?)

Today, gentle readers, we bring you really good news in our joint quest to finally overcome the problem of antibiotic resistant micro organisms. And it comes of course from Nature Briefing, that indispensable source of all good science news and reporting. Let’s start with their summary Antibiotic was hiding in plain sight, and then briefly run through all the implications

Scientists have discovered a powerful antibiotic while studying the process through which a soil bacterium naturally produces a well-known drug. The compound — called premethylenomycin C lactone — is more than 100 times more active against bacteria than the final product, antibiotic methylenomycin A, which was first identified in 1965. Tiny doses of the surprise discovery killed strains of bacteria known to cause hard-to-treat infections.Nature | 5 min read
Reference: Journal of the American Chemical Society paper

Okay, so wanted the implications? Firstly for us at LSS. Great reassurance to see progress in our core area of real, old-skool antibiotics. Now, if these make a comeback, can they please be used sparingly, and in conjunction with therapies like vaccines and bacteriophages, so we are not in this whole mess again around the year 2065? Secondly, the new compound premethylenomycin C , though only a precursor is a hundred times more powerful than methylenomycin A. As Dr Challis, one of the co-authors of the work observes, that’s a turn up for the evolutionary book if ever there was one. But for us the Big One is how many years of painstaking research this all took, how many tiny detailed steps in the synthetic chain had to be weeded out. They started back in 2006 when one George W Bush was still President of the United States and everyone thought that Katy Perry was the way of the future. Blue sky abstract research; done as much out of intellectual curiosity as anything else. Which is odd. Because every so often one of our Right Leaning media outlets comes up with tropes such as WOI ARE VE WYESTIN ORL DIS TEXPAYUHS MUNNI ONNER RESURTCH WOT DON’T DO NUFFINK? SPEN IT ON SUMFIN USEFUL GUVNOR, INNIT! Which raises a deep question; how do you measure the value of research like premethylenomycin ? The costs are small but substantial enough to cash-strapped Universities. But the pay-off is almost infinite. That one we will leave to you, faithful readers of our words.

[1]https://www.nature.com/articles/d41586-025-03595-3?utm_source=Live+Audience&utm_campaign=f5bcecac99-

#antibiotics #biochemistry #microbio;ogy #medicine #health #antibiotic resistance

Does this whale hold the secret of eternal youth?

I have lived long enough, my way of life is fall’n into the sere, the yellow leaf…..Macbeth Act V scene 3)

Most of us would pretty much agree with the Thane of Glamis. But up to now, achieving that Pan-like state of eternal youth has been no more than a dream, whatever the cosmetics companies say. Until today, when recent discoveries of a protein in the Bowhead whale suggests that this same eternal dream may actually come true. We’ve two takes on the story: a popular one from Ashleigh McCaul of the Mail: and a more in-depth view from Nature Briefings Secrets of a 200 year old whale which carries, as ever, links to deeper coverage (no whale pun intended)

A cold-activated protein that helps to repair broken DNA could be the bowhead whale’s secret to living sometimes for more than 200 years. Researchers travelled to northern Alaska to collect samples of tissue from the whales (Balaena mysticetus) from Iñupiaq Inuit communities. The team found that the whale’s cells produce a protein called CIRPB, which helps to mend potentially cancerous DNA mutations. The results show that an efficient DNA repair system is “a very effective strategy to confer this extreme longevity”, says molecular biologist Zhiyong Mao.Nature | 4 min read
Reference: Nature paper

And our opinion? it’s interesting how science is fine when its discoveries coincide with the deepest wishes of the population. Yet science is not so convenient when it reminds of certain uncomfortable truths, such as the imminence of catastrophic climate change, The response of some is to launch culture wars, wherein the conclusions and recommendations of the educated must not only be resisted, they must be actively torn down if at all possible. This article by Alex Heffron and Tom Carter-Brooks for the Conversation chronicles how this is currently playing out in the English countryside., where some persons are trying to foment opposition to the installation of solar panels on private land. Of course, motives will be mixed: and not all of us think an array of panels is quite as pretty as a meadow of waving wheat. But we must have clean power: or we will surely die, young and old alike.

We are certain you will find a comparable example near to where you live, gentle reader Yet it’s the psychology of all this that gives us this thought, for what it may be worth. Now, It was said of Peter Pan than he never grew up. The best definition of growing up is to realise not all your wishes can come true at once. It seems some people must do more to recognise that, however many decades they have accumulated.

[1]https://www.dailymail.co.uk/sciencetech/article-15247935/How-whales-hold-secret-humans-living-FAR-longer-scientists-discover-longest-living-mammal-repairs-DNA.html

[2]https://theconversation.com/you-cant-eat-electricity-how-rural-solar-farms-became-the-latest-battlefront-in-britains-culture-war-268128?utm_medium=email&utm_campaign=Latest%

[3]https://theconversation.com/you-cant-eat-electricity-how-rural-solar-farms-became-the-latest-battlefront-in-britains-culture-war-268128?utm_medium=email&utm_campaign=Latest%

#climate change #global warming #renewable energy #peter pan #ageing #whale

AI =New drugs and medicines 17 times faster

Good heavens, but it takes a long time to get a new medicine in use. To go from first concept to everyday pharmaceutical use in the high street can take from 10 to 15 years on average. There’s all that Discovery and Initial research: followed by Preclinical Testing, Clinical Trials, and Regulatory Review. Quite right too: we support all this red tape , as there no point in killing the people (or animals) we’re trying to cure. Occasionally things are permitted to speed up (think mRNA vaccines during the COVID-19 pandemic) But we admit the whole thing can be a tad frustrating, particularly for a blog like this one, ever campaigning for new forms of antibiotic and other ways to combat resistant micro-organisms,

Which is why we support every endeavour to speed the process of drug development up. None more so than when its exponents try fresh thinking, as the ingenious Dr Alex Shalek of MITI. Read this AI offers drug-screening shortcut from Nature Briefing

An artificial intelligence (AI) model trained on complex data from human cells could bypass the need for time-consuming drug-screening in the race to develop new medicines. The model, called DrugReflector, was trained on data about how each of nearly 9,600 chemical compounds perturbs gene activity in more than 50 kinds of cell. Researchers found that DrugReflector was up to 17 times more effective at finding compounds that could affect the generation of certain blood cells than standard screening, which depends on randomly selecting compounds from a chemical library.Nature | 4 min read
Reference: Science paper

Dr Shalek and his admirable team think they have accelerated the process by anything between 13 and 17 times, as you will discover if you drill down on the links which we have provided.

It’s easy to bemoan the modern trend for instant narcissistic gratification, where every want is satisfied by the click of a button and a funny little man showing up in a blue van a few hours later. Of course it is essential to test new drugs, and maintain the high standards which we in the educated community hold ourselves to. You can’t run a drugs company at the same moral and intellectual level that you run a popular newspaper. But anything that speeds things up safely, as this technique appears to do, will save many lives and much suffering. We hope we’ve cheered up your morning break.

#drug development #medicine #health #AI #research #mRNA vaccine

How good teaching won a Nobel Prize

For our next look at this year’s Nobels, we thought we’d showcase the three brilliant researchers who share the prize for Chemistry. For those who need to come up to speed here’s Nature Briefing’s story, Chemistry Nobel for Supersponge MOFs

Chemists Susumu Kitagawa, Richard Robson and Omar Yaghi have won the Nobel Prize in Chemistry for developing the world’s most porous solid materials, known as metal-organic frameworks (MOFs). Structured like molecular scaffolding, MOFs contain vast caverns of internal space; Nobel committee chair Heiner Linke likens them to “Hermione’s handbag in Harry Potter — it can store huge amounts of gas in a tiny volume”. In the 30 years since they were first developed, they have become part of efforts to capture carbon from the air and remove ‘forever chemicals’ from water, among many other applications.Nature | 4 min read

Now, we in no way would distract from the accomplishments of Drs Kitaga or Yaghi. But what we want to do here is tell a very human story of how the third laureate, Dr Robson, got involved in the first place.

One day he was constructing large wooden models of crystal structures for undergraduate chemistry lectures at the University of Melbourne. These models—representing structures like sodium chloride and fluorite—were made from coloured wooden balls (atoms) connected by rods (bonds), carefully drilled at precise angles using trigonometric calculations. We’ve all seen them, they are stand by of every A level and undergraduate teaching room

As Robson assembled these models, he noticed something profound: the components seemed “invested with information,” naturally predisposed to form the intended structure. This observation led him to wonder: what if molecules could behave similarly—self-assembling into predictable, extended structures using chemical bonds instead of rods? That question planted the seed for MOFs, which he began exploring seriously about a decade later.

It’s funny how learning is a holistic thing. Research informs teaching. And teaching informs research. Oddly enough artists like Leonard Bernstein and Stephen Sondheim found the same thing, if you substitute “creative writing” for research. Perhaps its the idea of responding to questions, looking at the bigger picture. Or in Robson’s case, taking time out to play creatively with models. If you have found the same, oh readers, let us know. Meanwhile tell your Government to keep funding research and universities. As we saw in the last blog- they’ll get their money back.

#chemistry #nobel prizes 2025 #metal organic frameworks #carbon capture #climate change #science #research

Are stress and trauma passed down the generations?

Does trauma pass down through the generations? Can someone who has been through a war, a genocide, or a famine in some manner pass that experience on to their children? Grandchildren, even? If so, how? Are the effects purely physiological-or could they even be psychological? It’s a fascinating question for our current dark times. And fortunately we have a carefully written article by Rodrigo Santodomingo of El País which thoughtfully assesses the current state of play [1] (English speaking readers-you are going to need your translator app for this one)

What impressed us was intellectual rigour of experts whom Rodrigo consulted, like Professor Isabelle Mansuy of the University of Zurich and Dr Anna García Gómez, a professional psychiatrist. Professor Mansuy is particularly sharp “it’s not the trauma that’s transmitted, it’s the effects.” she notes. Clear distinctions like this allow us all to wade through a morass of strong evidence, weak evidence, hopeful claims and provisional findings. That something is happening, and that it’s epigenetic seems reasonably certain. Studies of rats indicate that parents subjected to trauma or prolonged stress do indeed have observable consequences in subsequent generations. But-can these changes be genetic as well as epigenetic? The pioneering work of Dr Rachel Yehuda and on the survivors of concentration camps and their descendants is considered: but she always stresses that any alterations associated with the FKBP5 gene are in expression, not its structure. As Professor Mansuy concludes: “we know almost nothing about the epigenetic transmission of trauma. This doesn’t mean its not there, but it’s extremely difficult to prove” (LSS translation)

Why are we raising all this? We can never forget our excitement upon learning that life experiences can be transmitted down the generations even if only by epigenetic mechanisms (If you want to know more about this The Epigenetics Revolution by Professor Nessa Carey is a great place to start) [2] But at a deeper level, and as one presiding over a Whiggish sort of blog we want to live in a safer, more prosperous world where people are on the whole better educated and better off than their parents had been. If trauma from old wars and other catastrophes poisons minds and prevents future generations from achieving this then it’s a form of pollution just as evil as say plastics, pesticides or radiation. The Bible waxes lyrical in several places about the iniquity of sinners being inflicted on future generations. What a pity if the sinned-against must suffer the same fate!

[1] La alargada sombra del trauma: ¿Se transmiten sus efectos de padres a hijos? | Ciencia | EL PAÍS

[2] The Epigenetics Revolution: How Modern Biology is Rewriting Our Understanding of Genetics, Disease and Inheritance: Amazon.co.uk: Carey, Nessa: 9781848313477: Books

#genetics #epigenetics #stress #trauma #psychology #biology

Hello we’re back-and we have Nobel Prizes!

First of all, apologies for our forced and utterly unwanted absence. But Domestic Renovations, and the sorts of people who carry them out, can be as tiresome and time-consuming as any other human relationship which the Gentleman Scholar must negotiate -domestic staff mistresses and lovers, cleaners, mechanics, and countless others. All require patient listening, multiple cups of tea and hefty pay offs, if only to still their incessant demands for even a moment. But here we are back again where it counts-with you, gentle readers. And we are glad to say that we return with one of our favourite sequences of the year. It’s Nobel Prize season again. [1]

For us, the Nobel prizes are the very essence of what this blog is all about. That careful learning and scholarship are not only what lifts our lives above the miserable condition of wild apes (well, some of us): they constitute the only only possible escape route from our current plights, many of which are serious and grave. And this time we think we can prove it. with the help of three of the very winners themselves-how’s that for endorsement, ladies and gentlemen? That’s the prize which will receive our first detailed attention, in the next blog: but let’s start with a roll call of the stupendously intelligent people who have stood out this year as the cream of humanity

Physics: John Clarke Michel H Devoret John M Martins Amazing work “for the discovery of macroscopic quantum mechanical tunnelling and energy quantisation in an electric circuit” Yup, we kind of lost too it after the fourth word in the citation, but we’ll try to understand it better in time for a later blog

Chemistry Susuma Kitagawa Richard Robson Omar M Yaghi Want to capture Carbon dioxide, water in the desert, store toxic gases and many other things? These discoveries will let you do all of them. If this isn’t right on the raison d’etre of this blog, we don’t know what is. Again, come back later for more

Physiology and/or Medicine Anything in these fields must be close to an LSS reader’s heart. So the work of Mary E Brunkow, Fred Ramsdell and Shimon Sakaguchi on the tricky world of the immune system requires our most emphatic hats-off

Literature and Peace Intelligence can be of the Emotional kind as well as the academic, as many of us discover with agonising slowness and pain. So although these subjects lie outside the remit of our blog we are proud to give honourable mentions to László Krasznahorkai and Maria Corina Machado respectively (is she a relative of Antonio Machado the famous Spanish poet, we wonder?-ed)

But finally our first next blog on this subject, as t’were, will be devoted to the patient Economics work of Joel Mokyr, Phillipe Aghion and Peter Howitt. Because finally they have shown at Nobel level, what we have believed for so long. It’s science and learning that drives the economy. Which is where we go next time.

[1] https://www.nobelprize.org/all-nobel-prizes-2025/

#nobel prizes #economics #physics #chemistry #medicine #physiology #economics

How climate change drives the return of deadly diseases

We never thought we’d see it. But Malaria is making a comeback in the British Isles [1] According to the latest findings from the UK Health Security Agency(UKHSA) cases rose by a whopping 32% from 2022 to 2023 making them the highest in 20 years. More than 2000 cases in fact. Now some of this is due no doubt to travel bounce backs after the COVID 19 pandemic. But once put into a broader context. the real pattern becomes both clear and alarming. Global warming is driving a massive spread of insect vector diseases. Dangerous diseases that almost seemed under control until the oil companies unleashed climate change on an innocent world

Staying with Britain just for now, William Hunter of the Mail [2] reports on the appearance of two deadly mosquitoes in the UK: the Egyptian mosquito Aedes aegypti and the appropriately named Tiger mosquito Aedes albopictus. For now these are isolated events, and under current conditions their spread may even be containable. But every year the climate gets a little warmer. Every year brings a higher chance that these vectors will spread their deadly triple load: Dengue Fever, Chikungunya and Zika. With all the consequences which wel- seasoned readers of this blog will recall from our earlier outings on this theme (see LSS 25 3 25, 25 10 21 and many others)

We confess to becoming a little angry when we we write stories like this: such disasters could have been so avoidable. Once, not so long ago these diseases were unknown in this islands except as travellers’ tales, or as the province of medical specialists. Now a wave is crossing the world. We know what the remedy is. If by any chance you are a parent reading these lines: this story is one more line of evidence among many. Your children can never be truly safe until global warming is finally controlled and reversed.

[1]https://ukhsa.blog.gov.uk/2025/05/21/how-we-protect-the-uk-from-vector-borne-diseases/

[2]https://www.dailymail.co.uk/sciencetech/article-15151429/tropical-diseases-britain-mosquitoes-dengue-fever.html

[3]https://wellcome.org/news/how-climate-change-affects-vector-borne-diseases

#disease #malaria #dengue fever #climate change #g;obal warming #health

Heroes of Learning: Leonardo Pisano(Fibonacci)

Have you ever looked at the strange spiral in a broccoli floret and wondered how it got like that? Or hundreds of other things in nature from the shapes of waves on the beach to the arrangements of artichoke leaves? The answer to all this and much more was discovered by Leonardo Pisano, better known to the modern world as Fibonnaci.(C1170 AD-c 1245) [1] [2]

A bright lad from Pisa in Italy, his big break came when his father took him on a business trip to Bugia in what is now called Tunisia. Father and son met an Arab mathematician (the Islamic world was still far ahead in science and technology) who kindly showed them the amazing new numbering system which they had learned in turn from the Hindus. The young Leo realised at once that this strange numerical system of 0, 1 2-9 was utterly superior to the cumbersome Roman system of letters( V X MCXCCVL, etc) On his return to Italy he published the Liber Abaci, whose short 27 or so chapters are one of the most significant books in the canon of western learning. Not only did it update all and sundry on the new number system. Not only was it full of useful applications for this system. Above all it promulgated an intriguing new sequence of numbers which goes 0,1, 1, 2, 3, 5, 8, 13…..to infinity. Each number in the sequence is formed by adding the two before. Dividing one by its predecessor quickly gets to the Golden ratio, which artists and architects have been using as on of the most aesthetically pleasing constructions for centuries.

We have alluded here before to odd mathematical structures such as pi and Eulers number: which show up again and again in nature: Fibonacci’s sequence is another of them. We have no idea why, but then: nor does anyone else. But the real significance of Fibonacci was his timing. For the first time, and after a long sleep, Western Europe was starting to make original contributions in natural sciences. And it did it by borrowing humbly from other more learned cultures. A lesson we should not forget today.

[1] https://en.wikipedia.org/wiki/Fibonacci

[2]https://www.bbc.co.uk/bitesize/articles/zm3rdnb

#fibonacci #mathematics #middle ages ##tunisia #india #biology #architecture