Faith v Reason: Look at the results

We have two stories today, which if taken together, nicely illustrate the difference between Scientific Reason and Blind Faith.

CAR-T Therapy against Multiple sclerosis When we were young , Multiple Sclerosis was a dread disease, Slowly , understanding and therapies have evolved, and now as Nature Briefings explains, a powerful new method using the exciting new CAR-T system looks almost ready for large trials.

And we know how they did it The researchers looked at evidence. They designed and ran experiments . They discarded theories that the evidence showed was wrong. And eventually they came up with this, Engineered Cells for Multiple Sclerosis

The first US trials of CAR T cells to treat multiple sclerosis (MS) have started. These engineered cells could reset the malfunctioning immune system, halting the brain damage that defines MS. “I don’t want to get ahead of myself, but there’s a prospect here for a one-and-done therapy,” says neurologist Jeffrey Dunn, who is running a trial for Kyverna, a US biotech company. Safety is a concern because CAR T treatments can cause brain toxicity, which can result in confusion, seizures and death.Nature | 5 min read

Alabama Theocracy Over in the USA, the Faith-Based Folks of the Alabama Supreme Court have just outlawed IVF. You can read the full story from Robert Reich here [1] but a little of their motivation may be gleaned from the following

In a concurring opinion in last week’s Alabama supreme court decision, Alabama’s chief justice, Tom Parker, invoked the prophet Jeremiah, Genesis and the writings of 16th- and 17th-century theologians.

Today IVF….tomorrow.? Slowly, the tentacles of the Theocrats will close around every laboratory in the USA, banning this, forbidding that, until the US slips so far behind it can never catch up. It was by the Seventeenth Century trial of Galileo that the Catholic Church ensured its own eclipse by ensuring that thinkers fled to the Protestant lands of the north. Hitler found the same, ensuring that the best Jewish scientists fled to Allied countries, delivering their brains to his eventual defeat. That’s what happens when you discard evidence which the theory says is wrong.

Someone once observed that Knowledge and Belief are two different things. It can be hard to choose, we know. But if you need a little help, it may be worth looking at the outcomes of your choice. We can’t see the supreme court of Alabama coming up with a cure for disease any time soon. Nor will the Ayatollahs of Iran. But we hope the above evidence may help you, gentle reader, to support those who might.

[1] https://www.theguardian.com/commentisfree/2024/feb/23/republicans-american-theocracy

#religion #theocracy #christian nationalism #iran #science #empiricism #science

The Startling Truth about early-onset dementia

Of course it’s terrible when a family hears the dread news that Alzheimer’s disease, or dementia, has started to afflict one of their members. But until today, when we spoke with a most educated young woman from Alzheimer’s Research UK, we thought it was a disease of the elderly. We had no idea that it can affect relatively young people, that is to say, in their thirties or forties.

But it can and does, as our links for you make abundantly clear. [1] [2]. We apologise for using UK statistics, but Alzheimers UK estimate that there are 70, 800 cases of one of the various dementias in people who are under 65. You can scale that up or down according to the size of your own country with a simple calculator app (UK population 2024=67.33 million) Meanwhile, we invite you to browse the links, as you will be riding on the frontier of one of the great unresolved research questions of our time.

And what to take away from all this? Firstly, you never know when you will learn something unexpected. Especially when you have access to intelligent people. (If you can’t find any to hand right now, we hope this blog will go some way to ameliorating the deficit) Secondly, keep your brain alive. Puzzles, maths, learning a foreign language or even studying the rules of logic might help. Or at least stave the thing off, for a while [3]. So might keeping fit. And finally-if by some miracle we save the scientific method from the various fanatical culture warriors who are currently afflicting the globe, we might just one day find a method to find that no one ever has to live with it again.

[1]https://www.alzheimersresearchuk.org/dementia-information/types-of-dementia/young-onset-dementia/

[2]https://en.wikipedia.org/wiki/Early-onset_Alzheimer%27s_disease

[3]https://www.health.harvard.edu/blog/can-physical-or-cognitive-activity-prevent-dementia-202109162595

#Alzheimer’s disease #dementia #Alzheimer’s Research UK #scientific method #neurology #age