Antibiotic Resistance: predicting it before it happens

In war, Intelligence is just about the most vital thing you can have. You know, predicting the enemy’s next move before he makes it. How useful it would be to know which bacteria will show resistance to our next antibiotic, where, how , and when! That’s why some new work from Dr Kalen Hall and team of Tulane University, reported on Phys.org is so exciting [1]

They have identified a genetic signature in the bacteria Pseudomona aeruginosa which predicts the likelihood of developing genetic changes which facilitate resistance to antibiotics. Ingeniously, they studied the DNA mismatch repair pathway, which spurs rapid mutations in the genome. As every schoolchild knows, the more mutations you throw up, the more likely it is that one will give you resistance to antibiotics.

But for LSS homies there’s a deeper learning point. The team took their cue from similar research being carried out in the field of cancer treatment. The idea was to use it to predict carcinogenic mutations-but look what these antibiotic folk have done with it! Science breeds science. Knowledge and learning breeds more knowledge and learning. To our readers in the United States we would observe that this is a lesson you used to know well. Why have you started to forget?

[1]https://phys.org/news/2025-01-genetic-fingerprint-bacteria-drug-resistance.html

#microbiology #dna #antibiotic resistance #cancer #bacteria

Dementia and Resistance: Two Antibiotics stories from the front line, plus our take on Glasgow Rangers v Manchester United

A Cure for Dementia? What hope, what unexpected hope, there may be in antibiotic drugs! We knew that when we started this blog. We did it because we were scared of resistant bacteria. But we never anticipated this benefit: antibiotic drugs may protect us from dementia. So might antiviral drugs. So might vaccines too. Andrew Gregory of the Guardian has been following the work of Dr Ben Underwood. In a nutshell

…….One unexpected finding was an association between antibiotics, antivirals and vaccines and a reduced risk of dementia. The finding supports the hypothesis that some cases of the disease may be triggered by viral or bacterial infections. [1]

Of course, there are many questions to be answered. But for us the point is how precious these drugs are, how important it is not to waste them. Which leads us to:

War starts spike in microbial resistance Armed conflicts produce vast surges in traumatic casualties, in dirt and in squalor. All of which necessitate an understandable increase in prescription of antibiotics. Which in turn leads to rising levels of resistance. As Abdujalil Abdurasulov adduces for the BBC [2]

………war appears to have accelerated the spread of multi-resistant pathogens in Ukraine.Clinics treating war injuries have registered a sharp increase of AMR cases. More than 80% of all patients admitted to Feofaniya Hospital have infections caused by microbes which are resistant to antibiotics, according to deputy chief physician Dr Andriy Strokan.

Once started, these resistant strains of bacteria will not go away. They will spread and multiply. How ironic if many of us end up as casualties of a war between third parties, with whom we have no direct connection. Which leads us to:

War For all? We are beginning to suspect that the tendency to divide into hostile camps , who quickly resort to violence, may be a major cognitive defect in the brains of Homo sapiens. Here is our exhibit A: Recently the followers of the popular Association Football Team Manchester United were involved in violent fighting with the followers of the popular Association Football Team Glasgow Rangers. Why? What economic, intellectual or spiritual gains to they hope to make from such an expenditure of time and effort.?(not to mention the legal penalties which may accrue) What on earth divides them so deeply? Yet if people can fight over such infinitesimal differences as theirs, what hope for any of us? One thing is clear to this blog: there will be a lot more antibiotic resistance. Natural Selection does not forgive species that indulge in maladaptive behaviour. What is waiting in the wings to replace us?

[1]https://www.theguardian.com/society/2025/jan/21/antibiotics-antivirals-and-vaccines-could-help-tackle-dementia-study-suggests?CMP=Share_iOSApp_Other

[2]https://www.bbc.co.uk/news/articles/c20k5wrgz13o

[3]https://www.bbc.co.uk/news/articles/cy7gnd72xe8o#:~:text=Trouble%20before%20and%20during%20Manchester%20United%27s%20Europa%

#antibiotic resistance #medicine #health #ukraine #russia #football #manchester united #rangers

Panzootic Disease: When The Guardian and Daily Mail agree, be very afraid indeed

They’re new and they spread fast. They mutate, jumping species barries with ease. Many of them are new, meaning there are no vaccines and no established treatments. They seem to come in many forms- prions, viruses, bacteria, whatever. What are they? Panzootic diseases. They may turn out to be the most significant health risk of this decade, making it time we all thought more about them. So here are two articles which we hope will give you, gentle reader, a sort of jump-off point from which can can know more.

Let’s start with the eloquent Luke Andrews of the Mail, who concentrates specifically Chronic Wasting Disease, or CWD for short.[1] It is caused by our old friends Prions (remember CJD?) and seems to be fatal to every animal it infects. Infection is by simple contact with any body fluid; and as deer are widely hunted from Wyoming to Pennsylvania, Luke identifies a growing problem, at least in the United States. More worrying for us is Luke’s report that it has jumped to wild pigs (that’s it displaying panzootic behaviour); it causes us to worry what may come next,

Pulling back for a broader view, we come to the erudite Phoebe Weston of the Guardian.[2] Unsurprisingly to well-informed LSS readers, her classic example of a Panzootic is H₅N₁, the avian flu which is currently ripping through hecatombs of our most iconic species of mammals and birds. If you think in terms of hard cash, how good is that for the tourist trade? Intriguingly, she sees COVID-19 as a classic Panzootic disease as well, as it seems to have spread to 48 species (no, we didn’t know that either). Best of all, Phoebe praises a book by a man called Mark Honigsbaum called The Pandemic Century; we link to a quick review here.[3] Because the causes of this are actually quite simple: uncontrolled development. destructive short-term farming and an insatiable hunger for things which bring instant, short-term gratification. That is the real sickness.

[1]https://www.dailymail.co.uk/health/article-14280007/researchers-warn-chronic-wasting-disease-zombie-deer.html

[2]https://www.theguardian.com/environment/2025/jan/15/age-of-the-panzootic-scientists-warn-of-more-devastating-diseases-jumping-between-species-aoe?CMP=

[3]https://www.theguardian.com/books/2019/jun/23/the-pandemic-century-one-hundred-years-panic-hysteria-mark-honigsbaum-review-riveting

#panzootic disease #prion #pandemic #CWD #habitat loss #global warming #virus

Vaccine Doubts, Rational Fears

One of the curses of being an LSS reader is that we tend to see how everything is connected. The current dismays in politics, international affairs, popular perceptions of science and economics all merge into each other, meaning we cannot escape. Not even into the quiet groves and ivory towers of Académe. Not even for a moment.

Proof of this came from our reading of an excellent article in The Conversation from the learned Professor Sven Bōlte,[1] who has been investigating the depressing reasons that people, including the President-Elect of the United States of America still obdurately refuse to let go of: the idea that vaccines cause Autism. Because every one of the reasons he cites can also be cited to explain the decay of democracy. Let’s look at a few, and you’ll see what we mean

Unawareness of Evidence

“Reliably and accurately communicating research results to the public is difficult,” states Sven, “Popular media is typically superficial and often primarily interested in controversy that generates public attention.”

For research results read political issues Remember the £350 million on the side of the bus in the UK Referendum campaign? Quod erat demonstrandum

Challenges Understanding Science (shouldn’t that be “to understanding”?-ed)

“Science is complicated and in medicine there are rarely absolute truths. The public, however, might expect clear consensus or have difficulty grasping the precise nuance of the science and its findings”.

For science read economics or law. Yes they do struggle a bit with nuance, don’t they?

Doubts of science

“The human need for immediate and simple explanations for complex issues fuels misbelief”.

The word “research” does not mean sitting on the internet for 30 minutes and pasting up your favourite clicks.

Invisible success of vaccine programmes.

“Vaccination programmes are among the most cost-effective public health interventions available and have averted deaths and long-term disease on a global level in the last decades.

They take it all for granted when it works. Like everything else we’ve given them since The Enlightenment. You know. Soap, Schools. Scooters. Computers. Machines upon which to play their popular musical ditties. A certain entitlement has crept in; and a price must always be paid for that.

We could go on, and you may read the whole article for yourself, gentle reader, by clicking on the link. Does all the above suggest the bulk of humanity lacks the cognitive ability to live in a post industrial world? Or are they just festering with resentment because we stopped them from smoking and burning witches? We await your thoughts.

[1]https://theconversation.com/why-do-false-claims-that-vaccines-cause-autism-refuse-to-die-here-are-nine-reasons-246360?

#autism #vaccines #science #medicine #evidence #conspiracy #reason #emotion

hMPV: Shock Horror, or small pandemic, few hurt?

As all journalists know, there are two types of story. One is “HUGE SOMETHING SHOCK HORROR” the other is “small thing happens, Few hurt or injured” Which do you think catches more clicks/sells more papers/hooks more viewers? So it is with a certain caution that we approach the current media froth around the new hMPV virus that is clearly occupying the thoughts of so many members of the Daily Mail newsroom.

hMPV (human metapneumovirus) is a pretty standard seeming single strand RNA virus of the respiratory syncytial group.[1] It is one of many that surge in late winter in the northern hemisphere after people have been living close together for long weeks in the warm, but with regular trips out into the cold. It can be dangerous, there’s no doubt about it, especially to vulnerable groups such as young children the elderly and those with respiratory conditions. As it is not in our interests for any of our readers to die or lose family members, we urge you to take the sensible precautions enjoined by medical authorities.

What is interesting is the way it’s being reported, especially in western media. The two stories our researchers have put up, both from the Mail are actually pretty representative of all western media, regardless of political, social, racial, sartorial and gender affiliation. [2][3] The westerners are anxious for China to share more information and data on the current outbreak. The Chinese, with long memories of western interference, have their own concerns. Everyone recalls the bitter trading of accusations, suspicions and mistrusts during the COVID-19 pandemic, and are all about as calm and rational as a pair of nestling blackbirds in May.

And our thoughts ?Call us naive, but we long for a world where scientific and medical questions are treated as such, and the maximum co-operation is effected. Let the boys with their toys worry about things like who has most battleships later. Unfortunately it seems to be a human cognitive weakness to elide any possible phenomenon into a weapon to bash the enemy. We are not experts, but we suspect their may be bigger existential threats than this virus. Perhaps a more advanced species will one day make better distinctions.

[1]https://en.wikipedia.org/wiki/Human_metapneumovirus

[2]https://www.dailymail.co.uk/health/article-14254567/symptoms-HMPV-mystery-illness-surging-China-UK.html

[3]https://www.dailymail.co.uk/health/article-14258029/china-details-hpmv-outbreak-UK-experts.html

#hmpv #virus #pandemic #china #west

Materials Science Meets medicine-with a bonus for our Spanish amigos

There’s whole areas of learning and technology which we don’t cover much here. Because frankly, we are just too ignorant. So with the guidance of Dr José Manuel Torralba we present some truly startling advances in the field of Materials Science. What we found was so unexpected that you’ll have to forgive the slightly gushing Tomorrows World 1970- style vibe with which we serve it up. (One link is in English [1] but as we found the the Spanish one first, we present that, too [2])

Implants and artificial tissues Ever heard of nitinol? Neither had we. It’s a sort of alloy of titanium and nickel. already well tested by dentists and others. According to José, it should now be possible to create corneal implants which are capable of shape-memory. Yes, that was a new one on us too. But it looks as if this is going to be an exciting, but very practical area.

Batteries have memory too Our next surprise was batteries with anodes made from something called silicon nanofibres which apparently will be much better at storing energy than the current graphite ones. If nothing else, a real boost for renewable energies

and finally:

Metamaterials We thought this was like something out of a Terminator style movie. But it may be possible to to design materials which, in the words of José

We can modify a material’s surface by creating structures that cause waves to move, bend, or reflect in specific ways. This allows us to create invisible materials (manipulating light), radar-undetectable materials, or materials that completely isolate sound. By altering a material’s internal architecture, we can achieve unprecedented mechanical properties.

It’s so refreshing to dive into a little-visited area and find out what the clever people who work in it have been up to. Especially when it informs one of the main tropes of this blog, which is medical research. We hope you found this slight diversion useful, and will leave you with this thought:
There are more things in heaven and earth, Horatio, than are dreamt of in your philosophy- Hamlet Act 1 Scene 5

[1]https://materials.imdea.org/the-supermaterials-that-will-transform-our-lives-in-2025/

[2]https://www.bbc.com/mundo/articles/ckg9v74kvr2o

#metamaterials #nanotubes #medicine #implants #materials science

Can you Catch Cancer from a Cut?

Just because something is rare doesn’t mean that it’s insignificant. At least, not if it comes surrounded by well-attested research from trained professionals. Which is why this intriguing article by Alexa Lardieri of the Mail has really got us thinking.[1]

A man in Germany was operated on for a rare type of tumour. During the process, the poor surgeon cut his hand. It was cleansed and bandaged immediately. Six months later a tumour, which was genetically identical to his patient’s cancer, was found to be growing on the surgeon’s hand. This all happened back in 1996; but the case continues to excite speculation to this day.

Much more can be found in Alexa’s cogent article. Riffing on it, it suggests the following questions

1 How does transmission occur? Is it via nuclear DNA? Is there an epigenetic mechanism? Dare we speculate that a protein might be involved?

2 Alexa reports that the poor surgeon’s immune system may not have been quite as strong as it might have been. So…are we being bombarded with unknown carcinogens all the time, and it’s only our immune systems keeping us safe?

3 What do we mean by “cause” anyway? Does buying cigarettes give you cancer? Or is it smoking them? Or is it something in the smoke, like tar? Or could we even speculate that it is not the tar per se, but the molecular changes it induces in the cells of the victim? Where does cause end, and effect begin?

Yet it is in such cracks in logic that the most fruitful discoveries are to be found. This case, and the questions it raises are one such example. Thanks, Alexa, for bringing it back from 1996. Which was a great year for music too.

[1]https://www.msn.com/en-ae/public-safety-and-emergencies/health-and-safety-alerts/surgeon-catches-cancer-from-patient-in-first-of-its-kind-case/ar-AA1wRLpW?ocid=Bin

cancer #dna #epigenetics #immune system #health #medicine

Antibiotic resistance: is Magnesium the answer?

Magnesium: that abundant but essentially humble metal that finds so many uses: tin cans, consumer electronics, aviation, Epsom salts, transport…..and many more. But could it be the clue to an exciting new development in the study of antibiotic resistance? Tessa Koumoundouros of Science Alert seems to think so.

A team At UC San Diego think that magnesium is the “Achilles heel” of antibiotic resistance in the bacterium Bacillus subtilis. It’s classic Darwinian Natural Selection in action. Put them in an environment with lots of antibiotic, and, hey presto, one particular strain evolves resistance. They get a competitive advantage and start to out-breed their pals without the resistant gene. But: there is no free lunch in Nature. To get an advantage in one area you have to pay a price somewhere else. Because the non resistant, more generally adapted strain are much better at coping when the magnesium levels in the environment drop. As Tessa explains:

Depriving environments of magnesium could counter the bacteria’s ability to thrive. And because unmutated strains don’t share the same flaw, reducing the key nutrient shouldn’t adversely impact bacteria needed for a healthy microbiome.

Her article contains a really clear explanation, and some good images. Great journalism.

It’s funny how research in one area suddenly gets a boost from something slightly unexpected and left-field. If we are to overcome antibiotic resistance, yes, new drugs will be needed. But, eventually, resistance will develop to them. We need other techniques too, to work alongside the new drugs. And this idea of nutrient balance seems like a really fruitful one to us.

[1]https://www.sciencealert.com/achilles-heel-of-drug-resistant-bacteria-has-been-found-scientists-say

[2]https://www.science.org/doi/10.1126/sciadv.adq5249

#magnesium #antibiotic resistance #health #medicine #microbiology #natural selection

Pandemic and Storms: Two bad news stories suggest our escape window just got smaller

“It’ll be alright.” Somehow, we still cannot admit the the enormity of what we have brought upon ourselves. That clever scientists will still find a way to save us from the mass pandemics and climate change caused by our endless greed for stuff-cheap food, bright shiny junk, empty experiences-that most people persist with, like drunks dancing blindfold on the edge of a precipice. Well here are two stories which indicate that salvation may already be too late.

Winds wreck renewable energy plant. Two things we have always known. That renewable energies offer the only practicable salvation from runaway climate change. And that extreme weather events, caused by all the global warming we’ve already had, are growing worse. So where’s the way out, if those self-same hurricanes and things start tearing down the solar farms which might save us? Proof that this is already happening comes from this article by Richard Marsden of the Daily Mail. Apparently the Porth Wen solar Farm at Llanbadrig in Wales has been ripped apart by the recent Storm Darragh. Wind turbines were torn down too. It’s one plant in one location-so far. But to us it feels like being in a car where the act of going faster weakens the brakes. How scary is that?

Next Pandemic waiting in the wings. The desire for cheap greasy chicken has led to the mass incarceration of birds in crowded unhealthy conditions which make ideal breeding grounds for new viruses. We’ve warned before about the dangers of the H₅N₁virus on these pages (LSS 25 11 24. 25 4 24) Now a new study, reported by Kai Kupfer in Science suggests the virus is frighteningly close to jumping the barrier into our species Get this:

If the world finds itself amid a flu pandemic in a few months, it won’t be a big surprise. Birds have been spreading a new clade of the H5N1 avian influenza virus, 2.3.4.4b, around the world since 2021. That virus spilled over to cattle in Texas about a year ago and spread to hundreds of farms across the United States since. There have been dozens of human infections in North America. And in some of those cases the virus has shown exactly the kinds of mutations known to make it better suited to infect human cells and replicate in them.

There’s more, much more. It’s a fantastic article, we’d recommend it to anyone who wants to learn a bit of basic virology. But the writing is not just in the articles. It’s now very clearly on the wall.

[1]https://www.dailymail.co.uk/news/article-14175033/Storm-Darragh-UKs-Biggest-solar-farm-pieces.html

[2] https://www.science.org/content/article/why-hasn-t-bird-flu-pandemic-started?utm_source=Live+Audience&utm_campaign=8caf16c576-nature-briefing-daily-20241209&utm_mediu link via Nature Briefings

#pandemic #virology #global warming #extreme weather events #renewables

Did your long-ago BCG Vaccine save you from Dementia?

Ask elderly readers of this blog about their BCG vaccine and they will recall an age of 45rpm records, Ben Sherman shirts and George Harrison‘s Concert for Bangladesh. But they still bear tiny marks, high on their left arms from they day they lined up outside the school dispensary. Ostensibly, the vaccination was against TB. But it may have been doing something else which concerns them very much here and now. It may actually have been protecting them against dementia. Get this from an excellent article by Amy Fleming of The Guardian:

…...BCG vaccine was originally used against tuberculosis, but it is also often part of a treatment programme for bladder cancer. “It stimulates the immune system,” says Lathe. A team of researchers in Jerusalem, he says, decided to look at patients who survived bladder cancer and compare dementia prevalence among patients treated with BCG and those who weren’t. “Do they differ in the rate at which they get Alzheimer’s disease?” The answer is yes – the BCG group appeared to get 75% protection against Alzheimer’s. A number of studies have now found varying levels of protection from BCG, with an average, according to one meta‑analysis, of 45%. [1]

And that is only the tip pf the iceberg, gentle readers. For what Amy’s article is really all about is a set of discoveries that the brain’s privileged position as a microbe-free zone is now under serious challenge. It was a position suspected by no less a scientist than the great Alzheimer himself. But was then rather complacently dismissed for many following years. It’s a theme which we’ve alluded to here before (LSS 14 9 24) following leads by the excellent team at the New Scientist. If so, we could at least be on the verge of real cures for all kinds of mental disturbances. And when we think of the terrible suffering such illnesses inflict both on the immediate victim, and their families and carers, we see that as a step forward indeed.

The patient careful thought of researchers and scientists offers the only real hope of ameliorating the human condition. How sad to live in an age when it is eclipsed by the passionate emotion of savage, ignorant mobs. That’s a theme we shall return to, as well.

https://www.theguardian.com/lifeandstyle/2024/dec/01/the-brain-microbiome-could-understanding-it-help-prevent-dementia?CMP=Share_iOSApp_Other

#bcg #vaccines #dementia #alzheimer #immune system #brain #microbiology ]#new scientist