Is that an Antibiotic in the Azaleas?

We started out as an antibiotics blogs, and we’ll always defer to it when a good story comes up. So don’t be surprised as we offer you a really good story, which we found in Nature Briefing, that inestimable source of the very best stories on science and all its ramifications. Scientists unearth new anitbiotic-literally

Researchers searching far and wide for new antibiotic molecules have discovered one in their own backyard. The new molecule — found in soil samples collected from a lab technician’s garden — targets a broad range of disease-causing bacteria and doesn’t appear to be toxic to human cells. From the soil samples, the team spotted a lasso-shaped molecule they named lariocidin, which is produced by Paenibacillus bacteria. Lariocidin attaches to structures called ribosomes in bacteria, which disrupts their protein production. The molecule slowed the growth of a range of common bacterial pathogens, including many multidrug-resistant strains.Nature | 4 min read
Reference: Nature paper

We know, gentle readers that we can occasionally overdo the bad news a tad on these pages. Today we’re glad to tip the balance back a little the other way.

If you want to receive the very latest on science and cutting edge technology, you won’t do beetr than sign up to Nature Briefing. We don’t know of anything as good as this which is still absolutely free. What’s more they have some sub briefing sites on more specialist areas if your want to keep up with a particular area why not visit these sites and see for yourself?

briefing@nature.co

Nature Briefing: Careers — insights, advice and award-winning journalism to help you optimize your working life
Nature Briefing: Microbiology — the most abundant living entities on our planet – microorganisms – and the role they play in health, the environment and food systems
Nature Briefing: Anthropocene — climate change, biodiversity, sustainability and geoengineering
Nature Briefing: AI & Robotics — 100% written by humans, of course
Nature Briefing: Cancer — a weekly newsletter written with cancer researchers in mind
Nature Briefing: Translational Research — covers biotechnology, drug discovery and pharma
#antibiotic resistance #bacteria #microorganisms #medicine #health #research

Antimicrobial resistance: its not just bacteria Plus: see if you can spot the hidden message in this blog

Stop the press! Urgent! Even though it’s Thursday afternoon and we’ve done our blog for the day, a new story is bursting to be told. Because while leafing through the Interweb to see if we had been included in any top secret message groups, we came across a story by the assiduous Clara Harter of the Los Angeles Times: Deadly Drug Resistant fungus CDC calls urgent threat is spreading in hospitals [1] We won’t steal Clara’s thunder. But basically, it’s called Candida auris, it spreads rapidly in healthcare facilities. and it tends to target the sick and the old.

Wanting to know more , we went to the site of the Centers for Disease Control and Prevention (CDC)[2] whose purpose, as every schoolchild knows is goal is to protect public health and safety through the control and prevention of disease injury and disability both in the USA and throughout the world[3](fungi don’t stop at national borders, you see) We found their web page to be concise, easy to access and extremely helpful. How lucky Americans are, to have such a body that anticipates threats to public safety, co-ordinates the efforts of medical facilities and health agencies and keeps the public informed, free of charge!

Well until recently they were, Because we have learned that the CDCs are yet another target in the cross hairs of Mr Musk and his enthusiastic band of young cost cutters. [4] According to the independent Medical Economics:

The cuts include 1,300 U.S. Centers for Disease Control and Prevention (CDC) staff — about 10% of its workforce — and all first-year officers in the Epidemic Intelligence Service (EIS) — a disease response unit.

We are ignorant of Mr Musk’s motives; he may be a man of profound compassion and acute foresight. His economic learning may be profound; we cannot say. But if the fungus spreads, and if its economic cost is as great as its human one, we will know that it could have been prevented.

[1]https://www.latimes.com/world-nation/story/2025-03-27/deadly-drug-resistant-fungus-cdc-calls-urgent-threat-is-spreading-in-hospitals

[2]https://www.cdc.gov/candidiasis/antimicrobial-resistance/index.html#:~:text=At%20a%20glance%201%20Antimicrobial%20resistance%20happens%20when,common%20type

[3]https://en.wikipedia.org/wiki/US_federal_agencies_targeted_by_DOGE

[4]https://www.medicaleconomics.com/view/elon-musk-s-doge-and-its-impact-on-federal-health-agencies-explained

#DOGE #CDC #fungus #antimicrobial resistance #public health #disease prevention #medicine

Alphafold for RNA?

Model – Flu Virus Protein, CSIRO, circa 2000 by Photographer: Rodney Start is licensed under CC-BY 4.0

Back in 2023 we praised the achievements of Google Deep Mind and its Alphafold system for predicting protein structures (LSS 23 2 23) The step change in productivity , (no disrespect to human biochemists) was so remarkable that we compared it to the invention of stone tools. Since when it has pretty much become a standard tool in medical research.

So much for proteins. What about RNA? Advances in understanding its structure, maybe even making a little of our own, might convey enormous medical benefits. Read this from Nature Briefings Seeking an alphafold moment for RNA

Protein-structure-prediction tools such as AlphaFold have transformed biology. But RNA is a tougher nut to crack: it poses unique molecular challenges, and relatively few data are available to train computational models. So researchers have been getting creative, building a toolkit to aid the prediction of RNA structure that incorporates the latest developments in artificial intelligence.Nature | 10 min read

“A tough nut to crack” Indeed. For one thing RNA has always suffered from that “middle child” syndrome, lost between its more glamorous siblings, DNA and proteins. So there is a lot less data to feed into the AIs. And even the main forms, t-RNA and m-RNA are fiendishly complicated, like any biological macromolecule. Fortunately, there is a superb article from the main part of Nature by Diana Kwon[1] which lays out the problems and challenges with great clarity; well worth a glance, However the advantage of getting on top of RNA and bringing it, so to speak, into the twenty first century could be colossal, Never forget that it was an m-RNA vaccine that finally got the SARS-Cov-2 virus on the run. That is a glimpse of what might one day be acheived.

[1]https://www.nature.com/articles/d41586-025-00920-8?utm_source=Live+Audience&utm_campaign=bc74eaec70-nature-briefing-daily-20250326&utm_medium=em

#rna #AI #alphafold #medical research #biotechnology #nucleic acids #proteins #vaccines

24 Deadly Diseases that could land on our shores

Of all the ways to go, Ebola Fever is one we’d prefer to avoid. First, your temperature shoots up to an unhealthy 39 C. This is followed by agonising bowel cramps and uncontrolled bloody diarrhoea. Finally the patient starts vomiting blood. Death, which usually follows in 80-90% of such cases, may begin to seem a mercy. Readers with long memories may recall an epidemic of this disease in Africa between 2013 and 2016. Fortunately it was contained, due the efforts of public health officials and brave, skilful medical professionals. Who managed-just- to confine the death rate to 11 323 unfortunate souls. It doesn’t bear thinking about what might have happened had they failed. But according to Professor Harper, a pandemic caused by a similar disease broke the back of the Roman Empire and effectively ended the civilised world[1]

Now a report by the UK Health Security Agency[2] [3] lists Ebola as one of a group of 24 deadly diseases which could land on the shores of this sceptr’d isle at almost any time. As most readers will recall, Ebola is part of the Filoviridae family(an honour shared by the mortiferous Marburg virus) But travelling companions include the Flavoviridae (dengue, zika) Coronaviridae and all sorts of bacteria including the ones for bubonic plague and anthrax. Kat Lay of the Guardian has a nice quick take on the story. And its proximal causes, most of which come down to climate change and habitat destruction.

And our take? It’s good to have some sort of professional public health body that can at least take note of, and warn about, these sorts of things. But the poor old UKHSA has been starved of funds, largely to finance tax cuts to pay for the purchase of Bright Shiny New Things. The production of which leads to climate change, habitat destruction, and…………….you get the picture. If today’s seems a bit of a UK-centric blog, so be it. We are a pretty representative average sort of country, and you face the same threats that we do. If these diseases are appearing on our threat list. they’ll be coming up on yours soon. They have the same ultimate causes.

[1] Kyle Harper The Fate of Rome Princeton UP 2017

[2]https://www.theguardian.com/science/2025/mar/25/uk-experts-urge-prioritising-research-into-24-types-of-deadly-pathogen-families

[3] https://www.gov.uk/government/news/ukhsa-highlights-pathogens-of-greatest-risk-to-public-health

#pandemic #virus #bacteria #epidemic #climate change #global warming

The Next Pandemic: Not if, but when

Wars in Ukraine, Sudan and the Middle East. Falling stock markets. Huge new tariffs on trade. Another season of fires and floods as the Northern Hemisphere warms up to summer. Yes, this is all pretty bad………but we think there is something much worse lurking in the background. This blog was born among the incalculable human and economic damage of the COVID-19 pandemic back in long-ago 2020. We think another one is on the way. More to the point, our opinion is shared by some much better informed and cleverer people. So we thought we would bring you their thoughts.

Writing for the Conversation [1] the erudite Professor Anthony Staines takes a long cool look at the public health scene. Despite what you might have thought COVID-19 hasn’t really gone away: it’s still killing between 500 and 1000 people a week. Measles is on the uptick as well, especially in countries where vaccination is falling out of fashion. Bird flu is now crossing over both to humans and livestock herds. But the Professor still puts his money on some as yet unkownn virus, or one that is currently flying under the radar.

The prestigious Chatham House Institute[2] serves up a complimentary view as to what this might be. Bird flu is still a strong candidate. But they have a worrying take on the Ebola virus: could some new variant of this be Professor Staines’ unknown candidate? Above all Chatham riff on the mapping studies which might give us some clue. as to where the disease will be triggered. They point to run away urbanisation, deforestation and habitat destruction as key enablers, unleashing new organisms onto populations with no effective resistance at all.

The LSS board has no particular wish to die of Ebola: it’s a horrible way to go. And if it happened to any of you, dear readers, why, we would have lost a friend. Of course we need to respond to what is immediate and tangible, like the price of eggs. But it might be worth pointing out to our leaders that they need to think long term as well.

[1]https://theconversation.com/five-years-after-the-pandemic-the-world-is-poorly-prepared-for-another-one-249906?utm_medium=email&utm_campaign=Latest%20fro

[2]https://www.chathamhouse.org/2022/02/next-pandemic-when-could-it-be

#pandemic #virus #ebola #deforestation #bird flu #vaccination

Recycling the way to new antibiotics

If there was one thing that has always been too much for us, it is trying to understand the fiendish complexity of the immune system. At school, at our various universities, trying again during the COVID pandemic…..we have never really got past T and B. So when the BBC announced this morning that a whole new part of it had been discovered,[1][2] you might have expected us to hold our collective heads in our hands and groan.

Far from it, gentle reader. For the new discovery has opened the possibility of a whole new class of antibiotics sitting right there in every cell of the body. An astute group of scientists led by Professor Yifal Herbl at Israel’s prestigious Weiszman Institute of Science have found that proteases, a regular part of cell function, may be able to unleash significant antibacterial function. A protease normally functions like the recycle department of your local council, chopping down old proteins and getting them ready for use. But the team found that many of the little peptides produced have strong antibiotic properties. Like the good scientists that they are, they then ran two objective tests. Do the proteases work as well as conventional antibiotics? And if you disable them, does the cell become more vulnerable to infection? To which the answers, broadly speaking, are Yes and Yes.

Once again we stress that this research, and its development into useful therapies, is still at early stages. Which we always do when we cover new points of departure like this. Yet it is, indubitably, a new departure, And it has been sitting there unnoticed until now. Something which has always tickled our fancy here, as regular readers will know. Hats off to Professor Herbl and her team. And-readers! Every tome a journalist publishes on the antibiotics crisis, why not write a very short e mail of thanks to them? They’ll love you for it.

_{with thanks to Gaynor Lynch}

A note on today’s links We have two straight news stories and a link to the Weiszman Institute, to give you staring points. However, we could not get past paywalls to the Nature articles, and we doubt you will be able to as well

[1]https://www.bbc.co.uk/news/articles/cpv4jww3r4eo

[2]https://phys.org/news/2025-03-cellular-trash-reveals-immune-defense.html

[3]https://www.weizmann.ac.il/pages/

#antibiotics #proteases #immune system #peptides #microbes #bacteria #ealth #medicine

At last, another antibiotics story….but it’s not all good news

Yes, gentle readers, back to our Core Mission Values, our raison d’etre, our philosophical DNA (stop there-ed) We just wish it could be better news. For Andrew Gregory, that accomplished science journalist of The Guardian has just written up a magisterial survey of the UK’s efforts to contend with antimicrobial resistance by the National Audit Office(NAO). [2]”Could do better” is the verdict.

First the good news: UK Governments have recognised the problem and are” taking measures,” as the old saying goes. Good! We’ve been on this one for ten years now, and compared to then, the general awareness is indeed very high. Now for the bad: according to Andrew:

Of five domestic targets set in 2019, only one – reducing antibiotic use in food-producing animals – was met. Drug-resistant infections in humans have increased by 13% since 2018, despite a target to reduce them by 10%, the NAO said

There’s lots more good stuff in here, including some killer statistics about where we will be in 2050 if nothing is done. If you haven’t got time for the report, at least read Andrew’s piece.

The reason we take all this seriously is where it comes from. If there is one thing that still marks out a little of the old British excellence it lies in objective institutions like the Civil Service and the BBC, whose cool objectivity have long been the admiration of our overseas friends(we know this from personal experience) The reports assiduously collected facts and judicious observations are a model of intellectual clarity. Britain may not be great anymore, but it is still a pretty representative country. We suspect that much in this report may apply to where you live too, gentle reader. If so, our collective efforts still need to be stepped up. By a lot.

[1]https://www.theguardian.com/society/2025/feb/26/uk-falling-short-in-fight-against-rise-of-superbugs-resistant-to-antibiotics

[2]https://www.nao.org.uk/reports/investigation-into-how-government-is-addressing-antimicrobial-resistance/#:~:text=This%20report%20sets%20out%20information%20on

#amr #antibiotic resistance #microbiology #public health #NAO #medicine #hospitals

Lung cancer rising again Plus: is all that plastic in your brain doing you any good?

Photo by Andrea Piacquadio on Pexels.com

One of the great achievements that we progressives can still chalk up is the gradual elimination of smoking. Ok it’s still out there. But in western countries it’s in steep decline, and cases of lung cancer were falling accordingly. Or so it seemed. But since about 2020 it seems to be on the rise again. Among non smokers. Among women non-smokers in fact. Odd, isn’t it? The reasons are discussed by Dr Pinar Oysal Ongoner of the prestigious University of Westminster[2] *for the Conversation.[1] She is particularly interested in the rise in adenocarcinoma. The cause ? It looks as if air pollution is a strong candidate, with a strong pointer to our old friend PM_2.5 which is spewed out daily by millions of cars, lorries taxis and vans. Clean air zones, anyone?

As if one pollution story wasn’t bad enough, here’s another that may be worse. Ten years ago the idea of plastic micropollution getting into the brain was either ignored or scoffed at. Now we know better: Our Brains are full of plastic bits from Nature Briefings

Toxicologist Matthew Campen estimates that he can isolate about 10 grams of microplastics from a donated human brain; that’s about the weight of an unused crayon. Scientists are scrambling to understand how these tiny fragments, which have been found in every recess of our planet and our bodies, affect our health. They need clear data to communicate potential risks to policymakers, and with plastic production reaching new highs every year, they’re in a race against time. “It’s very scary to think the concentration of plastics in my brain will go up several percentage points before we have answers,” says Campen.Nature | 11 min read

A whole crayon’s worth of plastic in your brain? isn’t that, like, rather a lot? It took decades to discover the link between tobacco and lung cancer. And many more to overcome the vested interests and start saving lives. At that rate, how soon are we going to cope with this new plastic threat?

*_{The University of Westminster is not only famed for its academic excellence but also for the production of graduates of outstanding charm, good looks and modesty. Well, Postgraduates, actually}

[1]https://theconversation.com/why-is-there-an-increase-in-lung-cancer-among-women-who-have-never-smoked-249406?utm_medium=email&utm_campa

[2]https://www.westminster.ac.uk/

#cancer #pollution #traffic #pm2.5 #plastic #drinking straws

If you want to cure cancer, try paying more taxes

Cancer is the great unspoken truth running through our civilisation. Everyone knows someone who has it. Most people know someone who has died of it. The statistics suggest one in two of us will develop it in one form or another. When strangers discover that we run a science blog it isn’t long before cancer cures edge into the conversation. Everyone deep down wonders “will it happen to me?” You do, don’t you?

Which is why it gets a lot of coverage, and fresh discoveries always make the news. Following Ellyn Lapointe for the Mail [1] and the Korean owned Medical Life Sciences News,[2] we showcase the work of the brilliant Professor Kwang-Hyun Cho of the Korean Advanced Institute of Science and Technology. Instead of painful drawn-out chemical treatments it looks to cure cancer by manipulating the biochemical mechanisms of the cell. Admirable, and you can read more by following the links. But for us, for today, that is not the point.

Look again. The Korean Advanced Institute of Science and Technology. Turns out it’s state owned. Paid for by taxes, Its at the centre of an ecosystem of research institutes, university departments, private companies and assorted government and non-government organisations whose collective wisdom and output is far more than the sum of its parts. It’s not so much arriving at another cure for cancer that is important for us today. It is because this cure is part of a rolling programme of research and discovery that throws up such discoveries as it goes along. Creating a thriving centre of excellence and high value jobs.

The view taken by most people in the UK is that taxes are evil things. The State is an evil parasite holding back economic growth and thereby progress. But isn’t our story today prime evidence that the opposite is the case?

[1]https://www.dailymail.co.uk/sciencetech/article-14369821/breakthrough-switch-reverses-cancer-human-body.html

[2]https://www.news-medical.net/news/20241223/Groundbreaking-technology-converts-cancer-cells-into-normal-cells.aspx?form=MG0AV3
#cancer #medical sciences #economics #research

Rookwood Operations: Clearing phosphates AND capturing carbon

Today we have a good news story, brought to us by the ineffable Robin McKie of the Guardian, which brings genuine hope, Because it solves two problems for the price of one.[1]

To begin at the beginning. In the last fifteen years or so, England’s rivers have started to fill with huge, choking blooms of algae, which seize all the oxygen from the water, thus killing everything else before, dying back themselves . To leave a poisonous foul-smelling sewer , like the ones you used to find in old towns in the Industrial revolution. The cause? High levels of phosphates on agricultural lands, which runs off into the waterways, producing sudden spurts in the aforementioned algae-and down we go to death, for the ecosystem that is. Now, it could be argued that without high phosphate levels we could not feed our population ( feed or fatten?-ed) So how to square the circle?

The answer is to trap the run-off phosphates and return them to the land. And a small company called Rookwood Operations[2] is doing just that, down in the leafy county of Somerset. Their new Phosphate Removal Material just sits in the water, soaking up the phosphates until it’s full. Whereupon it is returned to the land ready for the farmers to exploit again. And get this:

For every metric ton of PRM produced, carbon is sequestered, locking CO2 for up to 1000 years.
PRM is made from completely natural circular sourced sustainable components

How’s that for two in one? There’s so much to like here for LSS readers. There’s even a feminist angle, as one of the company founders was up for the prestigious UK Women in Innovation Award.

Thinking new. Thinking differently. Using existing technologies to squeeze progress in a new way. Surely that trumps going round smashing your friends over the head because it makes you feel better?

[1]https://www.theguardian.com/science/2025/feb/02/uk-scientist-wins-prize-for-invention-that-could-help-avert-phosphogeddon

[2]https://rookwoodoperations.co.uk

#Rookwood operations #phosphates #river pollution #capture technologies #agriculture #technology