Avian Flu: A pandemic to make COVID look innocuous, may be about to happen

Imagine the COVID pandemic all over again. Hospitals full of dying people. Their overworked staff burnt out to the point of exhaustion. The masked survivors walking though haunted empry streets. The economies of the world in freefall. Only try to imagine that the pathogen is ten times more lethal than the COVID-19 virus. And you begin to get some idea of what the H₅N₁ virus will do.

So far the virus has been confined to birds Large scale factory farming of poultry is a sur- fire incubator of pandemic organisms. But, if you think you and your family are safe, read this from Nature Briefings Teenage Bird Flu rings alarm Bells

A teenager in Canada is in critical condition after being infected with a version of the H5N1 avian influenza virus that has researchers on high alert. Viral genome sequences suggest that this is a mutated form of H5N1 — which is related to the one infecting US dairy cattle but might be better at infecting the human airway. If true, it could mean that the virus can rapidly evolve to make the jump from birds to humans. “There is reason to be concerned,” says immunologist Scott Hensley. “But not reason to totally freak out.”Nature | 6 min read [1]

Obviously scientists and doctors will try to calm us down, it’s part of their job. But one chilling, ineluctable fact screams out from between the lines of these reports. The virus has jumped the barrier between species, Now only one last stage remains: to find a way to perfect human to human transmission. Every disease-ebola fever, smallpox, Bubonic plague, whatever- must pass these two tests. If it does so, it can kill at leisure-in enormous numbers. Remember the Spanish influenza panic of 1918? That was a similar virus(H₁N₁) and it carried off at least 50 million people from a world population of 1.8 billion. If we scale up to today’s population, the deaths will easily top 227 million. And that’s before we take into account the much faster communication and transport systems we now have, which will spread the virus so much more quickly.

So, while you are busy wondering the on line shopping malls, wondering whether Blagdon United will beat Nowhere City or trying to find a group of different people to hate, your nemesis may already be waiting in the wings. Question: does it serve you right?

[1]https://www.nature.com/articles/d41586-024-03805-4?utm_source=Live+Audience&utm_campaign=f0d788c2d2-nature-briefing-daily-20241122&utm_medium=emai

[2]https://en.wikipedia.org/wiki/Spanish_flu

#avian flu #pandemic #disease #health #medicine

Digital Technologies offer step change in Antibiotic resistance

If something isn’t going too well, you try to look to throw something new into the mix. Something different, from outside the field. We’ve been bashing away with new drugs, education, media ops for ten years now. And still the problem of microbial resistance to antibiotics hasn’t gone away.

Which is why we welcome this new idea covered in The Lancet. The application of advanced digital technologies in things like diagnostics, data collection, clinical decisions -the thousand and one everyday things of medical life-could be a real game changer. So we are rather proud to present these articles from The Lancet. the first [1] by Timothy Rawson and co-workers is a marvellously detailed road map for how it might all work. (Warning-there’s a lot of it, this is going to take more than one coffee break) The second is a general guide from the Lancet about how they will be promoting and covering the whole trope. Well done, them.

We need a game changer, gentle readers. We sincerely hope this is it. Remember- you read it here first. Well, sort of. Anyway, the less you have of us, the more time you will have to read the papers. Off you go!

_{Thanks to G Herbert}

[1]https://www.thelancet.com/journals/landig/article/PIIS2589-7500(24)00198-5/fulltext

[2]https://www.thelancet.com/series/AMR-and-digital-approaches?dgcid=facebook_organic_landigamr24_whod_landig&utm_campaign=landigamr24&utm_content=316076562&

#antibiotics #microbial resistance #digital technologies #the lancet

Pesky Plastic Particles Promote Antibiotic Resistance

Oh for those shiny days of the far-off 1960s, when all those brightly coloured plastics were new, and somehow modern. Your model of Thunderbird 2 was made of it. So were the seats in your dad’s new Austin 1100. So were bottles of fabric conditioner, drinking mugs and clothes of nylon. No more fuddy duddy old wood and cotton for us! This was the Space Age, and we even listened to David Bowie’s Space Oddity on a plastic record.

Except there was a catch. All this new plastic which was slowly filling up the world would one day break down into tiny indigestible particles. With no where else to go except into our blood, our brains, our tissues. So far so bad, but it gets worse. LSS started out as antibiotics blog, and this is where we close the circle. Read this: It’s from the admirable Science News website, a cornucopia of knowledge on many subjects

An international research team has investigated how nanoplastic particles deposited in the body affect the effectiveness of antibiotics. The study showed that the plastic particles not only impair the effect of the drugs, but could also promote the development of antibiotic-resistant bacteria.I

So what’s going on? Firstly, can we say how much we liked the simplicity of this study. It used a common antibiotic (tetracycline) and and some common as muck plastics (polyethylene, polypropylene and polystyrene) It looks as if microparticles of these things can bind antibiotics, which leads to both the reduction of effectiveness and the generation of new resistance. But read the paper and judge for yourselves, good readers.

And our thoughts? Well they’re more emotions really. A kind of vague melancholy at how progress in one area slow creeps up and vitiates progress in another. That Rachel Carson was right all along. And that all that glistens isn’t good.

[1]https://www.sciencedaily.com/releases/2024/10/241030150657.htm

#plastic #nanoparticles #antibiotic resistance #pollution #health #medicine

Microbes might be the best carbon catchers of all time

OK, we have spent the past four years urging you to hunt down those pesky little microbes with every antibiotic you can lay your hand on. Now we’re going to tell you microbes are just wonderful. When it comes to saving us from Global Warming that is Read this piece called Microbes against climate catastrophe from Nature Briefings

In a call to action published simultaneously across 14 journals today, microbiologist Raquel Peixoto and colleagues demand that the world “harness the power of microbiology” to safeguard the planet. From the enhancement of carbon sequestration to the cultivation of biofuels, there are a multitude of microbe-based solutions to climate problems, say the authors — but these are not being rolled out effectively at scale. It’s time to cut through the red tape, they argue, and gather a global task force to help test, fund and deploy the best of these microbiome technologies.Nature Microbiology (and 13 other journals) | 5 min read

When we ran this one through the editorial board, we agreed we could not be accused of mixed messaging. Antibiotics are in the medicines file. Carbon capture is in environment. They are two completely separate disconnected entities, like the utterances of certain well-known US politicians and the observable truth. But: are they? After we finished the meeting, and before putting quill to parchment, as t’were, we went for an uneasy walk with our conscience. Up and down the bleak streets of Croydon. Past Fairfield Halls. Something was niggling at the back of our mind. In the Porter for a quick three or four pints. What was it about antibiotics? Round the shopping centre. Something extra about antibiotics. Back past fairfield Halls. People were starting to look Then it hit us! All these excess antibiotics, running off farms and so on may actually be damaging the very microbes which we need to save us. Read this extract of an abstract if you don’t believe us, from the accomplished Professors Yaozong Cui, Yanhong Li Lihao Zhang and Nan Ziao Environmental behaviour and impact of antibiotics [1]

Antibiotics are widely used to treat or prevent human and animal diseases, as well as to promote the growth of animals in livestock breeding and aquaculture. As a type of antibacterial drugs, antibiotics have been widely applied in human/animal disease prevention, disease treatment, animal husbandry and aquaculture, etc. A majority of antibiotics introduced into human/animal cannot be utilized directly, leading to the result that more than 85% antibiotics were discharged into the environment. Once antibiotics enter the ecosystems, they could influence the evolution of the community structure, which according affect the ecological function of aquatic environment. Correspondingly, antibiotic resistant bacteria (ARB) have been found, which is threatening ecological safety and human health.

Perhaps the best take on this is from the world-weary Professor Peixoto. We need-and urgently- a very deep understanding of how we live and manage the whole microbiological biome. But where do our rulers spend our money?

[1]https://www.atlantis-press.com/proceedings/iceesd-17/25875046

#global warming #climate change #biofuels #carbon capture #microbiology

Ian Sample: Science offers five reasons to be cheerful

Just for kicks, we thought we’d change the slightly pessimistic zeitgeist of this blog, and offer you some stories of real hope. Those-and a little moral homily at the end which we hope will justify these humble inclusions. The stories come, as so often, from Guardian science writer Ian Sample, whose thoughts we often praise here.[1] We hope they might offer a glimpse of what we are about to lose if certain tendencies play out.

Stem Cell transplants could reverse diabetes. All that intricate and detailed work on stem cells may at last be finding a pay-off in the real world, with an almost infinite relief of human suffering. We respect the beliefs of the religious: but would just praying have got us this far?

Cancer vaccines from RNA We have covered this before here. If nothing else, the COVID-19 pandemic witnessed a major leap forward in vaccine technology, especially in mRNA. Where would cancer patients be now if all those anti-vaxxers had their way?

AI detects cancers To bring in another LSS old favourite: AI can now be used to screen and detect cancers more quickly than ever before. When we think of cancer, we think of old acquaintances who used to deny smoking had anything to do with cancer. Does that remind you of climate change deniers?

Occupants of interplanetary Space For lovers of pure science, there can be little more amazing the discoveries offered by the James Webb telescope. Once upon a time, the Inquisition threatened to burn Galileo for looking up at four little satellites around Jupiter. Will someone try the same on this new telescope?

Renewable energy is on the way. Remember all those programmes and articles that tried to suggest that renewables could never, ever replace fossil fuels? But there’s real hope now that renewables will displace fossils by 2030. Both China and India seem poised to lead the way ahead. USA take note.

Yet we promised you a moral on this one, so here it is. All these discoveries, all this science, which Ian has just showed us is dependent on the free and fearless interchange of information. Which in turn depends on open societies and the rule of law. There is strong reason to believe that this era is coming to an end. In some countries, religious obscurantists and zealots are close to extinguishing freedom forever. in others, violent ethno-nationalists have seized power, or are close to doing so. These societies may well offer social stratification and the appearance of security. Yet in all of them. the sole definition of value is “does this bolster the regime?” There can be no truth in science, no beauty in art, no trust in money which does not meet this criterion. Ultimately, such societies stagnate. And then decline. You still have time to change your minds. In some countries, at least.

[1]://www.theguardian.com/world/2024/nov/09/reasons-to-be-hopeful-five-ways-science-is-making-the-world-better?CMP=Share_iOSApp_Other

#science #learning #objective truth #empiricism #vaccines #rna #astronomy #medicine

Round Up: Unpleasant drinks, New antibiotics for old, weight loss and clever cats

What’s in the water? Water is good for you, beer is bad. True, up to a point, especially for those of us who worry about our girth. But think before you drink, as they say. There may be more in that innocent glass of tap water than you bargained for, as this piece from The Conversation makes clear. Forever Chemicals in our drinking water……………

https://theconversation.com/forever-chemicals-are-in-our-drinking-water-heres-how-to-reduce-them-241645?utm_medium=email&utm_campaign=Latest%20from%20The%

Clever moggy finds new virus Ailurophiles of all lands will applaud the tale of this serendipitous kitty who brought home a mouse that contained a hitherto-unknown, and rather scary virus, to his biochemist owner. Here’s the Daily Mail

https://www.dailymail.co.uk/health/article-14021477/florida-rodent-virus-human-infection-potential.html

Antibiotics from the past Leafing through our old pharmacopoeias and other databases may yet be an important new source of antibiotics. God knows we need to look anywhere and everywhere. Fortunately, Science Alert shows the way, with really good graphics(yes we always like those)

https://www.sciencealert.com/forgotten-antibiotic-from-decades-past-could-be-a-superbug-killer

Can weight loss drugs boost your mental health? We at LSS recommend no drug or substance, as we are not doctors. But we will report on new reports about those drugs, provided these are covered by reputable outfits such as New Scientist. Here’s one about new research into possible mental health benefits of these new weight loss drugs which are so fashionable in today’s Zeitgeist, as t’were. Two caveats: once again, don’t do anything with these until you’ve spoken to your doctor; and, moreover, you’ll have to jump the paywall on this one. _{Thanks to G Herbert}

https://www.newscientist.com/article/mg26234953-900-the-surprising-mental-health-and-brain-benefits-of-weight-loss-drugs/

#weight loss #mental health #antibiotic #cat #pollution #forever chemicals #serendipity #medicine health

Round up: Stem Cells, Venezuela, allergies, goodbye to Old King Coal, and the second-most-famous Austrian of all time

stories that caught our eye

Adios, Venezuela, Stage Left : It has always been a conceit on the Left that somehow, whatever bad things we do, we are still somehow the exclusive guardians of the flame of human progress. Whereas the Right, poor dears, are steeped in superstition and ignorance. But Left-wing Governments, at least extreme ones, can do just as much damage to the scientific culture of their country as any Right-wing theocracy, as this piece form Nature Briefings makes clear

Some researchers in Venezuela fear that science in the country is “going down the drain”. The country’s economy has been in crisis and national science funding is proportionally smaller than in comparable countries, leaving research institutions and universities struggling to stay open. Young scientists have left in droves seeking out high-quality education or stable career prospects. And an ‘anti-NGO’ law now requires non-governmental organizations to share information about their funding with the Venezuelan government. Researchers, who sometimes look to NGOs for support, worry that this gives the government discretion to prosecute anyone whose motives it does not agree with.Nature | 6 min read

Every Breath you take: We hear a lot about microplastics in water and food. Now it seems we are breathing them in from the very air itself. And what’s really scary is that the risks of this are quite, quite uncharted, a bit like tobacco in 1924. Here’s Michael Richardson and Meiru Wang for The Conversation:

https://theconversation.com/breathing-may-introduce-microplastics-to-the-brain-new-study-239347?utm_medium=email&utm_campaign=Latest%20from%20The%20C

Stem Cells give hope for diabetics About twenty or so years ago, we had the privilege of a few words with one of the greatest scientific entrepreneurs of this generation. And he told us that Stem Cells were going to be in the in thing for the future. Proof of this foresight comes in this second piece from Nature Briefings

A woman with type 1 diabetes started producing her own insulin less than three months after a transplant of reprogrammed stem cells. This case represents the first successful treatment for the disease using stem cells from the recipient’s own body, which could avoid the need for immunosuppressants. She was injected with the equivalent of 1.5 million stem-cell-derived islets in June 2023. While promising, the woman’s cells must continue to produce insulin for up to five years before considering her ‘cured’, cautions endocrinologist Jay Skyler.Nature | 6 min read
Reference: Cell paper

Allergies Rising? One of the few good things about the Covid-19 pandemic was the rise to prominence of Professor Devi Sridhar, that most clear-sighted of thinkers. So when she says: “allergies are really on the rise, this is not just a sampling error”, we sit up and take notice. So should you, via her article for The Guardian.

https://www.theguardian.com/commentisfree/2024/sep/30/food-allergies-children-england

Goodbye Coal and steel No one gloats at the loss of great workplaces and the terrible social changes their workers must now endure. And no one more than us, blissed-out children of the Enlightenment/Industrial Revolution can deny that coal and steel were really big steps forward in their day. But their comes a time both for individuals and societies when they really must move on, because it’s the future where reality lies. So Britain closes its last coal power station and blast furnaces. It is a brave step, and one day it will pay off.

https://www.bbc.co.uk/news/articles/ckgn4gg5y2yo

https://www.bbc.co.uk/news/articles/c8vdq6y56v0o

Mozart Rise and Fall of a genius few years ago we saw a rather nifty series called Rise of the Nazis. It was one of those drama documentaries where they mix a narrator over pictures of actors depicting real people, including such luminaries as Heinrich Himmler, Herman Goering and a certain Mr A. Hitler. It looks like the producers must have sat down and asked themselves; “Who’s the next most famous Austrian everyone’s heard of we can do?” No it wasn’t Arnold Schwarzenegger: instead they came up with this excellent series on Wolfgang Amadeus Mozart. We have always put him right up there in the top five or so musicians of All Time. So we loved it, and hope you will too Here’s a link which we hope works to the BBC i Player. Hasta la vista, baby!

https://www.bbc.co.uk/iplayer/episodes/m0021zdr/mozart-rise-of-a-genius#:~:text=Mozart:%20Rise%20of%20a%20Genius.%20Child%20prodigy,%20flawed

#allergies #microplastics #mozart #president maduro #venezuela #climate change #fossil fuels #stem cells #diabetes #medicine #health

Progress on antimicrobial resistance-it’s not all about new drugs

We’ve been in the habit of making clarion calls for new research on anti-microbial drugs here for donkey’s years now. Even reported, where we could, on promising new results. Progress has been slow, we admit. But if you lift your head up and look at the bigger picture, there’s quite a lot of stuff we could be doing to ward off the fateful day when every bacterium becomes resistant. And once again, it’s that excellent website Nature Briefings which suggests some simple, common sense steps people can take now to keep them safe. Particularly in poorer countries, where the stupidities of the world economic order have combined to make cash a little tight. They’ve put up two blocks today, with links, and they’re well worth a read.

HOW TO SAVE MILLIONS OF LIVES Last week, we learnt that more than 39 million people could die from antibiotic-resistant infections by 2050. But it doesn’t have to be that way, argues epidemiologist Ramanan Laxminarayan — if we make sure that people in low- and middle-income countries get the appropriate antibiotics they need. “Even a fairly modest global investment — in the range of hundreds of millions of US dollars — to help prevent bacterial infections and improve access to relatively inexpensive antibiotics could avert millions of deaths,” he writes.Nature | 5 min read
Reference: The Lancet report

STRAIGHTFORWARD SOLUTIONS TO AMR Better sanitation, improved infection control practices at health-care facilities and increased vaccination are among the solutions proposed by four specialists — from Bangladesh, Brazil, Nigeria and the Middle East — who spoke to Nature ahead of a United Nations meeting on antimicrobial resistance (AMR). For example, microbiologist Iruka Okeke says that access to clean water and toilets in Nigeria could reduce gastric infections and AMR simultaneously, yielding an estimated return of US$5 or more for every $1 spent.Nature | 10 min read

We always like it when brisk, cheap solutions, using existing ideas and technology make a real difference. We hope you do too, gentle readers.

#antibiotics #drug resistant micro-organisms #health #sanitation #clean water

Resistance -it’s not just bacteria, it’s evolution in action

Platodesu2013Plattentiere Kunstformen der Natur (1904) by Library of Congress is licensed under CC-CC0 1.0

Old hands on the LSS blog may be forgiven for thinking antibiotic resistance is all about bacteria, and that it all goes in in hospital with lots of medical folk in white coats and humming machines that do funny things with graphs, and all that sort of thing.

Well, it’s about a lot more than that. It isn’t just bacteria that are resistant to our drugs. Down on the farm, there’s a whole class of creatures called Playtyhelminths (aka flatworms) that can do untold damage to sheep, for example. For years their ravages have been controlled by drugs. Now theses pesky creatures are showing strong resistance to these drugs, And to make matters worse, these drugs are getting into nature from the sheep pastures, and starting to wreak havoc there. It’s a lose-lose situation. And we, that is to say humanity, are the losers.[1]

Why is this happening? It’s Natural Selection in action. The flatworms in the sheep guts are animals like any other. Expose them to a threat, (antagonistic drugs) and most will die. But a very few will carry resistant genes, thrown up by random mutation. They and their offspring will survive, and multiply. Mightily. Just like all those bacteria do with the drugs we send against them. The point is resistance is just an evolutionary response. It will happen everywhere at all times. The trick is to stay ahead of it. And the way to do that is to spend a little more on science and research labs. To plan to educate more people with the scientific habit of mind, where we suspend judgement and become open to evidence. And listen a little less to the kind of unreasoning. emotion driven story telling that pollutes so much of the Information Sphere. Some hope.

CREDIT We got this story by watching an episode of the popular BBC television programme Countryfile. [2] Not quite our normal cup of tea, you might think? Well, its amazing how their light, cheerful style gives you an in to some much deeper issues. Worth the odd watch, we say.

[1]https://www.nature.com/articles/s41467-024-45027-2

[2]https://www.bbc.co.uk/programmes/m002398g

#flatworms #sheep #agriculture #platyhelminths #antibiotic resistance

Antibiotic Resistance: Acute danger for the old

Photo by Andrea Piacquadio on Pexels.com

As if the threat from cancer, dementia and heart disease wasn’t enough, the world’s older inhabitants face a new danger. It’s our old friend antibiotic resistance-and it’s growing fast. That’s according to Kat Lay of the Guardian,[1] who has produced a fascinating review of the work of the Global Research on Antimicrobial Resistance Project.[2.3} They looked at data from 204 countries from 1990 to 2021, and have projected their findings forwards into the 2050s.

Young people will suffer from the problem it’s true. But their overall death rate from infections has been falling, partly from the success of things like improved hygiene and vaccination problems. It’s among the elderly that the situation gets bleak. Their death rates from antibiotic resistant organisms have skyrocketed by 80% over the last three decades. The authors estiamte by 2050 this demographic will be suffering 1.3 million deaths per year directly from resistant organism infections. And the resistance will be implicated, at least in part in a further 8.2 million annual deaths. Readers of LSS will observe, wearily, that every one of them will be avoidable.

So, what to say after all these years of blogging? After reporting on the work of so many fine researchers, and thanking so many fine journalists like Kat, and all her colleagues who labour tirelessly to keep this problem on the public eye? The fact that people are more aware of all this than when we started back in ’15 is something. And there have been signs of progress, as we have sometimes noted here. Keep people aware, readers. If you see a journalist who has raised it, try to find a way to thank them. Keep giving money to the charities who are trying to do something about it.[4] And, as with many things-don’t stop hoping

[1]https://www.theguardian.com/global-development/2024/sep/16/health-superbugs-antimicrobial-resistance-amr-39m-deaths-infections-bacteria-gram-study

[2]https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01867-1/fulltext

[3]https://www.tropicalmedicine.ox.ac.uk/gram

[4]https://www.antibioticresearch.org.uk/

#antibiotic resistance #medicine #health #hospital #2050