Can your cat save you from cancer?

Cats: our feline friends: variously cute, lovable, admirable and beautiful. They’re becoming more and popular as pets. Which brings several advantages in the treatment of cancer, believe it or not. Like dogs, their nearest rival, they are exposed to all the same molecular slings and arrows of everyday domestic life-cleaning products- foods, fuels, what have you-as we are. But we also share more genetic material with them then we do with our canine chums. Moreover cancer is rapidly becoming a major cause of mortality in middle aged to elderly cats just as it is to humans in that stage of. It’s a set up for ground breaking studies. And Miguel Ángel Criado for El País and Helen Briggs of the BBC have two excellent reports on a groundbreaking study which has done exactly that. (teaser: one of these links is in Spanish, and one in English-can you guess which?)

The study, co-led by the learned Dr Louise van der Weyden of the Wellcome-Sanger Institute is the first really large map of oncogenic(cancer related) aspects of the cat genome. It’s full of intriguing details, which you can read by clicking on the marvellous articles which we have hyperlinked. But we could not resist a tiny spoiler, concerning Dr Weyden’s discoveries around the gene FBXW7 , a tumour‑suppressor gene whose loss helps drive aggressive forms of human breast cancer. Intriguingly, the same gene is frequently mutated in feline tumours. This cross‑species echo suggests that cats and humans may share a conserved vulnerability in the FBXW7 pathway, making our kitties unexpected partners in understanding this cancer mechanism.

And the conclusion? We need to help cats to help us. You could give to a cancer charity [3] You could give to a cat charity[4] But knowing our readers to be generous types we have included sufficient hyperlinks for you to do both!

[1] El mayor mapa genético del cáncer de los gatos abre la puerta a tratamientos compartidos con humanos | Salud y bienestar | EL PAÍS

[2]https://www.bbc.co.uk/news/articles/cvg3n7j8xyqo?at_campaign_type=owned&at_link_type=web_link&at_format=link&at_ptr_name=facebook_page&at_link_origin=BBC_N

[3] https://www.cancerresearchuk.org/get-involved/donate?

[4] Cats Protection | UK’s Largest Cat Welfare Charity

#cancer #breast cancer #cats #medicine #health #research #genome #oncology

Two new stories give fresh hope on cancer

Two stories give us hope of real progress in understanding and treating cancer. The first from the excellent Emma Gritt of the Mail [1] concerns the work of the great Dr Mariano Barbacid whose work has been so crucial in elucidating and developing the whole theory of oncogenes and the role they play in cancer. His team has been studying the effects of three drugs on the KRAS gene, deeply implicated in the development of the pancreatic form of the disease. But: don’t read us, read Emma-she knows a lot more than we do

The second story, from the inimitable Ian Sample of the Guardian [2] concerns the application of the Google Deep Mind AI tool to study genetic drivers of cancer-and other diseases too. To quote Ian:

“We see AlphaGenome as a tool for understanding what the functional elements in the genome do, which we hope will accelerate our fundamental understanding of the code of life,” Natasha Latysheva, a DeepMind researcher, told a press briefing on the work.

Once again click!. You’ll get a lot more from Ian than you will from us.

Both stories blend into two of our old LSS favourites. Firstly, the use of AI to look at complex biological patterns which humans alone struggle to perceive. (LSS 1 12 20 et seq) Secondly, that repeatable frequencies in DNA may be tied, probabilistically, to repeatable patterns of symptoms. Veteran readers will recall our hopes that this methodology may apply to psychiatric disorders too: (LSS 18 12 25 and 29 12 25). Of course, we expect to learn of environmental and epigenetic factors as well. But if we are right, these genetic advances may provide a firmer starting point for future investigations than we have now. How much more is achieved when facts are sacrosanct, not convenient entities to be selected and disposed according to the immediate convenience of their user! A lesson which certain US politicians and the news channels which so fanatically support them would do well to learn.

[1] Huge pancreatic cancer breakthrough as scientists achieve ‘permanent disappearance’ of disease with new triple-threat approach tested in lab | Daily Mail Online

[2]Google DeepMind launches AI tool to help identify genetic drivers of disease | Genetics | The Guardian

#AI #deep mind #cancer #genes #DNA #medicine #health #oncogenes #psychiatric disorder #heart disease

On another year of blogging…….

As 2025 draws to a close we thought we’d look back over our posts and general contributions to the zeitgeist in what has been a white knuckle ride of a year for just about everyone one on the planet. After all we do believe in recycling, don’t we?

Antibiotics and the potential shortages thereof, has been a constant theme, and we think we’ve covered a story or two every month. Sources like Nature Briefing, The Guardian, El Pais The Mail and many others have been invaluable here and our most sincere thanks go to their journalists who are keeping this vital story at front and centre of public consciousness. In fact, If we see a journalist write a good story in this trope, we write to thank them: and beg you to do the same.

We are proud to cover other serious threats as we see them. None more so than Global Warming, which gets covered every month or so. It’s odd to recall that the fires that tore through Los Angeles in California happened nearly a year ago now (LSS 9 1 25) But they were prescient: every subsequent we made this year, to France, to Portugal, to Spain, wherever, the TV news has been dominated by ferocious fires. It was sad to discover how much of this might have been avoided(LSS 11 7 25) . As for the denialists-we thought the strange legend of The Fisher King might go some way to explaining why they feel as they do(LSS 27 10 25)

We tried to cover some more hopeful science stories as well. The progress in genetic editing techniques such as CRISPR-Cas-9 and Base Pair Editing hold out the hope for unlimited progress (LSS 19 5 25 was a working summary) and have also tried to track progress in technologies such as nuclear fusion, artificial intelligences as well as more recondite topics as evolution(LSS 19 3 25) Our usual series like Heroes of Learning and Friday Night fun have covered subjects as diverse as Fibonacci and Fish and Chips. We thought would like the new series on World Government (LSS 8 1 25 et seq) and Taxes(LSS 17 11 25 et seq) and the Best time to have been Alive (23 7 25 et seq) which by starting in China should avoid all accusations of Eurocentric bias

Of everything we covered the biggest stand out for us was the new discoveries in genetic mapping which may shed real light on the origins of psychiatric disorders(LSS 18 12 25) But for our readers it was the highly speculative Is Donald Trump a Socialist? ( LSS 7 4 25) in which we stated that, although he and his followers would recoil in horror from that label, he is acting like a socialist, however unintentionally. That one has almost never ceased to be read and commented upon. We are not sure why.

Once again thanks to all of you for your suggestions comments and ideas. It is a pleasure to read some of your blogs and postings which now cover the whole world. We in the educated community, the progressive community if you will, are few in number. But our influence is always outsize to our numbers, as it has been throughout History. You gentle reader are the hope of the world. Whatever your belief, enjoy the festivities.

#antibiotics research #microbiology #global warming #psychiatic disorders #health #medicine #environment #dona;d trump #china

Stem Cell Therapy: Lamarckism by Force Majeure

First of all hats off to Oliver Chu, the brave boy from California who has just undergone a successful trial of stem cell therapy for a terrible condition called Hunters Syndrome. [1] as Ian Sample of the Guardian explains. It’s caused by a simple mutation in a gene called IDS-1 which controls the production of a vital enzyme Iduronate-2-sulfatase; without which the body cannot break down key sugars, leading to organ damage of all sorts and cognitive decline. The trick has been to extract the stem cells from Oliver’s blood: replace the faulty gene with a true copy using a viral vector; and pop them back in to Oliver, whenceforth they will thrive happily, self reproducing from their own line, and producing bountiful quantities of the enzyme for life.

And this for us is the key part. Let’s repeat : the new stem cells with the engineered gene will start their own self replicating line. In Oliver. Now Oliver himself started from a single stem cell-a single fertilised ovum, as do all living things. With DNA that was used to build every single following cell as it grew . An Ur stem cell if you like. But now. young Oliver has two. All the cells from his original cell, Plus the new line, from the engineered stem cell. whose line is now flooding his system with the good enzyme..

The central tenet of biology up to now is that we all of us-tigers, pterodactyls, humans, whatever-have a single unmodifiable line of DNA in our cells. Random variations may be passed to the next generation and tested by Natural Selection. But the actual DNA deep in the cells cannot be changed or modified. That’s the Darwinian positioned its held up pretty well for centuries. The alternative, proposed by Lamarck is that organisms are modified by the environment and this information can be learned inthe genes and passed on. So far there has been no evidence to support this view whatsoever . But what if the environment contains clever humans who can choose to modify DNA, and thereby create what are in effect hybrid organisms with two separate DNA lines-like young Oliver? Is this Darwinian? It’s not how it happens in nature, and its been done by force majeur. But it sounds a lot like Lamarckism from where we sit.

[1]https://www.theguardian.com/science/2025/nov/24/groundbreaking-uk-gene-therapy-manchester-hunter-syndrome

#stem cells #hunters syndrome #darwin #lamarck #evolution #medicine #health

PERT: Next step in gene editing offers real hope for hereditary diseases

Almost a quarter of hereditary diseases can be put down to mutations which break an established pattern of DNA, so it can no longer be read. No wonder they are called nonsense mutations. Often these mutations are expressed as STOP codons: just a short three letter sequence that stops protein synthesis dead, like a bad piece of coding in a computer programme. Now a new technique called PERT (Prime Editing RNA Therapy)allows the cellular process to override glitch in the DNA and resume synthesis. The new technique equips cells with engineered tRNAs that override these stop signals, letting the ribosome continue translation and produce the full protein. Here once again is Nature Briefing with one of their excellent short explanations Versatile gene-editing tool fixes nonsense, plus hyperlinks if you wish to delve deeper.

A multipurpose gene-editing tool can correct several genetic conditions in mice by restoring proteins that have been cut short by disease-causing mutations. The method, called PERT, uses engineered RNA molecules that allow protein synthesis to continue even when a DNA mutation tells it to stop prematurely. These ‘nonsense mutations’ comprise nearly one-quarter of known disease-causing DNA variants. As such, if PERT proves effective in humans, it could overcome the need to design bespoke treatments for individual diseases.Nature | 5 min read
Reference: Nature paper

There’s a lot to like here. Firstly the prime editing is straight out of the same stable as the CRISPR and Base Pair Editing techniques which we have heralded here for years (LSS passim) Secondly, unlike most gene therapies, which must be tailored to each mutation, PERT could treat many different diseases with a single editing agent. This is a huge shift in scalability. And if the suppressor tRNA is permanently installed in the patients genome, it is possible that only one treatment may be needed. Once again we are reporting at the early stages (that’s our brief) so all parties are careful to emphasise we are nowhere near clinical applications yet. However, just as we learned during the COVID 19 pandemic , the ability to intervene at the RNA level, precisely between gene and protein, appears to be one of the most fertile areas in medical knowledge for years to come.

#hereditary disease #RNA #DNA #molecular biology #health #medicine

Heroes of Learning: Svante Pääbo

It’s hard to remember how different human evolution was before Svante Pääbo and his transformative discoveries in genetics. There were some bones, but they were bit few and fragmentary. People argued interminably over them like so many medieval nominalists and realists. There were tools, and heroic studies of the scratches thereon. People spent lifetimes following various primates in and out of the rain forest: but it is hard to say whether a chimpanzee is really like a human ancestor, or a baboon is : or is not.

Then in 1997 at the Max Planck Institute in Leipzig, Svante Paabo announced a breakthrough: the actual DNA from inside the mitochondrion of a real (dead) neanderthal. For the very first time here was something tangible, data rich, and available for statistical scrutiny. Now we knew who we were, and who they were. As if that were not enough, in 2009 his team announced a whole Neanderthal genome. Then came immortality: on the floor of a cave in distant Siberia came a tiny bone which Pääbo showed to be a third type of human: the Denisovans. The utter. twisted, anastomosing complexity of the modern human story became clear: and with it the implication that it had always been thus. Giving him the Nobel Prize in 2022 must have been the easiest decision since that monkey in 2001: a space odyssey thought a horse skull might be a good place to land a good thwack.

But the real significance of Svante Pääbo lies deeper. It’s in the observable phenomenon that every so often some genius comes along and turns a field upside down. That every debate, however heated and angry, will one day become futile as more gets found out. It’s like that in all sciences, and a good many non sciences too. The biggest mistake any of us can make is to think we have all the answers. Thanks Svante Pääbo for showing there’s always something new around every corner.

[1]https://en.wikipedia.org/wiki/Svante_P%C3%A4%C3%A4bo

#genome #dna #human #neanderthal #anthropology #evolution science

CRISPR gallops ahead (article contains a warning for xenophobes)

Warning: this article may make uncomfortable reading for xenophobes everywhere)

Progress in CRISPR-Cas-9 (Clustered Regularly Interspaced Short Palindromic Repeats)[1] and the associated enzyme is getting faster and faster. We started reporting on this truly innovative technique in 2020 and regular readers will recall updates ever since. Only four years ago it still felt a bit theoretical. But now radical applications are coming thick and fast Read this from Nature Briefing CRISPR horses spark debate reporting on the rather recondite world of polo pony breeding

the horses pictured above{*} are the first of their species to have been created with the help of the CRISPR–Cas9 gene-editing technique. They are clones of the prize-winning steed Polo Pureza, with a tweak to myostatin — a gene involved in regulating muscle development — that is designed to quicken their pace. Critics say that genetic manipulation has no place among polo’s traditional breeding practices — it has already been banned by some of the sport’s governing bodies. But a zoo of CRISPR-edited animals, from cows to sheep, is gaining acceptance in agriculture.Nature | 5 min read

^{{*} sorry LSS readers-we can’t show this}^-ed

In one sense there’s nothing new here. Humans have been modifying the genetics of plant and animal species since the dawn of the Neolithic. CRISPR and other base editing techniques have simply speeded the whole process up by making specific, designed changes and crucial nodes in the subject organism’s development. There is every reason to suppose that any number of new modifications to animals(and crop plants such as wheat) will be developed in the next few years. Some may even enable us the preserve the integrity of food supplies despite the ravages of things like plastics pollution and global warming. Also, as we have also reported here, gene editing is beginning to show real applications in medical fields such as sickle cell disease and certain cancer therapies. All of which leads us to an intriguing thought.

If ponies may be so easily modified, why not humans? One could start small by just modifying athletes and other small groups. Yet eventually the techniques could become ubiquitous in our species. Hang on-our species? Because the genetic differences between beings consisting entirely of CRISPR modified genes and the rest of us would then be far, far greater than those currently existing between our different races and ethnic groups. Are xenophobes everywhere already wasting their own time?

[1]https://www.yourgenome.org/theme/what-is-crispr-cas9/

#CRISPR Cas 9 #base pair #medicine #biotechnology #sickle cell #agriculture #stock breeding

How life evolved long ago is absolutely relevant today

Long suffering readers of this blog will recall our occasional sallies into the remote past. Like some latter day Doug McClure we occasionally take you into a world stuffed with dinosaurs, ape men and pterodactyls, to the detriment of more relevant stuff on antibiotics or the US Ten Year Bond. And so, although we were privately raving about this piece below called How did life get multicellular? from Nature Briefing, we thought we ‘d spare you from our private obsessions about things that took place between 800 -600 million years ago.

Until a chance encounter with one of more intelligent friends in the car park at our Spanish Conversation group produced the most inspiring thought. “All those Choanoflagellates. protometazoans. Filasterea. whatever, have to do several things if they are to succeed in living together. To glue up to each other. To signal little messages. To co-ordinate the cycles of cell division. Just like cancer cells have to, in fact. And then it hit us. These funny little organisms are the perfect way to model the behaviour of cancer cells. Not just the molecular and genetic mechanisms, but also the Information and Complexity models we must build to understand them: a cancer cell is a typical metazoan cell gone wrong.

Which confirmed a very old principle of this blog. All research however abstruse it may seem, will have a pay off somewhere one day. If it doesn’t benefit the economy, it will make us live longer; sometimes it may do both. These researchers are not just having fun on the edge of time: they may be contributing directly to the study of a disease which will kill half of us. There’s a thought for anyone who wants to cut university budgets or meddle with the findings of scientists.

To play out we shall first post the Nature Briefing paragraph. If you can get past that we’ve some supporting evidence for our basic proposition. We hope both will inform

Across all forms of life, the move from being single-celled to multicellular seems to have happened dozens of times — for animals, though, the jump was one-and-done. The unique cocktail of environmental and genetic factors that helped animal ancestors make that jump still eludes our understanding. To investigate, researchers are focussing on unicellular organisms that ‘dabble’ in multicellularity, occasionally forming colonies of many cells. By studying these organisms as they flit between the two states, scientists are hoping to illuminate how multicellularity stuck in animals — and what sparked the single successful event that gave rise to the animal kingdom.Nature | 11 min read

ASTRACT BECOMES APPLIED

This work discusses how cancer disrupts the gene regulatory networks (GRNs) that evolved to coordinate multicellular life. These networks balance genes inherited from unicellular ancestors (handling basics like metabolism and division) with newer multicellular genes (handling coordination, differentiation, and tissue integrity). https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03247-1

and this how somatic mutations in early metazoan genes specifically disrupt the regulatory links between unicellular and multicellular gene networks. The result? Tumours behave like rogue unicellular entities, ignoring the cooperative rules of multicellularity. Some of these disrupted genes even correlate with drug response, hinting at therapeutic relevance

thanks to R Muggridge

https://elifesciences.org/articles/40947

#cancer #evolution #multicellularity #medicine #health #choanoflagellates

Heroes of Learning: Steven Rose (and why things are never simple)

No book ever tore through the calm assurances of progress through co-operation like Richard Dawkins’ The Selfish Gene. [1] It wasn’t so much the book itself. That was an attempt to popularise, albeit sometimes in colourful language, the discoveries of an important group of evolutionary theorists such as William Hamilton and EO Wilson. It was the use made of it by political activists, zealous propagandists of the Free Market, to prove that every attempt at co operation, collective action and sharing resources was against the basic laws of nature. “Out upon your Trades Unions, your Keynesian economics” they thundered in a thousand articles in places like the Daily Mail “we are nothing but animals. Your only purpose is to pass on your DNA to make copies of yourself. Look at them lions. mate! When one of them takes over a pride he kills all the cubs and mates wiv the females to make sure his genes get frough! Go and do like wise!” It was not an experiment we felt disposed to try. Compete, for the other fellow is your genetic enemy was their credo. All barriers to that competition were both evil and deluded.

It was simple, it was seductive, it was based on some facts. It played well in the broken restless zeitgeist of the 1970s when the pillars of the old prosperity- high taxes, demand management for the common good, collective institutions like the IMF and UN seemed ineffective. It sold by the million; and swept ever more voters into the booths for one Margaret Thatcher in 1979, whose own simplistic and reductionist nostrums seemed to chime so well with those of the book.

One man did not buy. His name was Steven Rose, a remarkably accomplished scientist who spent most of his work in neurobiology and biochemistry [2] This obituary summarises his work better than us. But it was his insistence on complexity and the irreducible flexibility of the human mind, that still allowed hope for a way out from the genetic prison in to which we had been so neatly incarcerated

He wrote: “It is in the nature of living systems to be radically indeterminate, to continually construct their – our – own futures, albeit in circumstances not of our own choosing.”

Look at that carefully, then leap with us to another part of the scientific forest. Where the BBC showcases a new technique to rid the world of the scourge of inherited mitochondrial disorders [3] Basically you take a fertilised ovum from a normal male-female coupling, but put it as the nucleus in the egg of a different female. Which then develops as a normal embryo until nine months later a healthy baby emerges[3] A three parent child? Sort of. Two parents get to pass on their DNA, no doubt to the blissful delight of Dawkins’ more extreme followers. And a different mother sends her mitochondrial DNA cascading down the ages, which rather complicates matters for some. Now look at the Rose quote again what was that about continually constructing?

At the time of the great Dawkins controversy the old BBC Horizon programme ran a show in which the quoted one of the wiser and more humane scholars in the Selfish Gene camp. His name was John Maynard Smith. And he ended with this thought “humans are not just animals- we are not prisoners of simple genetics” At the time it seemed a forlorn hope. It has just been proved triumphantly real.

[1]https://en.wikipedia.org/wiki/The_Selfish_Gene

[2]https://www.theguardian.com/science/2025/jul/10/steven-rose-obituary

[3]https://www.bbc.co.uk/news/articles/cn8179z199vo

#richard dawkins #sociobiology #biochemistry #medicine #DNA #mitochondria

Weekly Round up: Air Pollution, Gene therapy and raspberries

Air pollution is the new smoking Stopping smoking has led to massive falls in rates of lung cancer. But this fearsome disease is still lurking out there. The current cause? Air pollution ,as Ian Sample explains for the Guardian

https://www.theguardian.com/science/2025/jul/02/air-pollution-lung-cancer-dna-mutations-study

Gene therapy chalks up another win Ok,today it’s one particular form of deafness, attributable to one particular gene, as Maoli Duan explains for the Conversation. But: the more science you do the more you learn. Meaning other disabilities may one day prove susceptible as well. And the more you spend on scientific research the more you get benefits like this. A lesson rapidly being forgotten in the United States of America

https://theconversation.com/gene-therapy-restores-hearing-in-toddlers-and-teenagers-born-with-congenital-deafness-new-research-258112?utm_medium

Machines that out think humans It’s the scary nightmare of science fiction films from Blade Runner to the Terminator series. Up until recently the idea still seemed to be fiction. All that may be about to change as Nature Briefing reports

An artificial-intelligence system called Centaur can predict the decisions people will make in a wide variety of situations — often outperforming classical theories used in psychology to describe human choices. Trained on data from 160 psychology experiments in which 60,000 people made more than 10 million choices, the system can simulate human behaviour in tasks from problem-solving and gambling, and even those it hasn’t been trained on. Using Centaur, “you can basically run experimental sessions in silico instead of running them on actual human participants”, says cognitive scientist and study co-author Marcel Binz.

Nature | 4 min read
Reference: Nature paper

Friday Night Feast Raspberries and Ice cream We are not all gloom and serious stuff here. Thinking it was time for a quick Friday Fun feature, we realised that we’d done strawberries several times (LSS passim), In which case the humble raspberry can make a really pleasant alternative, especially if combined with ice cream instead of cream. After all, even if we are on a diet-you, gentle reader may not be. So- eat a bowl for us we used to love it.

#cancer #AI ~pollution #gene therapy #raspberries