Why the Wolf of Wall Street (probably) won’t get prostate cancer

Ejaculation is good for you. That’s the message in a startling article from Daniel Kelly, a senior lecturer in Biochemistry, admirably showcased in the latest edition of the Conversation. [1] According to Daniel, it may even reduce the chances of prostate cancer. Now this is a real problem in men’s health; according to the article, this form of cancer is now the second-most-commonly diagnosed. In men in the UK( a reasonably representative country, gentle readers) it is actually the most commonly diagnosed one. Anything to reduce it has to be a good thing. And how might this be achieved? Well, according to Daniel:

Although the mechanisms are not completely understood, these studies fit with the idea that ejaculation can reduce prostate cancer by decreasing the concentration of toxins and crystal-like structures that can accumulate in the prostate and potentially cause tumours…..Similarly, ejaculation may alter the immune response within the prostate reducing inflammation – a known risk factor for cancer development – or by increasing immune defence against tumour cells…..Alternatively, by reducing psychological tension ejaculation may lower the activity of the nervous system which then prevents certain prostate cells from dividing too rapidly and increasing the chance of them becoming cancerous.

Yes, it’s far from conclusive yet; but that last point reminds us of an intriguing scene from the film The Wolf of Wall Street (2013) in which senior manager Mark Hanna (played by Matthew McConnaghy) is advising rookie broker Jordan Belfort (Leonardo di Capprio) about the perils of stress, and how to deal with them. He sings the praises of conventional remedies, such as cocaine and hookers. But then the conversation turns serious. [2] Hanna enquires if Belfort “jerks off” and if so, the frequency thereof. Disappointed on learning the answer is only three or four times a week, he counsels

” Gotta pump those numbers up .Those are rookie numbers in this racket.”

He goes on to provide detailed advice based on his own practice, which those of naive religious or philosophical persuasion may find hard to assimilate But we reproduce the link for you here, dear friends.[2]

Once again, we stress the provisional nature of these findings. We do not know the current state of health of Jordan Belfort, the real Wolf. But isn’t it intriguing to think that the brokers of Wall Street had stumbled onto something really useful for once, if only by accident?

[1]https://theconversation.com/does-ejaculating-often-reduce-your-risk-of-prostate-cancer-228166?utm_medium=email&utm_campaign=Latest%20from%20The%20Conversation%20for%20A

[2]https://www.bing.com/videos/riverview/relatedvideo?q=wolf+of+wall+street+matthew+mcconaughey+scene&mid=49C5DB555170FD1DC29749C5DB555170FD1

#wall street #prostate cancer #jordan belfort #mens health

More hidden numbers – Or a glimpse of the Mind of God?

A couple of years ago, we published a little blog in which we dared to suggest that the recurrence of certain numbers, such as pi and Euler‘s might hint at deeper universal phenomena that are not yet fully understood.(LSS 14 3 22) So we were more than gratified to come across an intriguing article by Steven Pappas for Live Science which further confirms our suspicions.

A team led by Vaibhev Mohanty at MIT has been trying to answer a simple but profound question. “How many mutations do you need in a genome before it changes the phenotype( i.e. proteins, etc) of the carrying organism? Now, we will confess at this point that our grasp of mathematics is appalling. However:

Scientists have discovered that a key function from a “pure” branch of mathematics can predict how often genetic mutations lead to changes in function. These rules, laid out by the so-called sum-of-digits function, also govern some aspects of protein folding, computer coding and certain magnetic states in physics.

The report explains, in verbal form, some more about how the team arrived at these conclusions. But for us the key is that the same mathematics applies across several fields of science, as though something much deeper is going on. Well, that’s what we speculate. But we were not the first. As educated readers will recall, Plato speculated that the universe was formed of deep underlying structures, which he termed “forms”. And in his view a single Divine mind had created the universe through these same forms. So we pose this question: have these scientists, and others, had a tiny glimpse of the Mind of God?

[1]https://www.msn.com/en-gb/health/mindandbody/scientists-uncover-hidden-math-that-governs-genetic-mutations/ar-AA1f95OM?ocid=msedgdhp&pc=HCTS&cvid=7d80

[2] https://academic.oup.com/edited-volume/41754/chapter-abstract/354205224?redirectedFrom=fulltext

#genes #proteins #mathematics #plato #theology #mutation

AI-designed Antibodies: Not another medical breakthrough story?

A 200X photomicrograph magnification of a direct by Centers for Disease Control and Prevention is licensed under CC-CC0 1.0

Oh no, not another medical breakthrough story on LSS? What happened to all those cocktails? What about all the economics and evolution stuff we used to get? Yet let us remind you of the words of our Founding Charter,* gentle readers: this started out as an antibiotics website, even more so when it was a post on Facebook. Of course when supplementary techniques like bacteriophages and improved antibodies came along, we welcomed those too. Which is why we have to give this new report from Nature Briefings AI helps design antibodies from scratch, front and centre on today’s blog. When you read this, you will understand why

For the first time, an artificial intelligence (AI) system has helped researchers to design completely new antibodies. Creating new versions of these immune proteins, which can be used as drugs, is usually a lengthy and costly process. An AI algorithm similar to those of the image-generating tools Midjourney and DALL·E was trained on thousands of real-world structures of antibodies attached to their target proteins. It then churned out thousands of new antibodies that recognize certain bacterial, viral or cancer-related targets. Although in laboratory tests only about one in 100 designs worked as hoped, biochemist and study co-author Joseph Watson says that “it feels like quite a landmark moment”.Nature | 4 min read
Reference: bioRxiv preprint (not peer reviewed)

Once again, we are at the start here. It’s still, at proof of concept stage, and awaits peer review. On the other hand, this is genuine landmark moment which people of the future will look back on. And whatever you are doing now as you read this, remember it. You were there on the day it happened.

a copy of the founding charter is still visible in the flowerbed round the side near the car park, the bit where all the smokers go. Actually, could we clean it up a bit?

Beat the winter gloom with two great stories on cancer

There’s something about the dark and cold of February that chills like no other month we know. But do not be disheartened, gentle readers! For today we offer not one, but two stories that promise hope, optimism, and , who knows, maybe even a long term cure for the terrible disease of cancer. So, without further ado:

Welsh Wizard You may have heard of Duran Duran, but what about Sir Christopher Evans? According to Maria Lally of the Independent, [1] Sir Christopher has been on the trail of a cancer cure since he was six years old, when his family in Port Talbot bought him his first chemistry set. Not only has he been working with Andy Taylor, a key member of Duran Duran. but he and his organisation are at the forefront of research, pioneering new techniques such as Lutetium-177. In an age of selfish aggression and violence, it’s nice to come across someone who has devoted his time to the public good!

Rwanda hope Cervical cancer is a deadly killer, blighting lives and quashing the hopes of millions. One sure way to eliminate it is better vaccines. But how to get a vaccine programme underway in world full of ignorant superstition, where all the money is spent on armaments and SUV motor cars? One country showing the way ahead is the plucky little East African State of Rwanda who realised the solution was social, not medical. To quote Nature, [1] the key insight was

As Rwanda shows, strong, trustworthy and reliable collaboration between all stakeholders is key

For us, the key concept is stakeholder. Get everyone onside, and you’ll be amazed what you can achieve. Degrading, despising and turning people into others is the sure way to fail. In anything.

So before you utterly surrender to the late winter blues, here are two stories to show that someone, somewhere out there is refusing to bend. And, maybe, Spring is just around the corner after all.

[1]https://www.msn.com/en-gb/health/other/top-cancer-specialist-explains-why-it-s-time-to-rethink-what-stage-4-means/ar-BB1hKxsp?cvid=30ca68cc771a4e11a5de2db2c08c992c

[2]https://www.nature.com/articles/d41586-024-00241-2?utm_source=Live+Audience&utm_campaign=5093011eda-briefing-dy-20240202&utm_medium=email&utm_term=0_ (via Nature briefings)

#cancer #medicine #celsis #cancer awareness trust

Three good news stories: where there is reason , there is hope

Reason is the tool we use to turn facts into knowledge. Societies which use reason will have better lives, on the whole, than societies based on belief. Here are three stories which illustrate the practice of reason, by scientific research, demonstrate exactly that.

Cohort Studies of Cancer It’s nice when wet chemistry work in a lab, all white coats and benches, is combined with data analyses and number crunching- both sides get more out of their skills. Here, Cancer Research report on their programme TRACERxEVO which looks at the long term evolution of lung cancer in a group of patients, It’s already throwing up findings like molecular markers which might indicate when a tumour could return, helping treatment patterns and diagnoses in all kinds of ways. That has to be better than applying crystals, right?

https://news.cancerresearchuk.org/2022/11/09/tracerx-evo-a-new-programme-to-transform-lung-cancer-research/?urn=765570556&utm_medium=email&utm_sou

Zapping the the Zombies to stay young The Science desk at the Mail never sleeps, not even over Christmas Here’s one about a new protein called HKCD1 which seems to work at the level of mitochondria and lysosomes, thereby removing tired old cells from the body’s metabolism and allowing fresher, younger ones to come on through, as t’were. Has to be more value long term than all those extravagantly priced creams you see advertised in all those glossy magazines!

https://www.dailymail.co.uk/health/article-12918377/protein-removes-zombie-cells-cancer-alzheimers-disease.html

INTERLACE-reducing the fear of Cervical Cancer We’ll let Cancer Research speak for themselves here, and just embed a link for the hyper-interested:

Over the last decade, the number of deaths from cervical cancer has decreased by around a sixth (18%) in females in the UK (2017-2019). Thanks to INTERLACE, a clinical trial we funded, that rate could decrease even further. INTERLACE showed that giving people six weeks of chemotherapy before standard cervical cancer treatment of chemoradiation (CRT) could cut the risk of death or of the disease progressing by 35% when compared to CRT alone.“This is the biggest improvement in outcomes in this disease in over 20 years,” said Dr Mary McCormack, the lead investigator of the trial.

Surely this is better than just praying?

For over twenty years now, we have made a small but steady donation to Cancer Research UK The individual monthly sums are tiny. But their steady accumulation, above all as a stream that CRUK can rely on, makes a tangible difference. If everyone did it, it would pay for no end of new scientists and techniques like the ones above. And, as have said before on these blog pages, discoveries in one area have a happy way of spilling over into others. And so our last link is to their donations page Go on, give them a go. Even £2.00 a month will slowly build, and you won’t know you’re doing it.

Overseas readers-is there something like this in your country?

https://donate.cancerresearchuk.org/donate

#ageing #protein #rationalism #cancer