If you want to know the truth about cancer, ask Liz O’Riordan

Because she’s seen it from both sides, is why. First she was a doctor, who like, worked in the field? And then because, she got it herself, right? Became a patient, and experienced all the heart stopping, roller coasting, will-I -won’t-I? chain of emotions that all her own patients did. If those aren’t qualifications enough, gentle readers, we don’t know what are. And-she has one other which seals the deal as far as we’re concerned. Read on, and you will learn what that is.

We came across Dr O’Riordan in the course of listening to a series called Marianna in Conspiracyland on BBC Radio 4 [1] Not having an especially large legal department we must be careful what we say. But the programme details the activities of the types of people who disparage reason-based science and evidence-based medicine. And instead offer a dubious range of alternative theories, explanations and prescriptions to people who are scared out of their wits by a cancer diagnosis. In the nicest possible way, the programme tried to explain the consequences of choosing these paths of treatment, And Dr O’Riordan was one of the speakers they called in their support. A little bit like the prosecution in a criminal case calling an expert witness in DNA or drugs, as t’were.

Because since her own diagnosis and treatment, Dr O’Riordan has spent her days ceaselessly writing, speaking, making media appearances, all to one end. Refuting fallacies, identifying illogicalities, reasoning with the unreasonable. In books like The Cancer Roadmap [2] she tries to explain the science behind why cancers develop and grow, what the best treatments are, and why so-called “alternative systems” don’t seem to be up to much. In this undertaking she joins a great tradition of rationalists and sceptics starting with Lucian of Samosata,[3] and stretching all the way through to people like Peter Medawar, Carl Sagan and Dr Ben Goldacre.

But she goes one step further. Because she never condemns or sneers at anyone. Instead she tries to ask why people turn from rational medicine to alternatives and faith. In other words she deploys human qualities of empathy and compassion. And we could all learn from that. For years on this blog we have bemoaned the growth of fake information, conspiracies and general rubbish which grows on the interweb like the digital equivalent of a cancer. Not just in cancer theory; in matters like global warming, politics and economics. Hasn’t done much good. Somehow, the easy, comforting answer outpaces the complicated rational one each time, and by ratios of thousands. We are in danger of becoming the last generation of enlightened, rational thinkers, perhaps for thousands of years. Time to listen to Liz and her methods. Soon.

[1]https://www.bbc.co.uk/programmes/m001mssm

[2]https://liz.oriordan.co.uk/author/

[3]https://en.wikipedia.org/wiki/Lucian

[4]https://en.wikipedia.org/wiki/Ben_Goldacre

#cancer #medicine #alternative medicine #rational #empirical #science #health

Cancer testing saves lives-and shows why science works

Today we a re going to talk about cancer. In the UK alone it kills 167 000 people annually, which is about 29% of all recorded deaths . Meanwhile about 3.5 million people are trying to live with it on a daily basis. The statistics for your country will be comparable, gentle reader. Nothing would cheer us more than to report some good news. And today we think we can, courtesy oft the far sighted Professor Peter Sasieni and his team at London’s Queen Mary University via the Mail [1] [2]

Professor Sasieni and his team are not pioneering cures directly. Their skill is devising new ways of testing. To detect the terrible disease early, before it can wreak havoc, and unleash the cures when they have the optimal chances of success. The linked article is a good summary of all the wonderful work they are doing. But we have filleted out this tiny quote which will give you some flavour of what they are achieving

Yearly screening under the fast tumour growth scenario led to a higher number of diagnoses than usual care – 370 more cancer signs were detected per year per 100,000 people screened. There were also 49 per cent fewer late-stage diagnoses and 21 per cent fewer deaths within five years than patients receiving usual care.

If that’s not hope we don’t know what is

But there’s a deeper story here. For us, the best working definition of intelligence is how you respond to reality. You may have a lot of money, talk well, and even have a genius IQ. But if you ignore facts, deny them, or distort them, then you are a fool. There’s no mystery about science. It is simply a way of collecting true facts and organising them according to the rules of logic, which is what Professor Sasieni has done. This works globally for things like changes in the climate. It works locally, for things like diseases in the human body such as a diagnosis of cancer To deny truth once is the start of denying it always. With fatal results.

[1]https://www.dailymail.co.uk/health/article-14694059/blood-tests-detect-earliest-signs-cancer-prevent-advanced-stage.html

[2]https://www.qmul.ac.uk/wiph/people/profiles/peter-sasieni.html

#cancer #testing #screening #health #medicine

Can you Catch Cancer from a Cut?

Just because something is rare doesn’t mean that it’s insignificant. At least, not if it comes surrounded by well-attested research from trained professionals. Which is why this intriguing article by Alexa Lardieri of the Mail has really got us thinking.[1]

A man in Germany was operated on for a rare type of tumour. During the process, the poor surgeon cut his hand. It was cleansed and bandaged immediately. Six months later a tumour, which was genetically identical to his patient’s cancer, was found to be growing on the surgeon’s hand. This all happened back in 1996; but the case continues to excite speculation to this day.

Much more can be found in Alexa’s cogent article. Riffing on it, it suggests the following questions

1 How does transmission occur? Is it via nuclear DNA? Is there an epigenetic mechanism? Dare we speculate that a protein might be involved?

2 Alexa reports that the poor surgeon’s immune system may not have been quite as strong as it might have been. So…are we being bombarded with unknown carcinogens all the time, and it’s only our immune systems keeping us safe?

3 What do we mean by “cause” anyway? Does buying cigarettes give you cancer? Or is it smoking them? Or is it something in the smoke, like tar? Or could we even speculate that it is not the tar per se, but the molecular changes it induces in the cells of the victim? Where does cause end, and effect begin?

Yet it is in such cracks in logic that the most fruitful discoveries are to be found. This case, and the questions it raises are one such example. Thanks, Alexa, for bringing it back from 1996. Which was a great year for music too.

[1]https://www.msn.com/en-ae/public-safety-and-emergencies/health-and-safety-alerts/surgeon-catches-cancer-from-patient-in-first-of-its-kind-case/ar-AA1wRLpW?ocid=Bin

cancer #dna #epigenetics #immune system #health #medicine

Ian Sample: Science offers five reasons to be cheerful

Just for kicks, we thought we’d change the slightly pessimistic zeitgeist of this blog, and offer you some stories of real hope. Those-and a little moral homily at the end which we hope will justify these humble inclusions. The stories come, as so often, from Guardian science writer Ian Sample, whose thoughts we often praise here.[1] We hope they might offer a glimpse of what we are about to lose if certain tendencies play out.

Stem Cell transplants could reverse diabetes. All that intricate and detailed work on stem cells may at last be finding a pay-off in the real world, with an almost infinite relief of human suffering. We respect the beliefs of the religious: but would just praying have got us this far?

Cancer vaccines from RNA We have covered this before here. If nothing else, the COVID-19 pandemic witnessed a major leap forward in vaccine technology, especially in mRNA. Where would cancer patients be now if all those anti-vaxxers had their way?

AI detects cancers To bring in another LSS old favourite: AI can now be used to screen and detect cancers more quickly than ever before. When we think of cancer, we think of old acquaintances who used to deny smoking had anything to do with cancer. Does that remind you of climate change deniers?

Occupants of interplanetary Space For lovers of pure science, there can be little more amazing the discoveries offered by the James Webb telescope. Once upon a time, the Inquisition threatened to burn Galileo for looking up at four little satellites around Jupiter. Will someone try the same on this new telescope?

Renewable energy is on the way. Remember all those programmes and articles that tried to suggest that renewables could never, ever replace fossil fuels? But there’s real hope now that renewables will displace fossils by 2030. Both China and India seem poised to lead the way ahead. USA take note.

Yet we promised you a moral on this one, so here it is. All these discoveries, all this science, which Ian has just showed us is dependent on the free and fearless interchange of information. Which in turn depends on open societies and the rule of law. There is strong reason to believe that this era is coming to an end. In some countries, religious obscurantists and zealots are close to extinguishing freedom forever. in others, violent ethno-nationalists have seized power, or are close to doing so. These societies may well offer social stratification and the appearance of security. Yet in all of them. the sole definition of value is “does this bolster the regime?” There can be no truth in science, no beauty in art, no trust in money which does not meet this criterion. Ultimately, such societies stagnate. And then decline. You still have time to change your minds. In some countries, at least.

[1]://www.theguardian.com/world/2024/nov/09/reasons-to-be-hopeful-five-ways-science-is-making-the-world-better?CMP=Share_iOSApp_Other

#science #learning #objective truth #empiricism #vaccines #rna #astronomy #medicine

Energy and Cancer: Three stories that give us hope in dark times

“The sleep of reason brings forth monsters” Goya’s famous painting never seemed so relevant as it does today, as humans divide themselves into mutually hating tribes in Europe, the Middle East and even the USA. “he that is quick to Anger exalteth folly” [1]. We here take the opposite view, Real progress is only achieved by slow, careful thought. And as evidence of that, we’d like to cite three examples, small in their own way of what can be done to fix real problems. When we pause to actually think, that is.

Seeing the cancer One of the most tragic moments in life is to here a cancer patient tell you “it’s come back” after an operation. This is not to blame the surgeons; it’s just that up to now they haven’t always been able to see all the cells. Now, according to Colin Fernandez of the Mail, a new technique will light up the tumorous cells, making them much easier to spot and excise altogether. By the way, some of this work was funded by Cancer Research UK,[2] a marvellous organisation whom we have often covered in these pages.

https://www.dailymail.co.uk/health/article-13511467/dye-prostate-cancer-tumours-glow-surgeons.html

Spotting the Cancer We have often hymned the praises of AI as well. Particularly in medical and biological research. One of its principal advantages is that it can carry out the routine stuff much faster than we can, without tiring. Kate Pickles of the Mail covers how it’s being applied to look at cancer scans to rapidly improve diagnostics. In the long term we could see AI applied to any number of laboratory techniques from Forensic science to Ecology, opening the way to boundless new knowledge and techniques

https://www.dailymail.co.uk/health/article-13518481/AI-better-doctors-spotting-prostate-cancer.html

Concrete Batteries? After they lost the battle on the reality of global warming, Big Oil and its lackeys have waxed lyrical on how difficult the transition to clean energy might be. “yes you can make clean energy, but how are you going to store it?” they would sneer. Well, lots of ways, it has turned out. But one we never dreamed of was the very concrete that makes up our roads, bridges and homes themselves. Unbelievable as it may seem researchers at MIT are looking at new types of concrete which will store and release energy exactly as we need it. What price oil and gas now? This excellent piece is from Victor Tangerman of the Byte:

_{Thanks to P Seymour}

https://futurism.com/the-byte/new-concrete-stores-electricity-homes-batteries

Tiny examples, perhaps. But the mark the dividing line between the Thoughtful and the Emotional. We’ll go with the former.

[1] Proverbs 14 29

[2]https://www.cancerresearchuk.org/get-involved/donate?gclid=69712e6308111b89fbbd480a7616017d&gclsrc=3p.ds&msclkid=69712e6308111b89fbbd4

#cancer #health #medicine #AI #global warming #climate change #renewables #concrete

What if you could detect cancer before it was cancer?

If you want to cure a cancer, identify it as soon as possible. That’s long been a truism among medical experts. But what if your techniques were so advanced that you could identify the precursor steps to cancers before they had even started to initiate a tumour in someone’s body? According to an article by Anna Bawden and Nicola Davis of the Guardian, the first steps to do just that are now feasible, as two studies suggest.

Instead of simply rehashing their excellent prose[1] upon which we urge you to click, we’ll provide a brief summary, and raise some interesting and rather hopeful observations. The first looked at 44000 samples from the UK Biobank. 618 proteins were identified, which could then be linked to 19 different types of cancer. In a different take on the same trope, a second study using a whopping 300 000 samples came up with 40 different proteins linked to 9 different types of cancer. We dare not comment, but dare to observe:

1 It’s amazing the amount of new discoveries you can make just by crunching data. As AI comes into its own, it should be able to handle bigger and bigger numbers. Think of alpha-fold, if you don’t believe us-and that quite old hat by now!

2 Talking of hats, let’s all take ours off to Cancer Research UK, whose steady, patient work down the decades has not only provided a congenial ecosystem for researchers, but also a steady stream of reliable income for the planners and the finance people. Come on, hands in pockets, please! [2]

3 We were impressed that the results were already identifying different types and subtypes of cancers. It suggests a subtlety of technique which has probably only just got going.

and, finally:

4 The bigger the database, the better. Without belittling today’s researchers and journalists, these are still relatively small numbers. Imagine an AI supercomputer tirelessly combing the biological samples of every human on the planet. And maybe their pets. Would might it not find.

Oaks and acorns times, gentle readers. Keep donating.

[1]https://www.theguardian.com/society/article/2024/may/15/proteins-blood-cancer-warning-seven-years-study

[2]https://donate.cancerresearchuk.org/donate?gclid=cf2827b39f4311a97ff841f589e5c887&gclsrc=3p.ds&utm_source=bing&utm_medium=cpc&utm_campaign=IMP%20%

#database #cancer #medicine #AI #protein #gene #prediction

Three good news stories: where there is reason , there is hope

Reason is the tool we use to turn facts into knowledge. Societies which use reason will have better lives, on the whole, than societies based on belief. Here are three stories which illustrate the practice of reason, by scientific research, demonstrate exactly that.

Cohort Studies of Cancer It’s nice when wet chemistry work in a lab, all white coats and benches, is combined with data analyses and number crunching- both sides get more out of their skills. Here, Cancer Research report on their programme TRACERxEVO which looks at the long term evolution of lung cancer in a group of patients, It’s already throwing up findings like molecular markers which might indicate when a tumour could return, helping treatment patterns and diagnoses in all kinds of ways. That has to be better than applying crystals, right?

https://news.cancerresearchuk.org/2022/11/09/tracerx-evo-a-new-programme-to-transform-lung-cancer-research/?urn=765570556&utm_medium=email&utm_sou

Zapping the the Zombies to stay young The Science desk at the Mail never sleeps, not even over Christmas Here’s one about a new protein called HKCD1 which seems to work at the level of mitochondria and lysosomes, thereby removing tired old cells from the body’s metabolism and allowing fresher, younger ones to come on through, as t’were. Has to be more value long term than all those extravagantly priced creams you see advertised in all those glossy magazines!

https://www.dailymail.co.uk/health/article-12918377/protein-removes-zombie-cells-cancer-alzheimers-disease.html

INTERLACE-reducing the fear of Cervical Cancer We’ll let Cancer Research speak for themselves here, and just embed a link for the hyper-interested:

Over the last decade, the number of deaths from cervical cancer has decreased by around a sixth (18%) in females in the UK (2017-2019). Thanks to INTERLACE, a clinical trial we funded, that rate could decrease even further. INTERLACE showed that giving people six weeks of chemotherapy before standard cervical cancer treatment of chemoradiation (CRT) could cut the risk of death or of the disease progressing by 35% when compared to CRT alone.“This is the biggest improvement in outcomes in this disease in over 20 years,” said Dr Mary McCormack, the lead investigator of the trial.

Surely this is better than just praying?

For over twenty years now, we have made a small but steady donation to Cancer Research UK The individual monthly sums are tiny. But their steady accumulation, above all as a stream that CRUK can rely on, makes a tangible difference. If everyone did it, it would pay for no end of new scientists and techniques like the ones above. And, as have said before on these blog pages, discoveries in one area have a happy way of spilling over into others. And so our last link is to their donations page Go on, give them a go. Even £2.00 a month will slowly build, and you won’t know you’re doing it.

Overseas readers-is there something like this in your country?

https://donate.cancerresearchuk.org/donate

#ageing #protein #rationalism #cancer