Antibiotic Resistance meets Global Warming: the scariest real-life movie ever

Which of the following is a true statement of the facts it purports to covey? Jesse James meets Frankenstein’s Daughter?[1] Billy the Kid meets Dracula? [2] Antibiotic Resistance meets Global Warming?[3] The answer is: the last one. As film fans will know, the first two are films, representing the final Directorial offerings of the late, great William “one-shot” Beaudine. As for the third: its truly scary. Here’s how Nature Briefings sum it up: Climate Change worsens Drug Resistance

Climate change and antibiotic resistance are both major threats to human health, and the risks multiply when they intersect. Increased average minimum temperatures have been linked to higher rates of antibiotic resistance — maybe by making it easier for them to evolve. And extreme temperatures can force people to spend more time indoors, where infection can spread. Tackling these issues together will require global action — and recognition of inequity between richer and poorer nations. Some public health researchers argue for a new UN treaty, similar to existing climate treaties, calling for a 35% reduction in drug-resistant infections by 2035.Nature | 9 min read

But we urge you-no, we will get on our knees and absolutely beg you-to read the linked piece, gentle readers, for it concerns the safety and futures of each and every one of us. Just so you have no excuse, we’ve hyperlinked it again at [3] below.

And now some advice. Much of the science we cover here comes from Nature Briefings, as our more astute readers will have observed, If you want tip-top, up to date science news, culled from the world’s most prestigious science journal, all you have to do is subscribe via this link. It’s free, by the way.

[1]https://en.wikipedia.org/wiki/Jesse_James_Meets_Frankenstein%27s_Daughter

[2]https://en.wikipedia.org/wiki/Billy_the_Kid_Versus_Dracula

[3]https://www.nature.com/articles/d41586-023-04077-0?utm_source=Live+Audience&utm_campaign=c020aa4ae2-briefing-dy-20240109&utm_medium=email&utm_term=0_b27a691814-c020aa

#global warming #climate change #antibiotic resistance #pandemic #william beaudine

More welcome news on antibiotics

More news from the antibiotics front. And this time, it’s overwhelmingly good. The first of a new class-type antibiotic, Zosurabalpin, is now in early trials. Today, our lead comes from the tireless Linda Geddes of The Guardian. [1] We urge you to read her excellent story, while picking just a few of the key points

From our earliest days Facebooking, then blogging in this area the great problem has been the gram negative bacteria with tough, almost leathery cell membranes which could exclude any antibiotic we could put up against them. The carbapenem class brought us few years respite. But systematic over prescription brought soaring levels of resistance. And this is what gave long faces to the scientists and doctors we used to chat with back around ’16 and ’17

As you will learn from Linda’s article, Zosorubalpin and other new antibiotics under development hope to weaken those cell walls by targeting the flow of lipopolysaccharides, thereby precluding their formation. It’s an ingenious way of re-thinking the problem, and we offer the researchers involved [2] our most heartfelt thanks. However, don’t think humanity is out of the woods. The same problems which wrecked the last generation of antibiotics could recur. Heedless over-prescription, driven by demand from ignorant, hysterical patients. Mass misuse in agriculture, in search of of short term production targets. Failure to develop successor molecule as resistance builds to Zosurabalpin and its peers. All these mistakes are out there, waiting to happen again. The scientists have given us one last chance. Have we the brains to take it?

[1]https://www.theguardian.com/science/2024/jan/03/scientists-new-class-antibiotic-kill-drug-resistant-bacteria?CMP=Share_iOSApp_Other

[2]https://www.nature.com/articles/s41586-023-06799-7

#antibiotics #resistance #gram negative #zosurabalpin