Suffer from Seasonal Affective Disorder? Here are some numbers that may cheer you up

Seasonal Affective Disorder (SAD), that debilitating melancholy that so many people report as autumn draws in is very real, according to Linda Geddes of the Guardian. [1]. It’s not just Linda’s article itself that intrigues, although it’s full of good facts and useful advice. Because the approach her scientists have taken illustrates one of the most exciting and hopeful trends in human learning since the Renaissance: the use of giant data sets combined with powerful IT tools to handle them.

The SAD researchers at the University of Edinburgh., led by the redoubtable Dr Cathy Wyse analysed four years of data, comprising records of 500 000 people from the UK Biobank,[2] a vast compendium of learning on all things medical in these islands To paste Linda’s killer quote

Large-scale resources such as the UK Biobank have transformed this area of research, allowing scientists to track seasonal patterns across hundreds of thousands of people over many years – something that was previously impossible.

It wasn’t long, gentle readers, before we found how this whole new area of learning, depending on whole new technologies such as AI, Cloud Computing and High Performance Computing is transforming our understanding in many areas such as medicine, biotechnology, meteorology, epidemiology…. remember our own praises for Deep Mind and its generation of the alpha fold proteins? (LSS passim). It is revolutionising human sciences like economics and can even help us understand more about the authorship of old texts such as The Bible and Greek Masters like Homer. Because only by looking at really huge data sets can you see patterns, meaningful patterns, which the close view of the human mind alone could never have detected.

Being the curious little monkeys we are, we couldn’t resist asking how this all works. It was like lifting the bonnet on a Rolls Royce when you don’t know what a variable valve timing system is-or anything else. For we were in an arcane mathematical world of Combinatories, Probabilities, Big O numbers, floating point approximations, Complexity, Catastrophe, and countless other recondite concepts which t will always remain beyond our comprehension. You try a few and see how far you get! But our admiration for the people who can handle such stuff, and use their computers to make all our lives richer, like the great Dr Wyse, grew even more limitless. Nevertheless, we will leave you with one fact hitherto unknown to us. If you shuffle one standard pack of 52 cards, there are 52! possible permutations: that’s 8.07x 10²⁷. More than all the atoms in the solar system. Good job no one has tried it with two packs, we say: or they would have to move the Smaller Magellanic Cloud out of the way to make room for all the possibilities.

[1]https://www.theguardian.com/society/2025/nov/02/how-to-beat-the-winter-blues-seasonal-affective-disorder

[2]https://www.ukbiobank.ac.uk/

#SAD #health #psychology #mathematics #computing #complexity #HPC #big data #medicine

Nature Briefing on a brand new antibiotic(or was it there all along?)

Today, gentle readers, we bring you really good news in our joint quest to finally overcome the problem of antibiotic resistant micro organisms. And it comes of course from Nature Briefing, that indispensable source of all good science news and reporting. Let’s start with their summary Antibiotic was hiding in plain sight, and then briefly run through all the implications

Scientists have discovered a powerful antibiotic while studying the process through which a soil bacterium naturally produces a well-known drug. The compound — called premethylenomycin C lactone — is more than 100 times more active against bacteria than the final product, antibiotic methylenomycin A, which was first identified in 1965. Tiny doses of the surprise discovery killed strains of bacteria known to cause hard-to-treat infections.Nature | 5 min read
Reference: Journal of the American Chemical Society paper

Okay, so wanted the implications? Firstly for us at LSS. Great reassurance to see progress in our core area of real, old-skool antibiotics. Now, if these make a comeback, can they please be used sparingly, and in conjunction with therapies like vaccines and bacteriophages, so we are not in this whole mess again around the year 2065? Secondly, the new compound premethylenomycin C , though only a precursor is a hundred times more powerful than methylenomycin A. As Dr Challis, one of the co-authors of the work observes, that’s a turn up for the evolutionary book if ever there was one. But for us the Big One is how many years of painstaking research this all took, how many tiny detailed steps in the synthetic chain had to be weeded out. They started back in 2006 when one George W Bush was still President of the United States and everyone thought that Katy Perry was the way of the future. Blue sky abstract research; done as much out of intellectual curiosity as anything else. Which is odd. Because every so often one of our Right Leaning media outlets comes up with tropes such as WOI ARE VE WYESTIN ORL DIS TEXPAYUHS MUNNI ONNER RESURTCH WOT DON’T DO NUFFINK? SPEN IT ON SUMFIN USEFUL GUVNOR, INNIT! Which raises a deep question; how do you measure the value of research like premethylenomycin ? The costs are small but substantial enough to cash-strapped Universities. But the pay-off is almost infinite. That one we will leave to you, faithful readers of our words.

[1]https://www.nature.com/articles/d41586-025-03595-3?utm_source=Live+Audience&utm_campaign=f5bcecac99-

#antibiotics #biochemistry #microbio;ogy #medicine #health #antibiotic resistance

Does this whale hold the secret of eternal youth?

I have lived long enough, my way of life is fall’n into the sere, the yellow leaf…..Macbeth Act V scene 3)

Most of us would pretty much agree with the Thane of Glamis. But up to now, achieving that Pan-like state of eternal youth has been no more than a dream, whatever the cosmetics companies say. Until today, when recent discoveries of a protein in the Bowhead whale suggests that this same eternal dream may actually come true. We’ve two takes on the story: a popular one from Ashleigh McCaul of the Mail: and a more in-depth view from Nature Briefings Secrets of a 200 year old whale which carries, as ever, links to deeper coverage (no whale pun intended)

A cold-activated protein that helps to repair broken DNA could be the bowhead whale’s secret to living sometimes for more than 200 years. Researchers travelled to northern Alaska to collect samples of tissue from the whales (Balaena mysticetus) from Iñupiaq Inuit communities. The team found that the whale’s cells produce a protein called CIRPB, which helps to mend potentially cancerous DNA mutations. The results show that an efficient DNA repair system is “a very effective strategy to confer this extreme longevity”, says molecular biologist Zhiyong Mao.Nature | 4 min read
Reference: Nature paper

And our opinion? it’s interesting how science is fine when its discoveries coincide with the deepest wishes of the population. Yet science is not so convenient when it reminds of certain uncomfortable truths, such as the imminence of catastrophic climate change, The response of some is to launch culture wars, wherein the conclusions and recommendations of the educated must not only be resisted, they must be actively torn down if at all possible. This article by Alex Heffron and Tom Carter-Brooks for the Conversation chronicles how this is currently playing out in the English countryside., where some persons are trying to foment opposition to the installation of solar panels on private land. Of course, motives will be mixed: and not all of us think an array of panels is quite as pretty as a meadow of waving wheat. But we must have clean power: or we will surely die, young and old alike.

We are certain you will find a comparable example near to where you live, gentle reader Yet it’s the psychology of all this that gives us this thought, for what it may be worth. Now, It was said of Peter Pan than he never grew up. The best definition of growing up is to realise not all your wishes can come true at once. It seems some people must do more to recognise that, however many decades they have accumulated.

[1]https://www.dailymail.co.uk/sciencetech/article-15247935/How-whales-hold-secret-humans-living-FAR-longer-scientists-discover-longest-living-mammal-repairs-DNA.html

[2]https://theconversation.com/you-cant-eat-electricity-how-rural-solar-farms-became-the-latest-battlefront-in-britains-culture-war-268128?utm_medium=email&utm_campaign=Latest%

[3]https://theconversation.com/you-cant-eat-electricity-how-rural-solar-farms-became-the-latest-battlefront-in-britains-culture-war-268128?utm_medium=email&utm_campaign=Latest%

#climate change #global warming #renewable energy #peter pan #ageing #whale

Steve Schifferes Part 2: where the next crash might come from-and the chilling consequences

Photo by John Guccione http://www.advergroup.com on Pexels.com

Our earnest recommendation of the second part of Steve Schirreres’ excellent diptych of articles for The Conversation

As Britain declined after world war one, no other power replaced it with the necessary financial, military and cultural power necessary to avert the political and financial instability that followed. The result was revolution, boom, crash and depression, leading rapidly to the Second World War. “Ah!” we hear you say, “Ah! That could never happen again. Look for example how well the world did to wriggle out of the consequences of the financial crash of 2007-2008!” But that, gentle readers, is to beg the question. For back in those days the world had two shots in its locker which are now fully fired. First, a spirit of co-operation among the great powers which let them co-ordinate rescue plans quickly: and the trust to make them stick. (Schifferes is rather good on this, having had a ringside seat) Now Mr Trump has declared that he will only ever consult American national interest. He may have valid domestic reasons for taking this line; but it will make any recovery from a future recession very much harder indeed.

Secondly, the America of those days still had deep and unrivalled capital markets, which enabled its Federal Reserve to act as a lender of last resort to the whole world. And this is where Schifferes gets really interesting. Firstly he details deep worries about the long term stability the US Bond market and the dollar. Remember- a hegemon needs both bonds and a currency to ensure global stability. Combine this with the threats to the US Stock market( a concern to many commentators at the time of writing) and you have not only the elements for a perfect storm, but no obvious lifeboat to climb into when it strikes.

If you want to know how the world really works, and get some glimpse of where it might be heading, then these articles are a must read. And remember- next time you get cross because the train is late, or service slow in your local restaurant: these troubles may be slight compared to what is coming down the line.

[1]https://theconversation.com/the-rise-and-fall-of-globalisation-why-the-worlds-next-financial-meltdown-could-be-much-worse-with-the-us-on-the-sidelines-267920?utm_medium=email&utm_campaig

#economics #history #US Bonds #dollar #trade #globalisation

Is Globalisation over? Steve Schifferes worries what comes next

Recently the residents of the Canadian State of Ontario irritated US President Donald Trump by running a series of TV ads showing former President Ronald Reagan disparaging trade tariffs,. Why would such hero of the global Right have taken such a heterodox view? The answer is that Reagan thought that free trade was the best way to distribute prosperity as widely as possible. Under the hegemonic power of the United States of America of course. And he had good evidence for this belief, as Steve Schifferes makes clear in this article for the Conversation.

Schifferes is such a good writer. His sentences are always short and to the point, He keeps away from jargon. Which clarity allows him to range over the last 400 years or so of history tracking the rise and fall of the various powers-China, France, The Netherlands, Britain the USA all of whom aspired to the hegemonic position in world affairs. In the first of two such called The Rise and Fall of Globalisation: the battle to be top dog he comes to one overarching conclusion. Things go better, and the world grows when there is one such dog. The period of British dominance , roughly 1815-1914 was marked by ever closer union of world markets and ever greater flows of capital and people. The American hegemon, roughly lasting from 1944 to 2016 was a second such example. The great problem for the world was that, as Britain stepped down in 1918, the USA did not step up to the plate. Leading to two decades of deep economic and international stability that culminated in the most destructive war in History. This one we shall urge you to read, gentle readers. It not only describes, it explains.

And now? Populists everywhere not only proclaim that globalisation is dead, they actively seek to undermine it wherever possible. Tariffs, restrictions on free movement of goods and people, hostility to learning and science-all indicate the flow of history is one way. Yet populist nationalists can point to one overarching weakness in the globalists argument. The whole system when it worked, depended on the successful nationalism of one nation,the hegemonic power. Their nationalism was a good thing. From which many concluded “if nationalism is a good thing, we want some of it too.” So as the hegemon declines, as America now does precipitously, they will assert their own nationalisms more and more. World war Three anyone?

[1]https://theconversation.com/the-rise-and-fall-of-globalisation-the-battle-to-be-top-dog-267910

#steve sciffereres #history #economics #trade #USA #war #globalisation

AI =New drugs and medicines 17 times faster

Good heavens, but it takes a long time to get a new medicine in use. To go from first concept to everyday pharmaceutical use in the high street can take from 10 to 15 years on average. There’s all that Discovery and Initial research: followed by Preclinical Testing, Clinical Trials, and Regulatory Review. Quite right too: we support all this red tape , as there no point in killing the people (or animals) we’re trying to cure. Occasionally things are permitted to speed up (think mRNA vaccines during the COVID-19 pandemic) But we admit the whole thing can be a tad frustrating, particularly for a blog like this one, ever campaigning for new forms of antibiotic and other ways to combat resistant micro-organisms,

Which is why we support every endeavour to speed the process of drug development up. None more so than when its exponents try fresh thinking, as the ingenious Dr Alex Shalek of MITI. Read this AI offers drug-screening shortcut from Nature Briefing

An artificial intelligence (AI) model trained on complex data from human cells could bypass the need for time-consuming drug-screening in the race to develop new medicines. The model, called DrugReflector, was trained on data about how each of nearly 9,600 chemical compounds perturbs gene activity in more than 50 kinds of cell. Researchers found that DrugReflector was up to 17 times more effective at finding compounds that could affect the generation of certain blood cells than standard screening, which depends on randomly selecting compounds from a chemical library.Nature | 4 min read
Reference: Science paper

Dr Shalek and his admirable team think they have accelerated the process by anything between 13 and 17 times, as you will discover if you drill down on the links which we have provided.

It’s easy to bemoan the modern trend for instant narcissistic gratification, where every want is satisfied by the click of a button and a funny little man showing up in a blue van a few hours later. Of course it is essential to test new drugs, and maintain the high standards which we in the educated community hold ourselves to. You can’t run a drugs company at the same moral and intellectual level that you run a popular newspaper. But anything that speeds things up safely, as this technique appears to do, will save many lives and much suffering. We hope we’ve cheered up your morning break.

#drug development #medicine #health #AI #research #mRNA vaccine

The Fisher King: an ancient legend for our sad modern times

I sat upon the shore/Fishing, with the arid plain behind me/Shall I at least set my lands in order?

Thus TS Eliot sets out his stall: The Waste Land (1922)is all about the legend of the Fisher King. His take on a world trying to recover from the traumatic wounds of World War. The what King? What’s a modern shiny AI powered science-and-business blog like LSS doing with some crusty old Medieval legend, reworked not only by the saintly Eliot but by such questionable characters as Richard Wagner? The answer is very much indeed. For if we do not confront the message which the King encodes, all our technology will bring us to less than nothing indeed.

For all its tellings, the central myth of the Fisher King hasn’t changed much The King is a wounded guardian of the Holy Grail whose injury renders his kingdom a barren wasteland. He cannot heal himself, and his land suffers with him—infertile, desolate, and spiritually dry. He spends his days fishing, a symbol of passive hope and suspended vitality. According to Grail legend, only a pure-hearted seeker(Parsifal) who asks the right question can heal the king and restore the land. The myth embodies themes of spiritual paralysis, inherited trauma, and the redemptive power of inquiry and compassion.

Festering trauma, unhealed wound. There must have been lots of those around after the First World War, as Freud knew well. And we have plenty today. As money moves at light speed across the world, dragging goods and people after it, familiar landscapes are shattered. Shops close; factories are shuttered and streets fill with strangers. All too many suffer a psychic wound like the Fisher King’s. Trauma that renders the landscape barren. The soul, unable to heal itself, turns to ancient identities, mythic lineages, and cultural relics as if they were sacred springs. Or Fentanyl. And the name of that wound is Loss. Of empire, of power, of innocence, identity: of the essence that they were. But nostalgia kills the future, and with it all hope. The healer must come, and find the right words, soon. For the next war is very close. Perhaps it will feel, briefly, like these other words from The Wasteland

What is that sound high in the air/Murmur of maternal lamentation

Who are those hooded hordes swarming/Over endless plains, stumbling in cracked earth?

Ringed by the flat horizon only/What is the city over the mountains?

Cracks and reforms and bursts in the violet air?/Falling towers

Jerusalem Athens Alexandria Vienna London

Unreal

All quotes from The Poetry Foundation a marvellous source of learning and wisdom if ever there was one

[1]https://en.wikipedia.org/wiki/Fisher_King#:~:text=The%20Fisher%20King%20%28French%3A%20Roi%20P%C3%AAcheur%3B%

[2] The Waste Land | The Poetry Foundation

##economics #politics #poetry #parsifal #TS Eliot #Wagner #The Fisher king #legend

Friday Night Feast: Sangria

“We’ve just got back from Spain” To those growing up as a child in 1960s London, especially in poorer working class districts, those words rang with magical prestige. Few of us had even been on an aeroplane, let alone to somewhere as warm, as sunnily sandy, and as downright distant as Spain. If you were lucky enough to have a holiday at all it would be a week in a Victorian boarding house in some windswept grey town like Blackpool or Bognor Regis. But these lucky people brought back tales of modern hotels with receptions, swimming pools ,and bars, just like the ones in James Bond films. And the artefacts! Curious little black bulls in hollow plastic. Dolls in exotic flamenco costumes, arms frozen in some eternal paso doble. And funny china jars with a picture of Minorca on them, drinking cups to match. Which, they proudly informed us, were all for the drinking of Sangria. A taste for it was born; and we think it still remains one of the best parts of an Iberian holiday today (you can get it in Portugal too)

The aim is to make it with lots of ice, so that beads of dew form on the outside and trickle down in the hot Spanish night to the sounds of a flamenco guitar(these days it’s more likely to be Rosalia or Aitana; but no somos nadie as they say in that country) After all the ice, there as many variations on the theme as there are bars in Benidorm. This BBC recipe produces an out come as good as any which we have tried down the years. [1] 3 parts of a good full red wine such as one from the Duero or Rioja, one part of orange juice and two of lemonade will get you over the line. After which you can add the sorts of fruits you want, though it being Spain and all that, oranges and lemons seem almost statutory. A little twiglet of mint will give the whole things a most Pimms like ambience, and the scaling up possibilities for two to fifty drinkers are manifest.

The word sangria of course comes from the Spanish word sangre, or blood, as anyone who has holidayed in somewhere like Magaluf or Torremolinos will recognise at once: a reference to the deep red colour of the wine. There are records of something like it in eighteenth century Spain and Portugal. Though the Romans had been experimenting with similar wine punches long before. Don’t accept ones made with rose or white. they are poor imitations , avoided by locals and experienced costa hands alike And so, even though the nights are drawing in we raise a metaphorical copa of the stuff to you all gentle readers, and hope it evokes memories of happy sunny holidays. Thanks again for all your comments, ideas and other general feedback.

[1]https://www.bbc.co.uk/food/recipes/sangria_93847

#Spain #Portugal #sangria #wine #holiday #costa

Pity Rachel Reeves-but Britain’s problems are as dreadful as everyone else’s

Pity poor Rachel Reeves, Britain’s beleaguered Chancellor of the Exchequer (that’s what we call our finance minister). According to Larry Elliott of the Guardian, [1] she faces some agonising choices as she tries to prepare November’s Budget. Being a British Chancellor has never been all beer and skittles. And Larry’s dissection of the fiscal and financial constraints she faces , to say nothing of organisations like The Office for Budget Responsibility (OBR) or the Bank of England breathing down her neck is as succinct and percipient analysis as you will get of the economic landscape of Britain today.

Or any where else. All the advanced nations seem to be in dreadful trouble at the moment. The USA, France, Italy: even the once vaunted Germany and Japan seem be in the same mire of rising debt, financial constraint and absolute inability to deliver the rising standards of living, education and health which their citizens had come to expect. Why do finance ministers suddenly seem so powerless?

They can still control some things of course: fiscal policy , debt issuance, regulatory frameworks and co-ordinating policy with Central Banks. What lie outside their control are immense things like global capital flows, stock market volatility, commodity prices and private investment decisions. At the time of writing over 80% of the world’s investment capital is in the hand of things like Hedge Funds, Sovereign Wealth Funds and Family Offices, as well as less shady entities such as pensions and mutual funds. And this has had very real consequences. For us Elliott’s key paragraph was this rather neat summary of the history of the world in the last twenty five years:

……..the big moves in inflation in recent decades have been globally rather than domestically driven. There was a long period in the 1990s and early 2000s when globalisation led to much cheaper imports, especially from China. More recently, the main reason inflation shot up above 10% was the sharp increase in gas and food prices caused by the war in Ukraine. Trying to hit a specific inflation target using the blunt instrument of bank rate is a mug’s game.

Which raises the question: is the Nation state still the best vehicle to deliver the thing its citizens really need? It’s a big question and the answer may not come down to a simple yes/no. But if it is to succeed, the nation must be immensely strengthened and reformed. Who will do it?

[1] Rachel Reeves is the face of this budget. But the really big decisions are not in Labour’s hands | Larry Elliott | The Guardian

#economics #history #inflation #rachel reeves #UK #Germany #France #finance #money #capital

How good teaching won a Nobel Prize

For our next look at this year’s Nobels, we thought we’d showcase the three brilliant researchers who share the prize for Chemistry. For those who need to come up to speed here’s Nature Briefing’s story, Chemistry Nobel for Supersponge MOFs

Chemists Susumu Kitagawa, Richard Robson and Omar Yaghi have won the Nobel Prize in Chemistry for developing the world’s most porous solid materials, known as metal-organic frameworks (MOFs). Structured like molecular scaffolding, MOFs contain vast caverns of internal space; Nobel committee chair Heiner Linke likens them to “Hermione’s handbag in Harry Potter — it can store huge amounts of gas in a tiny volume”. In the 30 years since they were first developed, they have become part of efforts to capture carbon from the air and remove ‘forever chemicals’ from water, among many other applications.Nature | 4 min read

Now, we in no way would distract from the accomplishments of Drs Kitaga or Yaghi. But what we want to do here is tell a very human story of how the third laureate, Dr Robson, got involved in the first place.

One day he was constructing large wooden models of crystal structures for undergraduate chemistry lectures at the University of Melbourne. These models—representing structures like sodium chloride and fluorite—were made from coloured wooden balls (atoms) connected by rods (bonds), carefully drilled at precise angles using trigonometric calculations. We’ve all seen them, they are stand by of every A level and undergraduate teaching room

As Robson assembled these models, he noticed something profound: the components seemed “invested with information,” naturally predisposed to form the intended structure. This observation led him to wonder: what if molecules could behave similarly—self-assembling into predictable, extended structures using chemical bonds instead of rods? That question planted the seed for MOFs, which he began exploring seriously about a decade later.

It’s funny how learning is a holistic thing. Research informs teaching. And teaching informs research. Oddly enough artists like Leonard Bernstein and Stephen Sondheim found the same thing, if you substitute “creative writing” for research. Perhaps its the idea of responding to questions, looking at the bigger picture. Or in Robson’s case, taking time out to play creatively with models. If you have found the same, oh readers, let us know. Meanwhile tell your Government to keep funding research and universities. As we saw in the last blog- they’ll get their money back.

#chemistry #nobel prizes 2025 #metal organic frameworks #carbon capture #climate change #science #research