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Today we unashamedly and wholeheartedly turn over our blog to a straight lift from The Conversation. And an excellent article from Professor Patrick Byrne of Liverpool John Moore University. Who has devoted his life’s work and formidable intelligence to tracking the sources of PFCs in the River Mersey (the one the Beatles grew up near)[1]
For those who want to come up to speed here are two paragraphs from Patrick’s article
Per- and polyfluoroalkyl substances (PFAS), more commonly known as “forever chemicals”, are a large family of human-made chemicals found in everyday products like food packaging, water-repellent clothes and fire-fighting foams. They are valued for their ability to resist very high temperatures and to repel water and oil, but these same properties make them extremely persistent.
Once released, some PFAS could take thousands of years to break down. They accumulate in the environment, build up – with different compounds accumulating at different rates – inside the bodies of wildlife and people, and have been associated with harms to health. The most studied types have been linked to cancers, hormone disruption and immune system problems.
And one elegaic, personal thought.Back in the 1960s when those same Beatles were growing up, the world was a different place. All those plastics and chemicals, now in Patrick’s rubbish dumps seemed part of a bright, dynamic new landscape of progress: a brave new world. There can indeed be progress, But be very careful how you go about it
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A few years ago we published a couple of blogs suggesting that the saliva of Komodo dragons (Varanus komodoensis) might be a possible place to look for new sources of antibiotic compounds. (LSS 27 10 20; 6 9 21) Poor dragons! It now seems that their tantalising resistance to infection may be due to other factors than miraculous antimicrobial molecules. But at least it got us thinking: might there yet be some useful aids to our antibiotic quest lurking out there, undiscovered?
The antimicrobial potential of some plants is quite well known. Garlic(Allium Sativum) turmeric Curcuma longa)and the tea tree(Malaleuca alternifolia) are classic examples. Best estimates suggest there are between 250 000 and 500 000 species of plant on out planet. Provided not too many are destroyed to make way for shopping malls, there may be hope of some more undiscovered potential among our leafy friends. [1] Turning to animals, our first candidate is the Matablele Ant (Megaponera analis) They not only produce antibiotics from their metapleural glands,(what they?-ed) but they also diagnose infected wounds in their nestmates and apply targeted treatment. Their secretions contain over 50 antimicrobial compounds, some effective against Pseudomonas aeruginosa, a notorious human pathogen When Matabele ants are wounded, their cuticular hydrocarbon profile changes, signalling infection. Nestmates detect this and apply antibiotic secretions from their thoracic glands. This is the first known example of non-human creatures performing sophisticated medical wound care [2]. Other animals such as frogs, insects, and marine life produce antimicrobial peptides (AMPs) as part of their innate immunity. These AMPs are being studied for their ability to combat resistant bacteria. And, if we were betting men, we might take a small punt on Sarcotoxin 1A and anti microbial peptide found in the saliva of flesh flies belonging, unsurprisingly, to the genus Sarcophaga [3]
Educated readers will recall how Alice met a Cheshire Cat in a wood. After imparting some words of wisdom, it vanished. But its smile remained. [4] So with our LSS dragon: it may be gone, but the smile of hope which it gave us lingers on.
Anyone who got beyond basic school science will recall the frustrating new level of complexity when the teacher first told you about stereoisometry. You recall-all biomolecules starting with the slightly complicated upwards really have two identical forms, left hand and right hand. Amino acids, proteins you name it. And life can only work with one. All amino acids in living things on this planet have left handed amino acids and right handed sugars. Of course living systems could work the other way round, It just has happened yet on this planet. Until now. Read this Debate heats up over mirror life from Nature Briefing
At a meeting this week in the United Kingdom, scientists are deliberating whether to restrict research that could eventually enable ‘mirror life’ — synthetic cells built from molecules that are mirror images of those found in the natural world. “Pretty much everybody agrees” that mirror-image cells would be “a bad thing”, says synthetic biologist John Glass. Such a cell might proliferate uncontrollably in the body or spread unchecked through the environment, because the body’s enzymes and immune system might not as readily recognize right-handed amino acids or left-handed DNA. But there are disagreements about where to set limits on research — the ability to evade degradation could also make such molecules useful as therapeutic drugs.Nature | 7 min read Read more: Life scientist Ting Zhu, whose work explores various mirror-image molecular processes, considers how to bridge divergent views on such research. (Nature | 11 min read)
Unfortunately its the down size that worries us here, Not only the uncontrolled spread alluded to by the learned scientists above. But, as the world falls into the grip of authoritarian dictators and ever more powerful plutocrats, the potential these tools give them to get rid of surplus and redundant sections of humanity. Forever.
Many decades ago, we often used to hear the argument “if all the money in the country were shared out, everyone would only get 20p” A tiny sum, which could not make any difference to daily life. This was the UK in 1973, Perhaps it was true then, there. Is it true of the world as a whole today?
The statement itself is a cognitive howler: because it equates wealth with money, carefully avoiding the inclusion of all the goods, capital infrastructure(IT systems, railways, etc.) and productive resources such as factories that make up the wealth of the world, which is best expressed as GDP. When we set out to find what that was, the best estimate was from the World Bank,[1] who put it at $105 trillion in 2023. Now, the population of the world is around 8 billion (8×109) people. What would happen if we found a way to share that GDP among all of them? The answer is: everyone ends up with an an income of $13 125 a year. Which surprised us greatly. Instead of being insignificant, its actually quite a lot. Let us explain why.
That same world bank defines four categories of national income by GDP. Low: $1 135 or less. Lower Middle: $1 136-$4 465. Upper Middle: $4 466- $13 845. High: $13 846 and anything above. There is enough wealth in the world to raise everyone almost to the level of high income countries, certainly to the very top of the middle range.
Now there may be very good reasons why this cannot be done. Some are practical. Some are moral. But if it were done, what difference might it make to such issues as mass migration, educational attainment, and the overall level of demand in the world economy? Let alone health, security and basic nutrition. Just a thought.
Paris. Everyone knows what that word means, even though most people have never been there. Style. Sophistication. Fashion. Learning. Power. Money. A place to be, a box that must be ticked. How did one more city in northern Europe get ahead of all its peers? What is the secret of Brand Paris?
We think the answer lies in the foundation of the University of Paris. Starting as an adjunct to the Cathedral school before 1100, it gradually expanded into a powerhouse of teaching which began to attract the best minds from all over the world. It drew the patronage of magnates such as King Phillipe Augustus and Pope Innocent 111, who recognised the value of cultural capital and soft power. While the roll call of alumni from the earliest time to the present includes such names as Peter Abelard, St Francis Xavier, John Calvin, Marie Curie, Louis de Broglie, Emmanuelle Charpentier, Simone de Beauvoir and Yann Le Cun. This was where it was at, to coin a phrase: and the network of hotels cafes, art studios, bookshops and spin-off enterprises simply grew around in a multiplying effect that would gladden the heart of any fan of Keynesian economics. (For the curious the Sorbonne started as one college of the University, but expanded so much that its name became metanymic for the whole thing)
It was one of the earliest Universities in Europe, and even today its successor institutions remain among the best. But if you had been a student there, perhaps of Abelard, you would have known yourself at the start of something big, new and world changing, that was going to last the ages. But let’s close when our own original thought When they set it up, the costs must have seemed rather large, the incomings rather small. No doubt the same argument was advanced against the Pyramids in Egypt or the monuments in Rome. But they have paid for themselves over and over again in tourist revenue alone ever since. As its greatest alumnus of all, St Thomas Aquinas said
“Sicut enim maius est illuminare quam lucere solum, ita maius est contemplata aliis tradere quam solum contemplari.”
“Just as it is better to illuminate than merely to shine, so it is better to pass on what one has contemplated than merely to contemplate.”
And we agree.
#france #middle ages #university of paris# #sorbonne #philosophy #learning
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It’s funny, we’ve been doing this blog for more than five years now. And in response to growing numbers of readers and requests, we thought it might be time to provide a round up, not of the week, but of our whole outpourings which might be interesting to those who seem to have been trawling avidly through our archives of late.
It all started back in 2020, around the time of the great COVID-19 epidemic. Our initial aim was to raise awareness of the problem of antibiotic resistance in microbes, and the health dangers that posed. The idea was a short three paragraph hit the sort of thing that informed readers could take in over a quick coffee, while giving them a few links and references if they wanted to follow up. Just to keep it interesting, we started throwing in other topics on other areas of science. And these widened to include economics, social issues like women’s safety, and of course our regular Friday cocktail night, which certain readers still recall fondly.
Antibiotics and associated matters have remained well represented. We have looked for untapped sources in nature, even including the unlikely Komodo Dragon( LSS 3 5 21) the evolutionary arms race between bacteria and antibiotics which humans have been forced to join(LSS 8 6 23) and all sorts of new discoveries and techniques including AI (LSS 6 6 24) Being who we are, and untied to the constraints of any institution, we were quick to suggest that bacteriophages might be a useful adjunct to the general theme of overcoming resistant bacteria(LSS 17 3 22, 10 9 25 et al) Ever mindful that lack of antibiotics might not be the only catastrophe waiting we have provided handy little guides to what might happen if the magnetic poles flip, sea levels rise and even more endocrine disruptors are poured out from our factories. Other scientific tropes like evolution get a look in too. We enjoyed posing you a few puzzles on things like Homo naledi (LSS 4 4 21) the tools of Socotra (LSS 17 6 22) and even the possibility of Denisovan Fine Art( LSS 9 8 23) But these last were mainly for entertainment.
Our general theme has, we think been broad but consistent. The scientific method, of gathering objective evidence and analysing it by the rules of logic are the most reliable manner to fashion a passingly decent way of life. To this end you will have noticed is praise all kinds of people from journalists like Larry Elliott and Simon Kuper to more general thinkers like John Rawls, EO Wilson and Carl Sagan. We have tried to keep away from obvious stars like Darwin, Einstein, Bach, Keynes and the others as these thinkers speak for themselves. Instead we have tried to put forward slightly overlooked figures such as Ada Lovelace, Peter Ramus or Cassiodorus. Our Heroes of Learning feature is the place to look for those.
But above all we thank you, our readers, contributors and researchers for all their good companionship. All those who posts likes, shares and comments-it shows someone out there is interested. We wish all of you well with your various blogs, careers, lives and families. As Gore Vidal observed , it is the top one or two percent who carry knowledge through and pass it from generation to generation. And you are in it.
News that the latest findings from the Mars Perseverance mission may have detected the best evidence yet of life on our neighbouring planet should provide a flurry of media attention in the next few days. it’s always good for disinterested science to get a little coverage. And we take our hats firmly off to the ingenious scientists, technicians and engineers who set up these missions and study their results with such assiduity. That said, dare we inject just a tiny note of caution into these heady proceedings? We think it’s what our readers have come to expect.
First to the results themselves, Which we admit are intriguing {1] Writing in The Conversation, Sean McMahon not only gives us a really clear exposition, he has ample links to the papers you’ll need if you wish to go further. Essentially, while exploring the Cheyava Falls region of Mars, Perseverance has found strong evidence of redox reactions, the very essence of life itself. What’s more the nature of the rocks and the visual clues, a scatter of pale spots associated with organic matter, strongly resemble similar patterns created by certain living processes here on earth. Slam dunk, get out the old David Bowie records? We would still urge caution.
Firstly because we,ve been here before. Twice actually. Older readers will recall the excitement generated by the Viking missions in 1976. [2] Two of the on board detectors, the Labelled Release and the Pyrolitic Release reported positive. However the crucial GCMS did not. And despite heroic efforts to reinterpret this data, such as the ones involving perchlorates, the Viking results must remain inconclusive in any rational. evidence based system of thought. Then there was the famous Allan Hills 84001 meteorite in 1996, which contained intriguing visual and chemical hints of microorganisms. Once again other explanations were possible. And the general consensus was the scientific equivalent of a hung jury. Quite right too, we think
And secondly because final proof will not be known until NASA and the ESA can whack up the ginger and the money for a Mars Sample Return mission. Which so far hasn’t really got beyond the talked-about stage. So Perseverance sits on Mars containing 30 tubes ready for collection, including the enigmatic Cheyvara Falls samples. Back on earth people speculate, bicker and wonder when the next war will begin. Until something happens to break this impasse, we say-don’t get out ahead of your data.
In 2023 Irene Nevado lay in hospital with little hope of anything much. She had been born with Cystic fibrosis. At he age of 8 she had contracted a persistent infection of Pseudomonas aeruginosa, which had filled her lungs with fluid, making them unusable. The bacterium was antibiotic resistant. And from that day on her life was filled with misery. All sorts of things were tried,: drugs, different antibiotics, even a lung transplant All to no avail. By 2023 she had come to the end of her road.
At this point Biologist Pilar Domingo-Calap enters the story( as told by the brilliant Nuño Domínguez of El País. For Pilar is an expert in phage therapy. She had been working closely with a team at the Centre for phage therapy at Yale in the USA. Together they had evolved a bacteriophage designed to attack and destroy exactly the strain of Pseudomonas which was plaguing Irene. They put her under ten days of treatment. The result? She now walks talks and leads as busy a normal active life as any human could wish for. She even does 4000m swims to raise money for cystic fibrosis charities. Bacteriophages saved the day.
We’ve often sang their praises here. And Nuño’s article is a brilliant summary of the current state of play, with lots of juicy links to big players, latest developments and so on. A go to for any one interested, although if you don’t speak Spanish you will need your AI translator. All in all it confirms the line we have always taken. Bacteriophage therapy is going to be a vital second method if we are to overcome antibiotic resistant microorganisms. Will you, dear readers, permit us a modest instant of self-congratulation?
Warning: this article may make uncomfortable reading for xenophobes everywhere)
Progress in CRISPR-Cas-9 (Clustered Regularly Interspaced Short Palindromic Repeats)[1] and the associated enzyme is getting faster and faster. We started reporting on this truly innovative technique in 2020 and regular readers will recall updates ever since. Only four years ago it still felt a bit theoretical. But now radical applications are coming thick and fast Read this from Nature Briefing CRISPR horses spark debate reporting on the rather recondite world of polo pony breeding
the horses pictured above{*} are the first of their species to have been created with the help of the CRISPR–Cas9 gene-editing technique. They are clones of the prize-winning steed Polo Pureza, with a tweak to myostatin — a gene involved in regulating muscle development — that is designed to quicken their pace. Critics say that genetic manipulation has no place among polo’s traditional breeding practices — it has already been banned by some of the sport’s governing bodies. But a zoo of CRISPR-edited animals, from cows to sheep, is gaining acceptance in agriculture.Nature | 5 min read
{*} sorry LSS readers-we can’t show this-ed
In one sense there’s nothing new here. Humans have been modifying the genetics of plant and animal species since the dawn of the Neolithic. CRISPR and other base editing techniques have simply speeded the whole process up by making specific, designed changes and crucial nodes in the subject organism’s development. There is every reason to suppose that any number of new modifications to animals(and crop plants such as wheat) will be developed in the next few years. Some may even enable us the preserve the integrity of food supplies despite the ravages of things like plastics pollution and global warming. Also, as we have also reported here, gene editing is beginning to show real applications in medical fields such as sickle cell disease and certain cancer therapies. All of which leads us to an intriguing thought.
If ponies may be so easily modified, why not humans? One could start small by just modifying athletes and other small groups. Yet eventually the techniques could become ubiquitous in our species. Hang on-our species? Because the genetic differences between beings consisting entirely of CRISPR modified genes and the rest of us would then be far, far greater than those currently existing between our different races and ethnic groups. Are xenophobes everywhere already wasting their own time?
Cars, don’t you love them? They cost a lot of money, they run people over, they allow cities to sprawl out over the countryside. Now comes evidence that the pollution that they cause, along with many other sources of pollution it has to be said, may be causing a special form of dementia called Lewy Body Dementia. [1] Ian Sample of the Guardian reports on a massive study of 56.5 million patients carried out by Dr Xiaobo Mao of Johns Hopkins University in the United States. The team found that fine particulate matter called PM2.5 (LSS passim) caused proteins in the brain to form toxic clumps which slowly destroy nerve function leading to cognitive decline characterised by to memory loss, poor attention spans, visual hallucinations and sleep disturbance. The team went further and found the deadly particles induced similar symptoms in mice, confirming their evidence from population studies in humans .
When we did out background research for this article we were quickly overwhelmed by the amount of available evidence. This report [2] by the UK Government waxes lyrical on the different types of air pollutants-particulates, NO2 SO3, ammonia. and many more.. as well as the many symptoms the pollution causes in the human body. And this from the Alzheimers Society [3] puts the ball in the polluters’ court when it comes to neurodegenerative diseases particularly. We weren’t ever going to fit all that in paragraph two of a three paragraph blog, so we won’t try
What we will do instead is ask where does all this pollution comes from. Cars? Sort of. Factories? In a way. But the real source is a set of misguided economic policies which value growth numbers above all else. You have to have more growth than your neighbours or younare not reaklly worth anything at all. There must be more new cars, new washing machines new mobile phones, bright new shiny anythings, so that we can create a frantic cycle of production and consumption to prove how rich and clever and successful we are. But is the definition of the good life really to drive an overpriced automobile over concrete flyovers for a few years, followed by a long cognitive decline into dementia, really such a good life? Answers please-we’d love to hear them.
Learning, Science and Society 