The Killer in the Lake

It’s a warm sunny day in southern England, the first after a long cold winter. And proud grandparents Brian and Karen are proud to take their only grandson, little Chesney, to a country park. It was where Brian himself played fifty years before. And it’ll give the child’s mother, a hardworking nurse, a break. The water of the lake looks so inviting that little Chesney begs to put on his arm bands and plunge in. Brian, remembering his own happy hours there, agrees. But as the adults watch their grandson splashing happily, little to they realise he has already entered the last painful hours of his short life.

Problems start after they return home. Chesney complains of feeling sick. He becomes listless and starts showing signs of a fever, which rapidly grows worse. The grandparents rush the boy to the local Emergencies section of the nearest hospital. Doctors report that the fever has spread to the little boys brain. It is they say Primary Amoebic Meningoencephalitis, a disease caused by the amoeba Naegleria fowleri. It has entered the boy’s nasal sinuses, and travelled rapidly up to the brain, which it has begun to feed on from the inside outwards. The fatality rate is 97%. There is just time to call the boy’s mother back from her shift before he dies in her arms.

Fanciful? It could become all too common according to this story by Rebecca Whittaker of the Mail.[1] What Brian didn’t know is that the planet has been warming steadily since his younger days , allowing the deadly amoeba to multiply to unprecedented levels in the lake. Now British lakes and rivers are as warm as those of the Southern United States. A paradise for Naegleria.

And what can be done? Well, there is some hope [2] Despite the colossal fatality rate some antibiotics and some steroids seem to ameliorate the disease in some cases. Better Government inspection and testing of lakes and other swimming places could help, although in Britain that seems a unlikely at the moment. Best of all might be to slowdown the breakneck pace of global warming. Good luck with the last one.

^{the names and family in the first part of this piece are entirely imaginary}

[1]https://www.dailymail.co.uk/health/article-13187827/Warning-brain-eating-parasite-99-death-rate-making-way-British-water.html

[2]https://www.cdc.gov/parasites/naegleria/general.html#anchor_91787

#meningitis #naegleria fowleri #water born disease #swimming #pollution #global warming

Our Choice for Easter: JS Bach, St John Passion

You don’t have to follow the Christian eschatology to realise that “easter” has a far deeper meaning which predates the birth of Jesus by millennia. Fans of The Golden Bough will recall that legends of the Reborn- God- in- Spring, are almost universal among people who live and farm across the northern hemisphere, and have been ever since the Neolithic. The sense of renewal after a hard winter, and the hope of fresh beginnings, address something extremely deep in the human psyche.

Bach‘s great Easter oratorios, the St Matthew Passion and the St John Passion speak to this sensibility as well as any work of art we know. Bach wrote the St John Passion in 1724. Like many such works, it was revised and cut many times, not least by the composer himself. The versions we hear now are are result of centuries of study, and of course the early music revival of the 1980s, when period instruments and orchestrations were rediscovered and tried out.

This year we have chosen the St John Passion as, frankly, we are a bit St Matthewed-out. So it is wonderful to try to understand a fresher set of rhythms and harmonies from a master artist, and relate them to Bach’s sense of the universal, creed-jumping essence of this work. Of course, we would not dare to tell you which bits to like, nor why. For one thing, we lack the musical knowledge. But we really liked the opening prologue, Herr, unser Herrscher, and we hope you will too. And meanwhile wish all of you a happy Easter, or whatever you call this break, and hope the world improves as the summer opens before us.

[1]https://en.wikipedia.org/wiki/St_John_Passion

[2]https://www.udiscovermusic.com/classical-features/bach-st-john-passion/

#JS Bach #St John Passion #Easter #Neolithic #belief #christianity #music

Four cheers for the minimum wage

They said it couldn’t be done. It would cause mass job losses and economic melt down. It undermined the morals of the poor. So screeched a whole bevy of right wing “news”papers, magazines and think tanks when Tony Blair’s Government introduced the UK’s minimum wage policy in 1999.[1] We’ll let the excellent Philip Inman of the Guardian give you the details. Our own gloss will be a little more historic.

Scholars scrabbling over the rubble of the Great Crash of 1929 soon discovered one simple, outstanding truth. The boom of the 1920s had held a fatal weakness. Wages stayed low, while tax reforms had ignited an unstable credit and spend boom among the rich. Demand was suppressed, and as the factories filled with unsellable goods, the stocks of the companies that made them were seen to be based on sand. The resulting crash became much worse, for the poor had no reserves to build in the good times to see them through. The message was an is clear to all of us who have managed to move beyond the simple verities of first year undergraduate economics. Helping the poor makes everyone richer.

So to all the pearl-clutchers, and to those who have their own reasons to conveniently believe in free market economics, we would observe this. Study the history of things like minimum wages, working hours directives and the abolition of serfdom. You disparage them not at your own peril, but at everyone’s.

[1]https://www.theguardian.com/society/2024/mar/27/minimum-wage-is-uks-most-successful-economic-policy-in-a-generation

#demand #economics #great depression #wall street crash #jm keynes #minimum wage

The Hidden Dangers #2: Endocrine disruptors

Photo by Andrea Piacquadio on Pexels.com

Well! Frankly, when we started this series, we didn’t know much about Endocrine disruptors. We thought we’d run you off a quick blog and disappear off down the pub to spiritually prepare for the Easter holidays. But when we opened up our first clicks, the whole thing was absolutely vast. We felt like that Spanish bloke Nuñez de Balboa who crossed a small ridge and suddenly found himself looking at the Pacific Ocean. So- how to summarise it?

An endocrine disruptor is a chemical which can insinuate itself into the human body in such a way that it interferes with your hormone driven functions. The trouble is that these chemicals have become incorporated into an unimaginably vast array of industrial and production processes. Our Chat GPT 4 gave the following cursory over view of the sorts of things we’re talking about and where they might be found:

Atrazine: A commonly used herbicide in crops like corn, sorghum, and sugarcane.
Bisphenol A (BPA): Found in plastics, food packaging, and toys.
Dioxins: Byproducts of manufacturing processes.
Perchlorate: An industrial chemical used in rockets and explosives.
Per- and polyfluoroalkyl substances (PFAS): Used in firefighting foam and nonstick coatings.
Phthalates: Found in food packaging, cosmetics, and fragrances.
Phytoestrogens: Naturally occurring substances with hormone-like activity found in some plants.

If you really want to delve deeper, this report is about as good as it gets, thought you’ll probably need three weeks solid to take it all in [1]

And our take? The real trouble with things like smoking, burning fossil fuels or putting lead into petrol was that the downsides took so long to emerge. That and the fact that many of the residua of past follies are still lying around. The processes we saw above are so deeply woven into the fabric of our civilisation that its hard to say when any useful substitutions can be made, let alone eliminating them from things like the food chain.

[1]https://www.europarl.europa.eu/RegData/etudes/STUD/2019/608866/IPOL_STU(2019)608866_EN.pdf

#endocrine disruptor #hormone #plastic #pollution #health #ecology

Why Easter is a time for understanding- a message from the Board

Once again we share one of our management to staff communiques, which we believe are a model for other companies and organisations

Now, it’s come to our attention that there have been certain ill-disguised whisperings and feelings about the staff leave arrangements for this Easter Bank Holiday weekend. Specifically-how come only the Editorial Board get Thursday afternoon off? The answer is both simple and complicated.

Firstly, the Thursday before Easter (Maundy Thursday) is an ancient time hallowed custom. So someone has to have time off. Obviously it can’t be everybody , as our productivity figures, already low, would just fall through the floor. So the Board got in consultants, who came up with a scheme based on geography, finance and above all peoples’ real needs. And this is how it works out.

Most of you it turns out live within 5 or ten miles of this building. OK, a couple of you trundle in from places like Kingston or Haywards Heath, but its really not too far to get way when the weekend begins, is it? Whereas we on the Board have our holiday homes in amazingly far-flung places. The Cotswolds. Perigord. Even Tuscany. Of course we need that extra time to get to the airport. And what about at the other end, we have to get to that shop in the village, the one that does that marvellous olive bread, and check the wine cellar, or the weekend’s half-gone. Whereas you lot, in some pub in Croydon-well you’re right on top of it as you stumble out of your little flats.

Each of us needs to understand other people and their different needs and pressures. Clearly we on the Board have somewhat different needs to the rest of you. Easter is a time of understanding. And with the annual salary reviews coming up, we hope you will understand once again.

AI-designed Antibodies: Not another medical breakthrough story?

A 200X photomicrograph magnification of a direct by Centers for Disease Control and Prevention is licensed under CC-CC0 1.0

Oh no, not another medical breakthrough story on LSS? What happened to all those cocktails? What about all the economics and evolution stuff we used to get? Yet let us remind you of the words of our Founding Charter,* gentle readers: this started out as an antibiotics website, even more so when it was a post on Facebook. Of course when supplementary techniques like bacteriophages and improved antibodies came along, we welcomed those too. Which is why we have to give this new report from Nature Briefings AI helps design antibodies from scratch, front and centre on today’s blog. When you read this, you will understand why

For the first time, an artificial intelligence (AI) system has helped researchers to design completely new antibodies. Creating new versions of these immune proteins, which can be used as drugs, is usually a lengthy and costly process. An AI algorithm similar to those of the image-generating tools Midjourney and DALL·E was trained on thousands of real-world structures of antibodies attached to their target proteins. It then churned out thousands of new antibodies that recognize certain bacterial, viral or cancer-related targets. Although in laboratory tests only about one in 100 designs worked as hoped, biochemist and study co-author Joseph Watson says that “it feels like quite a landmark moment”.Nature | 4 min read
Reference: bioRxiv preprint (not peer reviewed)

Once again, we are at the start here. It’s still, at proof of concept stage, and awaits peer review. On the other hand, this is genuine landmark moment which people of the future will look back on. And whatever you are doing now as you read this, remember it. You were there on the day it happened.

a copy of the founding charter is still visible in the flowerbed round the side near the car park, the bit where all the smokers go. Actually, could we clean it up a bit?

Two amazing stories from genetics that woke us up this morning

One of our great pleasures in life is to stand amazed when someone does something amazingly clever. Especially when you get that feeling that what they did was there, waiting to be done, all along. Which is why we bring you two such stories, all gift wrapped up by the admirable Nature Briefings and BBC, for you to click on at your delight.

A Cure for HIV? Anyone who lived through the 1980s will recall the terrible ravages of the AIDS pandemic, caused of course by the HIV virus. Even if you were lucky enough to be in a low-risk group, we all knew someone or a local community organisation who suffered the ravages. Sad. Sad. Sad. Now that old friend of LSS, CRISPR gene editing may actually offer some hope towards the final elimination of the virus from our genomes. It’s early days yet, as both Michelle Roberts of the BBC and the researchers themselves say. Proof of concept and all that. Good, it’s better to be cautious. But if they can “snip” the HIV virus out of your cells, what else might not be achieved?[1]

Ghost DNA made us brainy Talking of embedded DNA, many a 1980s conversation concerned all that mysterious DNA lying around our genomes that didn’t seem to do anything (no, it was mainly about EastEnders-ed) Was it some of it ancient embedded viruses that attacked our ancestors long ago, in some forgotten Permian Pandemic? Well, get this from Nature Briefings, Virus Helped Brain Evolution

Remnants of an ancient viral infection are essential for producing myelin, a protein that insulates nerve fibres, in most vertebrates. Certain viruses insert DNA into the genetic material of the cells they invade. Sometimes, these insertions become permanent and even aid evolutionary processes. Myelin helps nerves to send electrical signals faster, grow longer and thinner so they can be packed in more efficiently. “As a result of myelin, brains became more complex and vertebrates became more diverse,” says stem-cell biologist and study co-author Robin Franklin.Science News | 6 min read
Reference: Cell paper

The implications are rather profound. The idea of the single autonomous gene line, the pure selfish individual at the core of your biological identity is rather compromised, isn’t it? What if the genetic “you” isn’t just “you,” but is you+some (rather random )free riders, who may or may not be helpful? That Natural Selection is acting on several of you at once. and may force you to cooperate? What price The Selfish Gene now?

[1]https://www.bbc.co.uk/news/health-68609297

#genetics #dna #rna #hiv #aids #myelin #evolution #CRISPR #medicine

The Hidden Dangers #1:tetraethyl lead

Here’s what lead can do to you:

_{6 mL of tetraethyllead is enough to induce severe lead poisoning.^[89] The hazards of TEL content are heightened due to the compound’s volatility and high lipophilicity, enabling it to easily cross the blood–brain barrier.}

_{Early symptoms of acute exposure to tetraethyllead can manifest as irritation of the eyes and skin, sneezing, fever, vomiting, and a metallic taste in the mouth. Later symptoms of acute TEL poisoning include pulmonary edema, anemia, ataxia, convulsions, severe weight loss, delirium, irritability, hallucinations, nightmares, fever, muscle and joint pain, swelling of the brain, coma, and damage to cardiovascular and renal organs.^[90] Chronic exposure to TEL can cause long-term negative effects such as memory loss, delayed reflexes, neurological problems, insomnia, tremors, psychosis, loss of attention, and an overall decrease in IQ and cognitive functio}n.^[91]

_{The carcinogenity of tetraethyllead is debatable. It is believed to harm the male reproductive system and cause birth defects.} (Wikipedia: Tetraethyl lead [1])

Like it? That’s just tetraethyl lead, Pb (C₂H₅)₄ The brute metal itself has been in use for millennia, and even the Romans knew that it was toxic. For a broader view, try the main Wikipedia article here [2]

Glad you clicked, because now you will know why strenuous efforts have been made to phase out lead from human technology for the last few decades. Admirable; but it leaves two big problems. It’s bad enough that all that lead is still out there in the soil, in the water, in the air, still poisoning us all. But it gets worse when you realise someone is still adding to the pile. Allow us to explain.

Some readers will recall the bright wheeze they had back in the 1920s of adding tetraethyl lead to petrol, as an anti-knocking agent for engines. It worked! The trouble was that the resulting cloud of lead covering the earth was so dangerous that eventually even a cynical world had to introduce measures which have reduced it. Except in one area: aviation. To quote Wikipedia once more

_{TEL remains an ingredient of 100 octane avgas for piston-engine aircraft. The current formulation of 100LL (low lead, blue) aviation gasoline contains 2.12 grams per US gallon (0.56 g/L) of TEL, half the amount of the previous 100/130 (green) octane avgas (at 4.24 grams per gallon),^[84] and twice as much as the 1 gram per gallon permitted in regular automotive leaded gasoline prior to 1988 and substantially greater than the allowed 0.001 grams per gallon in automotive unleaded gasoline sold in the United States today.^[85] The United States Environmental Protection Agency, FAA, and others are working on economically feasible replacements for leaded avgas, which still releases 100 tons of lead every year.^[86] Children living near airports servicing small (piston-engine) aircraft have measurably higher concentrations of lead in their blood.}^[87][1]

Now to us, there can be few pleasures more innocent or admirable than the sport of leisure flying. Exponents of it are personally known to us. But isn’t it time that they, and everyone else, urged their Governments to look for alternatives? And is it unfair to add the phrase “as early as possible”?

[1]https://en.wikipedia.org/wiki/Tetraethyllead

[2]https://en.wikipedia.org/wiki/Lead

#lead #soil #toxin #neurological disorder #pollution

Hidden Dangers: Our new series begins today

Photo by u0410u043bu0435u043au0441u0430u043du0434u0440 u041cu0430u043au0435u0434u043eu043du0441u043au0438u0439 on Pexels.com

Are there risks in things we do or use every day, which could be harming us, our children and grandchildren? We spend a lot of time here talking about things like global warming, potential medicine losses and pandemics. In the next few blogs, we want to get you talking about every day things. Things closer to home, which may be slowly and insidiously spoiling our quality of life, and destroying the chances of future generations. We’ll be talking about things like certain metals and other poisons, as well as plastics, pesticides, fertilisers and other well-intentioned but short sighted practices which could be reformed or abolished without much harm, and to great general benefit.

And “well intentioned” is the key for us . Because unlike conspiracy theorists, we don’t think the people involved are necessarily evil. Very often, they were motivated by genuinely laudable ideals such as improving food supplies, or increasing technological performance. The biggest trouble comes from limited thinking, solving a problem here and now, without scoping the wider consequences. The fall-out, that chilling phrase from the last century. Which in turn implies that these problems could be solvable, with a little more thought. Wouldn’t it be nice if LSS came up with an optimistic set of blogs, for once? Try them, and see what you think. The first will be coming up next.

#heavy metals #plastics #pollution #pesticide #herbicide

Another big thanks-keep ’em coming

March has brought a really heart-warming number of likes, links and comments to our little blog. More in fact than we can confidently enumerate. Imagine if we tried to list all of you and forgot one, just one! The shame would be too great for us, and rightly so.

So the only way to deal with this is to, once again, just note how truly honoured we feel that you like this little blog. And take the time to tell us so. Once again, we wish you all success in all your enterprises, large and small. And to enjoy the rest of this great month, and the well-deserved Easter break at the end of it.

We will have a little more to say on Easter later, and how we think it may predate Christianity by several thousand years, But that really is for another day.

THE EDITORS