How an old History Book still has very real lessons for today

It’s funny how some books suddenly explain something you’ve puzzled all your life. One of our obsessions was always “What was the Roman Empire all about? And why did it fall?” And we ploughed our way through everything from Gibbon to Asimov’s Foundation series. Until we came across RH Davis A History of Medieval Europe”[1]. Suddenly, things began to fall into place.

Before the Industrial Revolution, it was far cheaper to transport goods by water than by land. The achievement of Rome was to be the culminating power that united the whole Mediterranean Basin into a single, prosperous trading area. Where cities could flourish, ideas spread and production be subdivided to the most efficient source. And to do it all with the minimum effort. This was partly by religious tolerance: before Christianity, all beliefs and none were accorded equal status. But it was also done by Law. As Davis explains

“…….[The Romans] knew that all the Mediterranean peoples had a common interest in the commerce of their sea…….they believed that all men had by nature an instinctive knowledge of what was right and what was wrong…and that it was possible to frame laws in accordance with the standard of nature. They distinguished between custom, which was of local significance and law, which appertained to justice and was of universal significance …...

But the barbarians who entered the Empire did not quite see things that way. Most of them-Goths, Burgundians , and so on, came to enjoy, not destroy. But:

“barbarian invaders claimed that their own laws were were particular to themselves, since they were not founded ..on reason, but on the dictates of their divine ancestors….[the Roman Empire] was… cracked by the determination of barbarian invaders to prefer the law of their ancestors to the law of reason, since that preference implied the superiority of loyalty to one’s race over loyalty to the civilised world. It was shattered when traders lost the freedom of the sea. When that happened , the greater part of Europe reverted to an agricultural economy, in which there was no place for the cities that made men civilised” (all quotes pp 4-6)

Today, after a brief period of globalisation, we live in an age of retreat. In most places, people are reverting into ethnic or religious tribes. There are cries to tear down even the few international laws we have, which might have done some thing to keep the peace. Now, there is a very respectable argument to say this is in accordance with the most basic instincts of human nature. And so it might be. But Davis tells us very clearly what the price must be if we now follow this that course. The Dark Ages.

[1] RHC Davis A History of Medieval Europe from Constantine to St Louis Longman 1988

#RHC Davis #Middle ages #medieval #trade #henri #pirenne #dark ages #antiquity #economics

Worms and trains gave us two unexpected shocks for the weekend

Photo by u0410u043bu0435u043au0441u0430u043du0434u0440 u041cu0430u043au0435u0434u043eu043du0441u043au0438u0439 on Pexels.com

A philosophy derailed For more than fifty years, the Mail and its collaborators in the right wing media have been pushing one simplistic mantra “Private Sector Good. Private Sector Bad.” So it came as a surprise to see this candid admission of the appalling state of Britain’s privatised railway system.[1] It’s a story that’s repeated across swathes of our economy. Public Housing, water and sewage, Forensic Science, energy regulation… the attempt to privatise and create a market at all costs has often been a costly failure. Now, anyone who has y worked in the public sector and seen its inefficiencies close up cannot remain a socialist. Or not enjoy the delight of pompous civil servants being exposed to a little competition. But the invariable prescription of a single nostrum, whatever the circumstances, that so appalled us. Good to see a little honest admission of error.

[1]https://www.dailymail.co.uk/news/article-13172415/Rail-cancellations-Avanti-Northern-CrossCountry-TransPennine-Express.html

Immunity to radiation? When we were young we thought “radiation is an ineluctable killer. It so affects the genetic material that there’s no way back.” Wrong again! As this intriguing article from the Independent shows, to our extreme chagrin. Apparently the famous nuclear disaster zone of Chernobyl in Ukraine has nurtured a whole new type of radiation resistant worms. [1] The implications for life on earth are intriguing enough. But even more so in our quest to find living creatures both in our own stellar system and in more distant ones. What a way to end the week.

_{thanks to p seymour}

[2]https://www.independent.co.uk/news/world/europe/chernobyl-worms-nuclear-power-plant-b2509161.html

#chernobyl #worms #radiation #privatisation #public sector

Could your gut microbiome be making you anxious?

We always like intriguing new stories about health and biology here. That’s why we’ve showcased this item from Peter Hess of the Mail, Do you have Social Anxiety? Scientists Find the Condition lives in your gut. Peter reports some results from University College, Cork. Essentially, scientists there have transferred gut material from people with Social Anxiety to mice. And found that they have thereby induced significant changes in the nervous systems of those creatures: specifically, making them more prone to anxiety and fear [1]

The work is undoubtedly interesting, and it’s good journalism to write it up Especially when it’s one of our old tropes, in this case the relationship between the the digestive system and the nervous system (LSS 9 3 23 and passim). Is it the answer to all our woes? It’s too early to say.

Essentially, journalists report two types of science story. Definitive ones, which answer all the questions and close the subject down. Or intriguing ones on early research which opens a subject up and sets the questions for future researchers. It’s our gut feeling that this work belongs in the second category. For one thing, the numbers are small (12 people and 72 mice, if our maths is anywhere near correct) Good start, but we’d like to see replication across much larger numbers. And what is Social Anxiety Disorder anyhow? Psychiatric conditions are notoriously hard to define exactly. Could there be other causes of anxiety, such as war service or growing up with violent parents? They need to be controlled for.

It’s good work in an intriguing area, and we hope these researchers are given more time and money to pursue it. But we still wait and see for definitive conclusions.

[1]https://www.dailymail.co.uk/sciencetech/article-13156095/social-anxiety-gut-scientists-treatment.html

[2]https://www.bbc.co.uk/news/health-46986709

#diestive system #nervous system #health #anxiety

An apology to Dr Joseph Ladapo,and all our readers: now, will our staff please come in from the car park?

Croydon Tram by Peter Trimming is licensed under CC-BY-SA 2.0

Today we published a blog which discussed the controversies around Dr Joseph Ladapo, [1]the Surgeon General of the State of Florida. We hope that the report was fair to both sides. Unfortunately, we committed one unforgiveable error. We got the name of poor Dr Ladapo slightly wrong, spelling it, for the most part, as Dr Lapado. We hope this oversight, this careless Spoonerism, will not cause unnecessary distress or anguish to Dr Ladapo, and undertake to be more careful in future. Unfortunately, it doesn’t stop there.

Upon learning of this very understandable error, nearly all the staff have walked out. They now occupy a position roughly between the car park and George Street. Moreover some reckless spirits among them have raised vulgar and garish placards, bearing simplistic slogans like: NO MORE MISTAKES AT LSS WE WANT TO WORK FOR A REPUTABLE BOSS and even PAY RISE NOW . This has excited unfavourable and ribald comments from passers by and has brought the company’s reputation even lower in Croydon. And it wasn’t very high after the Christmas Party.

Okay we’re sorry. It was the Board that got it wrong, not any of you lot. We know we’re paid a lot more than most of you, but that is the market rate for Company Directors. Obviously it’s very different to that for an average worker in ,say, IT, HR, telephone sales, or even comparable professions like nurses, teachers and delivery drivers. And the reason people like us get a lot more is because of the heavy burden of responsibilities we carry as the Directorial Classes. And this would be the same if we worked in, let’s see, a water company, the :Post Office or in a large Private bank, for example. And it’s because of all that work that mistakes creep in, like the one we made today. But look, you’ve made your point. Maybe we can look at new drinks machines and new chairs and tables. Maybe more money could be found to fix that leak in the third floor kitchen. But please come in. Please come back to work. We promise not to do it again. And be kinder and more considerate in the next pay round. Please?

THE EDITORIAL BOARD

[1]https://www.theguardian.com/us-news/2024/mar/03/florida-measles-outbreak-preventable

Florida’s Health Battle heats up

As if the US State of Florida didn’t have enough problems, what with coastline erosion and all that, it has now become the epicentre of of a mighty battle over public health, and who calls the shots over what is, and is not, scientific evidence. [1] This is how the two sides square up, according to Richard Luscombe of The Guardian

In the Red corner: Dr Joseph Lapado [2] Florida’s Surgeon General, whose principle back is State Governor Ron Di Santis, who, as older readers will recall, is a former Next President of the United States of America. In the Blue corner, most of what passes for orthodox medical and scientific opinion. And, before you take sides, gentle readers, note this. Dr Lapado is no unqualified quack, but an eminently learned and trained medical doctor. Who, as an immigrant from Nigeria had no doubt to fight more than his fair share of of prejudice before finding his way to a well-deserved place at the top. The trouble is that some of his opinions, are to say the least, controversial. As our sources report, huge storms are now swirling around his recommendations in matters concerning masks, vaccines the use of various medical and public health literature sources, and certain treatment methods [3] The outcome of many is still unresolved, we hasten to add. But, with Big Ron in your corner, does any of this matter? Everyone has a right to their opinion, as they say; maybe Dr Lapado’s is as good as anyone else’s?

The trouble with opinions is that they get get tested in fact. Now an outbreak of measles among the unvaccinated burghers of Florida is testing Dr Lapado’s practices and beliefs to destruction. And it’s not just matters of Life and Death, it’s more important than that. Florida’s economy depends more than most on tourism and real estate, and the guardians of that economy are beginning to realise this, as Richard notes:

Come for the Sunshine, Leave With the Measles, opined the Orlando Sentinel; “Measles? So On-brand for Florida’s Descent Into the 1950s”, was the take of the Tampa Bay Times.

Only time will tell who is correct, Dr Lapado or his detractors. . But we close with this thought. For a long time now- ten, twenty years-everyone has loudly, aggressively proclaimed their right to hold opinions Fair enough; but they cannot all be right. The one that really was right all along only emerges with the tests of fact and experience. Until they come along, a little humility might be in order for all of us. Otherwise that test might be very painful indeed.

[1]https://www.theguardian.com/us-news/2024/mar/03/florida-measles-outbreak-preventable

[2]https://en.wikipedia.org/wiki/Joseph_Ladapo

[3]https://www.newyorker.com/humor/borowitz-report/floridas-surgeon-general-urges-cvs-to-stock-leeches

# joseph lapado #ron di santis #vaccination #measles #florida #public health #empiricism#measles

Antibiotics: Why Keynes was good for your health

article of the week

Long, long ago, back in the 1940s, there was a set of beliefs called Keynesianism. It prized economic growth over financial targets and general welfare over the accumulation of vast quantities of lucre. Its prizing of State intervention and higher taxes won the Second World War, and led to thirty years of prosperity and technological advance. But it had its critics. And they had all the money, and therefore all the newspapers. Poor old Keynes was doomed.

Among the advances of those years of public-private partnership there were many advances. Computers and IT, semiconductors, aviation, space technology….but one has been forgotten. It was these years that Ernst Chain and others were able to take the discoveries of Alexander Fleming and turn them into the first generation of mass antibiotics. It was a revolution in health care. And, it has to be said a great reduction in human suffering. Yet enter the Free market Fundamentalists in 1979, and antibiotic development fell by the way. Why? There’s no money in it. And slowly resistance crept back, slowly at first until today, when we balance on the edge of another great pandemic.

But there is hope. Today Nature Briefings reveals that, by throwing out the profit motive, two exciting new antimicrobial drugs have been developed. Allow us to scrap this from Nature

Successful trials of two new antimicrobial drugs — zoliflodacin for drug-resistant gonorrhoea and an antifungal, fosravuconazole — were conducted by non-profit organizations that were founded specifically to bring such drugs to the market. Most legacy pharmaceutical firms have withdrawn from the field, and many of the small biotechnology companies that picked up the torch have gone bankrupt. These two latest achievements suggest that non-profits could help to solve the problem of drug access, while fending off the rise of drug-resistant microbes, which contribute to almost five million deaths per year.Nature | 10 min read

Now, there is a link there to a superb article by Maryn McKenna, which we honestly think you should read as well. But nothing so sums up the belief of this blog so fully. Wealth is about so many more things than just money.

#antibiotics #jm keynes #research #science #economics

Closing womens’ refuges is economic madness

Violence against defenceless women. You can be against it on many grounds. Cruelty, injustice or the rank cowardice of the bigger, stronger males who inflict it. But have you ever opposed it in the name of economic efficiency? We’ll explain this bit later, dear readers. First. the news item which prompted today’s little trope.

Fresh from previous hamfisted maladminisatrations, our beloved UK Government is due to preside over further budgetary reductions in our local governments and regional councils. And this will have a very dire effect in one area dear to the hearts of LSS readers; those shelters where women absolutely in the last stages of desperation can go to escape the attentions of their violent partners. And, according to Jessica Murray of the Guardian,[1] these centres are about to face what amounts to their final and irretrievable closures, dozens of them. Cruel. Barbaric, even. But is it also bad economics?

One of the surest ways to economic success is to ensure the mental and physical health of the workforce. Starving children make bad learners. So do the traumatised, anxiety ridden wretches who emerge from troubled, violent marriages. If you want a good workforce in twenty years’ time, start investing now. If there is such a thing as a British disease, it is underinvestment, particularly in human capital, in the name of balanced budgets and maintaining an ancient social hierarchy. Historians agree that Britain’s decline began in the late Victorian era, when its undernourished and undereducated workforce could no longer compete with those of advancing rivals. And just to show that nothing has changed, here we go again. save the mothers, educate the children and you might just get a few good workers. But doing things the way the current Government does them will just replicate the cycle again for another generation. And down we go again.

[1]https://www.theguardian.com/society/2024/feb/18/uk-charities-warn-of-devastating-council-cuts-to-womens-services

#jessica murray #domestic violence #domestic abuse #womens refuges

Will multicoloured hydrogen save the world?

Photo by Rafael Classen rcphotostock.com on Pexels.com

When we were young, hydrogen came in one colour-and you couldn’t see it. It was a just a load of bubbles the Teacher made in the chemistry lab. Fast forward fifty years, and it seems to come in a baffling spectrum of colours. There’s Green, pink, grey, gold, blue, black, brown and turquoise. [1] This handy guide from the National Grid will take you further. They’re all different industry nicknames where the stuff comes from. Just to confuse matters, different people seem to use the same nicknames to mean different things. But underneath all this lies one simple truth-hydrogen gas could represent a useful path to a sustainable future, and still enjoy what might pass for a tolerable lifestyle.

For reasons of space, we’ll concentrate on one exciting sounding candidate which insiders dub Gold hydrogen. The redoubtably named International Electrotechnical Commission waxes rather lyrical about it here [2] It’s a reputable outfit, and there are some good links for those with the coffee time to delve a little further. But-all that glistens is not gold, as Shakespeare once memorably observed. Writing in The Conversation, David Waltham produces a thoughtful balance sheet of the pros and cons of Gold Hydrogen (bewilderingly, his definition of it is a bit different to the IEC’s) He is far from anti; but this well-expressed caveat is well worth bearing in mind

The big question, though, is how seriously to take gold hydrogen. Will it turn out to be an over-hyped distraction of very limited utility? Or will it provide a pain-free path into a low-carbon future? The truth probably lies between these extremes, but only time (and further research) will tell us.

Well said Professor Waltham. That’s how LSS thinks. On just about everything.

[1]https://www.nationalgrid.com/stories/energy-explained/hydrogen-colour-spectrum#:~:text=Green%20hydrogen%2C%20blue%20hydrogen%2C%20brown%20hydrogen

[2]https://www.iec.ch/blog/could-white-and-gold-hydrogen-be-clean-fuel-options#:~:text=By%20contrast%20white%20hydrogen%20refers,conventional%20ways%20of%2

[3]https://theconversation.com/gold-hydrogen-natural-deposits-are-turning-up-all-over-the-world-but-how-useful-is-it-in-our-move-away-from-fossil-fuels-220230

#hydrogen fuel #fuel cell #green hydrogen #gold hydrogen #sustainable #global warming #climate change

Faith v Reason: Look at the results

We have two stories today, which if taken together, nicely illustrate the difference between Scientific Reason and Blind Faith.

CAR-T Therapy against Multiple sclerosis When we were young , Multiple Sclerosis was a dread disease, Slowly , understanding and therapies have evolved, and now as Nature Briefings explains, a powerful new method using the exciting new CAR-T system looks almost ready for large trials.

And we know how they did it The researchers looked at evidence. They designed and ran experiments . They discarded theories that the evidence showed was wrong. And eventually they came up with this, Engineered Cells for Multiple Sclerosis

The first US trials of CAR T cells to treat multiple sclerosis (MS) have started. These engineered cells could reset the malfunctioning immune system, halting the brain damage that defines MS. “I don’t want to get ahead of myself, but there’s a prospect here for a one-and-done therapy,” says neurologist Jeffrey Dunn, who is running a trial for Kyverna, a US biotech company. Safety is a concern because CAR T treatments can cause brain toxicity, which can result in confusion, seizures and death.Nature | 5 min read

Alabama Theocracy Over in the USA, the Faith-Based Folks of the Alabama Supreme Court have just outlawed IVF. You can read the full story from Robert Reich here [1] but a little of their motivation may be gleaned from the following

In a concurring opinion in last week’s Alabama supreme court decision, Alabama’s chief justice, Tom Parker, invoked the prophet Jeremiah, Genesis and the writings of 16th- and 17th-century theologians.

Today IVF….tomorrow.? Slowly, the tentacles of the Theocrats will close around every laboratory in the USA, banning this, forbidding that, until the US slips so far behind it can never catch up. It was by the Seventeenth Century trial of Galileo that the Catholic Church ensured its own eclipse by ensuring that thinkers fled to the Protestant lands of the north. Hitler found the same, ensuring that the best Jewish scientists fled to Allied countries, delivering their brains to his eventual defeat. That’s what happens when you discard evidence which the theory says is wrong.

Someone once observed that Knowledge and Belief are two different things. It can be hard to choose, we know. But if you need a little help, it may be worth looking at the outcomes of your choice. We can’t see the supreme court of Alabama coming up with a cure for disease any time soon. Nor will the Ayatollahs of Iran. But we hope the above evidence may help you, gentle reader, to support those who might.

[1] https://www.theguardian.com/commentisfree/2024/feb/23/republicans-american-theocracy

#religion #theocracy #christian nationalism #iran #science #empiricism #science

Out of Darkness-a brave attempt to get Cavemen right

Hoxne Cave Man Brakey Wood Hoxne Suffolk by Bob Pearce is licensed under CC-BY-SA 2.0

Fans of human evolution have always had a thin time at the movies. Back in the 1960s, the standard fare was stuff like One Million Years BC in which photogenic actresses in exiguous fur bikinis ran the gamut of pterosaurs, tyrannosaurs and beefcake co-stars sporting equally unlikely get ups and attitudes. Entertaining for some, but scientific nonsense. It felt like someone had tried to make Apocalypse Now using the cast and sets of The Sound of Music.

In our view, only two serious movies tried to paint an authentic picture of what everyday life might have been like for our ancestors. 2001: A Space Odyssey(1968) gave us 15 minutes at best of some pretty authentic australopithecines. Quest for Fire (1982) tried to pitch a later time, among the various human types of the late Paleolithic. And that was more or less that. Now some brave new filmmakers have tried again with Out of Darkness, here reviewed by Penny Spikins for The Conversation. We won’t spoil the review, which you should read for yourselves. [1] But we will note that Penny is an expert in the field, so approval from her is approval indeed. And the central idea of the film-who is “us”, and if they’re not, ought we to kill them?” is not without resonance today. So you don’t have to be a big caveman fan per se in order to go along and check this out.

Declaration of interest: at the time of writing, we have not yet seen this movie. But we sure as hell are going to, even if it means going alone. So there.

[1]https://theconversation.com/out-of-darkness-im-an-expert-on-human-origins-heres-how-this-stone-age-thriller-surprised-me-223614?utm_medium=email&utm_campaign=Latest%20from%20The%20Conversation

#science fiction #horror #film #stone age #human origins