Energy and Cancer: Three stories that give us hope in dark times

“The sleep of reason brings forth monsters” Goya’s famous painting never seemed so relevant as it does today, as humans divide themselves into mutually hating tribes in Europe, the Middle East and even the USA. “he that is quick to Anger exalteth folly” [1]. We here take the opposite view, Real progress is only achieved by slow, careful thought. And as evidence of that, we’d like to cite three examples, small in their own way of what can be done to fix real problems. When we pause to actually think, that is.

Seeing the cancer One of the most tragic moments in life is to here a cancer patient tell you “it’s come back” after an operation. This is not to blame the surgeons; it’s just that up to now they haven’t always been able to see all the cells. Now, according to Colin Fernandez of the Mail, a new technique will light up the tumorous cells, making them much easier to spot and excise altogether. By the way, some of this work was funded by Cancer Research UK,[2] a marvellous organisation whom we have often covered in these pages.

https://www.dailymail.co.uk/health/article-13511467/dye-prostate-cancer-tumours-glow-surgeons.html

Spotting the Cancer We have often hymned the praises of AI as well. Particularly in medical and biological research. One of its principal advantages is that it can carry out the routine stuff much faster than we can, without tiring. Kate Pickles of the Mail covers how it’s being applied to look at cancer scans to rapidly improve diagnostics. In the long term we could see AI applied to any number of laboratory techniques from Forensic science to Ecology, opening the way to boundless new knowledge and techniques

https://www.dailymail.co.uk/health/article-13518481/AI-better-doctors-spotting-prostate-cancer.html

Concrete Batteries? After they lost the battle on the reality of global warming, Big Oil and its lackeys have waxed lyrical on how difficult the transition to clean energy might be. “yes you can make clean energy, but how are you going to store it?” they would sneer. Well, lots of ways, it has turned out. But one we never dreamed of was the very concrete that makes up our roads, bridges and homes themselves. Unbelievable as it may seem researchers at MIT are looking at new types of concrete which will store and release energy exactly as we need it. What price oil and gas now? This excellent piece is from Victor Tangerman of the Byte:

_{Thanks to P Seymour}

https://futurism.com/the-byte/new-concrete-stores-electricity-homes-batteries

Tiny examples, perhaps. But the mark the dividing line between the Thoughtful and the Emotional. We’ll go with the former.

[1] Proverbs 14 29

[2]https://www.cancerresearchuk.org/get-involved/donate?gclid=69712e6308111b89fbbd480a7616017d&gclsrc=3p.ds&msclkid=69712e6308111b89fbbd4

#cancer #health #medicine #AI #global warming #climate change #renewables #concrete

AI and antibiotics-another good news story

We have always hoped that AI would do for antibiotics what it has already done for protein design. (LSS 1 12 20; 26 3 23) Now there is a real possibility that these hopes may come true. Eric Berger of the Guardian covers a truly remarkable set of research by Professor de la Fuente and his team at the University pf Pennsylvania. [1] They have used an algorithm to mine vast sets of data to sieve out any compounds with potential anti microbial properties. As any reader will know, it would have taken years, if not decades, if they had just used teams of scientists in labs. Click on to Eric’s article, its very easy on the eye. But we’ll leave you with these thoughts:

Is this a game changer? Potentially, yes. It could allow the construction of a vast library of potential antibiotic compounds. The real problem of the last forty years has been, not just the steady failure of existing antibiotics, but the lack of a stream of potential replacements as resistance builds up. But we see a deeper lesson, good for all science. There is nothing so cooperative, so international, as a library or a database. Its contents cut across divisions of nationality, race, class, time even. If we are to survive the antibiotics crisis, and many other looming threats, we will need this approach more. Something to think about when some journalist or politician turns a group of people into “others”. Maybe we can learn something from them, instead.

[1]https://www.theguardian.com/society/article/2024/jun/05/ai-antibiotic-resistance

#antibiotics #AI #microbiology #research #database

How to help viruses live longer and kill more of us

Illness is like gambling. It’s all about statistics. The longer you stand near a virus/bacteria/fungus, or whatever, the higher are your chances of contracting it. So what if the air we breathe becomes ever more virus-friendly, helping them to live longer and infect more people? No, we hadn’t thought of that either. But read this CO₂ boosts airborne Viruses from Nature Briefings:

Carbon dioxide is often used as a proxy for healthy air — such as when CO₂ monitors are deployed to determine COVID risk. Now it seems that high levels of CO₂ actually help viruses to survive in the air. Using an innovative instrument to study airborne pathogens in unparalleled detail, researchers determined that CO₂ appears to help keep the particles we exhale at a pH-level that is more hospitable to viruses. “By increasing the CO₂ in the air, we’re getting rid of a natural means by which viruses become inactivated,” said environmental chemist Allen Haddrell, who led the new work. “It’s fascinating, but it’s also horrifying.”STAT | 10 min read

The link from Stat, by the admirable Megan Molteni is so good that we’ve provided a double link [1]

Are all crises interlinked? We’ve run other blogs here suggesting, for example ,the link between habitat destruction and the release of new infectious diseases. How the floods brought on by global warming have acted as huge artificial vectors for old diseases like malaria. Or even that a steady rising background level of CO₂ could have disastrous consequences for health (LSS passim) This is just a further indication that this gloomy thought may be right. But any parent or grandparent reading this would do well to find out more.

[1]https://www.statnews.com/2024/06/04/co2-ventilation-research-virus-airborne-life-haddrell-celebs/?utm_source=Live+Audience&utm_campaign=2a53b9910b-nature-briefing-d

#global warming #climate change #disease #public health #virus #bacteria

Good news on antibiotics coming thick and fast this spring

More good news on antibiotics research for you today, gentle readers. And this time it’s the subtlety of the extra thinking that has captured our attention. Up to now antibiotics-and many other therapies- have been more of a bludgeon than a rapier. Yes they do a lot of good, smashing away dangerous bacteria from your system. But they can do a lot of bad, by killing all those beneficial bacteria in your biome, which help you digest your food, as well as performing many other Good Works. But what if we could design an antibiotic which only does the good stuff, while keeping harmful side effects to a minimum? According to Nature Briefings, Smart Antibiotic spares the Microbiome, lolamicin may do just that:

An antibiotic called lolamicin targets disease-causing Gram-negative bacteria without disturbing healthy gut bacteria. Broad-spectrum antibiotics against these pathogens wreak havoc on the gut microbiome and can allow potentially deadly Clostridioides difficile to take over. Mice infected with antibiotic-resistant Gram-negative bacteria survived after being given lolamicin, whereas almost 90% of those that didn’t receive the drug died within three days. Lolamicin did not seem to disrupt the gut microbiome and spared mice from C. difficile infections.Nature | 4 min read
Reference: Nature paper

For more stories like these, update your preferences to sign up to our free weekly Nature Briefing: Microbiology.

(We took their link a little further today, so you can see that they offer a special service for those who want to follow this whole trope more closely)

As you know we at LSS tend to be a tad wary of huge new, all-field-encompassing, breakthroughs. What we like is when someone tweaks existing learning in a small but significant way. This seems to be one such, and good luck to the researchers concerned.

#antibiotics #microbiology #microbial resistance #research #microbiology

Nature Briefings upsets the apple cart. Big Time

What if everything you learned forty and fifty years ago was wrong? Where would you be then. Something a bit like that happened to us this week when we read this piece from Nature Briefings, Bizarre bacteria scramble workflow of life

Bacteria have stunned biologists by reversing the usual flow of information. Typically genes written in DNA serve as the template for making RNA molecules, which are then translated into proteins. Some viruses are known to have an enzyme that reverses this flow by scribing RNA into DNA. Now scientists have found bacteria with a similar enzyme that can even make completely new genes — by reading RNA as a template. These genes create protective proteins when a bacterium is infected by a virus. “It should change the way we look at the genome,” says biochemist and study co-author Samuel Sternberg.Nature | 4 min read
Reference: bioRxiv preprint (not peer reviewed)
For more coverage of the most abundant living entities on our planet — microorganisms — and the role they play in health, the environment and food systems, update your preferences to sign up to our free weekly Nature Briefing: Microbiology

When we were young, there was a central doctrine in biology. Information was stored in genes, deep in the cell nucleus. These were made of DNA. This information was turned into RNA, then used to make proteins. The DNA code was unchangeable, inviolate which made the operations of natural selection all the easier to facilitate. If a large cat suddenly developed DNA to give it stripes, then it could hide better in the jungle, and pass on more copies of the DNA. Hence tigers evolved. Job done. To think the DNA could be modified by some environmental feedback was not only Lamarckian heresy, there was no obvious mechanism by which it could come about.

Now we are Not saying that the above discoveries overthrow the central tenet. Not yet. But remember how the Michelson Morley experiment in the 1880s posed a deep, unanswerable question at the heart of physics which was not fully resolved until Einstein came along a generation or so later. And we are certainly not going to make impulsive conclusions . But our story today, combined with all the recent advances in Epigenetics, do suggest however that the old model is now awaiting a major rethink.

[1]michelson morley experiment##biology #cell biology #dna #rna #darwin #lamarck #bacteria #protein #gene

Will Wetlands save the World?

Every so often we receive a well-meaning, but slightly plaintive communication from people who yearn for improved methods of carbon capture, by which they mean huge industrial undertakings not unlike the filthy power stations which they are meant to replace. “Good point!” we cry “but it’s going to take years to perfect the technology. Then scale it up. By which time it will all be much too late.” What if there are far more efficient carbon capture stations already out there, cheap to develop, quickly scalable, which might in addition act as huge natural flood defences. Before you reply “too good to be true” have a look at these two stories about wetlands which have recently crossed our screens.

Mangroves in Brazil Brazil has had more than its fair share of bad ecological news recently, what with chopping down massive swathes of the Amazon and so on. But now Mr Bolsonaro has gone, we are able to report a more hopeful story, by Maurice Saverese via Apple News.[1] A new project in the Guanabara Bay, near Rio De Janeiro has planted up to 30 000 mango trees. Not only will these act as a massive flood defence, stabilising the coastline against erosion, but will provide a valuable new source of income to local fisherman as crabs and other economically valuable species return to the healthy waters.

Wetlands in Washington Since the 1780s the USA has lost about half of its wetlands. Which is a shame because although wetlands comprise just 10% of the world’s surface, they contain perhaps 25% of its soil carbon. That at least is the estimate of a team from Washington University, who are investigating the potential of vast carbon-capturing wetlands beneath the rain forests of the Pacific Northwest [2] You’ll have to get past the paywall for this one from Natalia Mesa of the Atlantic, again via Apple News. but it’s well worth it. Because the rainy north west also includes parts of California, Oregon and much of western Canada. If the Americans can only keep out Trump and his supporters, then once again they might have saved the planet, this time on a massive scale.

Sometimes the answer lies not in doing new things, but adapting old ones to new uses.

thanks to P Seymour

[1] https://www.pbs.org/newshour/world/rio-de-janeiro-bay-reforestation-shows-mangroves-power-to-mitigate-climate-disasters

[2]https://www.theatlantic.com/science/archive/2024/05/wetlands-forest-unmapped-carbon-washington/678513/?utm_source=apple_news

#wetlands #carbon capture #mangroves #washington state #donald trump

Nicola Davis leads the way on antibiotics journalism

One of our stated purposes at LSS is to scan the media feeds, both news and scientific, to bring you the best possible stories on the continuing crisis caused by antibiotic resistant micro-organisms. That’s superbugs in short. And one journalist whose work we have featured time and again is the indefatigable Nicola Davis who writes for the Guardian. Well today she has done it again, in an intriguing new take. It’s going to take quite some time before new drugs can be tested and made ready. Meanwhile people are starting to die, in quite large numbers. What can we do? [1]

Well, quite a lot according to Nicola. Like a good journalist, she starts by reprising how truly awful the current situation is. The figures are eyewatering. To take 2019 as a good pre COVID baseline, antibiotic resistant microorganisms were implicated in 4.95 million deaths, with a definite attribution possible in 1.27 million cases. So are we just going to wait, to sit around and wring our hands until new antibiotics come along? No, quite a lot is possible in the meantime, Citing the work of Professor Laxminarayan of Princeton, she writes:

……………AMR-associated deaths in LMICs could be cut by 18%, equivalent to about 750,000 a year, through three key steps……..The team team suggests an estimated 247,800 deaths are preventable through universal access to clean water and improved sanitation and hygiene, while 337,000 deaths could be prevented through better infection prevention and control in healthcare settings…….Another 181,500 deaths are preventable by means of childhood vaccinations,

But Nicola’s article, and the link she provides to The Lancet, are far more detailed [2]

An our thoughts? After so many years bashing you on your heads, gentle readers, we see actual grounds for optimism First journalists like Nicola are getting on to this.( See also MD of Private Eye and Stacey Liberatore of the Mail) Secondly, there’s nothing so likely to wither effort as the thought that we are powerless. Beyond hope. Passive. And as this article shows, nothing could be further from the truth.

[1]https://www.theguardian.com/society/article/2024/may/23/huge-number-of-deaths-linked-to-superbugs-can-be-avoided-say-experts

[2]https://www.thelancet.com/series/antibiotic-resistance

#superbugs #antibiotic resistance #pandemic #health #vaccination #sanitation #preventive medicine #nicola davis #md private eye #stacey liberatore

Are Co operatives making a come back?

History: it’s a funny, cantankerous old thing. Any action seems to produce its opposite. It may be happening again. Starting in the South east London Borough of Lewisham.

As every schoolchild knows, the Industrial Revolution produced an atomised, nihilistic society where the overwhelming majority lived in slums, and worked every hour for pitiful wages. The new metropolises like Manchester drew waves of strangers into disease ridden slums. The results were far indeed from the hopes of the philosophers of the Enlightenment whose heady thoughts on free markets had kick-started the whole sorry mess. Yet somehow, in those desperate places, people began to come together. New community organisations began to thrive. Methodist Churches were one example. Trade Unions another. There were things like Working Mens clubs and libraries. Building Societies. And of course the Co operative movement, where poor people could club together to make their purchases at their own shops.(overseas readers might like to know it still exists today, but is barely differentiable from any other hight street grocer) Each in turn contributed to the foundation of the Labour Party. Fast forward one hundred years, what with the collective experience of wars and depressions and most people assumed that collective actions were the optimal solutions to most of our problems.

Following the world crisis of 1973-74,everything changed. Free marketeers saw their chance to exalt the individual above all else. Writers like Hayek and Friedman paved the way for politicians like Thatcher and Reagan. Even popular books like The Selfish Gene could be read in such a way as to exalt the cult of the sovereign individual . Down with the state! Taxes were an imposition on human liberty! Although the adherents of such doctrines could never explain how the National Health Service was Communist, but the Army was not, the individualistic tendency bit deep into our lives and culture. With the results we see today. Once again, atomised communities. Poverty. Capital in the hands of a very few, who invest with a grudging reluctance that would make Mr Gradgrind envious indeed. Pollution, rack rented slums, and growing poverty, especially among children.

Once again there seems to be a reaction setting in. Starting at the bottom, people are beginning to come together in groups to save what is important to them, from the all -dissolving solution of unrestricted free markets. As Kemi Alemoru explains in this article for The Standard [1], it seems to begin around the need to preserve collective things like music venues and pubs. Her piece treats the Southeast London area of Lewisham as a sort of living field experiment. But the thought strikes us. If it works for things like those, why not for bigger ones? Like housing. Controlling air pollution. Making roads safe. Even, whisper it, schools and collective education.

To borrow from another area of learning “every action produces an equal and opposite reaction. Maybe this is the start of one.

[1]https://www.standard.co.uk/homesandproperty/property-news/the-battle-for-lewisham-how-coops-are-reinvigorating-communities-b1157728.html

#free markets #collectives #cooperatives #hayek #keynes #methodist #coperative society #friendly society #trade union

The Guardian takes the lead on antibiotics. Make your newsfeeds do the same

LSS readers, being an informed and engaged bunch, will each of us have our favoured little cluster of news and media feeds we go back to time and time again. Regular readers of this blog will have largely discerned what our little regular handful comprises. And among them is the famous UK platform The Guardian.

Recently they stepped up to the plate with an interesting take on the work of Dame Sally Davis, which we noticed on this blog earlier this week(LSS 13 5 24). We also wrote personally to the journalist concerned to thank them. Lo and behold, the Guardian followed up on Friday with a major leader article on the whole subject, pushing the new UN initiative, and hymning the praises of Dame Sally[1]. As is only right and proper. Dare we, could we, hope that our letter of praise to the first prompted the second? Unlikely. But it got us thinking.

Readers, there are several hundred of you now, scattered around the four corners of the globe. From the lonely coves of Patagonia to the bustling metropolises like Barcelona, each and every one of you will have mediafeeds. You know, former newspapers, TV stations, news sites, visual channels and all that. Each one of them will have an editor. Each one of those editors will be hungry to catch the latest trend, to find a story, to get ahead of the competition. So why don’t we give them a story? Why not write a brief note now to two of your favourite news supremos? You know the themes to riff on. Antibiotics are running out. Not enough new ones are being developed. If this goes on, all modern medicine and surgery will revert to the dark ages. And so it goes. You’re an intelligent lot, we can’t tell you how to write it.

But write it you could, and send it. Each one in less than two minutes. And it could, it might, just make a difference. Over to you.

[1]https://www.theguardian.com/commentisfree/article/2024/may/17/the-guardian-view-on-antimicrobial-resistance-we-must-prioritise-this-global-health-threa

#microbial resistance #antibiotics #medicine #public health #dame sally davis #microbiology #pandemic #e.coli

What if you could detect cancer before it was cancer?

If you want to cure a cancer, identify it as soon as possible. That’s long been a truism among medical experts. But what if your techniques were so advanced that you could identify the precursor steps to cancers before they had even started to initiate a tumour in someone’s body? According to an article by Anna Bawden and Nicola Davis of the Guardian, the first steps to do just that are now feasible, as two studies suggest.

Instead of simply rehashing their excellent prose[1] upon which we urge you to click, we’ll provide a brief summary, and raise some interesting and rather hopeful observations. The first looked at 44000 samples from the UK Biobank. 618 proteins were identified, which could then be linked to 19 different types of cancer. In a different take on the same trope, a second study using a whopping 300 000 samples came up with 40 different proteins linked to 9 different types of cancer. We dare not comment, but dare to observe:

1 It’s amazing the amount of new discoveries you can make just by crunching data. As AI comes into its own, it should be able to handle bigger and bigger numbers. Think of alpha-fold, if you don’t believe us-and that quite old hat by now!

2 Talking of hats, let’s all take ours off to Cancer Research UK, whose steady, patient work down the decades has not only provided a congenial ecosystem for researchers, but also a steady stream of reliable income for the planners and the finance people. Come on, hands in pockets, please! [2]

3 We were impressed that the results were already identifying different types and subtypes of cancers. It suggests a subtlety of technique which has probably only just got going.

and, finally:

4 The bigger the database, the better. Without belittling today’s researchers and journalists, these are still relatively small numbers. Imagine an AI supercomputer tirelessly combing the biological samples of every human on the planet. And maybe their pets. Would might it not find.

Oaks and acorns times, gentle readers. Keep donating.

[1]https://www.theguardian.com/society/article/2024/may/15/proteins-blood-cancer-warning-seven-years-study

[2]https://donate.cancerresearchuk.org/donate?gclid=cf2827b39f4311a97ff841f589e5c887&gclsrc=3p.ds&utm_source=bing&utm_medium=cpc&utm_campaign=IMP%20%

#database #cancer #medicine #AI #protein #gene #prediction