Friday Night Feast of Fun: Strawberries, cream and what to drink

As May rolls into June, England hits peak summer. All those muddy football players yield to natty cricketers and immaculately coiffured green wickets . Gardens fill with flowers. At Wimbledon and a thousand other places, the air is filled with the thwack of racket on balls. Nothing captures the ambience like a well-turned bowl of strawberries and cream, that near quintessential accompaniment to a day out at the tennis or the Derby. Ok there’s one rival, but we’ll be doing that next week

People have been eating strawberries as a summer dessert since at least the sixteenth century. However the big ones we take for granted today didn’t really come about until the middle of the eighteenth, [1] as a result of a wheeze by an enterprising Frenchman called Amédée-François Frézier . Frankly we found all the botany and genetics in the Wiki article a little cognitively challenging: suffice to say he crossed a North American version with one from the southern continent to produce that plump juicy berry which not only tastes good, but is admirable to look at. And our recommendation to go with them? Cream, single or maybe double. Not ice cream, not clotted, not that funny squirty stuff that comes out of tins from some of our cheaper supermarkets. And certainly no sugar. Just good, old fashioned cowsmilk cream. Gottit?

Now for the really important question: what to drink? Our Intelligent researchers came up with the following list, each perfectly tailored to a different aspect of your dish. Bowl. Whatever.

 Sauternes – A classic French dessert wine with honeyed sweetness that complements the creaminess.

Coteaux du Layon – A Loire Valley wine with citrus and honey notes, perfect for the richness of cream.

Pinot Noir Rosé – Light and fruity, with strawberry and peach notes that enhance the fresh berries.

Demi-Sec Champagne – The bubbles and brioche flavors contrast beautifully with the sweetness of strawberries.

Riesling (Spätlese) – A German Riesling with floral and orchard fruit notes that highlight the strawberries.

Prosecco – Slightly sweeter than Champagne, making it a great match for ripe strawberries and cream.And much, much cheaper!

Gewürztraminer – Aromatic and floral, with lychee and ginger notes that pair well with strawberries.

And with the end of that list, may we wish you another happy Friday night feast.

[1] Strawberry – Wikipedia

#strawberries #cream #summer #wine #garden #tennis #cricket #wimbledon

AIDS breakthrough shows what science can do

We now live in an age when science (and the rational habits of mind it depends upon) is under attack. Heirs to the rational tradition have always had to live with religious fundamentalists who deny inconvenient truths like evolution. But nowadays attacks come thick and fast from those who wish to deny climate change, the dangers of smoking, the efficacy of vaccines and much besides. From people who nevertheless cheerfully accept other scientific findings which suit them. So, just to redress the balance we thought we’d showcase this breathtaking new advance in AIDS research which, for the first time, holds out the hope of a permanent cure.

It comes from Kat Lay of the Guardian,[1] reporting the work of the Peter Doherty Institute in Australia.[2] The background will be familiar: the great evolutionary survival trick of the HIV was to bury itself deep in certain white blood cells of the immune system, where it was immune to our attack. In the words of Kat:

In a paper published in Nature Communications, the researchers have shown for the first time that mRNA can be delivered into the cells where HIV is hiding, by encasing it in a tiny, specially formulated fat bubble. The mRNA then instructs the cells to reveal the virus. First AIDS was a death sentence: then it could be slowed with drugs. Now at last comes hope of a real cure for its 40 million or so sufferers

Science itself is a process, not a monolithic entity. It evolves, refines, and corrects itself over time. But when people selectively accept only the parts that align with their worldview, they undermine the very foundation of rational inquiry This kind of cherry-picking often stems from cognitive biases, ideological commitments, or economic incentives. Climate change denial, for example, is frequently tied to political or financial interests, while opposition to vaccines or smoking regulations can be fuelled by misinformation or personal convenience. But the deniers should remember one thing: if they do decide to overthrow the rationalists, will they put anything better in our place?

Truth is compared in Scripture to a streaming fountain; if her waters flow not in a perpetual progression, they sicken into a muddy pool of conformity and tradition.”

Milton: Areopagitica

[1]https://www.theguardian.com/global-development/2025/jun/05/breakthrough-in-search-for-hiv-cure-leaves-researchers-overwhelmed?CMP=Share_AndroidApp_Other

[2]https://www.doherty.edu.au/

#HIV #AIDS #disease #mRNA #medicine #science #climate change #smoking

Why we agree with Liz Truss

Its not often that we agree with Liz Truss, our erstwhile Prime Minister. The one who, you will recall, received such harsh criticism for her brief stewardship of the British Economy. And who has since spent their time since trundling the rounds of right wing meeting rooms and assembly halls reprising her old lines.. Typical of her critics is one Rafael Behr of the Guardian [1] who asseverates:

Apparently her big lesson from government was” to learn that British institutions have been captured by a leftist doctrine and that they “hate western civilisation”. She couldn’t possibly counter this threat …..because supposedly the real power was wielded by a well-financed “globalist network”, operating through such engines of anti-democratic subterfuge as the International Monetary Fund and the World Health Organization.

Harsh words, bro! In one sense we think Behr is right. There are no conspiracies .Human beings do not have the cognitive ability nor attention span, nor ability to keep their mouths shut, to organise any worthwhile conspiracy. But there are people who think and act like globalists. Because it is their job to turn a profit for their shareholders. From everyday things like drinks and clothing, to cars and IT successful corporations operate at a global scale. Almost half available investment funds are now held in shadowy entities like sovereign wealth funds, hedge funds, family trusts and shell companies. Where Truss and co are right is that they are acutely aware of this at a subconscious level. And see the dangers more clearly than most . That the nation state is rapidly ceasing to be an effective vessel to effect the dreams and aspirations of its members. Hence the inefficacy of voting and the despair in democracy.

It’s happened before. Think if you were an inhabitant of a small but substantial little state like Mercia in the Middle Ages. Around the time it was being slowly absorbed into England. Suddenly your King has to worry about foreigners in far off places like Sussex or the City of London. Suddenly your church must accommodate the views of parishioners in Canterbury and York as well as those in Litchfield. Suddenly power is exercised through a well financed English network through such subversive organisations as the Church and the Assize courts. It’s easy to see how such changes may seem unfamiliar, bewildering: frightening even. This is the problem of our time too. Truss and her kind should not be laughed at. Like the canary in the coal mine, their fears should be taken very seriously indeed. Or we shall all blow up,

https://www.theguardian.com/commentisfree/2025/jun/04/liz-truss-british-politics-nigel-farage-kemi-badenoch

The spirit of Liz Truss, ridiculous but relentless, still stalks British politics | Rafael Behr | The Guardian

#gloablisation #democracy #capitalism #nationalism #nation state #corporation #liz truss #finance

Renewable energy from seaweed Now there’s a thought

If we are going to get through the current climate crisis, and come out alive at the other end, we ‘ll need to consider every new idea, however outre it may sound at first sight, Which is why we want to showcase, via the Conversation,[1] the work of Mike Allen , Professor of Genomics at the University of Exeter and founder of SeaGen,[2] a company which has the courage and vision to think differently. ]For Mike thinks that by using robotics, he can harness the enormous biomass of seaweed in the sargasso sea, and other places

Now we’ve always been pro- seaweed here. Veteran readers may recall our promotion of the new Sussex kelp forest, both on this site and in articles in local newspapers and websites [3] and we certainly talked about how the stuff, especially kelp, could be a source of all kinds of useful things like food and fertiliser. But as his article and website makes clear, Mike is taking this to a whole new level. By using autonomous robotic systems, the harvesting and processing of the weeds can be done on an ergonomic and industrial scale.

We have no financial or any other connection to this man or his company. But we are massive fans of the hopeful start-up. Because we believe that progress, real progress grows form that complicated network of new companies , university departments, government agencies and anonymous little industrial estates where the real dreams of the future are born. We’ve done stories like this before, and will do more in the future. If you really need a declaration of interest it is this: they may help us to survive.

[1]https://theconversation.com/how-seaweed-is-a-powerful-yet-surprising-climate-solution-251195?utm_medium=email&utm_campaign=Latest%20from%20The%20Conversation%20for%

[2]https://www.seagen.io/

[3]https://www.sussexgreenliving.org.uk/sussex-kelp-forest-leads-the-way-by-keir-hartley-first-published-in-west-sussex-county-times/

#seagen #seaweed #sustainability #robotics #ocean #climate change

Bit of a round up: Yes Men, Fusion, Bowel Cancer, molecular shuttles and seething in the Sahel

Overwhelmed by a huge flood of suggestions , the only way we could cope was to pull them into this handy easy to access guide to some of the most significant happenings of the week. You don’ have to click on all of them

Will the Yes men Bring Down Donald Trump? As organisations get successful they attract more people who are adept at climbing the ladder rather than doing the job. The USA is somewhere near peak Trump at the moment. The Conversation warns how bad advice could end all in tears

https://theconversation.com/trump-surrounds-himself-with-sycophants-its-a-terrible-way-to-run-a-business-and-a-country-257391?utm_medium=email&utm_campaign=Latest%20from

Fusion on Trent The person who sent us this idea has had to endure our enthusiasm for nuclear fusion for more than fifty three years, despite the fact that it hasn’t worked for fifty of them. Now all that may be about to change in Nottinghamshire in the UK as The I newspaper explains https://inews.co.uk/news/politics/limitless-clean-energy-nuclear-fusion-3711971

^{thanks to P Seymour} ^{via Apple News}

Weighing the risks of bowel cancer Inequality leads to poor diets. Poor diets lead to obesity. Obesity leads to bowel cancer. How ironic, therefore, to see a riff on this theme in the Mail, of all places. But there it is so, there you go, as they say(that’s enough cliches-ed)

https://www.dailymail.co.uk/health/article-14756279/Doctors-discover-vital-new-clue-search-cause-mystery-bowel-cancer-explosion-50s.html

Shuttle and open We’ve riffed a bit ourselves here about the blood brain barrier over the years. It’s a pretty tough problem for those who would like to treat various disorders of the central nervous system. Now new hope come sin the form of molecular shuttles as Nature Briefing explains

To reach the brain, drugs must pass through the highly-selective blood-brain barrier. Large molecules, such as antibodies, don’t cross easily, if at all. Now, small chemical tags that can ‘shuttle’ drugs across the barrier are offering a way forward. Several such shuttles, which take advantage of natural transport systems, are in the works. Some have already been trialled in rare diseases, with signs of success. The field is in its infancy, but these shuttles promise to revolutionize treatments for diseases from Alzheimer’s to cancer.Nature | 10 min read

When scientists have a bone to pick It is an invariable law in paleontology , especially of the human kind, that the rancour of the disputes between its protagonists is in inverse proportion to the numbers of remains they have to work with. There is no better example of fear and loathing than the disputes over the bones of Sahelanthropus, the famous Toumai, which was once hailed as the uber-ancestor of us all. Before you hand over the world to an Aristocracy of the Educated, as some advocate, read this.

https://www.theguardian.com/science/2025/may/27/the-curse-of-toumai-ancient-skull-disputed-femur-feud-humanity-origins?CMP=Share_iOSApp_Other

#cancer #bowel #nuclear fusion #dona;d trump #health #medecine #alzheimers #sahelanthopus

Simon Kuper on how to Make the Transition to Intelligence and Wisdom

One of Saturday morning’s great pleasures, an hour or so before Spanish class, is to settle down in Costa with a coffee and a hard copy of the Financial Times. And one of the best writers in that journal is Simon Kuper. He’s clear, he’s brief, he deals in the currency of short sentences and defined concepts. He’s also a polymath, covering subjects as diverse as politics, urban planning and football(he’s even done a very workmanlike guide to the affairs of Barcelona FC . [1] In fact, he’s exactly the sort of writer we ought to showcase here, because he believes in our core LSS values of evidence, reason, and reserved judgement.

How appropriate therefore that his last column was called Seven Intellectual Habits of the best thinkers., for there can be no better short guide. [2] The problem is that access is behind a paywall. As LSS is such an important institution, and our readers so avid for wisdom, we rang the Editor of the Financial Times a to demand that this be lifted as a Special Case., and that he/she/ they might like to buy us lunch to discuss the matter further. The young person on the switchboard thanked us very much and promised they would call us back. So far they have not done so(that was three days ago) but doubtless there were other callers. So, while we are waiting, we thought that we could offer you a distilled reproduction of Simon’s thoughts:

1 Read Books ” Their complexity is a check on pure ideology” People who simplify the world are the ones who fall for conspiracy theories or the offers of charlatans.

2 Don’t use screens much Apparently, biochemist Jennifer Doudna, who invented CRISPR technology gets her best insights when she’s out weeding her tomato plants. Obviously you have to use screens a bit, or you couldn’t read this! But we get Simon’s drift: a little screen time is a lot.

3 Do your own work, not the world’s The same Doudna got a gig at Genentech, leading their research. She lasted two months before hightailing it back to Berkeley where the true intellectual freedom led her to the Nobel Prize. We agree: people who spend all their time on office politics actually accomplish very little that is either interesting or of value.

4 Be multidisciplinary Kuper cites the examples of Hayek, Godel, Van Neumann and others who all studied one thing, trained in another and did their best work in a third. Daniel Kahneman is cited as another multi-disciplinarian polymath of formidable intellectual power. Rather worryingly, our AI system has set his book as homework for us. Where’ are John and Sarah Connor when you really need them?

5 Be an empiricist who values ideas Kuper cites the case of Isaiah Berlin and his marvellous work the Hedgehog and the Fox , a masterpiece of political philosophy. Incidentally Winston Churchill got him mixed up with Irving Berlin and invited the wrong one to dinner.”My British Buddy” as Berlin himself would later remark in song.

6 Always assume you might be wrong Yep: in this country we are still trying to repair the effects of the blissful certainties of Brexit. You will doubtless have examples from your own lands

7 Keep learning from everyone “Only mediocrities boast as adults about where they went to University at 18.They imagine that intelligence is innate and static. In fact people become more or less intelligent through life depending on how hard they think. The best thinkers are always learning from others, no matter how young or low status” We quote Kuper rather fully here as the first part seems one of the most admirable and accurate summaries of the sorts of people one met on a daily basis during long decades in the Scientific Civil Service. Now there’s intelligence indeed.

[1]https://www.worldofbooks.com/en-gb/products/barca-book-simon-kuper-9781780725543?sku=NGR9781780725543&msclkid=6c7699156a7f1cc4c9f2f1238

[2]https://www.ft.com/content/c42cb640-a03c-441b-868f-d1a92d78bcb7

#wisdom #intelligence #FC Barcelona #isaiah berlin #daniel kahneman #thinking #financial times #simon kuper

Brand New Antibiotic- a last hurrah for Harvard University?

Today we are brining you news of one of the best stories we’ve covered in many a long year of campaigning. Today Hofman-La Roche have announced late stage trials of a brand new antibiotic called Zosurabalpin. If all goes well it could be ready for clinical practice very soon. [1] We’ve been following this for a while now (LSS 1 4 24; The Conversation 5 1 24)[3] : it’s extraordinarily gratifying to see the long process so near to fruition.

There’s much to be excited about at a pure scientific level. Zosuralpin is designed to go after the particularly deadly bacterium Acinobacter baumannii, which can kill up to 50% of its victims. It’s one of those gram negative ones with a double cell wall. Zosurabalpin tackles this in a new way, specifically targeting lipopolysaccharides which the organism uses to maintain the integrity of those walls. For the first time since we entered the world of antibiotics, a gram negative bacteria, the ones which used to really concern the great Professor Garner and the other founders hasa been cornered. But that’s not our main learning point today.

Because Hofman did not develop this alone. Like all modern research it was international and collaborative. The international partner they chose was Harvard University, the oldest in the United States Of America, and one of the best in the world. Until recently. For as astute readers will know, this institution has recently been on the end of a tremendous kicking from President Donald Trump (pictured above with some of his supporters) and other members of his government. We are not certain yet if this will end terminally for Harvard. But at the very least, the time they spend defending themselves from their barbaric assailants would be time better spent developing new antibiotics. It’s worth balancing consequences like that against the savage impulses of the unreasoned, the unlearned and the unintelligent.

[1]https://www.ineosoxford.ox.ac.uk/news/new-antibiotic-class-shows-promise-against-drug-resistant-bacteria

[2]https://www.lbc.co.uk/news/health/new-antibiotic-could-defeat-resistant-superbug-human-test-zosurabalpin/

[3]https://theconversation.com/new-antibiotic-zosurabalpin-shows-promise-against-drug-resistant-bacteria-an-expert-explains-how-it-works-220564

#antibiotic resistance #hofman La roche #zosurabalpin #gram negative #medicine #healh #harvard #donald trump #harvard

Is this a collapse of Civilisation?(they’ve happened before)

Do Civilisations collapse? Do elaborate trade networks fall apart? Giant cities turn into uninhabited ruins? Ancient systems of law, education and custom vanish entirely ? Leaving nothing but an illiterate dark age, racked by violence and disorder? Yes, they can. We’ve alluded once or twice here to the collapse of the Greco-Roman world (LSS 10 3 21; 17 12 22) Professor Harper makes a convincing case for climate change and disease pandemics as the causes of that one. We in western countries are haunted by the Fate of Rome; it was relatively close in time. But there have been others.

The Bronze Age collapse 1200 BCE is further back in time, and has left fewer records, That it occurred there is no doubt. [2] For several centuries a large network of trade had built up across regions which we now call the Near East and Europe. There were cities, elaborate systems or wring and belief, Considerable prosperity; for some, and by the standards of the time. Around 1200 BCE all this was suddenly and violently cast down, with waves of wars and invasions. It took four or five hundred years at least for order of a sort to be restored and progress to resume, Further afield , the collapse of the Shang dynasty in China (c. 1050 BCE) and the Olmec Civilisation of Central America (c, 400 BCE) are chilling reminders that civilisational collapse is not unique to the West.

Art this distance in time it is possible to see a pattern. The natural human instinct to trade and ma make a bit of spare cash gradually leads to the growth of larger and larger cities. These require common systems of law to maintain the rising levels of prosperity. The resulting peace is very pleasant to live under for a few generations. But lurking in the trade routes are the pandemic diseases which can shake societies to their foundations. When you combine that with the ability to cause massive changes in climate(no one would dream of blaming the Myceneans for that!) the potential for sudden catastrophic failure is multiplied exponentially.

Such an event would confront the educated classes(of which the readers of this blog are such valuable members) with a number of inconveniences. We will look at possible responses in the next few blogs,

[1]Kyle Harper The Fate of Rome Princeton University Press 2017

[2] https://en.wikipedia.org/wiki/Late_Bronze_Age_collapse

#olmecs #shang dynasty ##kyle harper #pandemic #climate change #global warming #collapse

Another big Thank you-and a small musing

Another big thank you to readers, commentators, and the indefatigable ideas people including our researchers and fellow members of the Editorial Board. We are indeed getting mote readers, more followers and above all more likes and comments. All of which keep us in mid season form, as Wodehouse would have it: full of the joys of nature’s second season, with the old ginger whacked up absolutely to the top of the tank.

If you can bear it, we thought we’d throw away a couple of lines on who is reading, and about what. Unitedstatespersons make up the biggest contingent. Odd when you think this stuff is tapped out in England. Astute readers will not be much surprised to note that English speaking countries such as the United Kingdom, Canada, Australia etc joining the line up roughly in proportion to the old demographics. By the time we get down to the more far flung outposts however, the figures do not look so good. Why so few responses from St Helena or Pitcairn Island? We don’t know. But we’re working on it. As for the rest of the world: India always big- a country on the rise with a strong science base, and a large number of English speakers. We had hoped for more from the Spanish Speaking world. Sadly our command of that language is not quite good enough to write articles in it. But if any of you amigos want to comment in the language of Cervantes, we’d love to hear from you. After that, many countries. China figures above the random level; we’d love to know which latter day Kong Qiu peruses our offerings, and where they work.

And what are you reading? The one where we suggested that the President of the United States was a closet Socialist is cantering in at the top of the field everyday. It was meant to be more wry and ironic than a serious discourse on Political Economy. But some like it- a lot. After that- human evolution seems quite popular. Our own idees fixees of antibiotic resistance and climate change are high in the betting, but not always favourites. We need to do more there, we think.

Overall, since we started-progress. Like that new bloke they have at Manchester United, who is being given time. Give us some more too, The world is a big bad place, and once again to paraphrase the Immortal Wodehouse; we thinking Johnnies need to stick together.

THE BOARD

#United States #United Kingdom #China #india #antibiotics #climate change #science

Genetics: a whole new perspective on human evolution?

Every so often it pays to look at the same problem from a completely different perspective. For the past 57 years or so we have been collecting and grading reports of human fossil bones and old tools the way that cricket fans collect the records of every game their team has played. But today, with the help of one or two of our redoubtable AI chums, we present a whole new perspective on the old story. Much of it is locked in our genes and has been uncovered by the amazingly intelligent efforts of genetics researchers.

Their discoveries are so extensive that there is too much for a tiny blog: so we’ve summarised the findings below. But look at the timing of the mutation in the famous FOXP-2 gene, and the human species which were running around at the time. True humans fall naturally into two groups. One one side, big -brained essentially modern forms : Homo heidelbergensis, Denisovans, Neanderthals and Homo sapiens. On the other? Poor old Homo erectus, significantly smaller-brained and with a much more exiguous technological and cultural life. In this light, the mutation is almost eerily coincident.

Of course the time lines of the mutations are a bit open ended; but the picture from the fossils is a bit vague too. What really impresses us is the way that, give or take an Ice Age or two, the geneticists provide independent validation of the fossil finders’ picture overall. And there’s an even deeper lesson. The same truth can be seen in two completely different ways, Like those night sky apps you can get which can show the same firmament through visual light, x-rays, microwave or radio waves; whichever you choose. Next time you argue with someone ask yourself and them: are we really talking about two different things? There’s a cognitive advance for the ages.

_{all based on peer reviewed or reputable pre pubs sources (microsoft assistant)}

Time (Million Years Ago)	Key Genetic Mutation	Hominins Present
~6 MYA	ARHGAP11B (linked to brain expansion)	Sahelanthropus tchadensis (early bipedal ape-like species)
~4.4 MYA	Changes in genes affecting bipedalism	Ardipithecus ramidus (early upright walker)
~3.3 MYA	SRGAP2C (enhanced neuron connectivity)	Australopithecus afarensis (Lucy and her relatives)
~2.4 MYA	MYH16 (jaw muscle reduction, allowing brain growth)	Early Homo habilis (first tool users)
~2 MYA	SCN9A (pain sensitivity mutation)	Homo erectus (first hominin to leave Africa)
~700,000 YA	FOXP2 (language-related gene)	Homo heidelbergensis (ancestor of Neanderthals and modern humans)
~900,000 – 4.5 MYA	Chromosome 2 fusion (reduced chromosome count from 48 to 46)	Various early Homo species
~300,000 YA	Microcephalin & ASPM (brain development genes)	Early Homo sapiens (our direct ancestors)

#genteics #paleontology #tools #fossils #anthropology #human evolution